Did you find that your comprehension was good viewing like that ? & did you have the words running at the bottom (the name for that is on tip of tongue but eluding me)
@@DjokerNole42 U are beyond smart !!!! I have to watch then watch again and take notes . Then watch again, but then it seems like the information slows down and I’m able to understand and form questions ( lol which don’t lead to answers but more questions)
@@anthonyroberson5199 That's a good practice too, I just can't help myself watch more and more and faster and faster and take in all of the brilliant information!
Thank you. I came across your lectures in my feed and think they're great. I'm an embryonic stem cell biologist brushing up on my immunology. Best resource I've come across yet. Thanks again
Thanks so much for these wonderful lectures, Dr. Racaniello. Much respect for being a spectacular virologist and teacher. I just wanted to make a quick correction to the chromatin terminology you've been using throughout your videos. For instance, the statement at 14:03, "DNA is wrapped around nucleosomes, which are made of chromatin," is incorrect. DNA wraps around histones. A nucleosome refers to DNA wrapped around a histone octamer, and chromatin is an array of nucleosomes.
Hi Vincent. Excellent lecture, as well as your other lectures. One small correction: the name of tetherin is CD317, not CD137. Also, as far as I know, human tetherin is counteracted by HIV-1 Vpu protein, not by HIV-1 Nef protein. HIV-1 Nef may have some minor activity in the absence of Vpu in only some HIV-1 variants.
I have a question if it is our immune response which makes the condition severe then why it is said that people who have weak immune response are targeted by the virus easily? I mean when virus enters immune system over expresses itself that is why condition becomes complex then why it is called weak immunity?
amazing profesor! thank you..im a public health care worker and i finally know something about viruses.. but i am asking, do you worry because virus is spreading so fast?
I have more risk factors than my coworker. My BMI is 33 but I am a bodybuilder. He has that perfect BMI and runs marathons. I don't understand why I had less than a cold but he almost went to the hospital.
These people who get extremely sick with covid-19 do they have less effective innate immunity? In people who have a mild upper respiratory infection does our innate immunity control the virus until the antibodies clear it? I had covid-19 the uk strain I had less than a cold for 3 days. I tested positive then tested negative twice by pcr. I had a coworker younger than me catch it I reckon from me he was out for 20 days and looked like death when he came back. I tested positive for the antibodies I reckon the innate immunity was able to confine the virus my upper respiratory tract until the adaptive immunity cleared it?
Just fitting an exponential to the existing data from the last 1.5 weeks indicates that Arizona will surpass the infection/death rates of Washington State in about a week and a half. That's pretty far out from today to make a prediction, but the fits do look rather good, suggesting the data are in the exponential rule, so here it is: pattimichelle.com/Prediction_03-25-2020.png (Note: This only works because the exponential function has the "same shape everywhere.") It's a little difficult to do, but you *can* visually compare the slope of the data in each polity shown. Washington State appears to have done an EXCELLENT job of "flattening their curve." California appears to have done less well, but also has a much larger and more spread-out population. Arizona's curve appears slightly worse than the U.S. average. (Washington state and Arizona have similar population sizes.)
Now in mid-May Arizona has half the inflated Covid deaths that Washington has. More bad math using exponential function. But it makes it all much more frightening.
Great content, a true public service!
I just binge watched most of the lectures starting from #1 at x2 speed. Thank you so much, this is gold!
Did you find that your comprehension was good viewing like that ? & did you have the words running at the bottom (the name for that is on tip of tongue but eluding me)
@@Jjungler yep, if you focus and don't try to multitask, you can comprehend everything even at x2. And nope, had the subtitles off
Subtitles that's it thanks cool on the comprendo!
@@DjokerNole42
U are beyond smart !!!! I have to watch then watch again and take notes . Then watch again, but then it seems like the information slows down and I’m able to understand and form questions ( lol which don’t lead to answers but more questions)
@@anthonyroberson5199 That's a good practice too, I just can't help myself watch more and more and faster and faster and take in all of the brilliant information!
"The music group, not the law enforcement" - appreciated this joke.
Excellent presentation, much appreciated.
Thank you. I came across your lectures in my feed and think they're great.
I'm an embryonic stem cell biologist brushing up on my immunology.
Best resource I've come across yet.
Thanks again
Great lecture! thanks a lot. Please note that Tetherin is antagonized by HIV-1 Vpu (and not Nef!). Best Alessia
thank you Prof. Vincent Racaniello for your efforts continuous teaching us every new about viruses
The only thing better than learning is a good teaching.. Thanks Vincent!
I have been watching you videos since 2003 and it's interesting how your voice change.
It's amazing all these very complicated things going on at a molecular level.
Thanks so much for these wonderful lectures, Dr. Racaniello. Much respect for being a spectacular virologist and teacher. I just wanted to make a quick correction to the chromatin terminology you've been using throughout your videos. For instance, the statement at 14:03, "DNA is wrapped around nucleosomes, which are made of chromatin," is incorrect. DNA wraps around histones. A nucleosome refers to DNA wrapped around a histone octamer, and chromatin is an array of nucleosomes.
Hi Vincent. Excellent lecture, as well as your other lectures. One small correction: the name of tetherin is CD317, not CD137. Also, as far as I know, human tetherin is counteracted by HIV-1 Vpu protein, not by HIV-1 Nef protein. HIV-1 Nef may have some minor activity in the absence of Vpu in only some HIV-1 variants.
I wish you were on the advisory committee
I have a question if it is our immune response which makes the condition severe then why it is said that people who have weak immune response are targeted by the virus easily? I mean when virus enters immune system over expresses itself that is why condition becomes complex then why it is called weak immunity?
amazing profesor! thank you..im a public health care worker and i finally know something about viruses.. but i am asking, do you worry because virus is spreading so fast?
thanks for your enlightening lectures !!! small typo: tetherin = cd317 (not cd137)
I have more risk factors than my coworker. My BMI is 33 but I am a bodybuilder. He has that perfect BMI and runs marathons. I don't understand why I had less than a cold but he almost went to the hospital.
These people who get extremely sick with covid-19 do they have less effective innate immunity? In people who have a mild upper respiratory infection does our innate immunity control the virus until the antibodies clear it? I had covid-19 the uk strain I had less than a cold for 3 days. I tested positive then tested negative twice by pcr. I had a coworker younger than me catch it I reckon from me he was out for 20 days and looked like death when he came back. I tested positive for the antibodies I reckon the innate immunity was able to confine the virus my upper respiratory tract until the adaptive immunity cleared it?
is the PFU in aerosol high enough to infect people ?
Prof Racaniello, BTW, your lecture #12's (Infection Basics) title remains unnumbered.
32:52 nothing like a bit of anthropomorphizing to make a point clear :)
Das war ja toll! That was awesome!
Just fitting an exponential to the existing data from the last 1.5 weeks indicates that Arizona will surpass the infection/death rates of Washington State in about a week and a half. That's pretty far out from today to make a prediction, but the fits do look rather good, suggesting the data are in the exponential rule, so here it is: pattimichelle.com/Prediction_03-25-2020.png
(Note: This only works because the exponential function has the "same shape everywhere.")
It's a little difficult to do, but you *can* visually compare the slope of the data in each polity shown. Washington State appears to have done an EXCELLENT job of "flattening their curve." California appears to have done less well, but also has a much larger and more spread-out population. Arizona's curve appears slightly worse than the U.S. average. (Washington state and Arizona have similar population sizes.)
Now in mid-May Arizona has half the inflated Covid deaths that Washington has. More bad math using exponential function. But it makes it all much more frightening.
Oh wow I remember this series from iTunes U.
thank you
thanks