I have no allegiance to any particular strategies. I only want to use what makes sense, that does not harm the patient, and makes them better. Thank you for your support.
@@DrCaseyPeavlerwhat are your thoughts about Georgi Dinkov’s theory and approach on cancer? He uses B1,B3,B7 and aspirin to help mitochondria work properly again and restore cells to a non cancerous state. It’s interesting how similar yet very different his theory and treatment is compared to Dr Seyfried’s. Maybe melatonin would help both approaches?
A very timely video indeed with the safe and effective taking its toll. Thank you for this. ❤ Glycine and cysteine (Glycine found in collagen, cysteine found in NAC) should be avoided in leukemia patients. Leukemia cells use GSH (Made with cysteine and glycine) to protect themselves.
@@DrCaseyPeavler Indeed it will be. Sister has just been diagnosed with oral cancer. Your series of evidence based reviews will be invaluable in informing her treatment outlook. Thanks again!
Casey, you are bringing this stuff to another level of clarity for the rest of us my friend. Seyfried often talks about the big hammer (i.e. DON) vs the less significant hammers (EGCG, etc. ) when it comes to glutamine inhibition. Would be kinds nice to have a sense of the gradient of effectiveness of all these compounds relative to each other at some point.
Patrick, hang in there with me. This glutamine series will be solid. It will be hard to take things head to head though since there are no large human trials on anything but the pharmaceuticals. I’d like to try to talk to Seyfried about doing some studies on these other glutamine inhibitors for us.
Thank you for explaining the different ways to target glutamine metabolism. However, I would appreciate it if you could clarify pulse therapy and how to practically use safe medications like metformin, ivermectin, and mebendazole. What are the appropriate dosages, and for how long should these medications be taken? Many discussions focus on using pulse therapy to inhibit glutamine, in addition to strategies like a ketogenic diet and fasting to restrict glucose. It would be helpful if you could dedicate a video to this topic. Have you come across any guidelines on using above simple medications in glutamine-restricted protocols? Most studies seem to focus on compounds like DON, which are not easily obtainable. I'm particularly interested in this aspect because I apply metabolic therapy to observe effects in cancer patients. Thank you!
I am going to do you better. I am going to produce a video course on how to implement metabolic therapy in the near future. I cannot provide dosages though, that would be the practice of medicine and I cannot do that on youtube. This is why I stress in finding a like minded local licensed healthcare provider to help you with the details like that and for monitoring.
Thoughts on nicotine ? I'm following Dr. Ardis and he showed an NIH paper regarding Glioblastoma and nicotine. The tumor cells shrank when the nicotine was used. I'm thinking it can also neutralize the effect of a certain pharmaceutical that was introduced 👀.
Interesting. I believe nicotine can change ROS output (particularly superoxide) at Cytochrome 1 of ETC. This may change redox chemistry to assist in either creating oxidative stress in cancer cells and/or make them more susceptible to apoptosis. I not know enough about it to give definitive answers, but can look into it.
is anyone looking at food and non-drug options that selectively/intelligently block glutamine from cancer cells but not from immune cells? Ginger perhaps?
@@DrCaseyPeavler Joe Tippins would be a great guy to interview, the current Fenbedazole protocol for cancer originated from his experience of surviving stage 4, metastasized cancer.
I guess a glutathione supplement might not be a good thing if you have cancer... I'm doing Keto diet with daily turmeric, berberine and possibly hops (not here yet). Will share if any side effects. I'm doing it mostly as preventative - had some "wasting" in my calf a while back (and some simultaneous high BP)
Thank you! I am deathly allergic to free glutamic acid & have struggled to get it out of my diet! The hidden MSG is a bitch to detect on labels since FDA allowed Corporations to lie on their packaging! I do wish there were a way to get it out of chocolate so I could occasionally enjoy a chocolate treat.
Glucose I do not consume,haven’t for years. So whatever glucose my body gets , is from it making it. I’ve been taking fen Ben and iverm for a year now, not working for me. Frustrating because people I know have put their cancer in remission with Fenben. Did chemos, it did nothing. Fast a lot, only way to increase ketones. Still has not helped with the metasis of tumors. Am I the only one out there this is happening to? 2 years been dealing with this. Ya survived 2 years, but uncomfortably. I hear about so many success stories with my same cancer. Started as ovarian cancer,now spread different organs. Thanks for listening to me
It is impossible to stop consuming glucose because sugar is everywhere, as is glutamine . You can only limit your consumption as best as possible exerting your best discipline, thus blockers are necessary. I use berberine, vitamin D, C & baby aspirin, and melatonin. FenBen did not work for me. My process is five fold: 1 Prayer & Meditation, 2 Visualization and the laying on of MY hands. 3 Diet: you must make radical changes to your diet (Keto). 4 Exercise, resistance training is necessary. 5 FASTING, both intermittent and longer water fasts. The first time I did a 3 day fast I noticed a massive drop in my inflammation. Still working this 5 Fold Protocol, but feel great. Hopefully a New Administration will allow HISTOTRIPSY for the treatment of ALL cancers. The current FDA is suppressing this sound therapy to protect the revenues of BIG PHARMA.
I don't know if I agree with the glucose comment. I do agree with the glutamine comment, but in a roundabout way, because your body can create glutamine itself. But I do applaud you for a very comprehensive integrative approach and for taking responsibility for your health. That I can totally get on board with.
Did you take multi vitamins with fenbendazole? FYI, "Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins" Conclusion: "Our study showed that fenbendazole alone did not significantly affect growth of the P493-6 human lymphoma cell line in SCID mice. Most importantly, our observation that fenbendazole in combination with supplemented vitamins significantly inhibited tumor growth has implications for its use during antitumor studies because it may cause unpredictable interactions with test substances and thus alter research results." Vitamins used in this study, A Retinol D3 Cholecalciferol E K3 B1 B2 Available niacin B6 Pantothenic acid B12 Available biotin Folate
Thanks for all the information you provide. I understand that, apart from EGCG that you mentioned, other natural substances such as berberine also inhibit glutamine uptake. Is that correct? I suppose that if one doesn't have access to products such as DON, one would have to resort to these more natural supplements to at least obtain some level of success in inhibiting glutamine uptake by cancer cells?
Yup, there a couple key inhibitors that we absolutely have access to and are natural. There is at least one that is a medication that could be easily accessed. Then there is DON and the other more research chemicals..
@@DrCaseyPeavlerje suis désolée mais vous n'êtes pas d'une grande aide pour nous les malades.on a pas lenoms des inhibiteurs ni la dose 😢😢😢 nous sommes délaissés.
I can empathize with what you are saying. I cannot practice medicine on youtube. My main goal with this channel is to raise awareness and provide scientific backing for the approaches to cancer proposed by Seyfried and others. I do educational consults or patient consults where I can be more specific.
Casey, what about metformin? I have heard Pro and Con. Would it lower glutamine? Merrick has it in his recommended off label Drugs in his book. Also off subject NIR and commercial red light therapy to help mitochondria?
Metformin is more involved in the glucose/AMPK process than glutamine. But if I find metformin also influences glutamine, you best believe I will be sharing it here with you all!
@@DrCaseyPeavler I was asking about your experience with the effectiveness of multi spectrum near infrared sauna and 900 nanometer red light bed. Anything there to activate the mitochondria ? Do you have an opinion ? Do you use it on your patients ? I have read Mark Sloan’s Red Light Therapy {miracle Medicine} book.
I would say I have an advanced understanding of photobiomodulation. I shy away from using the word expert because there is so much to know. That being said I’m a huge fan of PBMT/LLLT. Most of the most well studied biologic wavelengths are in the 600 and 800nm range. I’m not saying 900nm is useless but would not be my first choice if using LEDs. If you’re using more of a full spectrum bulb like therabulbs or sauna space then you wouldn’t have to worry because they cover from 600-3000nm in a pattern very similar to solar spectrum.
Casey …. I take lots of supplemental glycine.. and cancer cells love that too.. and methionine etc etc.. So a low protein diet for cancer patients ?? I can see eliminating glucose, but not amino acids ….
Any way to prevent excessive oxidative stress, inflammation, and to augment autophagy, mitophagy, and mitochondrial biogenesis is a winning strategy for prevention.
Great video! Thank you for your efforts! As to the natural glu inhibitors (berberine, EGCG) there is a problem with their low bioavailability. Which makes their administration ineffective if consume in “normal” dose. Would be great if you could provide info regarding the recommended therapeutical dosage of natural glu inhibitors. Thank you in advance!
I appreciate your kindness and feedback. As much as I want to give therapeutic doses of anything, I cannot. That could be misinterpreted as practicing medicine. Sadly, that being said, most of the natural inhibitors will never be part of clinical trials where dose and scheduling regimens are devised. It will likely be trial and error based off best evidence we have available. I would also say, likely best way to achieve success is a thoughtful combination approach.
We are the edge of science and what you are asking for is not yet settled. I can understand the frustration and need for urgency. This should have been figured out 50 years ago. We had DON in 1950 and Warburg’s theory before that.
How come the people in countries that get absolutely no vitamin d over winter don't seem to be much worse health wise compared to people that live near the equator?
That is a great question. I am not sure if it is a pH issue or not. The mechanism I understand is that it activates PDK, PDK inactivates PDH, less Acetyl-CoA which stabilizes HIF1a and drives Warburg Metabolism. Interestingly enough, the lack of Acetyl CoA inhibits cancer cells from creating melatonin...
No medical advice on here, but I do not personally recommend supplementing with vitamin D. I have made my stance quite clear on that during the vitamin D series. I do want blood 25OHD3 levels to be high (without causing hypercalcemia). This needs to be tracked by your local treating physician.
Non-cancer 60-80ng/mL. Cancer as high as you can obtain without causing hypercalcemia. Ideally unsupplemented. To be clear, obtaining this level via Sun exposure. You will need a doctor to monitor you.
Not as strong as I would like to see it. I would love to see huge robust human trials but unfortunately we never will. No one will ever fund the studies. There is no money in it for government or pharma who owns government. There are too many variables to see at once, no standardized protocol, and no way to blind the studies. I think what will happen is there will be an overwhelming amount of N=1 cases that shape our knowledge and understanding of how to best implement these interventions into clinical practice.
I will tell you this. If you look at the landscape of the literature objectively. The pieces fit nicely together and it all points back to Seyfried being spot on.
@@DrCaseyPeavlerthank you so much for the reply. Good to hear. Someone very close to me (stage. 4 breast cancer) got into NED after 7 months of very strict theraputic ketosis and tamoxifen among many other therapies (RGCC supplements). Recent petscan showed some uptake back on spine but she got somewhat lax on carb control. Always very clean just too many carbs etc. she's back on the strict ketosis AND taking her tamoxifen back to full dose (was 1/2). Also doing the care oncology off label drug protocol to block signaling pathways etc).
That is amazing news. So happy to hear about her progress to NED status. If it seems to be coming back, seems like environment needs to radically change. Are you all doing oxidative therapies?
So, I wonder if consuming glynac to help a person with glutathione production is actually tumor promoting? I have found it keeps my energy levels up and my immune system is benefitting. If what these theories say is true, we are doomed. We cannot kill cancer and not destroy our good immune cells and mitochondria at the same time. 😢
I have glynac powder from Pure Encapsulations in my bag right now. I also like it. But if I had cancer, no way. Not until I take care of that tumor/cancer would I go back to it. Cancer cells hijack glutathione for their benefit not yours. Not taking glynac will not destroy your immune system.
@@DrCaseyPeavler Thank you. I had no idea that glutathione used by cancer cells. I knew they used glucose and glutamine. What is even more disturbing is that we all have cancer aka rogue cells in our bodies now and then. So is supplementing a bad idea in general? I like the increased energy I have when I take GlyNac but I do not want to encourage tumor growth. I had hoped strengthening the immune system with increasing my glutathione production (I am 58 and I don't have as much as I used to) would help my immune system to conquer those bad cells. Now it seems I could be encouraging it. 💔
Do you have cancer? If not, you are probably ok and it will help protect healthy mitochondria and normal cells from oxidative damage. However yes, if one had cancer, not a fantastic idea and may be harming you. Cancer uses glutamine to make extra glutathione to protect itself.
Casey …. This a quote from a publication in Science Direct. … please comment … A large body of evidence in vivo suggests that supplemental glutamine does not make tumors grow but in fact results in decreased growth through stimulation of the immune system. When given with radiation or chemotherapy, glutamine protects the host and actually increases the selectivity of therapy for the tumor Thanks !
Great video! Unfortunately, as you mentioned, most glutamine inhibitors are either unavailable or hard to access. Given this, how can someone fighting cancer effectively address the glutamine aspect of metabolic therapy?
@@DrCaseyPeavler also, do you know if metformin is helpful in the context of metabolic therapy for keeping the glucose-ketone index (GKI) and blood glucose levels low?
Hey Doctor. I would like first of all to introduce my conditions: celiac disease with Ms/ another autosomal neurodegenerative disease, thyroiditis and polymorphism in my mthfr genes. What is going to happen to glutamine when it gets converted by the tissue transglutaminase 2 ? My neurodegenerative disease has the locus on the chromosome 2 on the Arg/Cys pathway. Since spatin in highly reactive to glutamate, is there any connection with the transglutaminase enzyme?
Hey there. I think you have introduced yourself to me a couple of weeks ago, perhaps a month. Certainly the blockade of glutamine uptake and utilization is not ideal under most circumstances. Unless a person had cancer, I am not sure why you would want to have that be a goal. Certainly the excitatory neurotransmitter glutamate can be problematic when in excess leading to neurotoxicity. I am unclear if blocking the transglutaminase enzyme would be of clinical utility or not. I have to say, I would need to study the disease process, brush up on neurotransmitter pathophysiology, to give you a more educated answer.
Giving a 5-10% protein range (of calories) is very dangerous advice, this will yield terrible results regarding muscle mass and general health for almost everybody, except maybe huge men that eat a 3k calorie diet. it's more like 15-20% with a minimum of 1-1,2 grams per kg of bodyweight, if lean, probably more like 1,5 grams
I appreciate your concern. Really I do. But a therapeutic ketogenic diet, is a low protein and an ultra-low carb diet. I did an entire video comparing different ketogenic diets. It is not sustainable for most people long term, that I agree on. But it is what it is. I am a physician. I understand risk vs benefit conversations with patients. I do it on a daily basis. I do believe it should be a case by case basis.
@@DrCaseyPeavler There has been more information that protein doesn't get turned into sugar like some think, so eating less protein isn't going to make a difference in being in ketosis. Besides, there is a real thing called "insulin suppression" in that people that never eat carbs and never get an insulin response start to see an increase in fasting blood sugar levels because gluconeogenesis is never getting a signal to shut off. I personal have seen this after about 3 years in a very low carb diet.
I have heard that from a variety of keto heavy folks, about a secondary insulin resistance. I think that is much less of a concern for most folks. Epidemiologically, the vast majority of Americans are overweight and obese with some degree of insulin resistance. I do believe these interventions are performed on a case by case basis and I do not believe they are to be used long term. But most people will highly benefit from fasting and a true calorie restricted ketogenic diet as the foundation of their cancer fight.
@@DrCaseyPeavler Sadly, I agree with you 100% We are in a sad state of affairs with our health and most people would benefit from dietary change, but a high carb diet is also a high processed diet full of garbage and seed oils, so what is the real driver of chronic disease? Clearly in the past we have consumed carbs and there are cultures that are high carb as well, without the chronic disease we see today. So is it carbs, seed oils, artificial ingredients or high deuterium levels of a highly processed diet? Not sure, but I know there are strong opinions on both sides, some saying absolutely no carbs and others saying only natural carbs. One thing that never gets talked about is that fresh meat (within 24 to 48 hours) contains glycogen. So hunter gathers eating fresh meat are getting carbs. So how ketogenic were our ancestors eating 99% meat? There's also sugar in the blood of these animals, so is a lion in ketosis?
Thanks for the video! I'm still trying to get DON to reduce glutamine. HBOT will be almost impossible at this point. My family is planning a trip to meet Dr. Seyfried in Boston, so maybe we can finish my Glioblastoma (or Gliosarcoma) treatment. I'm still curious how Ivermectin and Fenben could be helping. Sounds like Metformin i'm taking is already helpful.
Dr Casey, I just seen your DON video got censored !! Do you have a rumble channel yet ? It's probably time to move it over there. Dont lose faith, the truth is like a lion ❤ It can't be contained.
Excellent video 👍, Is it possible to target glutamine with fasting? Would fasting 2 days per week achieve the same as pulsing don? Is ecgc supplements better than drinking green tea either side of meals? Obviously this wouldn't be medical advice, just your opinion.
Green tea has CAFFEINE. Caffeine will fuel your inflammation (and your cancer) as will green Tea supplements. That is MY observation. Supplement with egcg and drink Hibiscus tea which has its own benefits and NO caffeine.
@@DrCaseyPeavler I am reporting MY experience. I am not saying that these substances CAUSE inflammation, but they definitely exacerbate it; so they must be feeding my cancer in some way. That's why I drink black decaf coffee and hibiscus tea.neither of which have caffeine, and neither of which increase my inflammation. I also eat 85% dark chocolate to fight inflammation and boost my immune system and stem cell production. Thanks again.
Over the years lf studyung this area i have determinee that Chemical theraputics are too nonspecific to be avke to deliver the nessary materials to control cancer and other pathologies with. Second, viral based therapies are too specific and are one time use methods. So the future really lies in creatung generic circuits on DNA to respond to the cell state of interest intracellularly and being able to spread from tissue to tissue like a non-specific virsus like particle whike replicating to be able to monitor all corners if the body simultainously.
@DrCaseyPeavler The safety aspect is important for sure. I do prefer a technique that doesn't require on a an external supply chain to sustain once it's used once and one that doesn't require dna cutting. Therefore, the middle ground I was getting at is a non integrating episome that replicates and loves between cells until every cell in the body has one. It's like how bacteria pass on new plasmids to each other. The method is viral, like in that it is secreted as an integrin binding particle that is composed of the episome enveloped by the cellular membrane it got from engainating into the er from the nucleus. There is a virus that dies that, and I forget which that this is inspired from. Anyway, an ejection system is needed regardless. For that, using the tet-on system is what I'd be interested in. Ejection safety systems make particles that can not enter cells while disabling their own replication and, therefore, clear the body in time. The design is complex but an alternative or generation after taking pills. Any pills efficacy of which remains to be seen and which has a more magical stigma associated. In particular I don't prefer small molecule sulotions because they go everywhere, when emwere they shouldn't and to be honest, I think we need dozens of those substances to be taken at rhe same time with loads of side effects for each. We won't be forever 20-30 with that, I'd think, and that is the goal.
@DrCaseyPeavler the second safety precautions I'd take with dna based designs is precisely why I'd want it able to spread by integrin binding, using ideally all integrin dimers as targets is immunogenicity. If the vector goes everywhere, then it will go into the immune training centers, too, and after a shirt, the immune suppression course is now recognized as self and therfore it can express protien from any species. Thus leads to the next safety factor, that is usin a dead cruspr based multi component system with a sgrna array. Thus way each can be expressed by a symtom or hallmark of the target disease or condition and come one when you want it to. Thus, we are a second-generation cruspr on/off. Next, the cruspr system itself is ferther safer due to its inability to bind compacted promoters, histone dense regions, or methylation islands. Therfore rhe while plethora of guides can be expressed at once everywhere and only the ones with clear spots bind to effect gene activity. Therefore, the intention is to use cell type unique chromatin states to control for cell type specificity in the therapy. And so a large set of guides will be needed to cover a range from all tissues. The complexity and time consumption to make for a single species is large. The cost to print this out is still high, so it will be a gen 2 or 3 for aging, cancer, and so forth if started now before prints are cheap enough. My biggest worry is the inability of the regulators to be up to date to honor the miracle promises I keep hearing about. Therefore, I feel like things may go independent pretty soon in this regard. The time span is of concern because these have to be out by a set time, or demographics will be terminal, and we're cooked.
Well I will say this, you seem to have a plan. I would have to humbly admit, you are talking well over my head in terms of the genetics. But what I can tell you is that I am not crazy about genetic engineering. The only person I would trust giving an opinion on what you are saying is Dr. Jack Kruse. If he signed off, I would be more ok with it. I do not believe cancer as a nuclear genetic disease. I can get more on board with it being the result of increased mitochondrial heteroplasmy, bioenergetic decline, increases in ROS which can downstream damage the nuclear genome. Ultimately the cell due to bioenergetic decline, excess mitophagy due to over expression and stabilization of HIF1a will drive Warburg metabolism, setting up the acidic TME, leading to immune failure and therapy resistance.
Because it is one of 2 fermentable fuels for cancer cells. You may benefit from listening to some of the earlier videos to better understand Warburg metabolism
I have put out over 100 videos for free. I will continue to put out videos for free. Every video probably takes me 5-6hrs of time to shoot and edit for free. If you are referring to my educational consults or patient care, yes I do charge without shame. If I didn’t think I could help people I would abandon the channel and helping people around the world. I became a doctor to help people get well.
Cells are supramolecular hierarchical complex systems, in which energy, information and matter circulate in all possible dimensions. Therefore, it is impossible to identify the starting event leading to malignant transformation. I am sure that the genetic model of tumorigenesis that assumes one-directional flow of information from DNA to RNA to some critical proteins, is not correct. However, the mitochondrial model of tumorigenesis seems to be at least incomplete. Complexity of cancer cells is a reason why we should not expect that inhibiting certain metabolic pathway will stop tumor growth. Prostate cancer is an example that show us how smart cancer cells can be if they are deprived of glucose or glutamine. Of course, they search for the other sources of energy. Clinical studies show that prostate cancer patients who eat a lot of animal fat, present, for example, in diary products have 600% higher risk to develop aggressive metastatic cancer than those patients who avoid animal fats. Probably, it is wise to keep in mind that each method including diet possesses its limitations. In particular, what works fine for glioblastoma does not have to work the same way for prostate cancer and vice versa.
I agree with you this is complex in terms of initiation and transformation. But the mitochondrial etiology of complex disease as proposed by Dr Doug Wallace explains at least the mechanism of how one goes from healthy person, or healthy tissue to diseased person or tissue. He proposes something called mitochondrial heteroplasmy. I think this likely explains heterogeneity in tissues and why most parts of your body can be relatively healthy and some other tissue has cancer, or dementia or heart failure or CKD. The stimuli are impossible to find for every individual person yes. Not exactly. But, we know the language that damages mitochondria, and that language is ROS/RNS, inflammation, hormone and catecholamine imbalance, hyperglycemia, nutrient deficiencies, etc etc etc. So it would stand to reason, that if you knew major drivers, and performed a thorough investigation, you could pretty easily imagine what causes the disease in a given person. When you are in clinical medicine, and ask patients questions, do even routine labs. The story is pretty clear for most folks. For some others, you gotta dig. But the answers are there. So it would stand to reason
@@DrCaseyPeavler Biochemical reactions in cells are not like chemical reactions in a chemical reactor. Rather, they are based on the precise molecular mechanisms that apply also quantum effects (seen specifically in DNA mutations). The latter ones can be easily modified by a variety of physical or chemical factors leading in consequence to alterations in the entire macromolecular machinery, not just in DNA. I suppose that the damage to mitochondria is a late event. Alterations must accumulate in such a specific manner that both mitochondria and cells continue to live with a modified phenotype without aktivating the apoptosis pathway. The concept of controlling tumor growth by both the modified diet and fasting is very interesting. However, it may be necessary to distinguish between different stages of tumor. Prostate cancwr patient right after the radical procedure may require a diet with a lot of glutamine to allow wound healing (although this glutamine may stimulate growth of dormant cancer cells). If tumor recovers, then cutting glucose and glutamine may be sufficient (I wonder if a cocktail of Quercetin, Resveratrol, melatonin and green tee extract will do good job in those cases). In the case of metastatic disease, it may be necessary to cut off animal fat (fatty meat and diary products) since metastatic cells seem to take benefit of fat for speedy, aggressive growth.
I disagree it’s a late event. You have thousands of mitochondrial in some cells and each mitochondria have many copies of mtDNA. It can be a slow insidious 10% heteroplasmy per decade under good circumstances and more accelerated depending on environmental factors.
I’m not sure how much I agree with the fat aspect. Per researchers like Seyfried no types of cancer that his group has studied can live on fat. Maybe there is some minimal ETC going on and can use it to some extent but cannot live without glucose and glutamine. The things you mentioned quercetin, resveratrol, green tea/EGCG all have pleotropic actions on cancer cells, not the least important impacts on glucose and glutamine metabolism.
@@DrCaseyPeavler Yes. Accumulation of molecular alterations occurs gradually and both mitochondria and cells adopt to that situation changing their phenotypes to the malignant ones. If they cannot adopt, they decay. Manipulation with nourishment and with different metabolic pathways eliminates those atypical cells restoring their capability for production of chemical energy and apoptosis or, simply, by cutting access to energy sources such as glucose and glutamine. How about fatty acids? Do you have any data on that issue?
I appreciate the feedback. I am not a drug first or drug forward doctor so it’s a bit surprising you should notice that. I would say that most people watching this channel because of Dr. Seyfried’s work and awareness campaign want to know about the glutamine drug DON. That is true, and that will be covered next. But probably 90% of this glutamine micro series will be dedicated to natural phytonutrient agents. Hope that helps
Hello, I am from Germany, so English is not my native language. I am therefore not sure whether I have understood everything correctly. I am 53 years old. A tumour was removed from my breast 2.5 years ago - hormone positive. All follow-up examinations have so far been without any further findings. I have been suffering from chronic diarrhoea for many years due to irritable bowel syndrome. I therefore take L-glutamine for the intestinal mucosa. Now I am very unsure and don't know whether taking L-glutamine is counterproductive with regard to (breast) cancer. Could you give me some information on this? Thanks in advance for your help.
That is a fantastic question. What a hard place to be in… Well a hard choice has to be made for sure. No matter if you choose to avoid glutamine or use glutamine blocking substances that cannot be forever, and the use of glutamine for gut health is also not forever and should be done on a limited basis. You will have to talk to your physician and come up with a plan.
@@DrCaseyPeavler Thanks for your quick reply. I have asked my alternative practioner already. As he is not familiar with this topic, he could not give me an answer. And I am not anymore in treatment with the Cancer-department. Nevertheless I think they could answer this question as they even didn't talk to me about food, Vitamin D (just to name the basics). That's why I try to get as much knowledge as possible by myself through videos like yours and other literatures. A wide field... And I am struggling a bit.
Good for you. If more patients/clients/people were like you, took ownership over their own health, the world would be a better more healthy place. Look into Dr. Jack Kruse by the way
@@inkahansen7123 Best of luck to you from Miami, Florida. I agree, there is so much good information here on RUclips. I like the Physionic channel and also Dr. Gil Carvallo.
The sign of a true scientist: being prepared to adapt and change course when the data indicates. Many thanks for your essential work.
I have no allegiance to any particular strategies. I only want to use what makes sense, that does not harm the patient, and makes them better. Thank you for your support.
@@DrCaseyPeavlerwhat are your thoughts about Georgi Dinkov’s theory and approach on cancer? He uses B1,B3,B7 and aspirin to help mitochondria work properly again and restore cells to a non cancerous state. It’s interesting how similar yet very different his theory and treatment is compared to Dr Seyfried’s. Maybe melatonin would help both approaches?
What about Ozone Casey ?
Precisely. "Consistency is the hobgoblin of a weak mind." - Albert Einstein
@@scarter176 I’m not impressed with the data we have on ozone. Mechanistically should work similar to HBOT…
A very timely video indeed with the safe and effective taking its toll. Thank you for this. ❤
Glycine and cysteine (Glycine found in collagen, cysteine found in NAC) should be avoided in leukemia patients. Leukemia cells use GSH (Made with cysteine and glycine) to protect themselves.
So glad I have found you! I will learn so much from you!
I am so glad you found us! I have tons left to share!!
Thank you for the excellent work you have been doing!
Very kind of you, it is my pleasure to bring this information to you all
Such a lucid and exciting presentation
I am really happy you think so!
Thank you so much for your in-depth reviews of the literature regarding the metabolic treatment of cancer. This is invaluable.
It is my pleasure. I hope it is helpful to you or someone you love.
@@DrCaseyPeavler Indeed it will be. Sister has just been diagnosed with oral cancer. Your series of evidence based reviews will be invaluable in informing her treatment outlook. Thanks again!
You are very welcome.
You may benefit from this video also.
ruclips.net/video/ikSlMlMFS7M/видео.htmlsi=wj5fwAQ7NaW6ptlV
I just added DCA and Thiamine to my nutraceuticals.
Please only do so under the care of a healthcare provider 🙏
Casey, you are bringing this stuff to another level of clarity for the rest of us my friend. Seyfried often talks about the big hammer (i.e. DON) vs the less significant hammers (EGCG, etc. ) when it comes to glutamine inhibition. Would be kinds nice to have a sense of the gradient of effectiveness of all these compounds relative to each other at some point.
Patrick, hang in there with me. This glutamine series will be solid. It will be hard to take things head to head though since there are no large human trials on anything but the pharmaceuticals. I’d like to try to talk to Seyfried about doing some studies on these other glutamine inhibitors for us.
Excellent. Thank you.
You are very welcome!
I need a Mitochondriak TShirt..thank you for your efforts.
We should make some!
Thank you for explaining the different ways to target glutamine metabolism. However, I would appreciate it if you could clarify pulse therapy and how to practically use safe medications like metformin, ivermectin, and mebendazole. What are the appropriate dosages, and for how long should these medications be taken?
Many discussions focus on using pulse therapy to inhibit glutamine, in addition to strategies like a ketogenic diet and fasting to restrict glucose. It would be helpful if you could dedicate a video to this topic. Have you come across any guidelines on using above simple medications in glutamine-restricted protocols? Most studies seem to focus on compounds like DON, which are not easily obtainable. I'm particularly interested in this aspect because I apply metabolic therapy to observe effects in cancer patients. Thank you!
I am going to do you better. I am going to produce a video course on how to implement metabolic therapy in the near future. I cannot provide dosages though, that would be the practice of medicine and I cannot do that on youtube. This is why I stress in finding a like minded local licensed healthcare provider to help you with the details like that and for monitoring.
Has anyone figured out how much time it takes the cancer cell to switch from glucose to glutamine as fuel?
It’s happening simultaneously
Thoughts on nicotine ? I'm following Dr. Ardis and he showed an NIH paper regarding Glioblastoma and nicotine. The tumor cells shrank when the nicotine was used. I'm thinking it can also neutralize the effect of a certain pharmaceutical that was introduced 👀.
Interesting. I believe nicotine can change ROS output (particularly superoxide) at Cytochrome 1 of ETC. This may change redox chemistry to assist in either creating oxidative stress in cancer cells and/or make them more susceptible to apoptosis. I not know enough about it to give definitive answers, but can look into it.
@@DrCaseyPeavler I am also interested in nicotine - again dosage and timing - and gum or patch etc.
Go to Dr. Ardis Show website. He has all that info in a pdf.
Cool thanks!
@@filomenamillermiller3035 what is the show called if you don't mind me asking
Thanks for sharing 🙏 much appreciated
You are very welcome! I am glad you like it!
is anyone looking at food and non-drug options that selectively/intelligently block glutamine from cancer cells but not from immune cells? Ginger perhaps?
Yes. But we unfortunately will likely never have large human clinical trials. No money in it sadly.
Can you interview dr seyfried?
I could try. Is that something that would interest you?
@@DrCaseyPeavler yes, and many others too
Who else besides Seyfried?
@@DrCaseyPeavler Joe Tippins would be a great guy to interview, the current Fenbedazole protocol for cancer originated from his experience of surviving stage 4, metastasized cancer.
@@DrCaseyPeavler barbara o'neill
I guess a glutathione supplement might not be a good thing if you have cancer...
I'm doing Keto diet with daily turmeric, berberine and possibly hops (not here yet).
Will share if any side effects. I'm doing it mostly as preventative - had some "wasting" in my calf a while back (and some simultaneous high BP)
Negative. Stay away.
great information Dr. thank you
I am glad you enjoyed it David! Hope you are well man!
Have you come across any of these that one can get even OTC or Supplements safely
That is at least the major point of this micro series. Although we will discuss DON next, the next several videos will be natural alternatives.
EGCG (Green tea extract) and berberine
2 of many.
Lithium oratate is another one.
Thank you! I am deathly allergic to free glutamic acid & have struggled to get it out of my diet! The hidden MSG is a bitch to detect on labels since FDA allowed Corporations to lie on their packaging! I do wish there were a way to get it out of chocolate so I could occasionally enjoy a chocolate treat.
What about raw organic cacao nibs or beans?
Glucose I do not consume,haven’t for years. So whatever glucose my body gets , is from it making it. I’ve been taking fen Ben and iverm for a year now, not working for me. Frustrating because people I know have put their cancer in remission with Fenben. Did chemos, it did nothing. Fast a lot, only way to increase ketones. Still has not helped with the metasis of tumors. Am I the only one out there this is happening to? 2 years been dealing with this. Ya survived 2 years, but uncomfortably. I hear about so many success stories with my same cancer. Started as ovarian cancer,now spread different organs. Thanks for listening to me
First off I am sorry about your diagnosis. I applaud your strength and dedication to healing using an integrative approach. Where do you live?
It is impossible to stop consuming glucose because sugar is everywhere, as is glutamine . You can only limit your consumption as best as possible exerting your best discipline, thus blockers are necessary. I use berberine, vitamin D, C & baby aspirin, and melatonin. FenBen did not work for me. My process is five fold: 1 Prayer & Meditation, 2 Visualization and the laying on of MY hands. 3 Diet: you must make radical changes to your diet (Keto). 4 Exercise, resistance training is necessary. 5 FASTING, both intermittent and longer water fasts. The first time I did a 3 day fast I noticed a massive drop in my inflammation. Still working this 5 Fold Protocol, but feel great. Hopefully a New Administration will allow HISTOTRIPSY for the treatment of ALL cancers. The current FDA is suppressing this sound therapy to protect the revenues of BIG PHARMA.
I don't know if I agree with the glucose comment. I do agree with the glutamine comment, but in a roundabout way, because your body can create glutamine itself.
But I do applaud you for a very comprehensive integrative approach and for taking responsibility for your health. That I can totally get on board with.
Did you take multi vitamins with fenbendazole?
FYI,
"Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins"
Conclusion:
"Our study showed that fenbendazole alone did not significantly affect growth of the P493-6 human lymphoma cell line in SCID mice. Most importantly, our observation that fenbendazole in combination with supplemented vitamins significantly inhibited tumor growth has implications for its use during antitumor studies because it may cause unpredictable interactions with test substances and thus alter research results."
Vitamins used in this study,
A
Retinol
D3
Cholecalciferol
E
K3
B1
B2
Available niacin
B6
Pantothenic acid
B12
Available biotin
Folate
I have to ask, did you recieve the 💉? I believe that is what is going to hinder success.
Thank you!
You're welcome!
Thanks for all the information you provide. I understand that, apart from EGCG that you mentioned, other natural substances such as berberine also inhibit glutamine uptake. Is that correct? I suppose that if one doesn't have access to products such as DON, one would have to resort to these more natural supplements to at least obtain some level of success in inhibiting glutamine uptake by cancer cells?
Yup, there a couple key inhibitors that we absolutely have access to and are natural. There is at least one that is a medication that could be easily accessed. Then there is DON and the other more research chemicals..
@@DrCaseyPeavlerje suis désolée mais vous n'êtes pas d'une grande aide pour nous les malades.on a pas lenoms des inhibiteurs ni la dose 😢😢😢 nous sommes délaissés.
I can empathize with what you are saying. I cannot practice medicine on youtube. My main goal with this channel is to raise awareness and provide scientific backing for the approaches to cancer proposed by Seyfried and others. I do educational consults or patient consults where I can be more specific.
@@DrCaseyPeavler At least you can name what "There is at least one that is a medication that could be easily accessed" you refer to?
6-diazo-5-oxo-L-norleucine (DON) is available for the resourceful. This happens to also be the most well studied.
Casey, what about metformin? I have heard Pro and Con. Would it lower glutamine? Merrick has it in his recommended off label Drugs in his book.
Also off subject NIR and commercial red light therapy to help mitochondria?
Metformin is more involved in the glucose/AMPK process than glutamine. But if I find metformin also influences glutamine, you best believe I will be sharing it here with you all!
What is the question you are asking about red/NIR? I am sorry, no following exactly what you are asking
@@DrCaseyPeavler I was asking about your experience with the effectiveness of multi spectrum near infrared sauna and 900 nanometer red light bed. Anything there to activate the mitochondria ? Do you have an opinion ? Do you use it on your patients ? I have read Mark Sloan’s Red Light Therapy {miracle Medicine} book.
I would say I have an advanced understanding of photobiomodulation. I shy away from using the word expert because there is so much to know. That being said I’m a huge fan of PBMT/LLLT. Most of the most well studied biologic wavelengths are in the 600 and 800nm range. I’m not saying 900nm is useless but would not be my first choice if using LEDs. If you’re using more of a full spectrum bulb like therabulbs or sauna space then you wouldn’t have to worry because they cover from 600-3000nm in a pattern very similar to solar spectrum.
Hope RFK JR will fund mega dose Vitamin D research base on dose similar to COIMBRA PROTOCOL
RFK is close to Dr. Kruse. Imagine Dr. Jack Kruse as surgeon general lol
I follow some people trying to do metabolic therapy. It seems extremely difficult.
It can be extremely hard logistically and can be expensive.
Casey …. I take lots of supplemental glycine.. and cancer cells love that too.. and methionine etc etc.. So a low protein diet for cancer patients ?? I can see eliminating glucose, but not amino acids ….
I’m not providing any medical advice. BUT if you look at what a therapeutic ketogenic diet is, it is a low protein 5-10%.
Sr9009 sr9011, rapamycin, metformin?
I think we have a lot more to work with than that which is a good thing.
…many research papers discuss the efficacy of Urolithin A as an adjunct in the metabolic pathway for cancer prevention…any comments?
Any way to prevent excessive oxidative stress, inflammation, and to augment autophagy, mitophagy, and mitochondrial biogenesis is a winning strategy for prevention.
Great video! Thank you for your efforts!
As to the natural glu inhibitors (berberine, EGCG) there is a problem with their low bioavailability. Which makes their administration ineffective if consume in “normal” dose. Would be great if you could provide info regarding the recommended therapeutical dosage of natural glu inhibitors.
Thank you in advance!
I appreciate your kindness and feedback. As much as I want to give therapeutic doses of anything, I cannot. That could be misinterpreted as practicing medicine. Sadly, that being said, most of the natural inhibitors will never be part of clinical trials where dose and scheduling regimens are devised. It will likely be trial and error based off best evidence we have available. I would also say, likely best way to achieve success is a thoughtful combination approach.
yes please, some ideas on therapeutic doses and timing - ie. do we bother 'pulsing' or no point ?
We are the edge of science and what you are asking for is not yet settled. I can understand the frustration and need for urgency. This should have been figured out 50 years ago. We had DON in 1950 and Warburg’s theory before that.
@@DrCaseyPeavlerappreciated your response. Thank you!
You’re welcome. I would love to have robust data to show you, but that isn’t where we are in 2024. Sadly.
How come the people in countries that get absolutely no vitamin d over winter don't seem to be much worse health wise compared to people that live near the equator?
That isn’t the case if you look at epidemiology.
does the ph of ammonia have any impact on the warburg effect?
That is a great question. I am not sure if it is a pH issue or not. The mechanism I understand is that it activates PDK, PDK inactivates PDH, less Acetyl-CoA which stabilizes HIF1a and drives Warburg Metabolism.
Interestingly enough, the lack of Acetyl CoA inhibits cancer cells from creating melatonin...
How about mega dose Vitamin D to down regulate Glutamine?
No medical advice on here, but I do not personally recommend supplementing with vitamin D. I have made my stance quite clear on that during the vitamin D series. I do want blood 25OHD3 levels to be high (without causing hypercalcemia). This needs to be tracked by your local treating physician.
@@DrCaseyPeavler
What is 250HD3? How high do you recommend?
Non-cancer 60-80ng/mL. Cancer as high as you can obtain without causing hypercalcemia. Ideally unsupplemented. To be clear, obtaining this level via Sun exposure. You will need a doctor to monitor you.
Great Video
Thanks
You are very welcome!
Dr P. Would like to get your thoughts on the strength of the evidence supporting the reverse Warburg effect?
Not as strong as I would like to see it. I would love to see huge robust human trials but unfortunately we never will. No one will ever fund the studies. There is no money in it for government or pharma who owns government. There are too many variables to see at once, no standardized protocol, and no way to blind the studies. I think what will happen is there will be an overwhelming amount of N=1 cases that shape our knowledge and understanding of how to best implement these interventions into clinical practice.
I will tell you this. If you look at the landscape of the literature objectively. The pieces fit nicely together and it all points back to Seyfried being spot on.
@@DrCaseyPeavlerthank you so much for the reply. Good to hear. Someone very close to me (stage. 4 breast cancer) got into NED after 7 months of very strict theraputic ketosis and tamoxifen among many other therapies (RGCC supplements). Recent petscan showed some uptake back on spine but she got somewhat lax on carb control. Always very clean just too many carbs etc. she's back on the strict ketosis AND taking her tamoxifen back to full dose (was 1/2). Also doing the care oncology off label drug protocol to block signaling pathways etc).
That is amazing news. So happy to hear about her progress to NED status. If it seems to be coming back, seems like environment needs to radically change. Are you all doing oxidative therapies?
Is there a way to see/measure if these methods are working?
I suspect the way we measure anything else, tumor specific antigens and markers and imaging studies such as PET/CT, MRI, etc
So, I wonder if consuming glynac to help a person with glutathione production is actually tumor promoting? I have found it keeps my energy levels up and my immune system is benefitting. If what these theories say is true, we are doomed. We cannot kill cancer and not destroy our good immune cells and mitochondria at the same time. 😢
I have glynac powder from Pure Encapsulations in my bag right now. I also like it. But if I had cancer, no way. Not until I take care of that tumor/cancer would I go back to it. Cancer cells hijack glutathione for their benefit not yours. Not taking glynac will not destroy your immune system.
@@DrCaseyPeavler Thank you. I had no idea that glutathione used by cancer cells. I knew they used glucose and glutamine. What is even more disturbing is that we all have cancer aka rogue cells in our bodies now and then. So is supplementing a bad idea in general? I like the increased energy I have when I take GlyNac but I do not want to encourage tumor growth. I had hoped strengthening the immune system with increasing my glutathione production (I am 58 and I don't have as much as I used to) would help my immune system to conquer those bad cells. Now it seems I could be encouraging it. 💔
Do you have cancer? If not, you are probably ok and it will help protect healthy mitochondria and normal cells from oxidative damage. However yes, if one had cancer, not a fantastic idea and may be harming you. Cancer uses glutamine to make extra glutathione to protect itself.
Casey …. This a quote from a publication in Science Direct. … please comment …
A large body of evidence in vivo suggests that supplemental glutamine does not make tumors grow but in fact results in decreased growth through stimulation of the immune system. When given with radiation or chemotherapy, glutamine protects the host and actually increases the selectivity of therapy for the tumor
Thanks !
Can you suggest a place where I can find some info on keto diet protocols?
This video may help:
ruclips.net/video/Bl8nMzhp0LQ/видео.html
How about taking cimetidine and supplementing glutamine at same time? Will that work?
A thoughtful combination approach is likely the most successful strategy.
Great video! Unfortunately, as you mentioned, most glutamine inhibitors are either unavailable or hard to access. Given this, how can someone fighting cancer effectively address the glutamine aspect of metabolic therapy?
Yes man, we are in a bind. But there are several natural inhibitors that are readily available. DON is available for the resourceful as well.
I've heard berberine and ashwaganda inhibit glutamine
I will try to give an exhaustive list over the next few days and weeks. Berberine yes. I have not seen Ashwaghanda yet.
@@DrCaseyPeavler also, do you know if metformin is helpful in the context of metabolic therapy for keeping the glucose-ketone index (GKI) and blood glucose levels low?
That is a commonly added medication to metabolic therapy yes.
Hey Doctor.
I would like first of all to introduce my conditions: celiac disease with Ms/ another autosomal neurodegenerative disease, thyroiditis and polymorphism in my mthfr genes.
What is going to happen to glutamine when it gets converted by the tissue transglutaminase 2 ?
My neurodegenerative disease has the locus on the chromosome 2 on the Arg/Cys pathway. Since spatin in highly reactive to glutamate, is there any connection with the transglutaminase enzyme?
Hey there. I think you have introduced yourself to me a couple of weeks ago, perhaps a month. Certainly the blockade of glutamine uptake and utilization is not ideal under most circumstances. Unless a person had cancer, I am not sure why you would want to have that be a goal.
Certainly the excitatory neurotransmitter glutamate can be problematic when in excess leading to neurotoxicity. I am unclear if blocking the transglutaminase enzyme would be of clinical utility or not. I have to say, I would need to study the disease process, brush up on neurotransmitter pathophysiology, to give you a more educated answer.
Giving a 5-10% protein range (of calories) is very dangerous advice, this will yield terrible results regarding muscle mass and general health for almost everybody, except maybe huge men that eat a 3k calorie diet. it's more like 15-20% with a minimum of 1-1,2 grams per kg of bodyweight, if lean, probably more like 1,5 grams
I appreciate your concern. Really I do. But a therapeutic ketogenic diet, is a low protein and an ultra-low carb diet. I did an entire video comparing different ketogenic diets.
It is not sustainable for most people long term, that I agree on. But it is what it is.
I am a physician. I understand risk vs benefit conversations with patients. I do it on a daily basis. I do believe it should be a case by case basis.
@@DrCaseyPeavler There has been more information that protein doesn't get turned into sugar like some think, so eating less protein isn't going to make a difference in being in ketosis. Besides, there is a real thing called "insulin suppression" in that people that never eat carbs and never get an insulin response start to see an increase in fasting blood sugar levels because gluconeogenesis is never getting a signal to shut off. I personal have seen this after about 3 years in a very low carb diet.
I have heard that from a variety of keto heavy folks, about a secondary insulin resistance.
I think that is much less of a concern for most folks. Epidemiologically, the vast majority of Americans are overweight and obese with some degree of insulin resistance.
I do believe these interventions are performed on a case by case basis and I do not believe they are to be used long term. But most people will highly benefit from fasting and a true calorie restricted ketogenic diet as the foundation of their cancer fight.
@@DrCaseyPeavler Sadly, I agree with you 100% We are in a sad state of affairs with our health and most people would benefit from dietary change, but a high carb diet is also a high processed diet full of garbage and seed oils, so what is the real driver of chronic disease? Clearly in the past we have consumed carbs and there are cultures that are high carb as well, without the chronic disease we see today. So is it carbs, seed oils, artificial ingredients or high deuterium levels of a highly processed diet? Not sure, but I know there are strong opinions on both sides, some saying absolutely no carbs and others saying only natural carbs. One thing that never gets talked about is that fresh meat (within 24 to 48 hours) contains glycogen. So hunter gathers eating fresh meat are getting carbs. So how ketogenic were our ancestors eating 99% meat? There's also sugar in the blood of these animals, so is a lion in ketosis?
My guess it’s all of the above. Never one thing.
Thanks for the video! I'm still trying to get DON to reduce glutamine. HBOT will be almost impossible at this point. My family is planning a trip to meet Dr. Seyfried in Boston, so maybe we can finish my Glioblastoma (or Gliosarcoma) treatment. I'm still curious how Ivermectin and Fenben could be helping. Sounds like Metformin i'm taking is already helpful.
Check Japan the treatment they have for gliblastima… try piperlongumine
Just curious, what is their treatment?
I am glad you enjoyed the video! I am excited for your meeting with Dr. Seyfried in Boston. Please keep us all updated!
@@gulms1352 Just curious, what is their treatment?
Me too!
Dr Casey, I just seen your DON video got censored !! Do you have a rumble channel yet ? It's probably time to move it over there. Dont lose faith, the truth is like a lion ❤ It can't be contained.
It got removed, demonetized and blocked within an hour
This is the first time this has ever happened to me
They called it medical disinformation
Unreal !!! Its published in the literature !!
Apparently scientific research on the U.S. government library of medicine is misinformation…
Excellent video 👍, Is it possible to target glutamine with fasting? Would fasting 2 days per week achieve the same as pulsing don? Is ecgc supplements better than drinking green tea either side of meals?
Obviously this wouldn't be medical advice, just your opinion.
These are excellent questions. We will attempt to tackle those questions in this glutamine micro series!
Green tea has CAFFEINE. Caffeine will fuel your inflammation (and your cancer) as will green Tea supplements. That is MY observation. Supplement with egcg and drink Hibiscus tea which has its own benefits and NO caffeine.
I’m not aware of caffeine or green tea specifically causing inflammation. Can you send me a link to a study to confirm this?
@@DrCaseyPeavler I am reporting MY experience. I am not saying that these substances CAUSE inflammation, but they definitely exacerbate it; so they must be feeding my cancer in some way. That's why I drink black decaf coffee and hibiscus tea.neither of which have caffeine, and neither of which increase my inflammation. I also eat 85% dark chocolate to fight inflammation and boost my immune system and stem cell production. Thanks again.
@@DrCaseyPeavler I think you misread, I was asking whether it is best to get ecgc from green tea or supplements, ecgc is in green tea I believe.
Over the years lf studyung this area i have determinee that Chemical theraputics are too nonspecific to be avke to deliver the nessary materials to control cancer and other pathologies with. Second, viral based therapies are too specific and are one time use methods. So the future really lies in creatung generic circuits on DNA to respond to the cell state of interest intracellularly and being able to spread from tissue to tissue like a non-specific virsus like particle whike replicating to be able to monitor all corners if the body simultainously.
I’m not a big fan of genetic engineering. I think there is a safer more simple solution.
@DrCaseyPeavler The safety aspect is important for sure. I do prefer a technique that doesn't require on a an external supply chain to sustain once it's used once and one that doesn't require dna cutting. Therefore, the middle ground I was getting at is a non integrating episome that replicates and loves between cells until every cell in the body has one. It's like how bacteria pass on new plasmids to each other. The method is viral, like in that it is secreted as an integrin binding particle that is composed of the episome enveloped by the cellular membrane it got from engainating into the er from the nucleus. There is a virus that dies that, and I forget which that this is inspired from. Anyway, an ejection system is needed regardless. For that, using the tet-on system is what I'd be interested in. Ejection safety systems make particles that can not enter cells while disabling their own replication and, therefore, clear the body in time. The design is complex but an alternative or generation after taking pills. Any pills efficacy of which remains to be seen and which has a more magical stigma associated. In particular I don't prefer small molecule sulotions because they go everywhere, when emwere they shouldn't and to be honest, I think we need dozens of those substances to be taken at rhe same time with loads of side effects for each. We won't be forever 20-30 with that, I'd think, and that is the goal.
@DrCaseyPeavler the second safety precautions I'd take with dna based designs is precisely why I'd want it able to spread by integrin binding, using ideally all integrin dimers as targets is immunogenicity. If the vector goes everywhere, then it will go into the immune training centers, too, and after a shirt, the immune suppression course is now recognized as self and therfore it can express protien from any species.
Thus leads to the next safety factor, that is usin a dead cruspr based multi component system with a sgrna array. Thus way each can be expressed by a symtom or hallmark of the target disease or condition and come one when you want it to. Thus, we are a second-generation cruspr on/off.
Next, the cruspr system itself is ferther safer due to its inability to bind compacted promoters, histone dense regions, or methylation islands. Therfore rhe while plethora of guides can be expressed at once everywhere and only the ones with clear spots bind to effect gene activity. Therefore, the intention is to use cell type unique chromatin states to control for cell type specificity in the therapy. And so a large set of guides will be needed to cover a range from all tissues. The complexity and time consumption to make for a single species is large. The cost to print this out is still high, so it will be a gen 2 or 3 for aging, cancer, and so forth if started now before prints are cheap enough. My biggest worry is the inability of the regulators to be up to date to honor the miracle promises I keep hearing about. Therefore, I feel like things may go independent pretty soon in this regard. The time span is of concern because these have to be out by a set time, or demographics will be terminal, and we're cooked.
Well I will say this, you seem to have a plan. I would have to humbly admit, you are talking well over my head in terms of the genetics. But what I can tell you is that I am not crazy about genetic engineering. The only person I would trust giving an opinion on what you are saying is Dr. Jack Kruse. If he signed off, I would be more ok with it.
I do not believe cancer as a nuclear genetic disease. I can get more on board with it being the result of increased mitochondrial heteroplasmy, bioenergetic decline, increases in ROS which can downstream damage the nuclear genome. Ultimately the cell due to bioenergetic decline, excess mitophagy due to over expression and stabilization of HIF1a will drive Warburg metabolism, setting up the acidic TME, leading to immune failure and therapy resistance.
Why would anyone want to inhibit glutamine given all of its essential rolls
Because it is one of 2 fermentable fuels for cancer cells. You may benefit from listening to some of the earlier videos to better understand Warburg metabolism
I didn’t realize until now you’re making money from all this. I hope you are helping people. Otherwise, we have a problem.
I have put out over 100 videos for free. I will continue to put out videos for free. Every video probably takes me 5-6hrs of time to shoot and edit for free. If you are referring to my educational consults or patient care, yes I do charge without shame. If I didn’t think I could help people I would abandon the channel and helping people around the world. I became a doctor to help people get well.
Cells are supramolecular hierarchical complex systems, in which energy, information and matter circulate in all possible dimensions. Therefore, it is impossible to identify the starting event leading to malignant transformation. I am sure that the genetic model of tumorigenesis that assumes one-directional flow of information from DNA to RNA to some critical proteins, is not correct. However, the mitochondrial model of tumorigenesis seems to be at least incomplete.
Complexity of cancer cells is a reason why we should not expect that inhibiting certain metabolic pathway will stop tumor growth.
Prostate cancer is an example that show us how smart cancer cells can be if they are deprived of glucose or glutamine. Of course, they search for the other sources of energy. Clinical studies show that prostate cancer patients who eat a lot of animal fat, present, for example, in diary products have 600% higher risk to develop aggressive metastatic cancer than those patients who avoid animal fats. Probably, it is wise to keep in mind that each method including diet possesses its limitations. In particular, what works fine for glioblastoma does not have to work the same way for prostate cancer and vice versa.
I agree with you this is complex in terms of initiation and transformation. But the mitochondrial etiology of complex disease as proposed by Dr Doug Wallace explains at least the mechanism of how one goes from healthy person, or healthy tissue to diseased person or tissue. He proposes something called mitochondrial heteroplasmy. I think this likely explains heterogeneity in tissues and why most parts of your body can be relatively healthy and some other tissue has cancer, or dementia or heart failure or CKD.
The stimuli are impossible to find for every individual person yes. Not exactly. But, we know the language that damages mitochondria, and that language is ROS/RNS, inflammation, hormone and catecholamine imbalance, hyperglycemia, nutrient deficiencies, etc etc etc.
So it would stand to reason, that if you knew major drivers, and performed a thorough investigation, you could pretty easily imagine what causes the disease in a given person.
When you are in clinical medicine, and ask patients questions, do even routine labs. The story is pretty clear for most folks. For some others, you gotta dig. But the answers are there.
So it would stand to reason
@@DrCaseyPeavler Biochemical reactions in cells are not like chemical reactions in a chemical reactor. Rather, they are based on the precise molecular mechanisms that apply also quantum effects (seen specifically in DNA mutations). The latter ones can be easily modified by a variety of physical or chemical factors leading in consequence to alterations in the entire macromolecular machinery, not just in DNA. I suppose that the damage to mitochondria is a late event. Alterations must accumulate in such a specific manner that both mitochondria and cells continue to live with a modified phenotype without aktivating the apoptosis pathway.
The concept of controlling tumor growth by both the modified diet and fasting is very interesting. However, it may be necessary to distinguish between different stages of tumor. Prostate cancwr patient right after the radical procedure may require a diet with a lot of glutamine to allow wound healing (although this glutamine may stimulate growth of dormant cancer cells). If tumor recovers, then cutting glucose and glutamine may be sufficient (I wonder if a cocktail of Quercetin, Resveratrol, melatonin and green tee extract will do good job in those cases). In the case of metastatic disease, it may be necessary to cut off animal fat (fatty meat and diary products) since metastatic cells seem to take benefit of fat for speedy, aggressive growth.
I disagree it’s a late event. You have thousands of mitochondrial in some cells and each mitochondria have many copies of mtDNA. It can be a slow insidious 10% heteroplasmy per decade under good circumstances and more accelerated depending on environmental factors.
I’m not sure how much I agree with the fat aspect. Per researchers like Seyfried no types of cancer that his group has studied can live on fat. Maybe there is some minimal ETC going on and can use it to some extent but cannot live without glucose and glutamine.
The things you mentioned quercetin, resveratrol, green tea/EGCG all have pleotropic actions on cancer cells, not the least important impacts on glucose and glutamine metabolism.
@@DrCaseyPeavler Yes. Accumulation of molecular alterations occurs gradually and both mitochondria and cells adopt to that situation changing their phenotypes to the malignant ones. If they cannot adopt, they decay. Manipulation with nourishment and with different metabolic pathways eliminates those atypical cells restoring their capability for production of chemical energy and apoptosis or, simply, by cutting access to energy sources such as glucose and glutamine. How about fatty acids? Do you have any data on that issue?
Why so drug heavy? Enabling people through diet empowers them and stops dependence on the drug industry… focus on natural options please 🙏
I appreciate the feedback. I am not a drug first or drug forward doctor so it’s a bit surprising you should notice that. I would say that most people watching this channel because of Dr. Seyfried’s work and awareness campaign want to know about the glutamine drug DON. That is true, and that will be covered next. But probably 90% of this glutamine micro series will be dedicated to natural phytonutrient agents. Hope that helps
Random question. Any idea on how to block progesterone?
Why would you want to? Hormone driven cancer?
Hello, I am from Germany, so English is not my native language. I am therefore not sure whether I have understood everything correctly.
I am 53 years old. A tumour was removed from my breast 2.5 years ago - hormone positive. All follow-up examinations have so far been without any further findings.
I have been suffering from chronic diarrhoea for many years due to irritable bowel syndrome. I therefore take L-glutamine for the intestinal mucosa.
Now I am very unsure and don't know whether taking L-glutamine is counterproductive with regard to (breast) cancer.
Could you give me some information on this? Thanks in advance for your help.
That is a fantastic question. What a hard place to be in…
Well a hard choice has to be made for sure. No matter if you choose to avoid glutamine or use glutamine blocking substances that cannot be forever, and the use of glutamine for gut health is also not forever and should be done on a limited basis.
You will have to talk to your physician and come up with a plan.
@@DrCaseyPeavler Thanks for your quick reply. I have asked my alternative practioner already. As he is not familiar with this topic, he could not give me an answer.
And I am not anymore in treatment with the Cancer-department. Nevertheless I think they could answer this question as they even didn't talk to me about food, Vitamin D (just to name the basics).
That's why I try to get as much knowledge as possible by myself through videos like yours and other literatures. A wide field... And I am struggling a bit.
Good for you. If more patients/clients/people were like you, took ownership over their own health, the world would be a better more healthy place.
Look into Dr. Jack Kruse by the way
@@inkahansen7123 Best of luck to you from Miami, Florida. I agree, there is so much good information here on RUclips. I like the Physionic channel and also Dr. Gil Carvallo.