Two further natural extracts that you might not know that selectively inhibit both glutamine and glucose in cancer cell metabolism. Black Seed and Ashwagandha. * Black Seed (Nigella sativa) Mechanism of Action: Black seed, primarily through its active compound thymoquinone, exhibits anticancer effects by modulating multiple cellular pathways, including NF-?B and PI3K/Akt, which influence cell survival, inflammation, and proliferation. Effects on Glucose and Glutamine Metabolism: Glucose: Thymoquinone in black seed inhibits glucose uptake and glycolysis by downregulating glucose transporter proteins, effectively limiting the primary energy supply for many cancer cells. Glutamine: Thymoquinone has been shown to reduce glutaminase activity, decreasing the conversion of glutamine to glutamate, a critical fuel for cancer cell energy production and raw material for cell reproduction. By targeting both glucose and glutamine pathways, black seed creates a double metabolic blockade. * Ashwagandha (Withania somnifera) Mechanism of Action: Ashwagandha's active compounds, especially withaferin A, target multiple cancer-related pathways, including AMPK and mTOR, making it effective in reducing cancer cell growth and survival. Effects on Glucose and Glutamine Metabolism: Glucose: Withaferin A in ashwagandha inhibits glucose uptake and glycolysis by reducing GLUT transporters and inhibiting glycolytic enzymes, disrupting the Warburg effect in glucose-dependent cancer cells. Glutamine: Ashwagandha also inhibits glutaminase, thereby limiting glutamine's conversion to energy and building blocks, and weakening cancer cells' metabolic flexibility, particularly in glutamine-reliant cancers.
Cancer's Metabolic Shift as a Survival Mechanism (the 'why') : Cancer's metabolic shift, including its reliance on glucose and glutamine, can be viewed as a survival mechanism - a partial reversion to more primitive, single-cell behaviors. In normal multicellular organisms, cells are specialized and coordinated, with tightly regulated growth and metabolic processes. Through evolution, these have been built on top of the single cell DNA code, which is still there. Cancer cells lose some of these characteristics of differentiation, adopting a strategy of autonomous survival. This shift allows them to maximize resource acquisition and metabolic flexibility to sustain rapid growth and proliferation, even in challenging environments, such as low oxygen or nutrient scarcity within tumors. By prioritizing metabolic pathways that enhance biosynthesis (rather than just energy production), cancer cells essentially operate as independent entities that ignore signals from surrounding tissues, similar to single-celled organisms. This reversion supports their survival and unchecked growth, allowing them to thrive despite the body's regulatory efforts. Finally, rather than say “glucose and glutamine fuel cancer” it would be better to say : “glucose and glutamine serve as critical substrates for cancer, supporting its growth by providing essential building blocks for biosynthesis.” Specifics : Cancer cells prioritize glycolysis because it provides several intermediates (such as glucose-6-phosphate and pyruvate) essential for building blocks of new cells. These intermediates are crucial for synthesizing nucleotides (for DNA), lipids (for cell membranes), and amino acids (for proteins), all of which cancer cells need for fast growth. Although glycolysis is less efficient in terms of energy (ATP) production, it generates these biosynthetic intermediates in a quick and controlled manner, supporting cell growth and division. Similarly, the glutamate produced from glutaminolysis is an intermediary for the building blocks needed for proliferation. Not only to synthesize extra glutathione to protect itself from ROS. Quite clever, in a way.
@@doejohn8674HIT ( high intensity traning - check it out), resistance training so hit the gym sir,.remember your training must be " to failure" so that your muscles gets the strong enough signal so that they adjust, adopt what is mainly new mitochondria creation
Good luck my fingers are crossed for you, sending you positive vibes. Bouncing on a small trampoline or on the balls of your feet for 10 to 20 minutes a day is great for lymph drainage as the lymph system needs muscle pumping to keep the fluids moving around the body and avoiding lymph system problems.
I would suggest LOW population density and LOWest latitude possible for your healing journey. You need maximum sun exposure, light stability, and lack of light/EMF pollution.
Great video! I never stopped riding my bike. 10-20 miles 3 times a week. I would always work around my house, sometimes just moving stacks of wood from one side of my yard to another. Just keep moving. Stage 4 in 2023… tomorrow’s scans will show me what has been happening for the past three months CMF
It make sense but I think especiallly in prevention as the excersise should help improve the the energetic " well being" of the cell that is already healthy but what is more important it can change the metabolic trajectory of the cell that is already struggling and is on the brink of getting into the fermentation for good ..... indeed sport can help in keeping the healthy ratio of mitofagy and creation of the new mitochondria.
Thank you, Dr., for all you do. I am 100% onboard. In fact, just ordered a treadmill and vit D sunlamp. Additionally, I hope to be in therapeutic ketosis in approx. 4-weeks. Thanks again.
Great video Dr. Peavler! Certainly does explain some of my own observations - that exercise definitely helps fight cancer. I’m not sure about prevention as mine popped up when I was very fit (top few % of my age group) but no question that Exercise does help the fight. I found the best response was if I prepared my body first by taking the supplements that work for me - that you’ve already covered. Then I use cycles of HBOT for half an hour followed by whatever I can manage on the cross trainer (usually 15 minutes) then HBOT & repeat. Take care as this regimen is very draining… best not to do it alone. I’ve only ever managed two cycles… but I only have one functioning lung. Good Luck all!
Fantastic as usual! I started using an exercise ball to sit on and bounce while I lift weights and wear ankle weights. Infinite gratitude to you and this group!
I was diagnosed with metastatic melanoma in my brain, lung and liver. The oncologist put me on Ipilimumab and Nivolumab once every three weeks for a projected four treatments. After three my liver enzymes shot up so he paused and suggested I go get scans to check for progress. The scans found Zero evidence of cancer. Immediatley upon diagnosis I implemented a keto diet and I lift three days/week and do HIIT three days/week. Every morning I go for a two mile brisk walk. All summer I went shirtless within 30 min of sunrise. Every afternoon I got 15-30 minutes of direct sunlight. Are there any studies that address the amount and timing of excercise to maximize the effect of tumor stravation? I really enjoy and appreciate your content.
I am really sorry about your diagnosis, but am happy the recent scans came back showing NED. In terms of exercise timing, not that I have seen no. I think being active all day, in some way shape or form would be beneficial. Essentially, don't be sedentary for long periods of time.
I'm glad you covered this. Serious exercise is now the 3rd leg to my cancer fighting program. I heard that just the blood circulating fast when your heart rate is up will shear the fragile cancer cells that might be trying to spread though your body. An example of 2 women beating breast cancer in their 40s with a vegan diet to lower methionine and get nutrients and doing some serious running is (Ruth Heidrich no standard treatments) and Jenette Murray Wakelin, now near 80 yrs old and still cancer free. Chris Wark of Chris beat cancer fame. I don't know if he exercised or not.
No idea when it comes to cancer, but for general health it looks like strength training is superior. Remember when you strength train, you also train the heart and aerobic to some degree. Lift those weights baby!!! Having said that, do what you can. Movement is better than no movement.
Hi. I’ve seen many experts now saying high intensity interval training is best, so lifting heavy things / working muscles hard for short periods of time until they feel fatigued will give you the most benefit.
I like to think about mechanisms. Which type of exercise relies on glucose, glycolysis exclusively? Anaerobic right by definition. Anaerobic activities also are strong activators of mitochondria biogenesis. Aerobic exercise relies on by definition aerobic metabolism through healthy mitochondria. Also likely the exercise that would need the most glutamine would be weight training. So to me, it stands to reason that a few sessions of weights and or HIIT and perhaps daily aerobic exercise would be a good place to start. Of note, red/infrared light lower blood glucose substantially, so exercising outdoor would be highly encouraged. If it’s too cold perhaps consider workout under red light as a possible biohack.
@@DrCaseyPeavlerA small body of research by Glen Jeffrey in London suggests an important circadian (time of day) effect. He has found much greater benefit when using red light within a few hours of waking. Possibly another synergy to add to the others you suggest……?
I do yes. Especially if you do it outside in natural light. Red/infrared also lowers blood glucose and improves mitochondrial function in other parts of the body. Would be a double whammy. Also cold water immersion (cold plunging)…
when we fast, do we reduce the amount of glucose we make or is it like exercise where we become better at taking it therefore leaving less for the cancer?
Just look at Sami Tugano. Her regimen blows me away . Stage 4 colon cancer with metastasis. Looking at her you would never know it . That would be a great interview!
Definitely! She is applying metabolic therapy , a carnivore diet, and she uses blue blockers ! And fenben. She is from Japan. Has very little support and is doing this all on her own . She is on Facebook/instagram . Her RUclips channel is constantly getting censored. But she is incredible.
So, glycation of RBCs and small vessel walls by blood sugar excess, is further causing hypoxia pressure, affecting HIF1a? So, is this what the fasting is getting at? Perhaps, helping to maintain the mitochondria functioning that cancer is causing decline?
Ray, it would be impossible to talk about all the things fasting does in a reply comment. I think in terms of cancer: deepening ketosis, further shutting down insulin and anabolic signaling. Likely boosts immunity also, but I need to look into that.
I will start to this at some point, but right now I am barely able to shoot the videos and edit them in a timely fashion. But I will in the future when I have a team helping me.
Sounds like it would be a good idea to exercise before or after eating maybe both, so cancer cells get less of all those nutrients. maybe this means one could increase the protein in the diet aswell, which would make the diet easier.
Maybe like a walk or resistance training then eat and then another walk or light jog? I think cold can be integrated in and can also rob the tumor of glucose.
Probably there is a limit where you are doing more harm than good. Also high intensity training leads to more hunger which might make OMAD difficult. Gotta find that balance…
Hello Doctor, Could you please advise whether taking L-glutamic acid is safer than L-glutamine? I have a prostate condition and a thyroid nodule, but I also have leaky gut / gut dysbiosis, so I need these amino acids for healing. Any recommendations would be greatly appreciated.🙏
I empathize with your situation but I cannot provide medical advice on the internet. What I would say is have a risk vs benefit conversation with a local qualified like minded doctor. It’s a difficult discussion depending on the case.
@DrCaseyPeavler ok I read about it in a book by Author Dr. Fred Pescatore. He states that OAA helps flush a neurotransmitter called glutamate out of the body, and mice with gliomas fed OAA had a 237% better survival rate. I may give it a go!
That's interesting to know. I'm starting to watch the video so you may have covered this. But it stands to reason that you would need to exercise either fasted or in keto. I know a number folks who died from cancer who ran marathons while fighting it and passed. But if they followed the conventional wisdom and consumed an insane amount of carbs while running those marathons I could see why that would negate the effect of the exercise.
Context is everything. Everyone is an N=1. Exercise is also a continuum in terms of benefit. Over-exercise may cause more harm than good. Being sedentary, the other end of the extreme is definitely more harm than good.
@@eliasvonbernstorff6762: It might work to some extent. But here is the problem: Exercising, especially something like marathon running, requires a lot of energy and the typical advice is to "carb up." If one doesn't know about and rejects fasting/keto and has cancer and wants to run marathons then they probably will end up consuming an insane amount of carbs. The Warburg Effect: Those carbs feeds most cancers at vastly disproportionate rates. I know personally of marathon runners fighting aggressive cancers and who died according to the prospective timeline.
Hi Dr Case, its great what youre doing. Your chanell should grow. Tip: think of " cross- pollynation" meaning you host some guests who run similar channels and then they host you. Folks will subscribe you. Keep going ❤
Amen. Prevention is ALWAYS better than even the best treatment. The issues is most humans aren’t willing to make the changes they need until they hit rock bottom…
Hey, does anyone know if doing resistance training / aerobic exercise can prevent the degradation of muscle during autophagy fasts? I’ve seen in some places that exercising can stimulate autophagy in noncontractile tissues….just don’t want to be shooting myself in the foot :) thanks
Iam sorry y want ask you how about if we do all protocol but we are not do ketogenic diet but we take Metformin,,as we know Metformin can stop gluconeugenesis,,and lower glucose blood level also make insulin more sensitive,,can flow glucose to muscle,,,sorry about my inglish
It would better to follow the rules of the foundations of metabolic therapy. Therapeutic Ketogenic diet, calorie restricted in the right person, with a therapeutic Glucose ketone index. Any medications or supplements would be in addition to the foundation.
@@DrCaseyPeavlerif both protein(methionine and lucine) can feed cancer as well as fat/ketones, why wouldn’t it be better to eat a low fat vegan(carbohydrate)diet? A video on this would be great, thanks!
I’m going to do a video on it. We’ve known about mitochondrial boosting effects of cold plunging but the cancer portion is really fascinating and similar to exercise…perhaps even more powerful
I have a question that you may not the answer to...but if you know where I can find it I would appreciate that too. why does our body store toxins and heavy metals rather than discard them through the digesstive process?
I think they are absorbed just like everything else. Especially the fat soluble toxins which can get through membranes easily. The body doesn’t likely see them as foreign agents or dangerous. If I give you 10,000mg of acetaminophen despite us knowing it will destroy your liver, your body will absorb it. I think why it is not excreted, once it’s absorbed, is maybe the most important question. Dr. Kruse always says redox before detox. Even in my functional medicine training, there was a very particular order of handling toxins.
@@DrCaseyPeavler wow that speaks poorly to the innate intelligence of the body...I would have guessed anything unrecognized would be discarded rather than absorbed and stored...My guess ia an UNeducated one since I have no formal training in biology or physiology...Perhaps I need to adjust my paradigm😄
This isn't a pie with a fixed radius, is it? If glutamine is a non-essential amino acid where the body will proactively make it because it needs it, then when the healthy cells in the myriad of organs start demanding more because of exercise, would not the cancer cells also signal that the body produce more because it's another customer in need? Would our body make that pie bigger to satisfy all customers?
I am not aware of any signals to make more glutamine but that doesn’t mean it doesn’t exist. I would say that is why I personally believe that we need to block glutamine uptake as well as utilization at multiple steps as a way to shut the process down to the greatest degree for a successful outcome.
Dr. So far i havnt gotten any answer from any doctor on utube but i know you cant give advice but if you had a brother that had squamous cell carcinoma and he was medically using marijuana for various reasons and not doing any cancer treatments but eating right cutting out as much sugar would you tell him he should not smoke that for various reasons like lowering his immune systen. Anybody else's opinion would be appreciated. Thank You
Cannabis, CBD, THC have been shown to be beneficial. There is likely synergy between THC/CBD which is why the 1:1 RSO is so popular. I however am not a fan of smoking anything.
Unfortunately, biological reality is much more complex than all those figures with molecular interactions. One example from many that I see almost every day: fitness expert, everyday about 15 miles on the bicycle + other exercises, vegetarian diet, supplements such as vit D3, melatonin, green tea extract, resveratrol and ... one year after radical prostatectomy biochemical recurrence with the current PSA 0.25 ng/ml ... Is he doing anything wrong or is nutrition a method with some limits that exclude better outcome?
Context is king. Would need a LOT more information than that. Everyone is an N=1. Even if I exercise the same and eat the same, my environment can be radically different than theirs. Something is obviously wrong. A big change seems to be mandated. As Dr. Kruse says "you cannot get well in the same environment in which you got sick."
@DrCaseyPeavler Well, how much more information do you need? This is exactly what makes all complex systems so unpredictable! Physicists in the Niels Bohr era were convinced that knowing speed of electron, they can predict precisely its location in space at the same moment in time. We know owing to Heisenberg it is impossible. In the case of complex systems, you deal with a similar situation. Even if you increase amount of information concerning all possible metabolic pathways, their behavior remains unpredictable and, frequently out of control. That is why I consider some ingredients of a diet as important elements of maintaining the proper antitumor environment; yet, with the limited influence on the entire process
It is obvious you are intelligent with your arguments. But if you are right, and we have little influence over our health, why even do anything at all? I don’t believe that we are helpless, but are not God either. I do believe we have a great deal of control over our health destinies. If I didn’t, I wouldn’t be doing these videos or interested in alternative medicine.
@@DrCaseyPeavler I think it is important to recognize the importance of natural remedies and methods. However, one must be realistic and realize the existence of limitations. Of course, the chance for survival is much better if you apply those methods early enough, even before malignant tumor appears. I study prostate cancer as a model. I can see right away how PSA concentration changes under a variety of interventions. I would love to see some rapid and deep changes under those dietary interventions.
Thanks for that. I would really like to know your take on prostate cancer and the ability or not to utilize fat and or ketones for fuel. Seyfried adamantly says no. What is your experience?
50 minutes would by definition be about 5000 steps. I can’t give medical advice here but the goal should be at least 8000 probably better goal 10,000 steps and adding in some resistance training would be also beneficial.
My degree is in Exercise Science so I have long been aware of the many benefits of exercise. I am thankful I have always been super active throughout my life. Now...too much aerobic metabolism (cardio) can induce cancer.
Who here wants to rob glucose AND glutamine from tumors? Exercise must be a tool used in your toolbox 🧰!
Any idea on which type of exercise gives the most bang for the buck to reduce glutamine and glucose in cancer cells? Cardio? Resistance training?
@@doejohn8674Anything outside the model "coach-refrigerator" will do fine
Two further natural extracts that you might not know that selectively inhibit both glutamine and glucose in cancer cell metabolism. Black Seed and Ashwagandha.
* Black Seed (Nigella sativa)
Mechanism of Action: Black seed, primarily through its active compound thymoquinone, exhibits anticancer effects by modulating multiple cellular pathways, including NF-?B and PI3K/Akt, which influence cell survival, inflammation, and proliferation.
Effects on Glucose and Glutamine Metabolism:
Glucose: Thymoquinone in black seed inhibits glucose uptake and glycolysis by downregulating glucose transporter proteins, effectively limiting the primary energy supply for many cancer cells.
Glutamine: Thymoquinone has been shown to reduce glutaminase activity, decreasing the conversion of glutamine to glutamate, a critical fuel for cancer cell energy production and raw material for cell reproduction. By targeting both glucose and glutamine pathways, black seed creates a double metabolic blockade.
* Ashwagandha (Withania somnifera)
Mechanism of Action: Ashwagandha's active compounds, especially withaferin A, target multiple cancer-related pathways, including AMPK and mTOR, making it effective in reducing cancer cell growth and survival.
Effects on Glucose and Glutamine Metabolism:
Glucose: Withaferin A in ashwagandha inhibits glucose uptake and glycolysis by reducing GLUT transporters and inhibiting glycolytic enzymes, disrupting the Warburg effect in glucose-dependent cancer cells.
Glutamine: Ashwagandha also inhibits glutaminase, thereby limiting glutamine's conversion to energy and building blocks, and weakening cancer cells' metabolic flexibility, particularly in glutamine-reliant cancers.
Cancer's Metabolic Shift as a Survival Mechanism (the 'why') :
Cancer's metabolic shift, including its reliance on glucose and glutamine, can be viewed as a survival mechanism - a partial reversion to more primitive, single-cell behaviors. In normal multicellular organisms, cells are specialized and coordinated, with tightly regulated growth and metabolic processes. Through evolution, these have been built on top of the single cell DNA code, which is still there.
Cancer cells lose some of these characteristics of differentiation, adopting a strategy of autonomous survival. This shift allows them to maximize resource acquisition and metabolic flexibility to sustain rapid growth and proliferation, even in challenging environments, such as low oxygen or nutrient scarcity within tumors.
By prioritizing metabolic pathways that enhance biosynthesis (rather than just energy production), cancer cells essentially operate as independent entities that ignore signals from surrounding tissues, similar to single-celled organisms. This reversion supports their survival and unchecked growth, allowing them to thrive despite the body's regulatory efforts.
Finally, rather than say “glucose and glutamine fuel cancer” it would be better to say : “glucose and glutamine serve as critical substrates for cancer, supporting its growth by providing essential building blocks for biosynthesis.”
Specifics :
Cancer cells prioritize glycolysis because it provides several intermediates (such as glucose-6-phosphate and pyruvate) essential for building blocks of new cells. These intermediates are crucial for synthesizing nucleotides (for DNA), lipids (for cell membranes), and amino acids (for proteins), all of which cancer cells need for fast growth. Although glycolysis is less efficient in terms of energy (ATP) production, it generates these biosynthetic intermediates in a quick and controlled manner, supporting cell growth and division.
Similarly, the glutamate produced from glutaminolysis is an intermediary for the building blocks needed for proliferation. Not only to synthesize extra glutathione to protect itself from ROS. Quite clever, in a way.
@@doejohn8674HIT ( high intensity traning - check it out), resistance training so hit the gym sir,.remember your training must be " to failure" so that your muscles gets the strong enough signal so that they adjust, adopt what is mainly new mitochondria creation
Excellent!!! I will up my exercise. I’m going for a needle biopsy today of my lymph nodes. Prayers appreciated. Thanks Dr; Peavler.
Good luck my fingers are crossed for you, sending you positive vibes.
Bouncing on a small trampoline or on the balls of your feet for 10 to 20 minutes a day is great for lymph drainage as the lymph system needs muscle pumping to keep the fluids moving around the body and avoiding lymph system problems.
Wishing you very well. Good luck!
God bless you! Let us know how you are doing after the biopsy
Wishing you all the best!
Needle biopsies spread the disease do some research
Going for a brisk walk in the sun right now!
🙏 amen!
I’m recently got to know that I have stage 4 lung cancer, I have started keto diet and cut off sugar and doing YOGA
I am sorry about your diagnosis. Where do you live?
@ I’m in North Carolina, but going back to india as here I just finished my masters
I would suggest LOW population density and LOWest latitude possible for your healing journey. You need maximum sun exposure, light stability, and lack of light/EMF pollution.
I'm also a bladder cancer patient since 2015@@DrCaseyPeavler
I am sorry to hear that also. Are you utilizing any integrative or alternative approaches?
Great news as I would much rather than exercise than fast!
I like options and synergist combinations…
Great video! I never stopped riding my bike. 10-20 miles 3 times a week. I would always work around my house, sometimes just moving stacks of wood from one side of my yard to another. Just keep moving. Stage 4 in 2023… tomorrow’s scans will show me what has been happening for the past three months
CMF
That is great david! Keep us up to date on your progress! Praying for regression and healing!
Great again.
Thanks for your unrelenting research.
It seems to make a lot of sense to include exercise.
Going for hiit training like yesterday.
Agreed!
It make sense but I think especiallly in prevention as the excersise should help improve the the energetic " well being" of the cell that is already healthy but what is more important it can change the metabolic trajectory of the cell that is already struggling and is on the brink of getting into the fermentation for good ..... indeed sport can help in keeping the healthy ratio of mitofagy and creation of the new mitochondria.
Exercise is a powerful metabolic stimulus no doubt
Thank you, Dr., for all you do. I am 100% onboard. In fact, just ordered a treadmill and vit D sunlamp. Additionally, I hope to be in therapeutic ketosis in approx. 4-weeks. Thanks again.
Don’t forget red/infrared! Can you put the treadmill in a garage and have the door open so natural light comes in?
Great video Dr. Peavler! Certainly does explain some of my own observations - that exercise definitely helps fight cancer.
I’m not sure about prevention as mine popped up when I was very fit (top few % of my age group) but no question that
Exercise does help the fight. I found the best response was if I prepared my body first by taking the supplements that work for me - that you’ve already covered.
Then I use cycles of HBOT for half an hour followed by whatever I can manage on the cross trainer (usually 15 minutes) then HBOT & repeat.
Take care as this regimen is very draining… best not to do it alone. I’ve only ever managed two cycles… but I only have one functioning lung.
Good Luck all!
It sounds very draining! I applaud your courage and determination!
Stunning
Very interesting science in my opinion
Interesting! I look forward to learning more.
Me and you both!
Excellent video Doc, amazing info
Thank you! I also thought it was amazing!
Fantastic as usual! I started using an exercise ball to sit on and bounce while I lift weights and wear ankle weights. Infinite gratitude to you and this group!
Fantastic! Don't forget to try to do this OUTSIDE in natural light. Synergistic effects.
Thank you so much! ❤
You are very welcome!
Thank you
You're welcome!
I was diagnosed with metastatic melanoma in my brain, lung and liver. The oncologist put me on Ipilimumab and Nivolumab once every three weeks for a projected four treatments. After three my liver enzymes shot up so he paused and suggested I go get scans to check for progress. The scans found Zero evidence of cancer. Immediatley upon diagnosis I implemented a keto diet and I lift three days/week and do HIIT three days/week. Every morning I go for a two mile brisk walk. All summer I went shirtless within 30 min of sunrise. Every afternoon I got 15-30 minutes of direct sunlight. Are there any studies that address the amount and timing of excercise to maximize the effect of tumor stravation? I really enjoy and appreciate your content.
I am really sorry about your diagnosis, but am happy the recent scans came back showing NED. In terms of exercise timing, not that I have seen no. I think being active all day, in some way shape or form would be beneficial. Essentially, don't be sedentary for long periods of time.
im gonna look into it. i will let you know
I'm glad you covered this. Serious exercise is now the 3rd leg to my cancer fighting program. I heard that just the blood circulating fast when your heart rate is up will shear the fragile cancer cells that might be trying to spread though your body.
An example of 2 women beating breast cancer in their 40s with a vegan diet to lower methionine and get nutrients and doing some serious running is (Ruth Heidrich no standard treatments) and Jenette Murray Wakelin, now near 80 yrs old and still cancer free.
Chris Wark of Chris beat cancer fame. I don't know if he exercised or not.
Thank you for sharing your experience. Exercise is very important and helpful!
What is the better choice of exercise: strength training or aerobic?
No idea when it comes to cancer, but for general health it looks like strength training is superior. Remember when you strength train, you also train the heart and aerobic to some degree. Lift those weights baby!!! Having said that, do what you can. Movement is better than no movement.
@allenbrost9564 thank you!
Hi. I’ve seen many experts now saying high intensity interval training is best, so lifting heavy things / working muscles hard for short periods of time until they feel fatigued will give you the most benefit.
I like to think about mechanisms. Which type of exercise relies on glucose, glycolysis exclusively? Anaerobic right by definition. Anaerobic activities also are strong activators of mitochondria biogenesis. Aerobic exercise relies on by definition aerobic metabolism through healthy mitochondria. Also likely the exercise that would need the most glutamine would be weight training.
So to me, it stands to reason that a few sessions of weights and or HIIT and perhaps daily aerobic exercise would be a good place to start.
Of note, red/infrared light lower blood glucose substantially, so exercising outdoor would be highly encouraged. If it’s too cold perhaps consider workout under red light as a possible biohack.
@@DrCaseyPeavlerA small body of research by Glen Jeffrey in London suggests an important circadian (time of day) effect. He has found much greater benefit when using red light within a few hours of waking. Possibly another synergy to add to the others you suggest……?
I recently started a new career, so I'm looking forward to catching up on your recent videos soon. Thanks for this helpful gem! ✨️
You are very welcome!
Another great video - Thanks for your work here!
You are very welcome!
Amazing video as always! Thank you for your efforts 🙏
You’re very welcome!
Do you think strenuous exercise during fasting would multiply the effect of robbing tumors of glucose and glutamine?
I do yes. Especially if you do it outside in natural light. Red/infrared also lowers blood glucose and improves mitochondrial function in other parts of the body. Would be a double whammy. Also cold water immersion (cold plunging)…
when we fast, do we reduce the amount of glucose we make or is it like exercise where we become better at taking it therefore leaving less for the cancer?
So far cortisol is not increased because that will spike glucose during a fast and during exercise
@@fonpol4925when fasting cortisol will spike however so does HGH which will buffer the cortisol spike
Just look at Sami Tugano. Her regimen blows me away . Stage 4 colon cancer with metastasis. Looking at her you would never know it . That would be a great interview!
Will have to check her out!
Definitely! She is applying metabolic therapy , a carnivore diet, and she uses blue blockers ! And fenben. She is from Japan. Has very little support and is doing this all on her own . She is on Facebook/instagram . Her RUclips channel is constantly getting censored. But she is incredible.
I watched some of an interview with her. Definitely a lot of energy but a bit hard to understand. I’ll keep watching
Thanks for sharing this important analysis and information
My pleasure!
So, glycation of RBCs and small vessel walls by blood sugar excess, is further causing hypoxia pressure, affecting HIF1a? So, is this what the fasting is getting at? Perhaps, helping to maintain the mitochondria functioning that cancer is causing decline?
Ray, it would be impossible to talk about all the things fasting does in a reply comment. I think in terms of cancer: deepening ketosis, further shutting down insulin and anabolic signaling. Likely boosts immunity also, but I need to look into that.
Can you please post the studies that you are referring to ?
I will start to this at some point, but right now I am barely able to shoot the videos and edit them in a timely fashion. But I will in the future when I have a team helping me.
thank you Doc, great video
You are welcome man. How are you holding up?
@@DrCaseyPeavler doing well atm. thank you.
I am glad to hear it!
Which type of exercise would be better, Aerobic exercise or Anaerobic exercise?
Thank you for your presentation.
You are very welcome! Likely both have unique benefits! A well thought out combination approach seems to make the most sense.
How about itraconazol sir
No immediate plans, but am not against it!
Could you do a video on a plant based keto diet?
Not a bad idea! I don’t advocate it personally but I know there are people who are trying that and could use some guidance.
sir can you do a video about zone 2 exercise benefits for mitachondrial health
I cannot say I have a lot of expertise in talking about that currently, but I am sure I can get up to speed on it for future videos!
@DrCaseyPeavler Thank u sir for your good work keep it up ❤️
Thank you for your support and encouragement!
I havent read yet, but the book "A race for life" from Ruth Heidrich came to my mind here.
I have never heard of it. I will have to check it out also
Janette Murray Wakelin is also a serious runner that beat cancer for good. Both on a vegan diet.
Sounds like it would be a good idea to exercise before or after eating maybe both, so cancer cells get less of all those nutrients. maybe this means one could increase the protein in the diet aswell, which would make the diet easier.
Maybe like a walk or resistance training then eat and then another walk or light jog? I think cold can be integrated in and can also rob the tumor of glucose.
The more you destroy the muscles the more they rob? Maybe OMAD and train really hard
Probably there is a limit where you are doing more harm than good. Also high intensity training leads to more hunger which might make OMAD difficult. Gotta find that balance…
what do you think about mitoQ?
In what context sorry?
Hello Doctor,
Could you please advise whether taking L-glutamic acid is safer than L-glutamine?
I have a prostate condition and a thyroid nodule, but I also have leaky gut / gut dysbiosis,
so I need these amino acids for healing.
Any recommendations would be greatly appreciated.🙏
I empathize with your situation but I cannot provide medical advice on the internet. What I would say is have a risk vs benefit conversation with a local qualified like minded doctor. It’s a difficult discussion depending on the case.
@@DrCaseyPeavler yea,sure doctor.
Thank you for the reply 🙏
You are very welcome
What about oxaloacetate to work on the Glutamine pathway? Do you have any information on this?
I have not seen a whole lot on this. Not saying it’s not possible but I haven’t seen a lot about it in my readings.
@DrCaseyPeavler ok I read about it in a book by Author Dr. Fred Pescatore. He states that OAA helps flush a neurotransmitter called glutamate out of the body, and mice with gliomas fed OAA had a 237% better survival rate. I may give it a go!
@DrCaseyPeavler also, thank you so much for your contribution to the research to help cancer patients. 🙏🏼
Interesting!
What type of exercise?
Likely both aerobic and anaerobic have benefits
That's interesting to know. I'm starting to watch the video so you may have covered this. But it stands to reason that you would need to exercise either fasted or in keto.
I know a number folks who died from cancer who ran marathons while fighting it and passed. But if they followed the conventional wisdom and consumed an insane amount of carbs while running those marathons I could see why that would negate the effect of the exercise.
Context is everything. Everyone is an N=1. Exercise is also a continuum in terms of benefit. Over-exercise may cause more harm than good. Being sedentary, the other end of the extreme is definitely more harm than good.
I didn't understand why exercise only works in those states. Do you mind explaining?
@@eliasvonbernstorff6762: It might work to some extent. But here is the problem: Exercising, especially something like marathon running, requires a lot of energy and the typical advice is to "carb up." If one doesn't know about and rejects fasting/keto and has cancer and wants to run marathons then they probably will end up consuming an insane amount of carbs. The Warburg Effect: Those carbs feeds most cancers at vastly disproportionate rates.
I know personally of marathon runners fighting aggressive cancers and who died according to the prospective timeline.
@@JonWRowe That makes a lot of sense thank you.
Hi Dr Case, its great what youre doing. Your chanell should grow. Tip: think of " cross- pollynation" meaning you host some guests who run similar channels and then they host you. Folks will subscribe you. Keep going ❤
I’m going on the MetCancer podcast today! Wish me luck!
Why not just get more sunlight to denote which mitochondria are failing for mitophagy before cancer arrises?
Amen. Prevention is ALWAYS better than even the best treatment. The issues is most humans aren’t willing to make the changes they need until they hit rock bottom…
Hey, does anyone know if doing resistance training / aerobic exercise can prevent the degradation of muscle during autophagy fasts? I’ve seen in some places that exercising can stimulate autophagy in noncontractile tissues….just don’t want to be shooting myself in the foot :) thanks
My bet is that yes resistance training can.
Iam sorry y want ask you how about if we do all protocol but we are not do ketogenic diet but we take Metformin,,as we know Metformin can stop gluconeugenesis,,and lower glucose blood level also make insulin more sensitive,,can flow glucose to muscle,,,sorry about my inglish
It Will work sir
I mean ,it is Will work or not sir,,, sorry about my inglish
It would better to follow the rules of the foundations of metabolic therapy. Therapeutic Ketogenic diet, calorie restricted in the right person, with a therapeutic Glucose ketone index. Any medications or supplements would be in addition to the foundation.
@@DrCaseyPeavler how about melanoma malignant ,,is ketogenic diet give improve for treatment that,,, sorry about my inglish
@@DrCaseyPeavlerif both protein(methionine and lucine) can feed cancer as well as fat/ketones, why wouldn’t it be better to eat a low fat vegan(carbohydrate)diet? A video on this would be great, thanks!
What is the synergy of exercising in fasted state? How about prolonged fasting with exercise under the sun?
I think there would be great synergy. Add in cold water immersion with sun as well!
@@DrCaseyPeavler What is the benefit of cold plunging? Is it similar to fasting exercise since its mentioned together with those?
I’m going to do a video on it. We’ve known about mitochondrial boosting effects of cold plunging but the cancer portion is really fascinating and similar to exercise…perhaps even more powerful
@@DrCaseyPeavler
Any research on cold plunging and glutamine?
Glucose yes! Glutamine, not yet…
I have a question that you may not the answer to...but if you know where I can find it I would appreciate that too. why does our body store toxins and heavy metals rather than discard them through the digesstive process?
I think they are absorbed just like everything else. Especially the fat soluble toxins which can get through membranes easily. The body doesn’t likely see them as foreign agents or dangerous. If I give you 10,000mg of acetaminophen despite us knowing it will destroy your liver, your body will absorb it. I think why it is not excreted, once it’s absorbed, is maybe the most important question. Dr. Kruse always says redox before detox. Even in my functional medicine training, there was a very particular order of handling toxins.
@@DrCaseyPeavler wow that speaks poorly to the innate intelligence of the body...I would have guessed anything unrecognized would be discarded rather than absorbed and stored...My guess ia an UNeducated one since I have no formal training in biology or physiology...Perhaps I need to adjust my paradigm😄
I am speculating given what I know. I also could be mistaken or wrong.
This isn't a pie with a fixed radius, is it? If glutamine is a non-essential amino acid where the body will proactively make it because it needs it, then when the healthy cells in the myriad of organs start demanding more because of exercise, would not the cancer cells also signal that the body produce more because it's another customer in need? Would our body make that pie bigger to satisfy all customers?
I am not aware of any signals to make more glutamine but that doesn’t mean it doesn’t exist. I would say that is why I personally believe that we need to block glutamine uptake as well as utilization at multiple steps as a way to shut the process down to the greatest degree for a successful outcome.
Dr. So far i havnt gotten any answer from any doctor on utube but i know you cant give advice but if you had a brother that had squamous cell carcinoma and he was medically using marijuana for various reasons and not doing any cancer treatments but eating right cutting out as much sugar would you tell him he should not smoke that for various reasons like lowering his immune systen. Anybody else's opinion would be appreciated. Thank You
Cannabis, CBD, THC have been shown to be beneficial. There is likely synergy between THC/CBD which is why the 1:1 RSO is so popular. I however am not a fan of smoking anything.
Thank you Doctor for your reply
You are very welcome! I’m sorry you or someone you know are dealing with SCC…
Unfortunately, biological reality is much more complex than all those figures with molecular interactions. One example from many that I see almost every day: fitness expert, everyday about 15 miles on the bicycle + other exercises, vegetarian diet, supplements such as vit D3, melatonin, green tea extract, resveratrol and ... one year after radical prostatectomy biochemical recurrence with the current PSA 0.25 ng/ml ... Is he doing anything wrong or is nutrition a method with some limits that exclude better outcome?
Context is king. Would need a LOT more information than that. Everyone is an N=1. Even if I exercise the same and eat the same, my environment can be radically different than theirs. Something is obviously wrong. A big change seems to be mandated. As Dr. Kruse says "you cannot get well in the same environment in which you got sick."
@DrCaseyPeavler Well, how much more information do you need? This is exactly what makes all complex systems so unpredictable! Physicists in the Niels Bohr era were convinced that knowing speed of electron, they can predict precisely its location in space at the same moment in time. We know owing to Heisenberg it is impossible. In the case of complex systems, you deal with a similar situation. Even if you increase amount of information concerning all possible metabolic pathways, their behavior remains unpredictable and, frequently out of control. That is why I consider some ingredients of a diet as important elements of maintaining the proper antitumor environment; yet, with the limited influence on the entire process
It is obvious you are intelligent with your arguments. But if you are right, and we have little influence over our health, why even do anything at all? I don’t believe that we are helpless, but are not God either. I do believe we have a great deal of control over our health destinies. If I didn’t, I wouldn’t be doing these videos or interested in alternative medicine.
@@DrCaseyPeavler I think it is important to recognize the importance of natural remedies and methods. However, one must be realistic and realize the existence of limitations. Of course, the chance for survival is much better if you apply those methods early enough, even before malignant tumor appears. I study prostate cancer as a model. I can see right away how PSA concentration changes under a variety of interventions. I would love to see some rapid and deep changes under those dietary interventions.
Thanks for that. I would really like to know your take on prostate cancer and the ability or not to utilize fat and or ketones for fuel. Seyfried adamantly says no. What is your experience?
I normally walk for 50 minutes after work is it enough doctor?
50 minutes would by definition be about 5000 steps. I can’t give medical advice here but the goal should be at least 8000 probably better goal 10,000 steps and adding in some resistance training would be also beneficial.
My degree is in Exercise Science so I have long been aware of the many benefits of exercise. I am thankful I have always been super active throughout my life. Now...too much aerobic metabolism (cardio) can induce cancer.
I totally agree you can overdo it. I also believe where you exercise matters as well. The question is how much is too much and how do you measure it?