Every time I review this video, I come away MORE amazed, and it clarifies many other research papers I have had important questions about! Such a productive rabbit hole, I'm diving back down right now!
Haha there are too many rabbit holes sadly and (I’ll speak for myself) not enough time in the day to jump down them all. Perhaps someday when this channel is decent sized and I don’t have to rely as much on working at the hospital I can be even more estudios and jump down a few more…
Most carnivores no longer sunburn. 88, 10 months carnivore to fight cancer with Tippens protocol - and this summer is the first of my life of never any sunburn. Started lying out under blazing sun for 25 minutes a day (for anti-cancer benefits) and got a healthy looking tan with zero burn. A new carnivore - old friend - was out in midday sun for four hours. Same thing, nice color, zero burn.👌💖
Might have more clues after PCP's consult in a few days. Will lay out all my false starts, new info that I'm trying out and unfortunate discovery - IE: Advanced cancer may GROW from fasting-generated autophagy, whereas early cancers are stopped by fasting's autophagy. Now concerned my OMAD eating might be spurring metastasis. I hope for guidance if not too late, period. Know that physical exercise (high arm swinging while walking, against lymphedema's arm swelling) does reduce swelling. But is it irrelevant at the point of advancing lymphedema? Don't know. How late is too late? Looking to create a miracle here. My willpower is flagging re the walking. Am so physically weak since a spleen attack and the encroaching lymphedema. 🙄😔🙏💖
First off. You have made significant lifestyle modifications to help yourself get better. Please try not to shame yourself. NO MATTER what intervention we make, there is a level of risk vs benefit. Fasting is a powerful autophagy activator yes. But it’s going to radically lower cancer growing insulin, IGF-1, glucose and glutamine! I am not God and do not know for sure, but I would bet that is a NET POSITIVE. You are doing what 95+% people are likely not willing to do. I am proud of you no matter what the next results show.
@@DrCaseyPeavler Thanks for that - I will stop seeing late stage cancer fasting autophagy as problematic, as it is one of the few tools I have left. 🙏💖
My 83 year old Dad had worked 18 years outdoors all day year round in the Key West sun and still had low vitamin D levels, and apparently many retired folks in Florida do, in spite of plenty of Sun exposure. We supplemented him with d3 and k til his levels reached 80 and he did better.
Sunscreen blocks production. Also diet can affect Vit D production. And what many do not know--its clinically proven-- if you shower after sun exposure (even without sunscreen) it will lower the amount of Vitamin D your body has just made. See studies referenced by the American College of Lifestyle Medicine--Dr Wes Youngberg speaks about this in his Diabetes Undone training videos.
I cannot agree with much of what you said. Vitamin D does not get converted to oxalates. It can increase intestinal absorption of calcium and oxalates yes. But if your diet is limited in oxalates that should not be a problem. I would not limit my sun or vitamin D intake based on that. I can also agree that nothing is within a vacuum. Yes we need minerals such as magnesium. They are critical in their own right for hundreds of chemical reactions.
I was diagnosed with parotid stage 4 squamous cell carcinoma in 2017. I had radical head and neck surgery 2018. I refused chemo and radiation and I am still alive. I attribute my success to God and the keto diet. Keto + 0 sugar + 0 dairy = effective results. How can someone obtain calcifol? Or 25 hydoxy vit D? What is the dose? Do you need a script? What in OTC supplements are compatible with these options? What are the doses? Would a person also require K2? Thanks, Rosie.
I am sorry you are going through that but what a miracle to be doing so well by the grace of God and a what sounds like strict keto diet. Sunlight depending on time of year and latitude from 10am to 3pm with as much of your body exposed as possible without getting arrested is the prescription.
@@DrCaseyPeavler That is honest but nice approach I must say! A bit technical-Medical. Some thoughts about practical dose, timing of for examample D3 IE 4000 per day at the end would be great.
I have type 1 skin that always burned and never tanned which greatly limited sun exposure. Melanotan 2 peptide was a miracle as I finally was able to be in the sun. Chronic viral infections improved radically. Waiting to try melanotan 1 to see if it works the same.
That is amazing that it helped you get started with the sun, but now that you are started, would let your body’s endogenous a-msh take over and make your own melanin at your body’s pace.
Since they never responded…As a powerful antioxidant it can reduce chances of burning, but also can possibly lower benefits. Would recommend just not pushing it to hard to the point of burning.
Very informative videos. I assume you have gotten this request before, but I would be very helpful to have the pubmed links to the papers you present in the description. Would save me a lot of time manually typing in titles and authors to locate them.
I have listened to many of Dr Sefried's presentations and understand the relatively simple idea of starving cancers of glucose with intermittent fasting to promote autophagy. I have also followed the need of also blocking glutamine. What do you mean more specifically when you talk about "pulsing" glutamine inhibition because it is essential to other cells in the immune system. Does this mean cycling intake of vitamin D. Also, how or where would we get 125 hydroxy vitamin D.
Great questions. I have a video called how Metabolic Therapy checkmates cancer you might find useful. How Metabolic Therapy CHECKMATES Cancer ruclips.net/video/O4sajpZ_SFM/видео.html
What would you do if you lived in a dark winter country that is dark for 5 months of the year? What amounts of vit d, and other supplements amounts would you be taking personally?
Very clever wording of the question , he cant tell you what amounts to take. But he can share what he does, or what he would do in a hypothetical situation . Everyone always remember how to word your questions to docs online !
I would look into using cold water immersion (should be fairly easy in cold northern climates), sauna (Finnish, Infrared), local seafood, perfecting sleep environment, making sure you get enough minerals. But in all reality for some people a Northern latitude will not suffice.
First of all, I am sorry you are in the position you are in. Remember you cannot get well in the same environment in which you got sick first and foremost. There needs to be a complete renovation of the environment, and no stone can be left unturned. Where are you located? I cannot practice medicine on youtube, but you want to your vitamin D to be in a range that conveys the maximum benefit. First, the source of the D needs to be from solar light (UV-B), and likely need to push the level as high as you can get away with without affecting calcium levels. Probably > 100ng/mL, but you will need to check your 25-OHD3 level regularly to know where you are on that scale.
@@sharonm.8411may I suggest at least 10,000 iu’s per day…….at least. My husband had Lymphoma stage 4 while he was having his treatment and was in hospital the ward came down with covid he had no symptoms and he has fully recovered from his cancer. I believe the vitamin D3 contributed to his getting through this condition.
I suggest asking the question why did my husband get cancer to begin with. I believe it is the duty of a good doctor to help answer that question. Likely not one thing, but a constellation of things. If you don't answer that, and address it to the best of your ability, disease will recur. You cannot get well in the same environment (conditions of existence) in which you got sick. Vitamin D is a powerful intervention. BUT much more powerful when obtained from the sun instead of a pill. I am glad you husband recovered from cancer!
Right now, given my location at 44 degrees N latitude, in rainforest of western Oregon US, and faced with low D3 potential all winter, I'm seriously wanting one of these new lamps! A long vacation into the tropics this winter is likely not 'in the cards' yet. But, a lamp could be my best bet in the short run? I had been relying on supplementation, but understand the inadequacies of that, and my D3 levels hovered around 33 to 36 w/o increasing much beyond my end of summer levels last year. I'm shooting for 60 to 80, so a lamp is likely my next best effort for this winter. I get a great deal of sun in the summer, working outside all day, but my levels did not reflect much increase last summer, so this summer I have greatly further increased sun exposure, and anticipate better results likely, heading into my dark winter months.
I have focused on increasing NIR in dawns early light, and having a low power incandescent bulb present when using computer in evenings, but understand more diligent reductions in blue light exposure are necessary if I cannot yet just live in dark after sundown. I am trying to build up my abilities to help family and anyone else come to better understanding about all things quantum, but it is such a slow process w/o pushing too much, and being counter-productive. Yet, so many around me are getting chronic diseases that are very likely able to be helped very much by such knowledge. Frustrating!
You are now the second person to ask me this. I am considering doing exactly what you ask. It’s just they are already a lot of work as is, each video takes me hours to shoot and edit
I love that you try and explain everything to us non doctors, but I can't understand any of it and I wish that I could.😢 how much vitamin D3 should I take a day
I appreciate your feedback. But. No one would know. Context is everything. For normal healthy people 60-80ng/mL blood level is good. If you have cancer then higher would be better. But that would require a doctor to check your levels and a titration of the dose.
For those with adverse VDR mutation - drop the 25 Hydroxy supplementation, and supplement directly with liquid 1.25 Hydroxy, the active form of Vitamin D. This will be your game changer. Weird for me so many talks on Vit D on the net, still so few doctors mentioning 1.25 supplementation, and which is incredibly mroe effective.
Just a friendly reminder. VDR mutations have nothing to do with synthesis. It’s the target tissue or cell that receives the signal via the VDR vitamin D receptor. Vitamin D can be maximally beneficial with normal VDR receptors, but there are many actions that do not require VDR, both classical vitamin D pathway and D3/L3 analogs. Most people who do not have significant renal disease do not need to take calcitriol active vitamin D, in fact it could be harming your potential.
@@DrCaseyPeavler Why would you feel it would be harming, could you elaborate on that and for our understanding? Also, you touch another very important point, of which few are aware I believe. If you wanna go "high" dose Vitamin D, and do it life long, make sure you're kidney can sustain the long term effort.
I think harmful may be a bit harsh of a word, but it’s possibly harmful yes. I think a better way to look at it, is that you are not capturing the most potential from the vitamin D system by using just 1,25OHD3 or calcitriol supplements. That I can say for sure.
Theres a study that showed an increase of 1,25 by using vitamin d3 nanoparticles (vit d3 embedded in micelles). Anyone can make such an emulsion at home using olive oil, vit d3, lecithin, and some water. Just blend it up real good.
1,25 although considered the classically active vitamin D, is one of about 30-40 vitamin D3 and L3 analogs that are also bioactive. Get it from the sun if possible.
Wondering if higher doses of Vit D would result in greater suppression of glutamine uptake. In other words, if 60 ng/mL is good, would it be even better to target >100 ng/mL in the presence of cancer? Also wondering if glutamine uptake is enhanced as an alternate cancer fuel source during ketosis?
My bet is yes. If I had cancer, I personally would push my un-supplemented vitamin D level the highest I could without causing hypercalcemia. But that is a discussion between you and your doctor of course.
Oh yes, very encouraging! And, brings up a host of concerns about the current medical/pharma paradigm in relationship to lack of funding and lack of continuing education in using the full scientific methodology, that should be primarily focused on finding mistakes rather than expensive products w/o adequate pointedly investigative integrity.IMHO
@DrCaseyPeavler Thank you for your informative videos! I have high-grade urothelial carcinoma in my right ureter (non-invasive) per CT (and biopsy in March) and a lesion on the para-aortic lymph nodes per PET. I have been intermittent fasting (and multi-day fasting periodically) since late last year and on the carnivore diet as well. My GKI average is about 2.0 I am on my 4th day of a 10 day water fast and my second day of high-dose IVC (15 grams yesterday, and 50 grams today). I intend on 10 consecutive days of 50 grams/day (I don’t know if that is high enough). Based on your Vitamin D videos, I will start supplementing 10,000 IUs tomorrow as well as sitting in the sun (my latest bloodwork had the level at 33 ng/mL). I have also been taking high-dose melatonin in powder form for about one month. A PET scan will be scheduled for someday next week and I am curious as to what, if any, difference from my May PET will result given my pursuit of adjunct methods. Your videos provide hope for possible improvement.
Wow man I am sorry you are having to deal with all that. Gotta get that GKI down but it sounds like you are on a great start getting back to health! The water fast should help. Are you working with an integrative oncologist? Please keep me updated on your progress and on your next PET! God bless your journey!
@@DrCaseyPeavler Thank you for responding. Seyfried recommends a GKI of at most 2. If you had cancer, what would be your target GKI? I am not working with an integrative oncologist-no such specialty in Las Vegas. When I asked my oncologist if I could pursue high-dose IVC, he had no issue with it but did not provide guidance as to dose and timing-he is following standard of care. I will circle back post next PET. Thank you!
Try to get your GKI sustained around 1, but definitely less than 1.5. Supplemental ketones or MCT could help facilitate that. You need guidance man, please try to find someone to help you on your journey. I look forward to hearing your results!
Glucose Ketone Index. I have a couple videos about it. How to use the Glucose Ketone Index (GKI) to Fight Cancer ruclips.net/video/e8yS9VQaXzM/видео.html
You can get really creative, using reptile bulbs that emit UV-A and B in different ratios. No matter what artificial UV source used, would use in combination of Red/IR as unopposed UV is never found in nature
Realize that age stops sun UV from turning to Vit d .. it’s why we have to also supplement .. I live in Florida and I’m still low.. plus ethnicity causes low vitD.. it’s great for young people that have anxiety & depression! Can save lives!
Thank you for your comment and the discussion! I cannot accept that answer. Ethnicity does not cause vitamin D deficiency. The darker your skin, more melanin, the more sun you would require. That is true. Would highly recommend not using supplements other than last resort.
Get your vitamin D level checked, lab cost about $35 out of pocket. Currently I take 50k IU every other day. My integrative doctor would like to see my level between 80-90, at my worst it was 34, last time 54.
A lot of this unfortunately goes over my head, but I believe I understand enough to know this channel is a goldmine. Is there a dummies guide to kinda understanding the basics? I'm fair skinned and live in Australia. The UV is extreme over here. Is there a recommended UV range one does not wish to step outside of? I've avoided the sun for the most part. I freckle easily. I've just started avoiding seed oils.. Thankyou
Thank you for your visit to the channel and for your great comment. So I would look for a Dr. Max Gulhane. He is a fantastic and bright young doctor who is your countryman. Look at learning to build your solar callus.
Nice video. I'm new to your channel, so you may have covered this previously, but I'm sorta confused about glutamine. I have seen Seyfried talk about glutamine helping cancer grow, but I have previously read that glutamine is an immune booster. Is there a sweet spot for glutamine? Also, I have had digestive issues my whole life and have figured it is leaky gut. I have read that glutamine is good for leaky gut. Is this something I should avoid? Thanks.
Somehow I believe this information as I’m battling stage 4 Merkel cell carcinoma now as a young black woman. And I say young black woman because I don’t meet the usual markers for this type of cancer. The markers for this type of cancer is over 50 years old (and the first time I got it I was 41 years old), light to fair skin(I’m biracial African/Mexican), and predominantly white males(black female over here🙋🏾♀️). However, one thing I have always dealt with my whole life is constant low iron levels and also dangerously low vitamin D levels (is what I was told by a physician, but no immediate therapy was offered). And I’ve always wondered that because I was in a constant state of having those very low levels of vitamins/minerals in my body, has it what has contributed me to getting shingles at 26 years old and now getting metastatic Merkel cell carcinoma which is a very rare aggressive skin cancer. Very interesting to see this research all coming out now. Going to try my best to get my vitamin D levels up there and remain up there in the hopes it helps me beat this cancer. We’ll see. I remain hopeful 🤷🏾♀️.
Thank you for your testimony. I would look into mitochondrial haplotype biology. I would guess your mitochondria are built for a topical or sub-tropical environment. Given you have darker skin (more melanin) you NEED much more sun (at stronger UV index) than me for example. And I need more than someone with very white skin. Remember you cannot get well in the same environment in which you got sick. You would probably do yourself a huge huge favor by getting yourself to the tropics minimum 20N latitude, closer to zero the better, in a rural non-populated area to avoid EMF maximumally to be able to get good sun from sunrise to sunset, minimize excess artificial light and EMF at night for healing sleep. Look into Dr. Jack Kruse and you likely need a like minded alternative/integrative local health professional to guide you on other things. Please keep me in the loop of how you are doing! God bless your journey back to health!
@@tsmilingatuI would mega dose with liposomal vitamin c every 2.5 hours to tissue saturation too. Also look into intravenous Vitamin C. It's been covered up as an anti cancer treatment.
You aren’t able to achieve the peak blood levels even with lower doses (10-25 grams) of IV vitamin C. No, no oral or liposomal formulations will do it. Doesn’t mean they are bad, just means it doesn’t have the oxidative effect we are looking for at those higher doses.
Fire is about the best possible light at night for not completely screwing up our circadian biology. Mostly red and infrared which have their own respective health benefits!
LOL, thats a clever one....You honestly would need a spectroscope to tell. If you actually see blue, there must be some blue/green light being emitted. Something like this below link. Even that is limited because it isn't including UV or into the IR range. www.bhphotovideo.com/c/product/1436631-REG/sekonic_401_800_c_800_spectomaster_meter.html/?ap=y&ap=y&smp=y&smp=y&lsft=BI%3A6879&gad_source=1&gclid=CjwKCAjwiaa2BhAiEiwAQBgyHtVUIbIcEe33bf-AqTki-rMIzmhajyVZ-4hNZkvQauLuGxzwg-POghoCyQIQAvD_BwE
I appreciate your comment and your concerns. Human’s were designed or evolved to be outside in nature. We spend the vast majority inside under artificial light. We are designed to get more than enough vitamin D through adequate sun exposure. You can never get the benefits of the sun in any pill no matter how well absorbed. I’m sorry I wish that were the case.
I could at some point, honestly we are smack in the middle of a large cancer series. Dr. Jack Kruse likely has discussed this in the past if you are familiar with him.
My half-brother, who was fish-belly white had to have a Melanoma removed with lots of extra skin (borders) from the top of his left arm that he would hang out the window of the car.
I am sorry your brother had a health issue such as melanoma. Its scary. If he was as white as you say, would suspect he did not get adequate whole body sun exposure, which raises vitamin D, vitamin D analogs, melanin, a,b,g-MSH, as well as melatonin, all of which are extremely protective against all forms of cancer, including melanoma. Just out of curiosity, did your brother have any other metabolic issues such as prediabetes or diabetes? Overweight or obese?
@@DrCaseyPeavler Hi and thank you, Dr. Peavler, for that information. Yes, he was slightly overweight when he died at 56, not quite obese. Maybe 40-50 lbs overweight on his 6’ frame. He used to be super duper skinny when he was younger. Most of his life he was quite slim. But at the time of his death (age 56) he had very high blood pressure and they were trying to find a different medications to control it. He had Xanthelasma under his eyes (I never had that), so I’m sure his cholesterol was sky high. Both he and I share the same mother. (She was Swedish, Belgium & French). Our Maternal Grandfather (from Sweden) died at age 33 of a heart attack (he did work in the Chicago Stockyards maybe ate a lot of saturated fatty meat?). We both inherited high LP(a); mine is 70 mg/dL and normal is less than 30 and I am heterozygous for Leiden V mutation. I’m guessing my brother had the same issues so our blood is hypercoaguable. His father was Polish, my father was olive skinned (Fitzpatrick 4). I am Fitzpatrick 3/4. I have light brown/olive skin as my dad did; I tan very easily. In my YT pic, I used super light foundation for effect but people have told me it looks like I have a year-round suntan. In terms of prediabetes, I’m not sure if he had that. I don’t think so otherwise he would have told me. Just really high blood pressure that took him out suddenly at 56 with an MI.
I am so sorry the the loss of your brother. It’s hard to lose the ones we love. And God 56 is young…If you look at the Doug Wallace Mitochondrial etiology of complex disease videos, anything from Dr Jack Kruse, they can help make the link between HTN, HLD, overweight, heart disease, and cancer. My gut tells me he has at least prediabetes. Unfortunately it’s not picked up by many doctors and if they find it, they don’t know what to do with it, and many of them don’t even document it in their charts. The Factor V, the Lp(a) also probably set him up for failure too sadly. I am sorry for your loss
Fantastic questions. I’d start by saying I don’t know of any autoimmune diseases that have antibodies against glutaminases. Doesn’t mean there aren’t any I just don’t know about them. I will look at the literature and see what I can find. Second, almost any autoimmune disease increases your risk for cancer, thought to be secondary to chronic inflammatory state. But if these transglutaminase enzymes are constitutively activated, I could see that becoming extremely problematic and another mechanism for setting up a cancer initiation and propagation.
@@DrCaseyPeavler Cancer due to the overexpression of TNF alpha and many cytokine? I have celiac disease which went undiagnosed for decades due to my seronegative. I know that celiac disease is associated with diabetes mellitus 1 but what I am searching is how glutamine change with transglutamine. ( I am studying the realtion between Gad65 and Nmda receptors due to my Ataxia)
Yes NF-KB which is the master inflammatory activator, TNF-a, IL-1b and others pro-inflammatory cytokines. That was the major mechanism I understood. I am sure there are several others.
You need a doctor to check your level. Aim for highest level without affecting calcium. Perhaps 100ng/mL. I would highly look at getting this from the sun if at all possible. Second best option would be artificial UV sources from manufacturers mentioned. Pill would be last resort in my book.
This part of the series is about cancer. Cancer will uptake and utilize glucose and glutamine 10-30x what normal cells do. I do not believe it will be a big problem for normal cells, normal kids’ growth and metabolism. Nor have I seen anything to suggest this in the literature. Deficiency on the other hand is well documented to cause growth and metabolism issues during development ie Ricketts.
Sperti sun lamp (UV-A), Sperti D lamp (UV-B), chroma light D-Lamp (red/infrared/UV), EMR-tek Krypton. I have discount codes in the description for EMR tek and Chroma.
@@DrCaseyPeavler merci, I'll see what is available in Europe. As a pale skinned red head age 75, what would you recommend or NOT recommend? My dad had melanoma.
Start low and go slow is the mantra of geriatrics. Usually in relation to medicines. But I think it could apply to your situation. I would not use artificial UV without being in combination with red/infrared. I would focus mostly on getting as much sunlight on your skin in the earlier morning and evening time to start to build your solar callus. Supplement that morning and evening light with red/infrared photobiomodulation. Then, gradual slow introduction of UV, in the form of sunlight always first and foremost. Again never unilaterally or unopposed if using artificial UV.
@@DrCaseyPeavlerI don't really understand the differences between all these. Im considering the chroma D lamp because its within my budget. is that just a less refined version of the last one? Will all three of these perform the functional purpose of supplying my body with the vitamin D? I live by the great lakes area in Indiana and we are encroaching winter. 😅
Thank you very much for the very comprehensive information you provided us. My question is, do you prefer vitamin D to be used as a supplement or obtained from sunlight? If you recommend vitamin D supplement, does it need to be taken with vitamin K2 or not? thank you very much
First and foremost from the sun! No question at all. Distant second would be artificial UV w/ photobiomodulation concurrently. Third/last resort would be supplemental. I would recommend K2 no matter where D comes from.
Context is everything, would depend on your disease burden and state of health. We make recommendations based on 25-OH vitamin D serum levels. Have you had this checked recently?
If you are going the lamp route, you also need IR exposure besides the UV-b exposure. I've had great success with vitamin D3 supplementation, it blocks seasonal colds, influenza and COVID.
Glutamine diet is not easy, and your body can make its own glutamine, which complicates things further. Are you struggling with cancer or are you talking in terms of prevention?
At 22S you shouldn’t need it! Start from sunrise until about 930-10am, and 330-6pm. At those times mostly visible, infrared and very little UV. Learn from a young Australian doctor named Max Gulhane. He has a RUclips channel. Great guy, he can teach you to build your “solar callus”. Take it slow.
God Bless you for this Huge Info. So this indicates taking an L-Glutamine supplement to increase Glutathione is contraindicated as Glutamine can increase cancer risks, correct?
I can’t say I would take it that far. Under healthy conditions, taking extra glutamine will probably be fine. BUT if I had cancer I wouldn’t want to be in the same room as a glutamine supplement…
Fantastic question. I am not sure if the answer is known. I think with K2 you just need enough. Then the question is how much is enough? Look at the terrible RDA recommendations for most other nutrients, why would their recommendation for K2 be any different. For Vitamin D, get your serum 25-OHD3 as high as possible without hypercalcemia using UV from the sun.
This and the video after it will talk about the catch 22 with autophagy and mitophagy for cancer: Eliminate DAMAGED Mitochondria and Transform your Health! ruclips.net/video/Ae3ofR3tKfw/видео.html
@DrCaseyPeavler thanks doc, so is fasting and keto beneficial to starve cancer or is it a double edged sword? How much low carbs is allowed per day and if fat intake is high then the amount of calories matter or not? Below 500 calories or around 800 is acceptable? Is taking green juice good or bad?Can Chia seeds be consumed for fiber? What about walnuts? Thank you and sorry for too many questions. My dad had cancer and now my mom has it so I am trying to maintain her diet.
I am really sorry about your dad. I imagine you have dozens if not more questions. Given cancer is a mitochondrial metabolic disease, and cancer cells require 10-30x more glucose than normal cells and cannot use fat for fuel, this explains why the absolute foundation for metabolic therapy is a calorie restricted ketogenic diet. This whole series is built for folks like you and your dad to learn. I suggest starting from the first video in the series and watching it all the way through.
How much Vitamin D should you take ? Or what level should you target? Should we follow COIMBRA PROTOCOL if you have cancer? Is there a drug for 1,25 Vitamin D?
Ideally keep your 25OH as high as possible without causing side effects. 1,25OH is also known as calcitriol. It’s given to patients with significant chronic kidney disease or end stage renal disease on dialysis.
My friend, I cannot underscore enough how I think relying on supplemental pills is a bad idea. In my opinion. Get it from the sun. If that isn’t an option consider artificial UV.
@@DrCaseyPeavler How about effects of near infrared lights during the early part of sunrise and sunset? What is the effect on glutamine? Most experts in internet are saying that Vitamin D is highest at noon time
I don´t understand the reason why supplementation with the active form of Vit D 1,25(OH) is different and worse than the same produced from the sun. Isn't it the same molecule anyway?
Great questions. You miss out on a lot by taking a pill only. Not only from vitamin D3 and L3 analogs. But a lot of other chemicals your body makes through POMC. Not to mention melatonin. You may get some benefit from watching this video here: Vitamin D's Superpower: MASTER Antioxidant Regulator and Cell Protector ruclips.net/video/quNUPGYMDnA/видео.html
Impossible to know to be honest. We do not routinely check 1,25 hydroxy as it is assumed to be good if 25 OH is good. It’s very expensive test. For most people we check the 25OHD3 levels. Do you have any renal issues?
It actually does more for glutamine than DON, blocks several steps of the uptake and utilization. However, DON is a drug and may have stronger effect on its target. We can use multiple glutamine blockers (natural and drug) to have synergistic effects.
I'm always wondering if we really need the DON. Between this, antiparasitic, green tea, and keto/fasting. It's why I wish trials could be conducted to see what would be effective.
I think we have too much faith in DON. I’m sure it does help but there are so many other things we can do. I think it’s the synergy that really makes the protocol successful, not just one part.
Can vitamin D from UVB, either from sun exposure or UVB lamps, penetrate the blood-brain barrier? I'm asking because I have GBM and I'm following metabolic therapy. Based on your presentation, it seems like this would be a great addition to my toolbox of anti-GBM strategies.
It would be a fantastic addition! Yes vitamin D and several analogs can cross the blood brain barrier. How are things going for you with your current approach?
@@DrCaseyPeavler I was diagnosed one year ago. Unmethylated, IDH wild-type, and 85% resection. Couldn't complete chemo due to low platelets. I've been without conventional treatment since December 2023. However, from the beginning, I adopted metabolic therapy, strict keto (GKI < 2, unrestricted calorie intake within a 6 hour eating window), and a handful of supplements and repurposed drugs. I've been trying to find a better way to target glutamine which is why I clicked on your video. On my last MRI, a month ago, the residual tumor shrank by 65%. I find your videos very helpful for my current approach.
Wow 😮 65% reduction in tumor size! That is AMAZING! Keep up the fantastic work. Might want to keep GKI closer to 1. Stay tuned to our channel for videos about glucose and glutamine inhibitors. If you are in FL we do offer consults for more personalized information.
That is a question to discuss with your doctor. We treat to a blood 25OHD3 level. That being said depending on your health condition you may want to push it up to a higher level. Always try to get vitamin D from the sun first and foremost, second best would probably be artificial UV-B
I am sorry you are having issues with your stomach. It’s probably better to take a BIG step back and look more critically about your overall habits and environment. Why is my vitamin D so low? What are my lifestyle practices that lead to that? Not enough consistent UV exposure? Too much blue light during day and night? Essentially a deficiency of darkness? Overexposure to nnEMF? Vitamin D supplements or injections would be the last resort…in my opinion
Nature is amazingly wise. Very informative. I hope, assume, Thomas Seyfried will bring this up as well. Can also tell that I would like to know more about what serum level range one should aim at. I am at 180 nmol/L and I was sharply advised by a Dr. that this is way too much. "Stop taking that supplement".... I personally believe that anywhere between 100 and 200 is a good level. Any comments? Where I live we have barely 4 months usable sunlight. UVB source might be wise to get???
I would have to make the conversion, nmol/L to ng/mL. But for ng/mL healthy range is 60-80, if you have cancer as high as you can keep it (un-supplemented) without causing hypercalcemia. Your doctor will need to check 25OHD3, calcium and albumin (CMP)
As kids in the 70ies our mother put us in front of a UV light in the winter months. For the moment I have only a red/infrared lamp for the winter and supplement vit D, will have to look into UV lamps here in Europe...
We are talking about vitamin D’s actions in relation to cancer in which inhibiting glutamine uptake and utilization is a good thing. You should not have to worry about your gut lining under normal conditions.
Glutamine is a secondary fuel source for cancer. It's in almost everything. It's also non-essential because our body can make it when we need it. Dr. Thomas Seyfried has a protocol called Press Pulse that pulses a U.S. banned drug into the body at certain time, on a certain schedule in a specific dosage. It wipes out glutamine for several hours to starve the cancer from this fuel source. No sugar, no glutamine makes cancer shrink and die off. There's a doctor in Grand Cayman that implements this protocol. Just do an online search and it will pop up.
Yeah, but this is just a part of metabolic proticol and is not enough. Search for clinical studies from Dr.Laurent Schwartz, cancer is highly adaptive, must be treated with a nubmer of different strategies, keto + vit D is not sufficent.
I couldn’t agree more, and I am not trying to sell that as the case. But, we have many tools in the tool bag to lower glutamine uptake and utilization than just DON.
I wonder if sun exposure has a negative effect after a certain point? Like, it’s good to get some sun exposure, but not so much you burn all the time. We do know that fair skinned people get melanoma more in Australia than in Ireland, right?
Supplement with astaxanthin and once it builds up in your tissues you will be protected from UV damage is what many who take it say. 12 milligrams to 40 milligrams is safe.
What is regular sun exposure doesn't work for a person say with long term metabolic issues? Then a lamp would be no better, becasue its a fault in the body not the exposure,wouldn't supplements be better than nothing?
@@DrCaseyPeavler Long term auto immune low thyroid and arthritis, weak muscles and tiredness come and go. I am normal weight. I have persistent low vit D and iron even though i'm beyond menstruating years in age and have a good diet and get plenty of sun and activity outside in all hours of the day. Never wore sunscreen and don't take any pharma besides thyroid hormone. Also I've never had skin cancer even with my low d levels in a family who does get lots of cancers. I did find D supplementation great for avoiding covid and only got sick when i forgot to keep taking it. btw thanks for taking the time to reply :)
Do me a favor. Look into contacting Dr. Max Gulhane. He lives in Australia. He is a good doctor and person. Also start watching as many podcasts from Dr. Jack Kruse as you can. Please. I want you well.
How about the fact that our ability to get vitamin D from the sun reduces significantly as we age making supplementation the only way to get good levels?
@@DrCaseyPeavler I'm surprised you aren't aware of that? Google "does the ability to make vitamin D from the sun reduce as we age" and there are many confirmations that it does. I saw a study some time ago that found from age 20 to age 70 our ability to produce vitamin D from the sun falls by as much as 75%. I am 75 and my skin that has been exposed to the sun is aged and damaged. My choice has been to take D3 with 5000iu in the winter and 2500iu in the summer daily needed to maintain healthy levels for me[tested]. Because I take D3 I also take K2 as MK7 to maintain healthy calcium levels in the blood by moving it to the bones and teeth.
I’ve seen that, but closer to 50%. But that is not taking into account the ability to develop a solar callus and maximize UV absorption nor factors that inhibit vitamin d conversion. I would point you towards Dr. Jack Kruse or Dr. Max Gulhane. My recommendation stands. Would rather you get it from the sun given the multiple other benefits aside from vitamin D. No pill contains what is available outside, and never will.
The polymorphisms you speak of would only make a difference at the target tissue, not synthesis. The best possible way to get vitamin D is through full spectrum sunlight with UV-B. If you cannot get that, you are at a huge disadvantage, perhaps artificial UV vitamin D lamps would be second best.
@@DrCaseyPeavler The Liposomal D3/K2 I spoke of, had women who could not (for decades) get their levels above 30 even with Rx D3 dosing, one was at 52 in a few weeks iirc and another at 80 in 3 months, their symptoms of low D3 alleviated as well.
I suspect it was likely an environmental issue. Where did she live just curious? I cannot stress this enough, getting vitamin D from a pill or sublingual liposomal formula is not equivalent to getting it from UV-B light from the sun. I am glad symptoms resolved that being said.
@@DrCaseyPeavler Don't know their whereabouts, try this, go to Google search for W h o l e F o o d s (Censorship evasion) and Dr. Tom Levy. Read the 2 part interview he did with Dr. Richard Passwater. See what you think.
@@DrCaseyPeavler sure thing. Because cancer is addicted to methionine. This has been proven. You can read many papers on this. It’s been known for 50 years. Go to Pubmed and search for Dr Robert M Hoffman. Cancer and Methionine. “The Hoffman effect”. This is a crucial factor that you and many others have overlooked and it is the most significant factor
@@DrCaseyPeavler that’s great, thank you. And if you ever want to meet Dr Hoffman and learn directly from him on this let me know and I can introduce you
I unfortunately cannot tell you. This would be context dependent and a discussion between you and your doctor. Most people need to regularly check 25-OH D3 levels.
I think you are missing my point. When you look at data from a wide range of cancers, vitamin D deficiency is commonly seen. However, when the supplement is given, the diseases do not completely go away. Therefore it is more than vitamin D. Its all of the other things you get from the sun and do not get in a pill.
@@DrCaseyPeavler Vitmin D3 is Cholecalciferol what you can buy mostly as a suplement IE 1000 IE 4000 or even get prescribde by doctor, also for ostoperose. In your slide en presentation you discus about an other form 25-Hydroxycholecalciferol? In Winter I use Cholecalciferol D3 daily what probabably is suboptimal to Sun. This D3 will probabably converted to 25-Hydroxycholecalciferol to give the sugested effect of extra glutamine blocking in Ketosis state, what my objective is.
You may want to re-watch a couple of the earlier vitamin D videos. 7-dehydocholesterol + UV-B = D3 Liver converts to 25OHD3 Kidney converts to 1,25OHD3 Mitochondria make all of the D3 and L3 analogs which are also biologically active
The rhythm of the talk reminds me of machine gun bursts. It's making the listening overwhelming and saturating. It's too bad because the content seems to be very valuable. I must admit my brain bailed out after a few minutes. Maybe it's me. Anyway thank you for this very interesting subject and your efforts at showing us where to look at.
That’s an interesting observation. I kind of like that nickname Machine Gun Peavler…joking aside, I am working on my speed and comfortability on camera. Little by little. I am glad the subject was interesting and the content was valuable for you!
Context is everything. A lot of factors to consider. You will need a doctor who can regularly check your 25OHD3 and CMP. Then you will need to figure out how much UV is available in your environment and see if it is even doable for you now. Lots to consider!
Thank you Dr. Peavler for those very important informations concernng the effect of Vit D, allthough i ´d like to mention, that you´re speaking like a bot 😀 And makes the Video pretty difficult to follow for poeple, whom aren´t native speaker. Please make much more Videos 😀😀😀
Thank you for your feedback. I am glad you got something out of the video that can be helpful for you. That is definitely my goals with these videos! In terms of my speaking, I appreciate the feedback. I’m trying to make every video better than the last.
Why would it not? If it blocks glucose uptake, utilization, PDK, Glutamine uptake and utilization, fatty acid synthesis, glutathione synthesis and acts to increase oxidative stress in cancer cells, how would it not?
The opening monologue is a waste of time. My dad died of basal cell from sunburns. Melanoma is not the only danger. It is definitely dangerous to get too much sun exposure and no one wants to look like a shriveled prune.
Thank you for your feedback and your point of view. Although local basal cell carcinoma can be problematic and wrinkles can be annoying and unsightly, I am much more concerned about what is killing off you and my fellow humans at an increasing and unbelievable rate.
m.ruclips.net/video/tmH0V0eoNQE/видео.html This is Sami Tugano from Japan. She gives a great breakdown as to how this really happens. She is also utilizing Seyfried's method to manage her stage 4 cancer.
Just the NIR alone protects against wrinkles. High end dermatology clinics use red and near infrared to built collagen and reverse skin aging. The sun is roughly 50% near infrared. The population has been systematically brain washed to think the sun is harmful. It’s sad really. And untrue.
What you experts always get wrong when discussing vitamin D is that your studies use synthetic vitamin D rather than natural vitamin D. Almost assuredly you are using vitamin D from lambs wool. How many people have lambs wool in their diet? Until you do a study using vitamin D derived from fish oil and compare the results with vitamin D derived from lambs wool you are misleading people. Let’s see a study using a natural vitamin D source before you make any more claims? Please don’t take this as negative because it’s just common sense constructive criticism.
Thank you for the feedback. Just out of curiosity, is this the first video you have watched? Reason I ask, is because every video kind of builds on the one before it. It would be hard for about anyone to start here.
Who else is shocked besides me about Vitamin D’s role in shutting down glutamine utilization?
WOW! I am! That is revolutionary information! Never heard that before. THAT IS AWESOME!! I need to move to Florida. Hate Chicago….
I am so excited ,l have been allways thinking of glutamine dielemma, D seyfried explained, This is revolutionary ❤
Awesome news. We know that cancer needs glucose and glutamine. A carnivore diet with high Vit D seems a good approach for starving cancer.
@@DrCaseyPeavler Yes that’s great news as DON is hard to get!
@@gotohellfastadd fenbendazole..
Every time I review this video, I come away MORE amazed, and it clarifies many other research papers I have had important questions about! Such a productive rabbit hole, I'm diving back down right now!
Haha there are too many rabbit holes sadly and (I’ll speak for myself) not enough time in the day to jump down them all. Perhaps someday when this channel is decent sized and I don’t have to rely as much on working at the hospital I can be even more estudios and jump down a few more…
Most carnivores no longer sunburn. 88, 10 months carnivore to fight cancer with Tippens protocol - and this summer is the first of my life of never any sunburn. Started lying out under blazing sun for 25 minutes a day (for anti-cancer benefits) and got a healthy looking tan with zero burn. A new carnivore - old friend - was out in midday sun for four hours. Same thing, nice color, zero burn.👌💖
Amazing testimonial! Thank you for sharing! How is your fight against cancer going?
Might have more clues after PCP's consult in a few days. Will lay out all my false starts, new info that I'm trying out and unfortunate discovery - IE: Advanced cancer may GROW from fasting-generated autophagy, whereas early cancers are stopped by fasting's autophagy. Now concerned my OMAD eating might be spurring metastasis. I hope for guidance if not too late, period. Know that physical exercise (high arm swinging while walking, against lymphedema's arm swelling) does reduce swelling. But is it irrelevant at the point of advancing lymphedema? Don't know. How late is too late? Looking to create a miracle here. My willpower is flagging re the walking. Am so physically weak since a spleen attack and the encroaching lymphedema. 🙄😔🙏💖
First off. You have made significant lifestyle modifications to help yourself get better. Please try not to shame yourself. NO MATTER what intervention we make, there is a level of risk vs benefit. Fasting is a powerful autophagy activator yes. But it’s going to radically lower cancer growing insulin, IGF-1, glucose and glutamine! I am not God and do not know for sure, but I would bet that is a NET POSITIVE. You are doing what 95+% people are likely not willing to do. I am proud of you no matter what the next results show.
@@DrCaseyPeavler Thanks for that - I will stop seeing late stage cancer fasting autophagy as problematic, as it is one of the few tools I have left. 🙏💖
A powerful intervention it is!
My 83 year old Dad had worked 18 years outdoors all day year round in the Key West sun and still had low vitamin D levels, and apparently many retired folks in Florida do, in spite of plenty of Sun exposure. We supplemented him with d3 and k til his levels reached 80 and he did better.
Interesting. What kind of work did your dad do?
W
Not sure what you mean, but thank you for watching!
It's because they have a copper deficiency. Look into Morley Robbins
Sunscreen blocks production. Also diet can affect Vit D production. And what many do not know--its clinically proven-- if you shower after sun exposure (even without sunscreen) it will lower the amount of Vitamin D your body has just made. See studies referenced by the American College of Lifestyle Medicine--Dr Wes Youngberg speaks about this in his Diabetes Undone training videos.
Dr.Berg also talking about vitamin D fighting cancer.
Vitamin D is amazing to be honest. But what the sun does for us, is more amazing…
I cannot agree with much of what you said. Vitamin D does not get converted to oxalates. It can increase intestinal absorption of calcium and oxalates yes. But if your diet is limited in oxalates that should not be a problem. I would not limit my sun or vitamin D intake based on that.
I can also agree that nothing is within a vacuum. Yes we need minerals such as magnesium. They are critical in their own right for hundreds of chemical reactions.
@@DrCaseyPeavler
Thanks for that clarity!
Happy to be of service!
@@DrCaseyPeavler Vitamin d-25 low means d-1,25 is formed and used... i think that copper that they say are the cause is the cure.
I was diagnosed with parotid stage 4 squamous cell carcinoma in 2017. I had radical head and neck surgery 2018. I refused chemo and radiation and I am still alive. I attribute my success to God and the keto diet. Keto + 0 sugar + 0 dairy = effective results. How can someone obtain calcifol? Or 25 hydoxy vit D? What is the dose? Do you need a script? What in OTC supplements are compatible with these options? What are the doses? Would a person also require K2? Thanks, Rosie.
I am sorry you are going through that but what a miracle to be doing so well by the grace of God and a what sounds like strict keto diet.
Sunlight depending on time of year and latitude from 10am to 3pm with as much of your body exposed as possible without getting arrested is the prescription.
IVERMECTIN ?
Why no dairy? I would like to take kefir
Appreciation and blessings from Sydney Australia .
God bless you!
Best doctor ever!!!!! 🙏🏽🙏🏽🙏🏽🙏🏽🙌🏽🙌🏽🙌🏽🙌🏽🙌🏽🙌🏽
Not true! But thank you for your support! God bless you!
@@DrCaseyPeavler That is honest but nice approach I must say! A bit technical-Medical. Some thoughts about practical dose, timing of for examample D3 IE 4000 per day at the end would be great.
I have type 1 skin that always burned and never tanned which greatly limited sun exposure. Melanotan 2 peptide was a miracle as I finally was able to be in the sun. Chronic viral infections improved radically. Waiting to try melanotan 1 to see if it works the same.
That is amazing that it helped you get started with the sun, but now that you are started, would let your body’s endogenous a-msh take over and make your own melanin at your body’s pace.
Add astaxanthin
That, or build up a solar callus by being exposed to infrared light and small increases in UV until your skin can tolerate it better.
@@smarzigwhy Asta?
Since they never responded…As a powerful antioxidant it can reduce chances of burning, but also can possibly lower benefits. Would recommend just not pushing it to hard to the point of burning.
Very informative videos. I assume you have gotten this request before, but I would be very helpful to have the pubmed links to the papers you present in the description. Would save me a lot of time manually typing in titles and authors to locate them.
I have listened to many of Dr Sefried's presentations and understand the relatively simple idea of starving cancers of glucose with intermittent fasting to promote autophagy. I have also followed the need of also blocking glutamine. What do you mean more specifically when you talk about "pulsing" glutamine inhibition because it is essential to other cells in the immune system. Does this mean cycling intake of vitamin D. Also, how or where would we get 125 hydroxy vitamin D.
Great questions. I have a video called how Metabolic Therapy checkmates cancer you might find useful.
How Metabolic Therapy CHECKMATES Cancer
ruclips.net/video/O4sajpZ_SFM/видео.html
What would you do if you lived in a dark winter country that is dark for 5 months of the year?
What amounts of vit d, and other supplements amounts would you be taking personally?
Very clever wording of the question , he cant tell you what amounts to take. But he can share what he does, or what he would do in a hypothetical situation .
Everyone always remember how to word your questions to docs online !
Great question, unfortunately no way to answer that. Would depend on your mitochondrial haplotype, your health status, and blood levels.
Yes we have to be very careful not to attempt to practice medicine over the internet. I wish the laws were different..
I would look into using cold water immersion (should be fairly easy in cold northern climates), sauna (Finnish, Infrared), local seafood, perfecting sleep environment, making sure you get enough minerals. But in all reality for some people a Northern latitude will not suffice.
Regarding the metabolic effect of vitamin D on the Walberg process, this video is ground breaking!
God willing, this is the FUTURE of medicine.
What is a good dosage of Vitamin D if already in late stage Leukemia!??
First of all, I am sorry you are in the position you are in. Remember you cannot get well in the same environment in which you got sick first and foremost. There needs to be a complete renovation of the environment, and no stone can be left unturned. Where are you located? I cannot practice medicine on youtube, but you want to your vitamin D to be in a range that conveys the maximum benefit. First, the source of the D needs to be from solar light (UV-B), and likely need to push the level as high as you can get away with without affecting calcium levels. Probably > 100ng/mL, but you will need to check your 25-OHD3 level regularly to know where you are on that scale.
@@sharonm.8411may I suggest at least 10,000 iu’s per day…….at least. My husband had Lymphoma stage 4 while he was having his treatment and was in hospital the ward came down with covid he had no symptoms and he has fully recovered from his cancer. I believe the vitamin D3 contributed to his getting through this condition.
I suggest asking the question why did my husband get cancer to begin with. I believe it is the duty of a good doctor to help answer that question. Likely not one thing, but a constellation of things. If you don't answer that, and address it to the best of your ability, disease will recur. You cannot get well in the same environment (conditions of existence) in which you got sick. Vitamin D is a powerful intervention. BUT much more powerful when obtained from the sun instead of a pill. I am glad you husband recovered from cancer!
Professor Thomas Seyfried talks about glutamine
Yes he does. Extensively
Right now, given my location at 44 degrees N latitude, in rainforest of western Oregon US, and faced with low D3 potential all winter, I'm seriously wanting one of these new lamps! A long vacation into the tropics this winter is likely not 'in the cards' yet. But, a lamp could be my best bet in the short run? I had been relying on supplementation, but understand the inadequacies of that, and my D3 levels hovered around 33 to 36 w/o increasing much beyond my end of summer levels last year. I'm shooting for 60 to 80, so a lamp is likely my next best effort for this winter. I get a great deal of sun in the summer, working outside all day, but my levels did not reflect much increase last summer, so this summer I have greatly further increased sun exposure, and anticipate better results likely, heading into my dark winter months.
I have focused on increasing NIR in dawns early light, and having a low power incandescent bulb present when using computer in evenings, but understand more diligent reductions in blue light exposure are necessary if I cannot yet just live in dark after sundown. I am trying to build up my abilities to help family and anyone else come to better understanding about all things quantum, but it is such a slow process w/o pushing too much, and being counter-productive. Yet, so many around me are getting chronic diseases that are very likely able to be helped very much by such knowledge. Frustrating!
The new EMR Tek Krypton lamps look amazing to be honest. They are designed with Dr Kruse in my understanding.
Not to mention improving my horrible NNEMF environment. Lots of work to do!
That is a job for most of us Ray. Myself included.
Any specific types or brands of lamps you'd recommend, please?
Would sure be great if you put LINKS to studies you cover in these videos ! Want to READ them ! Wonderful videos ! Thank you
You are now the second person to ask me this. I am considering doing exactly what you ask. It’s just they are already a lot of work as is, each video takes me hours to shoot and edit
I love that you try and explain everything to us non doctors, but I can't understand any of it and I wish that I could.😢 how much vitamin D3 should I take a day
I appreciate your feedback. But. No one would know. Context is everything. For normal healthy people 60-80ng/mL blood level is good. If you have cancer then higher would be better. But that would require a doctor to check your levels and a titration of the dose.
@@DrCaseyPeavler thank you so much Dr. Thank you.
You are very welcome!
For those with adverse VDR mutation - drop the 25 Hydroxy supplementation, and supplement directly with liquid 1.25 Hydroxy, the active form of Vitamin D. This will be your game changer. Weird for me so many talks on Vit D on the net, still so few doctors mentioning 1.25 supplementation, and which is incredibly mroe effective.
Just a friendly reminder. VDR mutations have nothing to do with synthesis. It’s the target tissue or cell that receives the signal via the VDR vitamin D receptor. Vitamin D can be maximally beneficial with normal VDR receptors, but there are many actions that do not require VDR, both classical vitamin D pathway and D3/L3 analogs. Most people who do not have significant renal disease do not need to take calcitriol active vitamin D, in fact it could be harming your potential.
@@DrCaseyPeavler Why would you feel it would be harming, could you elaborate on that and for our understanding? Also, you touch another very important point, of which few are aware I believe. If you wanna go "high" dose Vitamin D, and do it life long, make sure you're kidney can sustain the long term effort.
I think harmful may be a bit harsh of a word, but it’s possibly harmful yes. I think a better way to look at it, is that you are not capturing the most potential from the vitamin D system by using just 1,25OHD3 or calcitriol supplements. That I can say for sure.
Theres a study that showed an increase of 1,25 by using vitamin d3 nanoparticles (vit d3 embedded in micelles). Anyone can make such an emulsion at home using olive oil, vit d3, lecithin, and some water. Just blend it up real good.
1,25 although considered the classically active vitamin D, is one of about 30-40 vitamin D3 and L3 analogs that are also bioactive. Get it from the sun if possible.
Wondering if higher doses of Vit D would result in greater suppression of glutamine uptake. In other words, if 60 ng/mL is good, would it be even better to target >100 ng/mL in the presence of cancer? Also wondering if glutamine uptake is enhanced as an alternate cancer fuel source during ketosis?
My bet is yes. If I had cancer, I personally would push my un-supplemented vitamin D level the highest I could without causing hypercalcemia. But that is a discussion between you and your doctor of course.
Always get vitamin K. K is what pushes the calcium into your bones. D absorbs it from your food only.
K2 is powerful!
Good question
It’s a fantastic question!
I'm dreading the winter in the UK
Hopefully we get 15 good days of sun in September. After September 15, it's dark until March.
God…any way to move? Take frequent tropical vacation?
Same here in the Pacific Northwest 😢
I think it’s time for a tropical or sub-tropical vacation. Come down to Florida, we would love to have you!
@@martinknows1970
Count your blessings. Winter in the UK is a walk in the park compared to much of Canada!
😬 you better take some sunny tropical trips or invest in some photobiomodulation devices and a sauna…
Oh yes, very encouraging! And, brings up a host of concerns about the current medical/pharma paradigm in relationship to lack of funding and lack of continuing education in using the full scientific methodology, that should be primarily focused on finding mistakes rather than expensive products w/o adequate pointedly investigative integrity.IMHO
We need a complete paradigm shift..
So much of the healthcare establishment is morally stained, biblically, αδοκιμον. The whole apparatus is flux...
It’s a sad state of affairs we are in..
barking mad paradigm.
Truly.
@DrCaseyPeavler Thank you for your informative videos!
I have high-grade urothelial carcinoma in my right ureter (non-invasive) per CT (and biopsy in March) and a lesion on the para-aortic lymph nodes per PET. I have been intermittent fasting (and multi-day fasting periodically) since late last year and on the carnivore diet as well. My GKI average is about 2.0
I am on my 4th day of a 10 day water fast and my second day of high-dose IVC (15 grams yesterday, and 50 grams today). I intend on 10 consecutive days of 50 grams/day (I don’t know if that is high enough). Based on your Vitamin D videos, I will start supplementing 10,000 IUs tomorrow as well as sitting in the sun (my latest bloodwork had the level at 33 ng/mL). I have also been taking high-dose melatonin in powder form for about one month.
A PET scan will be scheduled for someday next week and I am curious as to what, if any, difference from my May PET will result given my pursuit of adjunct methods. Your videos provide hope for possible improvement.
Wow man I am sorry you are having to deal with all that. Gotta get that GKI down but it sounds like you are on a great start getting back to health! The water fast should help. Are you working with an integrative oncologist? Please keep me updated on your progress and on your next PET! God bless your journey!
@@DrCaseyPeavler Thank you for responding. Seyfried recommends a GKI of at most 2. If you had cancer, what would be your target GKI? I am not working with an integrative oncologist-no such specialty in Las Vegas. When I asked my oncologist if I could pursue high-dose IVC, he had no issue with it but did not provide guidance as to dose and timing-he is following standard of care. I will circle back post next PET. Thank you!
Try to get your GKI sustained around 1, but definitely less than 1.5. Supplemental ketones or MCT could help facilitate that. You need guidance man, please try to find someone to help you on your journey. I look forward to hearing your results!
GKI?
Glucose Ketone Index. I have a couple videos about it.
How to use the Glucose Ketone Index (GKI) to Fight Cancer
ruclips.net/video/e8yS9VQaXzM/видео.html
Could you suggest a good vitamin D light bulb or light? Does it need to emit UV-B?
Thanks!
What kind of budget do you have?
I bought a used Spertib. also, there's a RUclipsr that will show you how to make an even better one lamp off of Craigslist for $50
You can get really creative, using reptile bulbs that emit UV-A and B in different ratios. No matter what artificial UV source used, would use in combination of Red/IR as unopposed UV is never found in nature
Realize that age stops sun UV from turning to Vit d .. it’s why we have to also supplement .. I live in Florida and I’m still low.. plus ethnicity causes low vitD.. it’s great for young people that have anxiety & depression! Can save lives!
Thank you for your comment and the discussion!
I cannot accept that answer. Ethnicity does not cause vitamin D deficiency.
The darker your skin, more melanin, the more sun you would require. That is true.
Would highly recommend not using supplements other than last resort.
"Realize that age stops sun UV from turning to Vit d..." Reduces, not stops.
How many IU’s should we be taking if we have cancer?
Would be most appropriate to be a discussion between you and your local like minded doctor but generally we treat to a blood level: 25-OH vitamin D
Get your vitamin D level checked, lab cost about $35 out of pocket. Currently I take 50k IU every other day. My integrative doctor would like to see my level between 80-90, at my worst it was 34, last time 54.
A lot of this unfortunately goes over my head, but I believe I understand enough to know this channel is a goldmine. Is there a dummies guide to kinda understanding the basics?
I'm fair skinned and live in Australia. The UV is extreme over here. Is there a recommended UV range one does not wish to step outside of?
I've avoided the sun for the most part. I freckle easily. I've just started avoiding seed oils..
Thankyou
Thank you for your visit to the channel and for your great comment. So I would look for a Dr. Max Gulhane. He is a fantastic and bright young doctor who is your countryman. Look at learning to build your solar callus.
Nice video. I'm new to your channel, so you may have covered this previously, but I'm sorta confused about glutamine. I have seen Seyfried talk about glutamine helping cancer grow, but I have previously read that glutamine is an immune booster. Is there a sweet spot for glutamine? Also, I have had digestive issues my whole life and have figured it is leaky gut. I have read that glutamine is good for leaky gut. Is this something I should avoid? Thanks.
It is somewhat confusing and nuanced to say the least. Let me get you started.
Feeding Cancer: How Glutamine Fuels Tumor Growth
ruclips.net/video/_T1dEwdRgFk/видео.html
STARVING Cancer: Therapeutic Inhibition of Glucose and Glutamine
ruclips.net/video/SQHnhiu4bh8/видео.html
How Metabolic Therapy CHECKMATES Cancer
ruclips.net/video/O4sajpZ_SFM/видео.html
How to BLOCK Glutamine: SPECIFIC Targets
ruclips.net/video/HVJFj5qBXa4/видео.html
Somehow I believe this information as I’m battling stage 4 Merkel cell carcinoma now as a young black woman. And I say young black woman because I don’t meet the usual markers for this type of cancer. The markers for this type of cancer is over 50 years old (and the first time I got it I was 41 years old), light to fair skin(I’m biracial African/Mexican), and predominantly white males(black female over here🙋🏾♀️). However, one thing I have always dealt with my whole life is constant low iron levels and also dangerously low vitamin D levels (is what I was told by a physician, but no immediate therapy was offered).
And I’ve always wondered that because I was in a constant state of having those very low levels of vitamins/minerals in my body, has it what has contributed me to getting shingles at 26 years old and now getting metastatic Merkel cell carcinoma which is a very rare aggressive skin cancer. Very interesting to see this research all coming out now. Going to try my best to get my vitamin D levels up there and remain up there in the hopes it helps me beat this cancer. We’ll see. I remain hopeful 🤷🏾♀️.
Thank you for your testimony. I would look into mitochondrial haplotype biology. I would guess your mitochondria are built for a topical or sub-tropical environment. Given you have darker skin (more melanin) you NEED much more sun (at stronger UV index) than me for example. And I need more than someone with very white skin.
Remember you cannot get well in the same environment in which you got sick.
You would probably do yourself a huge huge favor by getting yourself to the tropics minimum 20N latitude, closer to zero the better, in a rural non-populated area to avoid EMF maximumally to be able to get good sun from sunrise to sunset, minimize excess artificial light and EMF at night for healing sleep. Look into Dr. Jack Kruse and you likely need a like minded alternative/integrative local health professional to guide you on other things.
Please keep me in the loop of how you are doing! God bless your journey back to health!
@@DrCaseyPeavler Thank you so much for this information. Much appreciated. I will definitely look into this and keep you updated. Take care.
You are very welcome!
@@tsmilingatuI would mega dose with liposomal vitamin c every 2.5 hours to tissue saturation too. Also look into intravenous Vitamin C. It's been covered up as an anti cancer treatment.
You aren’t able to achieve the peak blood levels even with lower doses (10-25 grams) of IV vitamin C. No, no oral or liposomal formulations will do it. Doesn’t mean they are bad, just means it doesn’t have the oxidative effect we are looking for at those higher doses.
What kind of light comes from a regular wood fire? How about more of those in winter?
Fire is about the best possible light at night for not completely screwing up our circadian biology. Mostly red and infrared which have their own respective health benefits!
@@DrCaseyPeavler What about a natural gas fire? That burns mostly blue. Maybe there's a reason we're being 'gaslit' all the time.
LOL, thats a clever one....You honestly would need a spectroscope to tell. If you actually see blue, there must be some blue/green light being emitted.
Something like this below link. Even that is limited because it isn't including UV or into the IR range.
www.bhphotovideo.com/c/product/1436631-REG/sekonic_401_800_c_800_spectomaster_meter.html/?ap=y&ap=y&smp=y&smp=y&lsft=BI%3A6879&gad_source=1&gclid=CjwKCAjwiaa2BhAiEiwAQBgyHtVUIbIcEe33bf-AqTki-rMIzmhajyVZ-4hNZkvQauLuGxzwg-POghoCyQIQAvD_BwE
@@DrCaseyPeavler Yikes. I don't need to know what a full spectrometer might cost...
Not cheap lol. A building biologist if you hire one should have one as well as various EMF meters
There's a lot of talk about vitamin D but not a lot about ways to increase its absorption... Can you comment on that?
I appreciate your comment and your concerns. Human’s were designed or evolved to be outside in nature. We spend the vast majority inside under artificial light. We are designed to get more than enough vitamin D through adequate sun exposure. You can never get the benefits of the sun in any pill no matter how well absorbed. I’m sorry I wish that were the case.
Are you suggesting we should not be taking any kind of Glutamine supplementation? As I always thought it was a highly recommended product.
If you have cancer, no. If you do not have cancer, there is a time and place for it.
I train a lot watch has brought about what I suspect to be GIT problems. Glutamine is strongly suggested as an answer
Thanks. What should be vit D level in blood to exert these anticancer effects???
I think I answered this on another thread for you! Thank you for the excellent question!
Many thanks ❤
I have a question about vitamin D supplement, mine containing sucralose. Isnt that sugar? 😢
It’s an artificial sweetener. Not ideal nope.
Can you talk about cateracts and sun? I find it troubling the standard treatment for that is surgery.
I could at some point, honestly we are smack in the middle of a large cancer series. Dr. Jack Kruse likely has discussed this in the past if you are familiar with him.
My half-brother, who was fish-belly white had to have a Melanoma removed with lots of extra skin (borders) from the top of his left arm that he would hang out the window of the car.
I am sorry your brother had a health issue such as melanoma. Its scary. If he was as white as you say, would suspect he did not get adequate whole body sun exposure, which raises vitamin D, vitamin D analogs, melanin, a,b,g-MSH, as well as melatonin, all of which are extremely protective against all forms of cancer, including melanoma. Just out of curiosity, did your brother have any other metabolic issues such as prediabetes or diabetes? Overweight or obese?
@@DrCaseyPeavler Hi and thank you, Dr. Peavler, for that information. Yes, he was slightly overweight when he died at 56, not quite obese. Maybe 40-50 lbs overweight on his 6’ frame. He used to be super duper skinny when he was younger. Most of his life he was quite slim. But at the time of his death (age 56) he had very high blood pressure and they were trying to find a different medications to control it. He had Xanthelasma under his eyes (I never had that), so I’m sure his cholesterol was sky high. Both he and I share the same mother. (She was Swedish, Belgium & French). Our Maternal Grandfather (from Sweden) died at age 33 of a heart attack (he did work in the Chicago Stockyards maybe ate a lot of saturated fatty meat?). We both inherited high LP(a); mine is 70 mg/dL and normal is less than 30 and I am heterozygous for Leiden V mutation. I’m guessing my brother had the same issues so our blood is hypercoaguable. His father was Polish, my father was olive skinned (Fitzpatrick 4). I am Fitzpatrick 3/4. I have light brown/olive skin as my dad did; I tan very easily. In my YT pic, I used super light foundation for effect but people have told me it looks like I have a year-round suntan. In terms of prediabetes, I’m not sure if he had that. I don’t think so otherwise he would have told me. Just really high blood pressure that took him out suddenly at 56 with an MI.
I am so sorry the the loss of your brother. It’s hard to lose the ones we love. And God 56 is young…If you look at the Doug Wallace Mitochondrial etiology of complex disease videos, anything from Dr Jack Kruse, they can help make the link between HTN, HLD, overweight, heart disease, and cancer. My gut tells me he has at least prediabetes. Unfortunately it’s not picked up by many doctors and if they find it, they don’t know what to do with it, and many of them don’t even document it in their charts. The Factor V, the Lp(a) also probably set him up for failure too sadly. I am sorry for your loss
@@DrCaseyPeavler Thank you for your kind words; he was a gem. I will look up those videos; appreciate that info.
Happy to be of any assistance
How does the glutamine chemical structure change when transglutaminase 2 or 6 are actived by autoimmunity ?
Fantastic questions. I’d start by saying I don’t know of any autoimmune diseases that have antibodies against glutaminases. Doesn’t mean there aren’t any I just don’t know about them. I will look at the literature and see what I can find. Second, almost any autoimmune disease increases your risk for cancer, thought to be secondary to chronic inflammatory state. But if these transglutaminase enzymes are constitutively activated, I could see that becoming extremely problematic and another mechanism for setting up a cancer initiation and propagation.
@@DrCaseyPeavler Cancer due to the overexpression of TNF alpha and many cytokine? I have celiac disease which went undiagnosed for decades due to my seronegative. I know that celiac disease is associated with diabetes mellitus 1 but what I am searching is how glutamine change with transglutamine. ( I am studying the realtion between Gad65 and Nmda receptors due to my Ataxia)
@@DrCaseyPeavler thank you for your answer
Yes NF-KB which is the master inflammatory activator, TNF-a, IL-1b and others pro-inflammatory cytokines. That was the major mechanism I understood. I am sure there are several others.
Keep digging and let me know what you find, I am very interested in this relationship.
What’s a good D3 dose per day? 12000IU ? How much K2 to take with it?
You need a doctor to check your level. Aim for highest level without affecting calcium. Perhaps 100ng/mL. I would highly look at getting this from the sun if at all possible. Second best option would be artificial UV sources from manufacturers mentioned. Pill would be last resort in my book.
@@DrCaseyPeavler Ok That’s Doc
Although ai live in the UK so supplementation will be necessary in the winter.
Sperti, Chroma D Light or EMR tek Krypton!
Thank you doctor Great news stay bless
Since vitamin D “shuts down” glutamine uptake does that then decrease growth hormone for adolescent kids as glutamine is a growth factor?
This part of the series is about cancer. Cancer will uptake and utilize glucose and glutamine 10-30x what normal cells do.
I do not believe it will be a big problem for normal cells, normal kids’ growth and metabolism. Nor have I seen anything to suggest this in the literature. Deficiency on the other hand is well documented to cause growth and metabolism issues during development ie Ricketts.
Hello doctor, thank you. Can you repeat the names of those lamps? I live in France…
Sperti sun lamp (UV-A), Sperti D lamp (UV-B), chroma light D-Lamp (red/infrared/UV), EMR-tek Krypton. I have discount codes in the description for EMR tek and Chroma.
@@DrCaseyPeavler merci, I'll see what is available in Europe. As a pale skinned red head age 75, what would you recommend or NOT recommend? My dad had melanoma.
Start low and go slow is the mantra of geriatrics. Usually in relation to medicines. But I think it could apply to your situation. I would not use artificial UV without being in combination with red/infrared. I would focus mostly on getting as much sunlight on your skin in the earlier morning and evening time to start to build your solar callus. Supplement that morning and evening light with red/infrared photobiomodulation. Then, gradual slow introduction of UV, in the form of sunlight always first and foremost. Again never unilaterally or unopposed if using artificial UV.
@@DrCaseyPeavlerI don't really understand the differences between all these. Im considering the chroma D lamp because its within my budget. is that just a less refined version of the last one? Will all three of these perform the functional purpose of supplying my body with the vitamin D? I live by the great lakes area in Indiana and we are encroaching winter. 😅
Thank you very much for the very comprehensive information you provided us.
My question is, do you prefer vitamin D to be used as a supplement or obtained from sunlight? If you recommend vitamin D supplement, does it need to be taken with vitamin K2 or not? thank you very much
First and foremost from the sun! No question at all. Distant second would be artificial UV w/ photobiomodulation concurrently. Third/last resort would be supplemental. I would recommend K2 no matter where D comes from.
@@DrCaseyPeavler Thank you, dear teacher. Thank you very much for your response.
You are very welcome! My pleasure
Higher Vit D, Less cancer risk? I take 5000iu daily with K2 and magnesium, correct ？ Too much? Thanks
Context is everything, would depend on your disease burden and state of health. We make recommendations based on 25-OH vitamin D serum levels. Have you had this checked recently?
@@DrCaseyPeavler::: Thank you. Any advice on improving the absorption of fat soluble vitamins that tank without a gall bladder?
If you are going the lamp route, you also need IR exposure besides the UV-b exposure. I've had great success with vitamin D3 supplementation, it blocks seasonal colds, influenza and COVID.
What if one follows a glutamine restriction diet along with vit d and melatonin supplementation. Plus turkey tail mushroom.
Glutamine diet is not easy, and your body can make its own glutamine, which complicates things further. Are you struggling with cancer or are you talking in terms of prevention?
One other question Dr Casey. Does having a shower wash vitamin d away? If so how long after sun bathing should we shower?
No, that is a myth.
Feel free to shower!
@@DrCaseyPeavler Thanks
No problem!
No problem!
Thank you for the video. I am a red head with very white skin. How much sunlight should i get each day and what time of the day for sunlight? Thanks.
I am glad you enjoyed it! It is a great question. Where do you live? Do you have access to red light panel or infrared sauna bulb?
@@DrCaseyPeavler I live in Queensland, Australia. The uv rating gets up to 15 in the summer. No I don't have access to either of those.
At 22S you shouldn’t need it! Start from sunrise until about 930-10am, and 330-6pm. At those times mostly visible, infrared and very little UV.
Learn from a young Australian doctor named Max Gulhane. He has a RUclips channel. Great guy, he can teach you to build your “solar callus”. Take it slow.
@@DrCaseyPeavler Thank you very much ❤️
You are very welcome!
God Bless you for this Huge Info. So this indicates taking an L-Glutamine supplement to increase Glutathione is contraindicated as Glutamine can increase cancer risks, correct?
I can’t say I would take it that far. Under healthy conditions, taking extra glutamine will probably be fine. BUT if I had cancer I wouldn’t want to be in the same room as a glutamine supplement…
youtube blocked a cancer video i titled Panacur Cancer Cure for some reason youtube did not block this cancer video
I am sorry to hear that. Probably because I don’t use the word cure ever. But it did block my last video on DON
Recommend ratio of d3 to k2
Fantastic question. I am not sure if the answer is known. I think with K2 you just need enough. Then the question is how much is enough? Look at the terrible RDA recommendations for most other nutrients, why would their recommendation for K2 be any different. For Vitamin D, get your serum 25-OHD3 as high as possible without hypercalcemia using UV from the sun.
Most obliged
My pleasure!
Very good video , can you also provide the information if autophagy protects cancer cells in some cases ?
This and the video after it will talk about the catch 22 with autophagy and mitophagy for cancer:
Eliminate DAMAGED Mitochondria and Transform your Health!
ruclips.net/video/Ae3ofR3tKfw/видео.html
@DrCaseyPeavler thanks doc, so is fasting and keto beneficial to starve cancer or is it a double edged sword? How much low carbs is allowed per day and if fat intake is high then the amount of calories matter or not? Below 500 calories or around 800 is acceptable? Is taking green juice good or bad?Can Chia seeds be consumed for fiber? What about walnuts? Thank you and sorry for too many questions. My dad had cancer and now my mom has it so I am trying to maintain her diet.
I am really sorry about your dad. I imagine you have dozens if not more questions. Given cancer is a mitochondrial metabolic disease, and cancer cells require 10-30x more glucose than normal cells and cannot use fat for fuel, this explains why the absolute foundation for metabolic therapy is a calorie restricted ketogenic diet. This whole series is built for folks like you and your dad to learn. I suggest starting from the first video in the series and watching it all the way through.
@@DrCaseyPeavler thanks
@@DrCaseyPeavler thanks but can you please answer those few questions as well. 😅I am really confused
How much Vitamin D should you take ? Or what level should you target? Should we follow COIMBRA PROTOCOL if you have cancer? Is there a drug for 1,25 Vitamin D?
Ideally keep your 25OH as high as possible without causing side effects. 1,25OH is also known as calcitriol. It’s given to patients with significant chronic kidney disease or end stage renal disease on dialysis.
@@DrCaseyPeavlerShould cancer patients take calcitriol with Vitamin D3?
Coimbra Protocol gives 1k IU Vitamin D3 per kg weight for multiple Sclorosis
My friend, I cannot underscore enough how I think relying on supplemental pills is a bad idea. In my opinion. Get it from the sun. If that isn’t an option consider artificial UV.
@@DrCaseyPeavler
How about effects of near infrared lights during the early part of sunrise and sunset? What is the effect on glutamine? Most experts in internet are saying that Vitamin D is highest at noon time
I don´t understand the reason why supplementation with the active form of Vit D 1,25(OH) is different and worse than the same produced from the sun. Isn't it the same molecule anyway?
Great questions. You miss out on a lot by taking a pill only. Not only from vitamin D3 and L3 analogs. But a lot of other chemicals your body makes through POMC. Not to mention melatonin.
You may get some benefit from watching this video here:
Vitamin D's Superpower: MASTER Antioxidant Regulator and Cell Protector
ruclips.net/video/quNUPGYMDnA/видео.html
I take 10000 d3. How does that compare to 125 hydroxy
Impossible to know to be honest. We do not routinely check 1,25 hydroxy as it is assumed to be good if 25 OH is good. It’s very expensive test. For most people we check the 25OHD3 levels. Do you have any renal issues?
Awesome...unbelievable...❤
Is it means vitamin D is equivalent for DON (glutamine inhibiter) ،D seyfried mentioned....?
It actually does more for glutamine than DON, blocks several steps of the uptake and utilization. However, DON is a drug and may have stronger effect on its target. We can use multiple glutamine blockers (natural and drug) to have synergistic effects.
@@DrCaseyPeavler
Thank you 💕
You are very welcome!
I'm always wondering if we really need the DON. Between this, antiparasitic, green tea, and keto/fasting. It's why I wish trials could be conducted to see what would be effective.
I think we have too much faith in DON. I’m sure it does help but there are so many other things we can do. I think it’s the synergy that really makes the protocol successful, not just one part.
Can vitamin D from UVB, either from sun exposure or UVB lamps, penetrate the blood-brain barrier? I'm asking because I have GBM and I'm following metabolic therapy. Based on your presentation, it seems like this would be a great addition to my toolbox of anti-GBM strategies.
It would be a fantastic addition! Yes vitamin D and several analogs can cross the blood brain barrier. How are things going for you with your current approach?
@@DrCaseyPeavler I was diagnosed one year ago. Unmethylated, IDH wild-type, and 85% resection. Couldn't complete chemo due to low platelets. I've been without conventional treatment since December 2023. However, from the beginning, I adopted metabolic therapy, strict keto (GKI < 2, unrestricted calorie intake within a 6 hour eating window), and a handful of supplements and repurposed drugs. I've been trying to find a better way to target glutamine which is why I clicked on your video. On my last MRI, a month ago, the residual tumor shrank by 65%. I find your videos very helpful for my current approach.
Wow 😮 65% reduction in tumor size! That is AMAZING! Keep up the fantastic work. Might want to keep GKI closer to 1. Stay tuned to our channel for videos about glucose and glutamine inhibitors. If you are in FL we do offer consults for more personalized information.
Any research on Coimbra protocol on Cancer?
I have not heart of it. Can you share a little more with me?
@@DrCaseyPeavlerCoimbra protocol gives mega dose Vitamin D to cure Multiple Sclorosis
@@DrCaseyPeavler ruclips.net/video/RfH8nkF-R5c/видео.htmlsi=NAmvplJKzGfGcnzX
@@DrCaseyPeavler
Coimbra protocol is giving mega dose Vitamin D to cure or reverse multiple Sclorosis
Is there a link for the red lamps? I was just diagnosed with stage 4 uterine cancer. thank you
I am so sorry for your diagnosis. Where do you live?
@@DrCaseyPeavler Upper Michigan
Is moving or a very long vacation an option whatsoever?
@@DrCaseyPeavler where to? I just moved here … so maybe long vacation
Somewhere within 20S and 20N aka tropics. Light stability, lower population density, year round strong sun.
vitamin d or vitamin d with k, and how much?
That is a question to discuss with your doctor. We treat to a blood 25OHD3 level. That being said depending on your health condition you may want to push it up to a higher level. Always try to get vitamin D from the sun first and foremost, second best would probably be artificial UV-B
Well back to Perineum sunning it is,😮😮
Don’t get arrested lol 😂
'Why are they doing this? They used to worship me...'
- Ra, The Sungod
lol..
So between ketovore, fasting and a huge amount of vitdamin d supplementation, one can destroy cancer and tumors?
I think you are on your way to success. I won’t say that is all that is needed likely…
Since long covid my stomach is always an issue. Dr ran tests and I seem my D is very low. Do you reccomend injections?
I am sorry you are having issues with your stomach. It’s probably better to take a BIG step back and look more critically about your overall habits and environment. Why is my vitamin D so low? What are my lifestyle practices that lead to that? Not enough consistent UV exposure? Too much blue light during day and night? Essentially a deficiency of darkness? Overexposure to nnEMF? Vitamin D supplements or injections would be the last resort…in my opinion
Nature is amazingly wise. Very informative. I hope, assume, Thomas Seyfried will bring this up as well.
Can also tell that I would like to know more about what serum level range one should aim at. I am at 180 nmol/L and I was sharply advised by a Dr. that this is way too much. "Stop taking that supplement".... I personally believe that anywhere between 100 and 200 is a good level. Any comments? Where I live we have barely 4 months usable sunlight. UVB source might be wise to get???
I would have to make the conversion, nmol/L to ng/mL. But for ng/mL healthy range is 60-80, if you have cancer as high as you can keep it (un-supplemented) without causing hypercalcemia. Your doctor will need to check 25OHD3, calcium and albumin (CMP)
As kids in the 70ies our mother put us in front of a UV light in the winter months. For the moment I have only a red/infrared lamp for the winter and supplement vit D, will have to look into UV lamps here in Europe...
Yes that is a better strategy, best strategy is to move to a place with year round sun!
Why does it shut down glutamine? I need glutamine for the gut but you can take the glutamate.
We are talking about vitamin D’s actions in relation to cancer in which inhibiting glutamine uptake and utilization is a good thing. You should not have to worry about your gut lining under normal conditions.
Glutamine is a secondary fuel source for cancer. It's in almost everything. It's also non-essential because our body can make it when we need it. Dr. Thomas Seyfried has a protocol called Press Pulse that pulses a U.S. banned drug into the body at certain time, on a certain schedule in a specific dosage. It wipes out glutamine for several hours to starve the cancer from this fuel source. No sugar, no glutamine makes cancer shrink and die off. There's a doctor in Grand Cayman that implements this protocol. Just do an online search and it will pop up.
Thank you for your input!
@@DrCaseyPeavler You're welcome but my comment was deleted by RUclips. Censorship is very real on this platform when the truth is laid out.
Wow 😮, yeah I don’t think I can tell when that happens on my end
Yeah, but this is just a part of metabolic proticol and is not enough. Search for clinical studies from Dr.Laurent Schwartz, cancer is highly adaptive, must be treated with a nubmer of different strategies, keto + vit D is not sufficent.
I couldn’t agree more, and I am not trying to sell that as the case. But, we have many tools in the tool bag to lower glutamine uptake and utilization than just DON.
@@DrCaseyPeavler agree
I will be going over as many glutamine and glucose inhibitors as I can find in the literature over the next weeks and months.
What’s the problem with vit d supplementation?
I try to cover that in a few videos before this one.
I wonder if sun exposure has a negative effect after a certain point? Like, it’s good to get some sun exposure, but not so much you burn all the time.
We do know that fair skinned people get melanoma more in Australia than in Ireland, right?
Burning is not a good thing. But much more of a problem is under exposure.
Supplement with astaxanthin and once it builds up in your tissues you will be protected from UV damage is what many who take it say. 12 milligrams to 40 milligrams is safe.
Vitamin D also acts as a hormone and can speed up certain cancers! The human body is truly amazing.
It is miraculous! That being said, nothing I have seen has even hinted at vitamin D speeding up cancers.
What cancers?
What is regular sun exposure doesn't work for a person say with long term metabolic issues? Then a lamp would be no better, becasue its a fault in the body not the exposure,wouldn't supplements be better than nothing?
Can you help me better understand what you mean? What fault in the body are you referring to?
@@DrCaseyPeavler Long term auto immune low thyroid and arthritis, weak muscles and tiredness come and go. I am normal weight. I have persistent low vit D and iron even though i'm beyond menstruating years in age and have a good diet and get plenty of sun and activity outside in all hours of the day. Never wore sunscreen and don't take any pharma besides thyroid hormone. Also I've never had skin cancer even with my low d levels in a family who does get lots of cancers. I did find D supplementation great for avoiding covid and only got sick when i forgot to keep taking it. btw thanks for taking the time to reply :)
Where do you live?
@@DrCaseyPeavler Australia
Do me a favor. Look into contacting Dr. Max Gulhane. He lives in Australia. He is a good doctor and person. Also start watching as many podcasts from Dr. Jack Kruse as you can. Please. I want you well.
HISTORY WILL SHOW THIS DOCTOR MADE THE BIGGEST CONTRIBUTION TO DEATH OF CANCER BY EXPOSING WHAT WORKS. GOD BLESS U DOC.
Thank you for your kindness. God bless you also.
How about the fact that our ability to get vitamin D from the sun reduces significantly as we age making supplementation the only way to get good levels?
Says who? If true, why wouldn’t the answer be we need more sun as we age…
@@DrCaseyPeavler I'm surprised you aren't aware of that? Google "does the ability to make vitamin D from the sun reduce as we age" and there are many confirmations that it does. I saw a study some time ago that found from age 20 to age 70 our ability to produce vitamin D from the sun falls by as much as 75%.
I am 75 and my skin that has been exposed to the sun is aged and damaged. My choice has been to take D3 with 5000iu in the winter and 2500iu in the summer daily needed to maintain healthy levels for me[tested]. Because I take D3 I also take K2 as MK7 to maintain healthy calcium levels in the blood by moving it to the bones and teeth.
I’ve seen that, but closer to 50%. But that is not taking into account the ability to develop a solar callus and maximize UV absorption nor factors that inhibit vitamin d conversion. I would point you towards Dr. Jack Kruse or Dr. Max Gulhane. My recommendation stands. Would rather you get it from the sun given the multiple other benefits aside from vitamin D. No pill contains what is available outside, and never will.
@@DrCaseyPeavler What's the point in commenting when it gets removed?
For people who have VDR polymorphisms, Liposomal D/K2 helps with absorption.
The polymorphisms you speak of would only make a difference at the target tissue, not synthesis. The best possible way to get vitamin D is through full spectrum sunlight with UV-B. If you cannot get that, you are at a huge disadvantage, perhaps artificial UV vitamin D lamps would be second best.
@@DrCaseyPeavler The Liposomal D3/K2 I spoke of, had women who could not (for decades) get their levels above 30 even with Rx D3 dosing, one was at 52 in a few weeks iirc and another at 80 in 3 months, their symptoms of low D3 alleviated as well.
I suspect it was likely an environmental issue. Where did she live just curious? I cannot stress this enough, getting vitamin D from a pill or sublingual liposomal formula is not equivalent to getting it from UV-B light from the sun. I am glad symptoms resolved that being said.
@@DrCaseyPeavler Don't know their whereabouts, try this, go to Google search for W h o l e F o o d s (Censorship evasion) and Dr. Tom Levy. Read the 2 part interview he did with Dr. Richard Passwater. See what you think.
I will see if I can check it out!
Yes and Methionine is more critical than anything either you or Dr Segfried have ever mentioned
I am going to assume your name is Scott. I appreciate your comment. Can you explain to me why you say that?
@@DrCaseyPeavler sure thing. Because cancer is addicted to methionine. This has been proven. You can read many papers on this. It’s been known for 50 years. Go to Pubmed and search for Dr Robert M Hoffman. Cancer and Methionine. “The Hoffman effect”. This is a crucial factor that you and many others have overlooked and it is the most significant factor
Thank you, I will read up on this.
@@DrCaseyPeavler that’s great, thank you. And if you ever want to meet Dr Hoffman and learn directly from him on this let me know and I can introduce you
I want to learn as much as I can to help patients get well. I am very open it.
I use 4000iu per day of vitamin D3. Should I really be using Calcitriol?
I unfortunately cannot tell you. This would be context dependent and a discussion between you and your doctor. Most people need to regularly check 25-OH D3 levels.
This guy is a beast. 💪🙏🔥
Thank you for your support haha!
…’discrepancy’?…vitamin D in supplement form is inactive…but it’s converted to the active form, so what discrepancy arises?
I think you are missing my point. When you look at data from a wide range of cancers, vitamin D deficiency is commonly seen. However, when the supplement is given, the diseases do not completely go away. Therefore it is more than vitamin D. Its all of the other things you get from the sun and do not get in a pill.
Can any one explain vit D3 with vit. D as explained here?
I am not understanding your question. Can you rephrase so I can try to answer it?
@@DrCaseyPeavler Vitmin D3 is Cholecalciferol what you can buy mostly as a suplement IE 1000 IE 4000 or even get prescribde by doctor, also for ostoperose. In your slide en presentation you discus about an other form 25-Hydroxycholecalciferol? In Winter I use Cholecalciferol D3 daily what probabably is suboptimal to Sun. This D3 will probabably converted to 25-Hydroxycholecalciferol to give the sugested effect of extra glutamine blocking in Ketosis state, what my objective is.
You may want to re-watch a couple of the earlier vitamin D videos.
7-dehydocholesterol + UV-B = D3
Liver converts to 25OHD3
Kidney converts to 1,25OHD3
Mitochondria make all of the D3 and L3 analogs which are also biologically active
1,25OH is what blocks SLC7A11 and SLC1A5 glutamine transporters, and also down regulates GLS enzyme (the enzyme that DON blocks)
The rhythm of the talk reminds me of machine gun bursts. It's making the listening overwhelming and saturating. It's too bad because the content seems to be very valuable. I must admit my brain bailed out after a few minutes. Maybe it's me. Anyway thank you for this very interesting subject and your efforts at showing us where to look at.
That’s an interesting observation. I kind of like that nickname Machine Gun Peavler…joking aside, I am working on my speed and comfortability on camera. Little by little. I am glad the subject was interesting and the content was valuable for you!
So wife has breastcancer could you lay it down simple terms,get plenty of son 1hr a day? Take supplements how many capsuls everyday?
Context is everything. A lot of factors to consider. You will need a doctor who can regularly check your 25OHD3 and CMP. Then you will need to figure out how much UV is available in your environment and see if it is even doable for you now. Lots to consider!
Will FaceB00k censor this information?
lol maybe not after Zuckerberg’s letter to congress yesterday…
Hadi len! Open a shop and sell lamps.
Eh, I prefer clinical medicine and education. EMR Tek and Chroma make great lamps. Would be hard to compete with them. Sun ☀️ trumps all lamps!
Thank you Dr. Peavler for those very important informations concernng the effect of Vit D, allthough i ´d like to mention, that you´re speaking like a bot 😀 And makes the Video pretty difficult to follow for poeple, whom aren´t native speaker. Please make much more Videos 😀😀😀
Thank you for your feedback. I am glad you got something out of the video that can be helpful for you. That is definitely my goals with these videos! In terms of my speaking, I appreciate the feedback. I’m trying to make every video better than the last.
Where are ppl supposed to get that vitamin D you talk about
The conversion of cholesterol in skin cells from being exposed to UV-B creates cholecalciferol.
I work outside shirt off.
You are probably better than 95% of population. I work in a hospital: blue light and EMF hell hole.
Proof??? Go talk to professor Thomas Seyfried!!!! Let's see
I am citing the medical literature which found it experimentally. Confirmed by multiple sources. I can send you the papers if you would like.
@@DrCaseyPeavleryes please
My pleasure. What is your email?
@@DrCaseyPeavler::: Please add links to source files in the comment section, if possible.
Great news...so keto diet and lots of sun / vitamin D supplements
Not the end of the story but definitely a great foundation!
A2
Can you please clarify what you mean?
Sorry but Vit D could help to but DON'T KILLS Cancer
Why would it not? If it blocks glucose uptake, utilization, PDK, Glutamine uptake and utilization, fatty acid synthesis, glutathione synthesis and acts to increase oxidative stress in cancer cells, how would it not?
I believe Dr Seyfried is providing an opportunity for the phama industry to play a part on this.
They won’t take it. They need us sick and dying, they need perpetual patients….
👍
I am glad you liked it!
how much does YT pays you for reading these data?
$0
I find you are difficult to take your in your information because you talk too fast.
I get that. I have been working on it. You could try lowering playback speed to 0.75x as a hack.
The opening monologue is a waste of time. My dad died of basal cell from sunburns. Melanoma is not the only danger.
It is definitely dangerous to get too much sun exposure and no one wants to look like a shriveled prune.
Thank you for your feedback and your point of view. Although local basal cell carcinoma can be problematic and wrinkles can be annoying and unsightly, I am much more concerned about what is killing off you and my fellow humans at an increasing and unbelievable rate.
m.ruclips.net/video/tmH0V0eoNQE/видео.html This is Sami Tugano from Japan. She gives a great breakdown as to how this really happens. She is also utilizing Seyfried's method to manage her stage 4 cancer.
From my understanding, it's mainly because of high carb diets and especially seed oils. The natural sun exposure is not the real problem!
Just the NIR alone protects against wrinkles. High end dermatology clinics use red and near infrared to built collagen and reverse skin aging. The sun is roughly 50% near infrared. The population has been systematically brain washed to think the sun is harmful. It’s sad really. And untrue.
Thank you
What you experts always get wrong when discussing vitamin D is that your studies use synthetic vitamin D rather than natural vitamin D.
Almost assuredly you are using vitamin D from lambs wool. How many people have lambs wool in their diet?
Until you do a study using vitamin D derived from fish oil and compare the results with vitamin D derived from lambs wool you are misleading people.
Let’s see a study using a natural vitamin D source before you make any more claims?
Please don’t take this as negative because it’s just common sense constructive criticism.
I am fairly clear I recommend getting D from the sun. Not food or supplements.
Too complicated. Break it down into 10 smaller videos.
Thank you for the feedback. Just out of curiosity, is this the first video you have watched? Reason I ask, is because every video kind of builds on the one before it. It would be hard for about anyone to start here.
Bro you talk like a Ai
For real i dont think i can trust what you are saying, too many edits
Sorry, I’m a medical doctor not a RUclipsr, will take some time for me to feel comfortable on camera. Doing the best that I can.
@@DrCaseyPeavler Drug company paid troll lol
@@jackbarton1830 🤷♂️
What is this terrible AI shit
Lol you guys are brutal haha. Thanks for the feedback.
what are you on about 😒
I am not following…lol