Sorry I commented before finishing the video.......Dr Derick Lonsdale was very insightful...Dr Peavler, can the PKD enzyme action be mitigated by higher doses of thiamine (a cofactor for pyruvate dehydrogenase?
One thing I’ve gathered from your videos, and those of others, is that the solution to most of the cancer problem is basically known. It remains only synthesize all these strands into a comprehensive framework. You are well placed to do that, unlike most of the rest of us.
I appreciate your kindness. I’m working on synthesizing it. But more important than that for my own edification, is that that knowledge is transferred to you all in a way that makes sense and allows for practical solutions.
What most don't understand is that imaging procedures such as CT scans, mammograms, PET scans, etc. have very high amounts of radiation that is downplayed but eventually causes cancer. The radiation induces cancer by disrupting the molecules and electrons in your cells. The radiation is strong enough to cause double strand damage and thus a gene mutation which eventually leads to cancer 6-7 years after exposure. Then when an allopathic medicine doctors sees you have cancer from an ultrasound or CT scan, they will tell you they need to do a biopsy. Yet, if they puncture the extracellular matrix where the cancer is encaged in, this will actually help the cancer. There are various scholarly articles that show this is the case. Cancer can migrate to areas of inflammation including a biopsy when the cancer can track across the needle. Now here's my favorite part, after they help your cancer spread, a doctor will tell you your choices are either chemo or radiation. Both Chemo and radiation do not distinguish between healthy and cancer cells. It kills all cells. So you're essentially killing all of your cells hoping that you survive and it kills the cancer. This oftentimes causes rebound cancers from the other healthy cells that have been affected if you even survive the treatment and are left with permanent side effects. When they actually give you chemo and radiation, they hope that one of your repair genes, such as BRCA1, BRCA2 and/or PARP activate and repair the damage to the rest of your immune system, yet there are millions of cells in your body and it's unavoidable to have some misrepaired cells, thus causing rebound cancers later on and making you a return customer in the system.
@@michaelzhelev4658 Dr. Yanagisawa prepped the workers that had to go into the hot zone at Fukushima, he loaded them up with C, Lipoic Acid, others..... When they came out of the hot zone, their blood work showed zero signs for future cancers, zero fragmented DNA, other markers. There is a PDF that is out there that lays it all out, I'm going to try and put it on my SubStack today.
YES! You are preaching to the choir. Our system is fundamentally flawed. Car accident, fall off a ladder, etc, we do amazing things. With chronic disease management, we do in many cases more harm than good.
Where is the research funding for junk food, junk light? For autopsy, for lifestyle disasters like the switch to LEDs w/o precautionary toxicologic funding? For non native EMF toxicity? For deuterium toxicology? For lifestyle continued use of lead fishing sinkers rolling around in millions of tackle boxes, creating pure lead black powder coating everything you touch, including the apples we hand out to our grandchildren while teaching them to fish? Lead in children's sandwiches, w/o regulatory agency due diligence for toxicology risks involved, is criminal and directly harms intelligence. How can these things go on, and on, and on, without dealing with them as a society that has ethics? Corruption abounds, censorship abounds, while no funding pointedly investigates to inform changes! It is criminal to have 'Environmental Protection' agencies that so obviously avoid doing due diligence because of political power not allowing enabling research and regulatory corrections!IMHO
Thanks for sharing your important cancer fighting information, and I like how you went back to highlight a prior Vit D and melatonin video. My brain needs to get this info hammered in over and over again to sink in.
Great question. I would love to be able to tell you yes. The official press pulse is not yet published, anyone who is doing any version of press-pulse is making educated guesses. I have made a point not to share dosages and specific protocols on RUclips. Not to hide any secrets or truth but this just isn’t the place. That is essentially the non-specific one size fits all approach to medicine and that isn’t how it is or how it should be. This is a powerful program, and there are potential side effects. That at least deserves a conversation about risks vs benefits with a doctor and close monitoring. I hope that makes sense.
AWESOME! You are my favorite RUclipsr. I've watched every video you have shared. I implement the findings in these studies immediately. Thanks so much Dr. Peavler! 🎉
I am happy to be someone’s favorite RUclipsr ha! Please do not do anything without consulting a doctor first please. Nothing is perfect and completely without side effects and that needs to be discussed on a case by case basis and monitored.
Omg. Thanks for the information!! My wife has GBM and we have been practicing metabolic therapy for 5 months now. HBOT and everything else to with it. An MD had just told me to look at DCA. Wow I don't know how I missed this one. Anyway, your video and other information has helped lots and we are in the process of adding this in. Thanks again 🙏
@@DrCaseyPeavler thank you. It has been helping. MRIs have not shown any real tumor progression. Just had another one the other day and will see the doctor about it tomorrow. We are hoping to see good results.. We are doing many things to press and pulse this that I cannot discuss openly or I'm sure my comments will be removed. Thanks again for your great content and help.
What a great video! i'll save this one. Regarding metabolic therapy for cancer: this is why i personally I like DCA combined with Berberine as a better alternative to lowering glucose than metformin, as metformin pushes the other way to produce lactate.
@@DrCaseyPeavler Sorry, to be clear my strategy is for my wife, stage 4, works a 5 day week with good quality of life. things seem to be improving with large % shrinkage of primary tumor, no further metastasis, lymph nodes back to normal. No Chemo, no radiation, no surgery, she does take fulvestrant, when I researched this substance from a metabolic perspective it does inhibit the SLC1A5 glutamine pathway also. This was not the primary reason for this drug, but it's interesting what you find when you look at things from a metabolic perspective. She also takes Ivermectin, Memben, Fenben, HCQ, EGCG, Melatonin, VitD, Allicin, B17 and some other things. Lots of exercise and sun if we can get it.
Dr. Peavler, just came across your videos and you are clearly a talented physician. Can you do a video and/or series on artemisinin as an adjuvant to metabolic therapy? Seems to use heme iron uptake in cancer (or other antigen) cells to mark targets for apoptosis.
Isn’t DCA available on Amazon even though it’s expensive? So if B1, D3, and melatonin combination has been tried with conventional therapy and patient not improved, people can also supplement with DCA if they choose to do so.
If you or someone you love is struggling with cancer, first off I am sorry. No treatment should be initiated without speaking to your healthcare provider, having a risk vs benefit conversation, and deciding what is best for your specific situation. Nothing is perfect or without some side effects. But this discussion is critical.
@@DrCaseyPeavler "speaking to your healthcare provider" 99% of time will be a pointless. Very few if any will not want to risk their license persuing unconventional treatments. Makes zero difference what any research suggests. Everyone is on their own and always has been. Coventional treatment outcome studies are all falsified. A patient that "recovered" is counted as a success because of said treatment regardless if thats what actually happened.
Re: B1, Dr. Stasha Gominak has clarified existing research about the necessity of adequate D3 presence first, in order to allow gut bacterial assemblage ecology in order to facilitate the four B vitamin-producing bacteria to dominate effectively for synergistic B vitamin production from the gut.
I have made it a point not to give doses, timing or scheduling. Don’t want to get accused of practicing medicine on RUclips. But it’s thiamine, imagine it, simple B1..
@@DrCaseyPeavler i love it and hate it-i hate the fact that something like dch/melatonin/vit d could treat cancer (along with lifestyle etc) but big pharma doesnt think its benefical to humanity. sad day. on the other hand, i truely appreciate your hard work on making these videos and the invaluable education you present. thank you!
I also find it sad these things are essentially buried. I just want to use this platform to spread awareness, obviously not all of these things will be right for every patient. But if it could help just one or even a handful…
Cellular reprogramming of cancer cells to a normal way of energy production might be a very elegant way of getting rid or even preventing cancerous cells.
Metabolic reprogramming is the ultimate strategy. By putting metabolism back the way it’s supposed to go. The cell either sinks (now has the ability to undergo apoptosis again) or can swim (revert back to normal cell).
If you're doing a ketogenic diet, is DCA ineffective or is there still some cancer glucose metabolism happening? Wonder if dose could be lowered in this context. I've heard the DCA can result in neuropathy - although it is reversible if you don't go too long.
DCA wouldn’t affect glucose uptake or glucose utilization by glycolysis. It affects the step between pyruvate and acetyl coA. This helps shut off the Warburg effect in one unique way. Yes peripheral neuropathy seems to be most common side effect.
When it comes to toxicity with substances such as curcumin, EGCG, others, Liposomes amplify absorption and bioavailability while allowing for reduced dosing. This is evident in the work Dr. Hancock is doing with Liposomal Ivermectin.
@@DrCaseyPeavler thanks, I'll look into it now,, I'm drinking Yarrow tea for the hormones and urinary flush supplement,, trying to get the uterus to flush out
@@DrCaseyPeavler my doctor is gaslighting me, she said I don't have any long haul Covid problem, and she just referred me to oncologist to have all my organs in that area removed,, I declined that immediately, after I read about the terrible side affects of getting a hysterectomy I can't even imagine getting the surgery and it spreads to somewhere else because they should be doing metabolic therapy on me and don't want to So now I'm my own advocate, looking for healing online from real caring doctors, like Dr Eric Berg and Dr Thomas Seyfried
Hi Doc. Just listening and at 7:16 I have a question. If the mitochondria are damaged/malformed will DCA work? The etc and mitochondrial processes surely will not work or will the mitochondria recover somehow? Will using DCA allow other medications to get into the tumour due to lowering lactic acid around it and is a dual approach with trying to get HKII. away from the VDAC a killer (of the c cell) combination allowing apoptosis to happen?
I can’t give medical advice on RUclips. But I think there has to be a thoughtful combination approach to this. There is no magic pill or silver bullet. Every intervention has side effects or potential side effects. Which is why I stress talking to some like minded local doctor before starting or stopping anything. Yes DCA helps shut down lactic acid tumor micro environment. The damage seen to mitochondria are on a continuum. Not healthy but not all completely trashed. For those who can be reprogrammed and saved they likely will be, for those that are not, DCA takes the brake off of apoptosis and makes cancer cells more susceptible to oxidative therapies.
@@DrCaseyPeavler watched! Many more new terms that I now can’t remember! At least I can watch your videos multiple times to try and get more information to stick. You’re a valuable learning resource for us lay people.
@ DADA is Diisopropylamine dichloroacetate. It’s a DCA analogue. Grey market meaning, it can be legally sold for “research purposes” not for human consumption.
@@DrCaseyPeavler www.ncbi.nlm.nih.gov/pmc/articles/PMC9871338/ I don’t know if this helps. It’s not from the lecture I listened to some days ago. I listened to a talk some days ago and the lecturer showed a slide of the reverse krebs cycle (which was new to me) but she said that the output was 2ATP which is the same as warburg effect atp output. So my naive brain thought that they are linked. I’m like a 1st week student so i apologise if my terminology and understanding is arse about face.
The paper on HGG had an unexpected statement in it: "...compared to differentiated glioma cells, and GSCs are thought to rely primarily on oxidative phosphorylation." I thought ALL cancer cells did NOT use OXPHOS? Including stem cells. What am I missing?
I am going to assume your name is Bob. So Bob, if you take a look at the video prior to this video on Checkmating cancer with metabolic therapy. It’s likely cancer cell is on some continuum of hybrid metabolism (partial utilization of oxphos, and aerobic glycolysis). Likely not all or nothing. Even at the extreme only 80-90% of ATP comes from Warburg exclusively. My guess is that there are going to be some cells in the tumor that will have some ability to use oxphos and that possibly explains why cancer stem cells are more quiescent. I have seen other papers suggesting metabolic therapy is still effective for cancer stem cells in a lot of cases. pubmed.ncbi.nlm.nih.gov/29045536/
If you look at his own papers, we know that is not true. Check out the metabolic therapy checkmates cancer video again, I talk about this at length. How Metabolic Therapy CHECKMATES Cancer ruclips.net/video/O4sajpZ_SFM/видео.html
Can you talk about the dosing? In this video you talked about repeated dosing to keep the pressure on. What would be the milligrams per kilogram of bodyweight and how many doses per day?
I appreciate your question and can understand the frustration of not getting that. But that is not the role of these videos. This is an awareness campaign with good scientific data backing me. The medicine must be practiced at the local level with a healthcare provider or doctor. I cannot legally or ethically provide that kind of advice on here. I hope that makes sense
Casey, I took DCA orally for 3months @ 3500mg per day. Developed tremors. Stopped. Now over the tremors and considering re starting DCA as it seemed to be working on my neck tumor. What other side effects have you heard of from oral DCA use ? I was told another patient that got IV DCA also got tremors.
Peripheral neuropathy is the most common side effect as discussed in the literature. So this is not without side effects as you experienced. I cannot give doses on here, it would be considered medical advice or practice of medicine. Email me.
The first paper I am going over shows that. But it’s not PDKs fault. It’s up regulated by HIF1a and ammonia among other things. And is it really HIF1a’s fault? Not really, it’s just doing its job. It’s all of the other underlying root causes that drive hypoxia and pseudohypoxia. That’s why you have to shut this metabolism down at as many levels as possible. No one magic pill or silver bullet.
No problem. You can subscribe to the channel, and come back anytime to reference later. You can even save videos to a watch later folder. That’s probably the easiest ways.
So there are animal studies and case reports of people doing it. No large human trials as a stand alone. There is I believe a human trial of ketogenic diet and chemo for glioblastoma going on at UCLA.
Please can you tell us the right cocktail of supplements and thee dose? Like melatonin ,VIT d or any other Thank you Just a prostate cancer patient (I already made a radiation therapy ) with good results!
I wish I could, but I make a point not to talk about dosing, scheduling, combinations on here. That could be considered medical advice and it wouldn’t be appropriate on RUclips. Those are conversations between you and your like minded local doctor. I am glad you are doing well but im sorry you have prostate cancer.
Agree with most of the video but have a word of caution. Definitely be careful with B vitamins. There’s a lot of contradictory evidence, especially with doses of thiamine found in supplements. IV level high doses mentioned in the video have better results but it could be a case where “low” doses (even 5000%) could be worse than nothing. More research is needed on thiamine.
I agree there is a lot of nuance. That being said, thiamine deficiency which surprisingly is 30-90% of the population, leads to malfunction of PDH, pseudohypoxia which can drive Warburg metabolism. Therefore I think it would be safer for most people to get enough thiamine to at minimum prevent deficiency. But yes for the PDK inhibition, it does take high doses.
Doctor Peavler any guidance on oral supplementation of B1? I have received a preliminary diagnosis of throat and neck cancer from my primary care and am awaiting imaging and ent/surgeon consult. Since the initial diagnosis two and half weeks ago I have been fasting and eating a strict ketogenic diet. Thanks to your information I have been supplementing melatonin. I’ve also been on 444mg of fenbendazole. The melatonin I do not tolerate well in the daytime. It totally zonks me like a low level unpleasant highness or drunkenness. Anyway I would like to try the B1 but the paper said “high dose”. How high is high dose? Thank you. Please keep this up. Good bless you man! (Ps. If I need to pay for a telemedicine consult I’d be glad to.)
Me too doc, highly need consultation. I am currently on ivermectin since one month for my lymphoma in addition to vit d. I need to know more about high dose vit B1???? I can't do high vit c as I recently discovered i have G6PD def😢 !!
No know toxicity. Many people feel mentally foggy and drowsy even at low doses. There is no known negative feedback loop which is good. Anyone who doesn’t have cancer should maximize their endogenous production. People with cancer need a risk vs benefit discussion with their doctor.
No need even consider taking it if non-cancer patient. Learn to maximize nocturnal pineal release. Get maximum solar exposure to radically increase intracellular melatonin production. My first 2 melatonin videos are about exactly this.
@@DrCaseyPeavler going to watch right now. Thanks! I know it’s popular to help people sleep, and sleep being as important as it is, I figured it would be good for insomniacs if it has no really bad side effects.
I am happy to be of assistance. The easy answer for me is just to say yeah take the pills. The right answer is perfect your light environment and circadian biology.
Much of the verbiage in this video was above my head. Exactly what is DCA? What types of cancer is it good for? Where can I get and what dosage should I take it? I’m a 75 year old male, 5’8”, down to 140lbs from 185, with stage 4 NSCLC with an eGFR19 mutation. Should I consider taking DCA, or something else? What about high dose IV vitamin C? Goo? Red light therapy? Good grief there’s way too much to take into consideration. I don’t know what to believe anymore or to talk to because traditional oncologists do believe in or know anything about metabolic alternative therapy. Mine thinks I’m crazy when I talk about fennel and menbenzadole etc.
@@DrCaseyPeavler Thanks. I'm in Queensland, Australia and the d minder says no vitamin d until 8.45am which is 4 hours after the sun rises here at the moment. It seems to be a long wait.
@@DrCaseyPeavler Sorry for the confusion. I was just wondering what the benefit of the sun from 4.30am was if there is no vitamin d until 8.30am. Thanks.
Circadian rhythm setting, increases in dopamine, serotonin, melatonin. UV-A arrives in environment earlier than UV-B and helps stimulate POMC, alpha, beta, gamma MSH, melanin, beta endorphin, met-enkephalin. UV-A also increases nitric oxide and sulfates cholesterol to inhibit arterial plaque formation. All of which prepares your skin for UV-B after 845am (for you).
I am so sorry to hear about your mom. Any treatment should be discussed with the patient and their healthcare provider. If you don’t have a doctor that is willing to even consider these types of therapies, then you should find someone in your local area who is more supportive. I hope your mom gets better.
Everything can be toxic in excess, even water. This is not something to be undertaken alone EVER. With this or any other intervention there needs to be a risk vs benefit discussion with your doctor and close monitoring.
Yes, scientific process necessarily has to oversimplify, for lab work, drug assessment, and clinical use (not to mention 'profit at any cost' econ pressure), to try to avoid competing reactions confusing the understandings, yet much of the science then does not go beyond these oversimplification pressures to effectively utilize additive and synergistic combinations. IMHO. 'First do no harm' should logically prevent most 'profit' development practices at the expense of utilizing highly effective existing drugs and methodologies because they are not considered profitable enough. To abandon off-patent drug use, or avoid clarification of clinical efficacy, in favor of profit, does often harm! This should give pause to ANY practitioner noticing these harmful mechanisms, and they need to ' Question Authority' if they are really upholding the oath! Vast opportunity to heal is lost in the drive to profit, without a questioning attitude. And, without CURIOSITY essentially driving the medical paradigm at the core. This IS essential medicine! Thank you.
@@DrCaseyPeavler regarding your vitamin d videos, have you seen the coimbra protocol for MS ? Full reversal with 100 000 - 300 000iu per day.... extremly intresting. Just started 100k per day, for autoimmune
Much of the verbiage in this video was above my head. Exactly what is DCA? What types of cancer is it good for? Where can I get and what dosage should I take it? I’m a 75 year old male, 5’8”, down to 140lbs from 185, with stage 4 NSCLC with an eGFR19 mutation. Should I consider taking DCA, or something else? What about high dose IV vitamin C? HPO? Red light therapy? Good grief there’s way too much to take into consideration. I don’t know what to believe anymore or to talk to because traditional oncologists either don’t believe in or know anything about metabolic alternative therapy. Mine thinks I’m crazy when I talk about fenben and menbenzadole etc.
honestly DCA shouldn't be at the top of your priorities. Get the GKI below 1 and implement glutamine inhibitors. stress and sunlight/darkness is next. Implement these and it should buy you a lot more time to then study.
I can understand how this could be a difficult video to start with. This is video about 75 or 80 in the series and the information builds on itself and is frequently repeated for repetition. I do educational consults if you are interested in a more personalized educational experience.
Can you now see the importance of HIF, lactate and PDK in maintaining the Warburg effect? And how the vicious cycle must be broken?
Sorry I commented before finishing the video.......Dr Derick Lonsdale was very insightful...Dr Peavler, can the PKD enzyme action be mitigated by higher doses of thiamine (a cofactor for pyruvate dehydrogenase?
Send an email to RFK
One thing I’ve gathered from your videos, and those of others, is that the solution to most of the cancer problem is basically known. It remains only synthesize all these strands into a comprehensive framework. You are well placed to do that, unlike most of the rest of us.
I appreciate your kindness. I’m working on synthesizing it. But more important than that for my own edification, is that that knowledge is transferred to you all in a way that makes sense and allows for practical solutions.
What most don't understand is that imaging procedures such as CT scans, mammograms, PET scans, etc. have very high amounts of radiation that is downplayed but eventually causes cancer. The radiation induces cancer by disrupting the molecules and electrons in your cells. The radiation is strong enough to cause double strand damage and thus a gene mutation which eventually leads to cancer 6-7 years after exposure. Then when an allopathic medicine doctors sees you have cancer from an ultrasound or CT scan, they will tell you they need to do a biopsy. Yet, if they puncture the extracellular matrix where the cancer is encaged in, this will actually help the cancer. There are various scholarly articles that show this is the case. Cancer can migrate to areas of inflammation including a biopsy when the cancer can track across the needle. Now here's my favorite part, after they help your cancer spread, a doctor will tell you your choices are either chemo or radiation. Both Chemo and radiation do not distinguish between healthy and cancer cells. It kills all cells. So you're essentially killing all of your cells hoping that you survive and it kills the cancer. This oftentimes causes rebound cancers from the other healthy cells that have been affected if you even survive the treatment and are left with permanent side effects. When they actually give you chemo and radiation, they hope that one of your repair genes, such as BRCA1, BRCA2 and/or PARP activate and repair the damage to the rest of your immune system, yet there are millions of cells in your body and it's unavoidable to have some misrepaired cells, thus causing rebound cancers later on and making you a return customer in the system.
@@michaelzhelev4658 Dr. Yanagisawa prepped the workers that had to go into the hot zone at Fukushima, he loaded them up with C, Lipoic Acid, others..... When they came out of the hot zone, their blood work showed zero signs for future cancers, zero fragmented DNA, other markers. There is a PDF that is out there that lays it all out, I'm going to try and put it on my SubStack today.
@@michaelzhelev4658 I loathe YT's censorship.
YES! You are preaching to the choir. Our system is fundamentally flawed. Car accident, fall off a ladder, etc, we do amazing things. With chronic disease management, we do in many cases more harm than good.
@@DrCaseyPeavler Prevention, prevention, prevention, early treatment!
Where is the research funding for junk food, junk light? For autopsy, for lifestyle disasters like the switch to LEDs w/o precautionary toxicologic funding? For non native EMF toxicity? For deuterium toxicology? For lifestyle continued use of lead fishing sinkers rolling around in millions of tackle boxes, creating pure lead black powder coating everything you touch, including the apples we hand out to our grandchildren while teaching them to fish? Lead in children's sandwiches, w/o regulatory agency due diligence for toxicology risks involved, is criminal and directly harms intelligence. How can these things go on, and on, and on, without dealing with them as a society that has ethics? Corruption abounds, censorship abounds, while no funding pointedly investigates to inform changes! It is criminal to have 'Environmental Protection' agencies that so obviously avoid doing due diligence because of political power not allowing enabling research and regulatory corrections!IMHO
Thanks for sharing your important cancer fighting information, and I like how you went back to highlight a prior Vit D and melatonin video. My brain needs to get this info hammered in over and over again to sink in.
Me too, don’t feel bad. It’s a a lot. And there is A LOT more…
@@DrCaseyPeavlerwill we perhaps get a protocol, that we can bring to our physicians to be able to say put me on this and monitor me
Great question. I would love to be able to tell you yes. The official press pulse is not yet published, anyone who is doing any version of press-pulse is making educated guesses. I have made a point not to share dosages and specific protocols on RUclips. Not to hide any secrets or truth but this just isn’t the place. That is essentially the non-specific one size fits all approach to medicine and that isn’t how it is or how it should be. This is a powerful program, and there are potential side effects. That at least deserves a conversation about risks vs benefits with a doctor and close monitoring. I hope that makes sense.
AWESOME! You are my favorite RUclipsr. I've watched every video you have shared. I implement the findings in these studies immediately. Thanks so much Dr. Peavler! 🎉
I am happy to be someone’s favorite RUclipsr ha!
Please do not do anything without consulting a doctor first please. Nothing is perfect and completely without side effects and that needs to be discussed on a case by case basis and monitored.
Has it had any affects yet?
Great, as always!
I am glad you enjoyed it!
So happy to see that you ran with the DCA (or into) rabbit hole 🎉 🐇
We are just getting warmed up…
Omg. Thanks for the information!! My wife has GBM and we have been practicing metabolic therapy for 5 months now. HBOT and everything else to with it. An MD had just told me to look at DCA. Wow I don't know how I missed this one. Anyway, your video and other information has helped lots and we are in the process of adding this in. Thanks again 🙏
I am so sorry about your wife. How has the metabolic therapy turned out for her thus far? I am glad the video helped you both!
@@DrCaseyPeavler thank you. It has been helping. MRIs have not shown any real tumor progression. Just had another one the other day and will see the doctor about it tomorrow. We are hoping to see good results..
We are doing many things to press and pulse this that I cannot discuss openly or I'm sure my comments will be removed. Thanks again for your great content and help.
I am hoping and praying for good results also. God bless your wife’s journey back to health!
Prayer & visualization is key with 18 to 24 Fasting and OMAD, seems to be the nail in the cancer coffin from my observation Good luck !!!
What a great video! i'll save this one. Regarding metabolic therapy for cancer: this is why i personally I like DCA combined with Berberine as a better alternative to lowering glucose than metformin, as metformin pushes the other way to produce lactate.
You are very welcome! I am sorry you have cancer. How has your strategy been going? Do you do anything else besides berberine and DCA?
@@DrCaseyPeavler Sorry, to be clear my strategy is for my wife, stage 4, works a 5 day week with good quality of life. things seem to be improving with large % shrinkage of primary tumor, no further metastasis, lymph nodes back to normal. No Chemo, no radiation, no surgery, she does take fulvestrant, when I researched this substance from a metabolic perspective it does inhibit the SLC1A5 glutamine pathway also. This was not the primary reason for this drug, but it's interesting what you find when you look at things from a metabolic perspective. She also takes Ivermectin, Memben, Fenben, HCQ, EGCG, Melatonin, VitD, Allicin, B17 and some other things. Lots of exercise and sun if we can get it.
Wow. What an absolutely amazing testimonial. Powerful!
@@DrCaseyPeavler I wonder why Y-T has hidden my com-ment....
I see it on my end. Not sure how it looks on your end.
btw great series. ty for your contribution to mankind, because that's exactly what it is. 😊
I am happy you are enjoying the series. We are really just getting started, a lot left to cover!
Powerful Presentation!
I am glad you think so! Hopefully it is helpful to you!
Kinda thought so: Synergistic Amplification of Oxidative Stress-Mediated Antitumor Activity via Liposomal Dichloroacetic Acid and MOF-Fe2
I think a beautiful second agent could be IV-C or HBOT.
@@DrCaseyPeavler I made a perfectly reasonable response, it vanished within seconds.
God helps us… 🤦♂️
@@DrCaseyPeavlercan I ask what hbot is please
Great. Loved it. Thank you so much.
Glad you enjoyed it!
Dr. Peavler, just came across your videos and you are clearly a talented physician. Can you do a video and/or series on artemisinin as an adjuvant to metabolic therapy? Seems to use heme iron uptake in cancer (or other antigen) cells to mark targets for apoptosis.
I will be covering artemisinin in great detail in the near future yes!
thanks for sharing this
You are very welcome!
@@DrCaseyPeavler love the biochemistry
Me too!
I like the idea of combining DCA with oxaloacetate. Dr. Akbar Khan has a MOMENTUM protocol which uses both
Sounds like a good start!
There are multiple cofactors that play a role in the function of pyruvate dehydrogenase.
Simple nutrient deficiencies can make it dysfunctional.
Absolutely true! That is called pseudo-hypoxia.
Isn’t DCA available on Amazon even though it’s expensive? So if B1, D3, and melatonin combination has been tried with conventional therapy and patient not improved, people can also supplement with DCA if they choose to do so.
If you or someone you love is struggling with cancer, first off I am sorry.
No treatment should be initiated without speaking to your healthcare provider, having a risk vs benefit conversation, and deciding what is best for your specific situation. Nothing is perfect or without some side effects. But this discussion is critical.
@@DrCaseyPeavler Indeed! But maybe not so easily found?
A resourceful person can find just about anything, but that doesn’t mean they should go it alone.
@@DrCaseyPeavler Yes!
@@DrCaseyPeavler "speaking to your healthcare provider" 99% of time will be a pointless. Very few if any will not want to risk their license persuing unconventional treatments. Makes zero difference what any research suggests. Everyone is on their own and always has been. Coventional treatment outcome studies are all falsified. A patient that "recovered" is counted as a success because of said treatment regardless if thats what actually happened.
Thanks for sharing
You are very welcome!
Re: B1, Dr. Stasha Gominak has clarified existing research about the necessity of adequate D3 presence first, in order to allow gut bacterial assemblage ecology in order to facilitate the four B vitamin-producing bacteria to dominate effectively for synergistic B vitamin production from the gut.
How high are effective dosages being seen?
For B1, that is.
I have made it a point not to give doses, timing or scheduling. Don’t want to get accused of practicing medicine on RUclips. But it’s thiamine, imagine it, simple B1..
@@DrCaseyPeavler Got it.
Gotta play it safe Ray, you know how it is.
simply amazing.
I am glad you like it!
@@DrCaseyPeavler i love it and hate it-i hate the fact that something like dch/melatonin/vit d could treat cancer (along with lifestyle etc) but big pharma doesnt think its benefical to humanity. sad day. on the other hand, i truely appreciate your hard work on making these videos and the invaluable education you present. thank you!
I also find it sad these things are essentially buried. I just want to use this platform to spread awareness, obviously not all of these things will be right for every patient. But if it could help just one or even a handful…
Excellent content.
A pleasure to listen to you. If thiamin works, benfothiamin might be even better.?
I am glad you enjoyed it! From oral administration, yes likely. IV thiamine is likely best for this to achieve rapid peak serum concentrations.
Cellular reprogramming of cancer cells to a normal way of energy production might be a very elegant way of getting rid or even preventing cancerous cells.
Aparently my first comment was not posted. It’s a little funny sometimes on here.
Metabolic reprogramming is the ultimate strategy. By putting metabolism back the way it’s supposed to go. The cell either sinks (now has the ability to undergo apoptosis again) or can swim (revert back to normal cell).
This sounds like magic
If you're doing a ketogenic diet, is DCA ineffective or is there still some cancer glucose metabolism happening? Wonder if dose could be lowered in this context. I've heard the DCA can result in neuropathy - although it is reversible if you don't go too long.
DCA wouldn’t affect glucose uptake or glucose utilization by glycolysis. It affects the step between pyruvate and acetyl coA. This helps shut off the Warburg effect in one unique way.
Yes peripheral neuropathy seems to be most common side effect.
When it comes to toxicity with substances such as curcumin, EGCG, others, Liposomes amplify absorption and bioavailability while allowing for reduced dosing. This is evident in the work Dr. Hancock is doing with Liposomal Ivermectin.
Liposomal technology is awesome.
Is there something that targets the hormones, against uterine cancer 🙏🏻 praying for breakthrough
@@casta9172 Consider reading up on Diindolylmethane.
Several things, have you looked into cruciferous veggies that contain: sulforaphane, I3C, and other natural aromatase inhibitors?
@@DrCaseyPeavler thanks, I'll look into it now,, I'm drinking Yarrow tea for the hormones and urinary flush supplement,, trying to get the uterus to flush out
You could ask your doctor about a Dutch test complete. Could also be helpful.
@@DrCaseyPeavler my doctor is gaslighting me, she said I don't have any long haul Covid problem, and she just referred me to oncologist to have all my organs in that area removed,, I declined that immediately, after I read about the terrible side affects of getting a hysterectomy
I can't even imagine getting the surgery and it spreads to somewhere else because they should be doing metabolic therapy on me and don't want to
So now I'm my own advocate, looking for healing online from real caring doctors, like Dr Eric Berg and Dr Thomas Seyfried
Hi Doc. Just listening and at 7:16 I have a question.
If the mitochondria are damaged/malformed will DCA work? The etc and mitochondrial processes surely will not work or will the mitochondria recover somehow?
Will using DCA allow other medications to get into the tumour due to lowering lactic acid around it and is a dual approach with trying to get HKII. away from the VDAC a killer (of the c cell) combination allowing apoptosis to happen?
I can’t give medical advice on RUclips. But I think there has to be a thoughtful combination approach to this. There is no magic pill or silver bullet. Every intervention has side effects or potential side effects. Which is why I stress talking to some like minded local doctor before starting or stopping anything.
Yes DCA helps shut down lactic acid tumor micro environment. The damage seen to mitochondria are on a continuum. Not healthy but not all completely trashed. For those who can be reprogrammed and saved they likely will be, for those that are not, DCA takes the brake off of apoptosis and makes cancer cells more susceptible to oxidative therapies.
@@DrCaseyPeavlerThank you very much. Is it possible to do mitogenisis in a c cell or is apoptosis the best option?
Great question! I do talk about that nuance in the mitochondrial biogenesis video
Supercharge Your Health With NEW Mitochondria
ruclips.net/video/o1TPIjarIzA/видео.html
@@DrCaseyPeavler watched! Many more new terms that I now can’t remember! At least I can watch your videos multiple times to try and get more information to stick. You’re a valuable learning resource for us lay people.
DADA is available in the grey market and is a PDK inhibitor very similar drugs. Look into it brother 🙏
Why would emperor Palpatine want to help humanity? Were you turned back to the light side?
I will check out DADA!
@
😂😂😂
Palpatine is a man of God now! ✝️
The Lord is working through you brother. God bless you. Keep up the good work🙏
Getting thrown down a Death Star shaft by Vader must have really shaken him up..
What is DADA? What is the grey market?
@ DADA is Diisopropylamine dichloroacetate. It’s a DCA analogue. Grey market meaning, it can be legally sold for “research purposes” not for human consumption.
Fantastic Video.
Does the warburg effect work exactly the same way as the reverse Krebs cycle? Ends up in the same number of ATP’s per mol of glucose.
No Warburg effect does not make much ATP at all. That is why these cells require 10-30x more glucose and glutamine than a normal cell.
@@DrCaseyPeavler Reverse Krebs produces same amount of atp. I think mitochondria are not damaged. It’s a growth function.
Can you show me some papers to help me better understand?
@@DrCaseyPeavler www.ncbi.nlm.nih.gov/pmc/articles/PMC9871338/
I don’t know if this helps. It’s not from the lecture I listened to some days ago. I listened to a talk some days ago and the lecturer showed a slide of the reverse krebs cycle (which was new to me) but she said that the output was 2ATP which is the same as warburg effect atp output. So my naive brain thought that they are linked.
I’m like a 1st week student so i apologise if my terminology and understanding is arse about face.
@@DrCaseyPeavler And, increased insulin driving increased glucose uptake rate? Problematic carbs, predisposing to much higher glucose uptake?
So, not patentable (DCA). Why cann't the supplement industry run with it?
Who is to say they haven’t…? It’s not all rainbows to be honest. It is a drug. Needs a doctor’s supervision.
The paper on HGG had an unexpected statement in it: "...compared to differentiated glioma cells, and GSCs are thought to rely primarily on oxidative phosphorylation." I thought ALL cancer cells did NOT use OXPHOS? Including stem cells. What am I missing?
Which paper? “Targeting Glucose Metabolism in Cancer Cells with DCA to radiosensitize high grade gliomas”?
@@DrCaseyPeavler Yes
I am going to assume your name is Bob. So Bob, if you take a look at the video prior to this video on Checkmating cancer with metabolic therapy. It’s likely cancer cell is on some continuum of hybrid metabolism (partial utilization of oxphos, and aerobic glycolysis). Likely not all or nothing. Even at the extreme only 80-90% of ATP comes from Warburg exclusively. My guess is that there are going to be some cells in the tumor that will have some ability to use oxphos and that possibly explains why cancer stem cells are more quiescent. I have seen other papers suggesting metabolic therapy is still effective for cancer stem cells in a lot of cases.
pubmed.ncbi.nlm.nih.gov/29045536/
@@DrCaseyPeavler Thanks. After hearing a lot from Seyfried (who oversimplified this detail) I have been stuck on "all or nothing."
If you look at his own papers, we know that is not true. Check out the metabolic therapy checkmates cancer video again, I talk about this at length.
How Metabolic Therapy CHECKMATES Cancer
ruclips.net/video/O4sajpZ_SFM/видео.html
Can you talk about the dosing? In this video you talked about repeated dosing to keep the pressure on. What would be the milligrams per kilogram of bodyweight and how many doses per day?
I appreciate your question and can understand the frustration of not getting that. But that is not the role of these videos. This is an awareness campaign with good scientific data backing me. The medicine must be practiced at the local level with a healthcare provider or doctor. I cannot legally or ethically provide that kind of advice on here. I hope that makes sense
Casey, I took DCA orally for 3months @ 3500mg per day. Developed tremors. Stopped. Now over the tremors and considering re starting DCA as it seemed to be working on my neck tumor. What other side effects have you heard of from oral DCA use ? I was told another patient that got IV DCA also got tremors.
Peripheral neuropathy is the most common side effect as discussed in the literature. So this is not without side effects as you experienced.
I cannot give doses on here, it would be considered medical advice or practice of medicine.
Email me.
Can any paper show that unregulating PDK inhibits PDH and creates the Warburg effect ? ie the opposite?
The first paper I am going over shows that. But it’s not PDKs fault. It’s up regulated by HIF1a and ammonia among other things. And is it really HIF1a’s fault? Not really, it’s just doing its job. It’s all of the other underlying root causes that drive hypoxia and pseudohypoxia. That’s why you have to shut this metabolism down at as many levels as possible. No one magic pill or silver bullet.
The commercials are preventing me from staying focused on this.
Sorry man!
Get a premium account...it's less than $15/mo and no commercials.
Getting premium for me as a heavy RUclips user has been huge. You can listen to the videos with the phone locked, no commercials..
Is DCA being used outside US for cancer therapy? Mexico or India for example?
I don’t honestly know. It would not surprise me.
Casey how can one get all your videos for reference later. I’m 75 years old and not a techie.
No problem. You can subscribe to the channel, and come back anytime to reference later. You can even save videos to a watch later folder. That’s probably the easiest ways.
Are there any real studies where people in ketosis take some glutamine blockers?
So there are animal studies and case reports of people doing it. No large human trials as a stand alone. There is I believe a human trial of ketogenic diet and chemo for glioblastoma going on at UCLA.
I wonder if there's a plant, herb, that mimics this lab medicine,, there might be... Kalanchoe Pinnata and Guanábana, are the best ones so far
Melatonin, Vitamin D, Thiamine just to name a few. There are others. I personally believe that God through nature has given us everything we need.
@DrCaseyPeavler I'm a RN for 30 years, and from what I've observed....I completely agree with you.
It’s really remarkable. All we need to do is just get out of our own way…and let the body heal
Please can you tell us the right cocktail of supplements and thee dose? Like melatonin ,VIT d or any other
Thank you
Just a prostate cancer patient (I already made a radiation therapy ) with good results!
I wish I could, but I make a point not to talk about dosing, scheduling, combinations on here. That could be considered medical advice and it wouldn’t be appropriate on RUclips. Those are conversations between you and your like minded local doctor. I am glad you are doing well but im sorry you have prostate cancer.
Probably a silly question, Is DCA similar to Undecylenic Acid?
There are no silly questions. I don’t think so. They can both increase apoptosis in cancer cells, but by different mechanisms.
What is considered high dose thiamine? Or high dose B1 ?
Email me.
Zeroing in on the reasons why we are slaves to healthcare premiums. ❤
We need a parallel system like Dr. Jack Kruse is trying to create in El Salvador.
@@DrCaseyPeavler Right country, right name, may he become one. ❤️
Uncle Jack is a beast.
Agree with most of the video but have a word of caution. Definitely be careful with B vitamins. There’s a lot of contradictory evidence, especially with doses of thiamine found in supplements. IV level high doses mentioned in the video have better results but it could be a case where “low” doses (even 5000%) could be worse than nothing. More research is needed on thiamine.
I agree there is a lot of nuance. That being said, thiamine deficiency which surprisingly is 30-90% of the population, leads to malfunction of PDH, pseudohypoxia which can drive Warburg metabolism. Therefore I think it would be safer for most people to get enough thiamine to at minimum prevent deficiency. But yes for the PDK inhibition, it does take high doses.
Doctor Peavler any guidance on oral supplementation of B1? I have received a preliminary diagnosis of throat and neck cancer from my primary care and am awaiting imaging and ent/surgeon consult. Since the initial diagnosis two and half weeks ago I have been fasting and eating a strict ketogenic diet. Thanks to your information I have been supplementing melatonin. I’ve also been on 444mg of fenbendazole. The melatonin I do not tolerate well in the daytime. It totally zonks me like a low level unpleasant highness or drunkenness. Anyway I would like to try the B1 but the paper said “high dose”. How high is high dose? Thank you. Please keep this up. Good bless you man! (Ps. If I need to pay for a telemedicine consult I’d be glad to.)
Just saw below you don’t native dosages online. Question withdrawn 😉
Where do you live? I am sorry for your recent diagnosis. Email me. The email address is in the description of every video.
@@DrCaseyPeavler Thank you. I emailed.
Great thanks!
Me too doc, highly need consultation. I am currently on ivermectin since one month for my lymphoma in addition to vit d. I need to know more about high dose vit B1????
I can't do high vit c as I recently discovered i have G6PD def😢 !!
Doc, do you have any insight on the potential negative effects of Melatonin?
No know toxicity. Many people feel mentally foggy and drowsy even at low doses. There is no known negative feedback loop which is good. Anyone who doesn’t have cancer should maximize their endogenous production. People with cancer need a risk vs benefit discussion with their doctor.
@@DrCaseyPeavler Great thanks!
Do you have recommendations on the dosing for non cancer patients?
No need even consider taking it if non-cancer patient.
Learn to maximize nocturnal pineal release. Get maximum solar exposure to radically increase intracellular melatonin production.
My first 2 melatonin videos are about exactly this.
@@DrCaseyPeavler going to watch right now. Thanks! I know it’s popular to help people sleep, and sleep being as important as it is, I figured it would be good for insomniacs if it has no really bad side effects.
I am happy to be of assistance. The easy answer for me is just to say yeah take the pills. The right answer is perfect your light environment and circadian biology.
Much of the verbiage in this video was above my head. Exactly what is DCA? What types of cancer is it good for? Where can I get and what dosage should I take it? I’m a 75 year old male, 5’8”, down to 140lbs from 185, with stage 4 NSCLC with an eGFR19 mutation. Should I consider taking DCA, or something else? What about high dose IV vitamin C? Goo? Red light therapy? Good grief there’s way too much to take into consideration. I don’t know what to believe anymore or to talk to because traditional oncologists do believe in or know anything about metabolic alternative therapy. Mine thinks I’m crazy when I talk about fennel and menbenzadole etc.
DCA is pretty cheap in Amazon
With medical supervision only please.
Thank you for the video. Are there any benefits to early morning sun? What sun angle does vitamin d start producing?
Huge benefits to AM Sun. Depends on latitude and time of year. You can use D minder app to help you figure this out for your location.
@@DrCaseyPeavler Thanks. I'm in Queensland, Australia and the d minder says no vitamin d until 8.45am which is 4 hours after the sun rises here at the moment. It seems to be a long wait.
That’s earlier than most places. What a blessing. What is your concern, I feel like I’m missing something.
@@DrCaseyPeavler Sorry for the confusion. I was just wondering what the benefit of the sun from 4.30am was if there is no vitamin d until 8.30am. Thanks.
Circadian rhythm setting, increases in dopamine, serotonin, melatonin. UV-A arrives in environment earlier than UV-B and helps stimulate POMC, alpha, beta, gamma MSH, melanin, beta endorphin, met-enkephalin. UV-A also increases nitric oxide and sulfates cholesterol to inhibit arterial plaque formation. All of which prepares your skin for UV-B after 845am (for you).
You don’t have “sodium” the DCA?Is “Sodium Dichloroacetate” the same thing?
Yup same thing!
Hello, my mother has a menengioma and brain edema. Can she use it for healing? thank you
I am so sorry to hear about your mom. Any treatment should be discussed with the patient and their healthcare provider. If you don’t have a doctor that is willing to even consider these types of therapies, then you should find someone in your local area who is more supportive. I hope your mom gets better.
be careful, it is toxic
2 options: 2 weeks on, 1 week off or 3 weeks on, 3 weeks off.
Everything can be toxic in excess, even water. This is not something to be undertaken alone EVER. With this or any other intervention there needs to be a risk vs benefit discussion with your doctor and close monitoring.
I wonder what form of B1 is best. Benfotamine, TTFD or the regular water soluble type
Yes, scientific process necessarily has to oversimplify, for lab work, drug assessment, and clinical use (not to mention 'profit at any cost' econ pressure), to try to avoid competing reactions confusing the understandings, yet much of the science then does not go beyond these oversimplification pressures to effectively utilize additive and synergistic combinations. IMHO. 'First do no harm' should logically prevent most 'profit' development practices at the expense of utilizing highly effective existing drugs and methodologies because they are not considered profitable enough. To abandon off-patent drug use, or avoid clarification of clinical efficacy, in favor of profit, does often harm! This should give pause to ANY practitioner noticing these harmful mechanisms, and they need to ' Question Authority' if they are really upholding the oath! Vast opportunity to heal is lost in the drive to profit, without a questioning attitude. And, without CURIOSITY essentially driving the medical paradigm at the core. This IS essential medicine! Thank you.
And criminality is frequently tolerated in the medical paradigm IMHO.
Fenben and IVY are making quite a splash in this arena.
I'm scared they will take them away. Make it impossible to implement.
Me too.
I personally took the Oath of Hippocrates. I revere it. I remember it. I try to keep it sacred in my own life and professional career.
R-Liopoic Acid
It’s on the list, don’t you worry!
DADA is better and no nerve damage as side like dca got
Thank you for your feedback!
www.ncbi.nlm.nih.gov/pmc/articles/PMC5356547/
@@DrCaseyPeavler regarding your vitamin d videos, have you seen the coimbra protocol for MS ? Full reversal with 100 000 - 300 000iu per day.... extremly intresting. Just started 100k per day, for autoimmune
No, I have not. Closer to equator, more UV = more D3, less MS and autoimmunity…
I would rather recommend sun than pills of anything
Obviously there is a time and place…
I can’t find our comment string, but needing your email address, please for my Mom.
I’m not understanding your email address.
Admin@integrafunctionalmedicine.com
It is in the description of every video also.
"it is too toxic for heart", look like u need professional monitoring
Thanks for your feedback. Can you help me understand what you mean? Do you mean like a computer monitor? Or like a chaperone?
Hi Dr. Idk if you seen my question on another video but can you do a video on if baking soda can fight cancer? Thank you
I am pretty sure I had answered it , but yes can at some point in the future.
@DrCaseyPeavler waiting for it
Waiting for what I'm sorry?
Much of the verbiage in this video was above my head. Exactly what is DCA? What types of cancer is it good for? Where can I get and what dosage should I take it? I’m a 75 year old male, 5’8”, down to 140lbs from 185, with stage 4 NSCLC with an eGFR19 mutation. Should I consider taking DCA, or something else? What about high dose IV vitamin C? HPO? Red light therapy? Good grief there’s way too much to take into consideration. I don’t know what to believe anymore or to talk to because traditional oncologists either don’t believe in or know anything about metabolic alternative therapy. Mine thinks I’m crazy when I talk about fenben and menbenzadole etc.
honestly DCA shouldn't be at the top of your priorities. Get the GKI below 1 and implement glutamine inhibitors. stress and sunlight/darkness is next. Implement these and it should buy you a lot more time to then study.
I can understand how this could be a difficult video to start with. This is video about 75 or 80 in the series and the information builds on itself and is frequently repeated for repetition. I do educational consults if you are interested in a more personalized educational experience.
@@DrCaseyPeavler I have already participated in your webinar series and I am going to call you for a private consult. Thanks, Ed