Cell Cycle Regulation | Cell Biology

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In this lecture, EKG is going to cover the regulation of the cell cycle, looking at what initiates the cycle and what stops it from continuing. We're going to break down the cell cycle checkpoints-the factors that determine whether or not the cycle will progress or not-and the cell cycle control system. Next, you're going to learn about the components and molecules that make up the regulatory system.
Lecture Overview:
0:00 Intro
0:25 Cell Cycle Overview
3:07 Checkpoints (G1, G2 & M Transition Points)
7:09 Cyclins
8:32 Cyclin-dependent kinases
12:09 Cyclin-Cdk Complex
12:49 Regulation Of The Cyclin-Cdk Complexes
15:35 Mitogens
18:28 DNA damage
20:00 S Phase Regulation
20:37 M Phase Regulation
21:46 Ubiquitylation
✏️ All diagrams were made by EKG.
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[@mariaandreinabruni5414]

You have such an amazing grasp of the subject. Beautiful video and explanation, congrats!

[@EKGScience]

Thank you, Maria! Appreciate the comment 💙

[@mijitv2862]

Good diagrams, nice& interesting explanation

[@renzbryantbalantad1222]

I appreciate you help so much. What a great way to elaborate the topic.

[@EKGScience]

Thanks Renz! Happy to hear it was helpful 🙌🏽

[@renzbryantbalantad1222]

@@EKGScience can i know you're specific ig to ask further questions about the course?

[@EKGScience]

@@renzbryantbalantad1222 Link in the description!

[@fatemaelzahraasaidmahmoud987]

PERFECT EXPLANATION! Thank youu

[@EKGScience]

Thanks Fatema! Glad it helped 🙌🏽

[@rosemosa3574]

clear and well-explained. Thanks. 😊

[@EKGScience]

Glad it was helpful!

[@caroleannelarochelle8777]

Thank you !!! So helpful!

[@EKGScience]

Happy to hear it was helpful 😇 Appreciate the comment!

[@racinggaming6983]

Amazing lecture mam. keep up the good work.👍

[@EKGScience]

Glad you enjoyed it! 🙏🏽

[@user-do4ii4ft9g]

Hello, I have a question, i need to know the role of s cdk on activation cdc25 i hope to get an answer as soon as possible thank u

[@EKGScience]

There are three human Cdc25 homologues: Cdc25A, B, and C. Cdc25 is a protein phosphatase (cell cycle regulator) important in the activation of CDKs. What they do is remove the inhibitory phosphorylation in Cdks. So cdc25A will activate the cyclin D-CDK4 complex and the cyclin E-CDK2 complex, which will then phosphorylate Rb, which will eventually be important for G1/S progression.
Hope that helps!