For anyone looking in the comments slightly confused like I did, this is what we learnt: G1 Phase - Cyclin D -> CDK 4 & CDK 6 G1/S Phase Boundary - Cyclin E -> CDK2 S Phase - Cyclin A -> CDK2 G2 Phase - Cyclin A -> CDK1 M Phase - Cyclin B -> CDK1 (DEAAB)
You help me out so much in medschool. Either stats, chemistry or biology- your videos are super concise and informative and I am really thankful for you!!
"So it's important to recognize that in order to pass these checkpoints, you need to have these cyclins present, so that they can go ahead and inhibit proteins that are blocking DNA synthesis or replication from occurring, or so they can promote the production of proteins that are needed for mitosis."
I enjoyed this video, but my text says: CyclinE-CdK2 inhibits pRb by phosphorylation, not CyclinD-Cdk4. pRb is a protein that binds to E2F to inactivate it and prevent cell division. If pRb remains unphosphorylated, it will bind and inactivate E2F, inhibiting S phase of interphase. [Lehinger Biochemistry, p 470, Figure 12-46]
On wiki it states that CDK4 "was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1phase. Just in case was curious and needed to look it up like I did. Also I found this for CDK2: "The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition." So now I'm still kinda confused haha. Either your textbook is wrong, wiki is wrong, or Im secretly 75 and going crazy
For G2 are you sure its's Cyclin B and CDK1? Because in the internet I see Cyclin A and CDK1? but it was very helpful with everything else, I was just a little bit confused there.
For anyone looking in the comments slightly confused like I did, this is what we learnt:
G1 Phase - Cyclin D -> CDK 4 & CDK 6
G1/S Phase Boundary - Cyclin E -> CDK2
S Phase - Cyclin A -> CDK2
G2 Phase - Cyclin A -> CDK1
M Phase - Cyclin B -> CDK1
(DEAAB)
Can we take a moment to appreciate his handwriting?
His hand writing looks like strands of DNA
@@mahadali619 hehe 😂✌👍
@@mahadali619 g
@@mahadali619هههههههههههههههههههه
@@mahadali619خرب يومك😂😂
You help me out so much in medschool. Either stats, chemistry or biology- your videos are super concise and informative and I am really thankful for you!!
You ri8😊
महान व्याख्या ,
बहुत बहुत धन्यवादl
"So it's important to recognize that in order to pass these checkpoints, you need to have these cyclins present, so that they can go ahead and inhibit proteins that are blocking DNA synthesis or replication from occurring, or so they can promote the production of proteins that are needed for mitosis."
Isn't it supposed to be having 3 checkpoints? Great vid btw
i was going to ask the same thing
Chris Jin there are many, like 12 or something. It’s subjective on whether a person includes them though. In AP, they focus on 3 though
Thank you so much, such a simple understandable vedio...
You saved me in my genetics exam.
What a simple and clear explanation! Thank you
Hey do you know something about Pgd, methods?or just some infos about preimplantation diagnosis
Wow wonderful!
I enjoyed this video, but my text says:
CyclinE-CdK2 inhibits pRb by phosphorylation, not CyclinD-Cdk4. pRb is a protein that binds to E2F to inactivate it and prevent cell division. If pRb remains unphosphorylated, it will bind and inactivate E2F, inhibiting S phase of interphase.
[Lehinger Biochemistry, p 470, Figure 12-46]
On wiki it states that CDK4 "was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1phase.
Just in case was curious and needed to look it up like I did.
Also I found this for CDK2: "The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition." So now I'm still kinda confused haha. Either your textbook is wrong, wiki is wrong, or Im secretly 75 and going crazy
Sir u r fabulous...really....!!!
Seeing the topic in the book I thought it's boring....bt sir ur explanation is mind blowing and really easy to understand.....
Thnku...sir
thanks a lot!!
you sound like the guy that plays the atom in dcs legend of tomorrow..............great video btw
Thank you
video on the RCP when?
Very helpful.. thank u
Thank you so much! This is a very useful video!!
Great video and good explanation thank you so much
Thank you so much :') ❤️
46 pairs implies 92 chromosomes, 23 pairs still remain 23 pairs of chromosomes, chromatids double
I'm like "oH MY GOSH; THANK YOU!! KA never disappoints
Great video
You explain things very clearly!
For G2 are you sure its's Cyclin B and CDK1? Because in the internet I see Cyclin A and CDK1?
but it was very helpful with everything else, I was just a little bit confused there.
Cyclin A is active in S-phase and Cyclin-B in important for the G2- to M-phase transition
Are you an angel???
Good job sir
u are awesome.
Wow!! You are amazing!!!! thanks a lot :D
Name of app please
what is CDK2 and CDK4???
Cyclin Dependant kinases 2 and 4
thank you so much ^.^
what is the use of cdk2-E complex
Is this present in plant cell?
nice
Very good if you are in highschool maybe
Your comment makes no sense
👏👏
where is cdk6?
What does cdk mean?
I thought Cyclin A - CDK-2 allows the cell to progress into mitotic phase?
could you make ur writing more clear? It's useless to do a video when I have trouble reading it.
If you have trouble reading it, then I suggest you get your eyes checked
also whatever he writes he also says right before. So open your ears