Hi friends 🙃 Here’s a link to the blog post, I hope you’ll check it out! www.pennsmithskincare.com/post/oneskin-slowing-the-velocity-of-skin-aging-really XXPenn
Thank you so much for all your hard work Penny! This was so fascinating!! Thank you too for getting us a fabulous discount!! I just made my first purchase and I'm hoping this product, along with my tretinoin will help reverse some of the sun damage from my younger sun worshipping days 🙏🏻. Hope you have a Happy Easter 🐇! xo EJ
Just ordered the face and body! You sold me because of the science and brilliant women behind the development! I have high hopes to slow the aging of my 40 yr old skin. Interested in becoming an affiliate once I’ve documented the results! Thanks for the PENN20 code as well🌷🌷🌷
Just ordered the face and body! You sold me because of the science and brilliant women behind the development! I have high hopes to slow the aging of my 40 yr old skin. Interested in becoming an affiliate once I’ve documented the results! Thanks for the PENN20 code as well🌷🌷🌷
I love skincare but I’m not a nerd when it come to the science side of it. I would probably not have clicked on it if it was some other person but I just love how you explain things when it comes to the science you make it sound easy. Loving brunette on you ☺️🤎
Penn, I'm waiting in my first order from OneSkin so I'm so relieved you "approve"!!! Keep the skin science coming!! We love it and need it!! thanks for all you do
So glad you did this video! I've been following OneSkin for a while but haven't pulled the trigger on ordering anything! Definitely going to give it a try! Your reviews and videos are always so informative! Thank you!
This is very compelling research, but I wonder, what happens to the cancerous cells that were turned into senescent cells to protect us? What happens to the process? Does os-1 bring the senescent "zombie" cells back to life to create a new "Frankenstein" problem, or will the body be able to discern? ... I have my coffee ready to go, I'm heading over to the blog right now to find out more information. As always, Penny, thank you for being at the forefront of these developments and passing on all of this information to us in a clear and concise way.
Hi Penny, Karla 61 and becoming a skincare junkie. LOL so glad I looked you up and joined your channel. This was so very interesting and makes so much Sence. Thank you. Can’t wait to be able to order the One Skinn as well as the other stars of your skincare routines.
I’ve been a fan of your videos for YEARS, and I’ve learned so much from you. I noted your tone when you very briefly mentioned using OneSkin with the promise of a full video to follow. That alone lead me to investigate for myself, and I ordered the product that night. I appreciate how your content is evolving, and I benefit tremendously from the knowledge and advice you pass on. Thank you, Penny!
Awesome and hopeful information!! As someone with multiple autoimmune problems, my skin/body is is in a constant battle! This information is incredible. Since I am 73, I may not have time to benefit from this research, but I sure hope so! P.S. You look great as a brunette- actually you are beautiful in every color!
I love getting nerdy with you! Your rabbit hole discoveries are always helpful and educational. Thank you for taking the time to make this new (seemingly complicated beyond my scope of comprehension) science; both interesting and understandable. Kinda mindblown by all of this new info. It really did make sense. You are a rockstar teacher, Penny! I'm def ordering this. I love supporting a bunch of kickass, brilliant women! BTW, you look sensational as a brunette. Gorgeous! xo
MIND BLOWN!!! 🤩🤩 if I didn’t like to write so much I would’ve majored in biology. It’s completely fascinating to me. Thank you for this, and now I’m heading over to the blog. But most of all I wanna know when these people are going to come out with their complete line! What amazing, bad ass women!! 😎
Just watched every bit if this and loved it. Never thought I'd be a skin need, but hey if the serum fits. Thank you for all your work...as always you are AWESOME. THANK YOU❤️❤️❤️
@@PENNSMITHSKINCARE .I love being here. Beginning to feel MY normal and just ordered this stuff. I'm very excited. So far, lately, I think I've ordered everything you mention or also everything. Love my RejuvatoneMD., and my myolift mini and my... etc, etc, etc.❤️
Thank you for this incredible review. I am 63, and always have had trouble using retinol/tretinoin...so, I pulled the trigger and purchased this...your code makes it quite affordable!
Thank you so much for all your info I ordered one of everything you mentioned. So far I love everything. I also used your codes and mentioned that I heard everything from you. Thanks so much!
I love this whole new scientific approach to skincare, the digitalization and the beauty tech device that are on the rise. I started using this micro current Bear device to firm my skin and facial muscles and I love it. I combine it with the facial yoga exercises . Totally recommend!
I've been waiting for a "One Skin" review from you. Been using it for a couple months. I'm seeing great results; smoother, firmer, more youthful looking skin, and it appears to gradually fade dark spots as well. I have both the body lotion and facial lotion. I use them judiciously, as the products are very pricey, but worth it. The cheapest, most effective way to induce autophagy (the recycling of damaged or senescent cellular organelles), is by doing a fast. There are different levels of autophagy. The deepest, chaperone-mediated autophagy, can be achieved with a 24-48 fast, not recommended more than once a month, and something one needs to build up to gradually.
I’m so excited that you’re seeing results! I’m so interested in the lifespan subject-and I’ve been binging David Sinclair (among others). It appears that adversity is key (which I’m sure you already know) and no doubt 24-48 hours of fasting would be adversity for me! 😂 But seriously, I’m going to continue to study this because it’s truly fascinating. I agree on building up to a fast-I’m going to start with simple intermittent fasting-like 12-12, shooting for 8-16 (I think. I’m definitely not an expert in this in any way). Thank you for being here ❤️ I love this conversation!
@@PENNSMITHSKINCARE Thanks for the reply! You are right about adversity. They call it the hormesis effect (low to moderate stresses on the body or system, provoking a beneficial response, which ultimately makes the system stronger). Weightlifting would be a good example, where you breakdown muscle, and it rebuilds bigger and stronger. I can definitely say that with intermittent fasting, the more consistently you do it, the easier it becomes. I'm a big Sinclair fan! As I'm over 50, I follow some of his protocols for sirtuin (longevity genes) activation; resveratrol and NAD+ supplementation, low dose metformin( 1 gram) daily to suppress blood glucose levels. My main takeaway from David Sinclair is that you can have growth ( mTor activated, which is just protein synthesis signaling), and you can have longevity ( mTor suppressed and AMPK activated, which is a signaling pathway to suppress cellular growth), but you cannot have both all the time. Solution...cycling periods where you can have the benefits of both.
I ordered before your video ended! Thank you for keeping up with the new discoveries in skincare! I have no doubt that our generation will be the first to be able to trial new formulas that Rapidly reverse the aging process, and I’ll be the first Guinea pig on that list!
LPD15ponce….where can I get this information you are discussing? I would love to learn more about this intermittent fasting! Mostly for weight loss but if it helps with the aging cells…that’s a huge bonus! I just purchased the One Skin line tonight! Super excited! I’m hoping to hear back from you. Thanks ❤️
@@leahgolden7242 Hi, if you're interested in healthy aging and longevity, I would recommend David Sinclair's "Lifespan" podcast series on RUclips (ruclips.net/user/DavidSinclairPodcast). David Sinclair is the Director of the Harvard University Laboratory on Aging Studies. He's a native Australian and one of the unintended benefits of listening to him is his calming, pleasant voice. Another RUclips channel for all things intermittent fasting and keto that I follow is Thomas Delauer. Here's a short video of his titled, "Over Age 50 Intermittent Fasting: Complete Benefits Guide" ruclips.net/video/la1Whdc5EHw/видео.html. There are a lot of sources. Additionally, for books(longevity) I would recommend "The Switch", by James Clement (everything you want to know about mTor), and (for healthy aging, especially for women) "Glow 15", by Naomi Whittel. If you are interested in longevity resources or supplements, two I like, although not cheap, are agelessrx.com and renuebyscience.com. If you're on a tight budget, here's a video by Dr. Michael Lustgarten, P.hD., in which he discusses natural foods which contain different flavonoids that inhibit CD38, a glycoprotein in the body which breaks down NAD+ (you want to preserve NAD+). He gets a little deep in the biochemical weeds, but if you hold out until the last few minutes, he lists those foods( black elderberries, blackberries, dried Mexican oregano, celery seeds, radicchio, Black Sorghum) ruclips.net/video/q-3GmgWO03k/видео.html. Hope this helps!
So glad you covered this topical skincare supplement, Pen! I ordered their sample size of the OS-1 Facial Moisturizer and I quite like it so far. It leaves the skin smooth and firm. Would love to see you interview the founders!
As soon as I saw this video I went to their website thinking I might want to buy this product, but afraid it would be like $500 or something. I couldn't believe how affordable it is, considering the expertise and research that went into it! I signed up for autoship 😬 I can't wait to try it
It’s interesting because I agree, it could be a lot more. I know it’s still spendy, but given all the research, the lab, the testing and formulating THEN all the normal stuff (packaging and business) it’s pretty incredible 🙂 And they’re generous (making their molclock available) with their science-truly remarkable women. ❤️
You are amazing! I love how you do your research & really know your stuff on products & devices. Thanks for sharing, I will be going to the blog to check it out!
OMFG I was senescent glued ( pun intended 😂) to the screen! This information is truly fascinating to me. It's the first time I've heard of these cells. I've got good skin overall for my age. I'm 60 and worked and played outside in the Australian sun most of my life. Definitely all my teenage years and into my 30s. I remember using SPF when I was a teenager because my skin is courtesy of my English heritage so I easily burned. Skin acclimates though and I stopped using it. Growing up in the 70s was all about getting lying on the sand at the beach to get a tan and many of us used oil. It was PROMOTED as was smoking which I did until 3 years ago. My only real problem is lost volume and the lines above the lips and some on the chin. I have good elasticity and no sagging. My neck is still good too. If I could find something to help the lines above my lips I think I'd cry. I spent 5K on fillers in 2015 which worked brilliantly on them. Really softened them and of course my lips looked great too. Thank you for sharing this amazing info. I'm off to read the blog. Cheers Penn x
Dear Penny, you brought the gift of explaining science to us. You are a great educator and this science incredible indeed! You truly are pretty as a brunette!! Love it! Kissie from Dutch tulipes, Jolina
excellent! I don't know if you are familiar with the work of Dr. david Sinclair, but he is a researcher at Harvard and is researching the science of aging and is a big proponent of NSM and Reserveratrol. He has a series on You Tube is an excellent teacher...puts things into an easy to understand format. He speaks about senescence and has a protocol of nutrients. He has been taking these for 10 yrs....he's 53 and looks about 40 and has beautiful skin. I think everyone here would enjoy his series as well. PS.......Penn...LOVE the hair!
Yes! I actually referenced him in the blog and shared his lifespan book! He’s an inspiration to say the least….I could listen to his podcast ALL day long’ lol! And thank you ❤️
@@suzannelevesque8368 ...Enjoy! The science is exciting! Another channel you might like is called The Pulse and is created by a fellow in Germany who has been on the protocol for 3 years and the change in his appearance is dramatic!
Wow. The founders of OneSkin are geniuses but so are you for presenting this compelling information in such a succinct blog. Thank you for taking the time to include the Q and A at the end. It would be so cool to have a Molclock like test to monitor progress at home. Would the OneSkin face product replace growth factor products like DefenAge, Anteage, TNS Recovery for those of us wanting to keep our routine simple? They seem to be all in the same general category but all work a little bit differently. All are pricey but I was pleasantly surprised OneSkin is the least expensive! Thanks again Penny.
@@PENNSMITHSKINCARE read your blog and printed it out for my aesthetician! This is huge and your endorsement (and code) make it that much more exciting. Thank you
Fascinating! Thank you for learning all this and posting it. There’s lots more to learn about microcurrent as well. Microcurrent is restorative the to the skin. Microcurrent is healing. I used microcurrent to heal a torn rotator cuff. I had an MRI that showed it. The doctor wantedTo do surgery. I use the microcurrent for six weeks. It was healed completely. I also use it to heal a torn meniscus in my knee. That only took four weeks. There’s so much good about microcurrent! The reason I learned about it is I owned a skincare business that only did microcurrent. I sold that business and I’m retired. The business I started called supreme skin is thriving! People see results in one session and can purchase a package of treatments. We emphasize that aestheticians know the muscles and how to work them. Even if people do microcurrent at home they will have better results with a well trained aesthetician.
This was fascinating Penn. Aside from your wonderful explanation on senescence, I had no idea Oneskin was headed up by four incredible women. I nearly missed this because I didn't recognise you! Wow, loving the brunette. And love your necklace. xx
I am so excited about this company product and technology! For sure I will check it out 😃 Thank you for the information and like always you look amazing! I love that hair color on you 🥰💕
@@PENNSMITHSKINCARE I have OneSkin, and I have been using it for months now. But, my confusion is about how to layer it. They say it’s like a moisturizer, but then they say put it on before serum. I’m confused on how to layer this product and I hope I haven’t been using it wrong.
Wow fascinating!! I just purchased both the face and body! Love the science behind it and all the advances that are being made. I hope by the time I’m 45 (preferably sooner) that we can just stop aging all together? Lol I’ll buy whatever it is!! Hahaha 😝 BTW! I love the new hair color! Makes your eyes pop!! Gorgeous lady as usual! Oh and the code “Penn20” that you offered us also works on the subscription as well as the one time purchase! I’ve never seen that before. Score!! ❤️🙏🏼
I absolutely loved this video and the blog post!! So informative!! The science behind this skincare, Is amazing!!! Thank you so much for all your hard work and research!! So we can have this information. To help us in our skincare journey. It Is truly appreciated. And I can’t leave without commenting on how absolutely gorgeous you look my friend !!! Loving that hair color on you !!! Stunning!!! ❤️❤️
Hi Penny! This was SO informative! Wow! Very fascinating and I'm very intrigued. Also, love the hair color. Pretty. It goes beautifully with your skin tone. Thank you! ♥️🙏
I just love listening to you, you are just down to earth, I'm 64 and trying to keep my face from to many lines. And that saggy stuff. I use the tria and evenskin and it really has helped on my lower face around the mouth. My lip lines have really improved. Ty❤
Great review - I am so pleased that you are covering the science behind OneSkin. You succinctly made understandable the scientific key elements of OneSkin's proven reversal of cellular senescence. I love OneSkin's OS-1 Face Supplement and plan to incorporate their newly released OS-1 Body Supplement into my skincare routine. I'm proud of the truly international female empowered advancement in the longevity sciences. I can't wait for the OneSkin products and scientific findings to become truly mainstream.
I have no doubt that it works, but my concern is that it targets just one part of ageing - cellular senescence. What about other pathways? If it’s patented and only available in this product that means that most people will still have to use other ingredients and multiple products.
@@AussieChick48 I've only used OS-1 Face for about two (2) months, so I cannot say that I have documented any noticeable changes yet because cellular turnover when in one's late fifties takes about 45 days. However, it's a great light moisturizer and I am excited, based on the proven science, to continue using OneSkin - extend to fully body use - and know that i am reversing cellular senescence. This is just one more thing that I can do, which I know is great for me, even if I cannot yet see the immediate benefits ... similar to using Retinol. 😊
Thank you Penny, loved this nerdy info sesh!! I am definitely going to give this range a try. I was also listening to a wonderful podcast on this topic Conversations - living to 120 and beyond with biologist David Sinclair. Feel like you would get a lot out of it and it may even give you some more lines of inquiry into age reversal science! Thanks again for your content I really value your incredible knowledge xx
I ❤️ ur channel & follow ur tips (almost) religiously! U look AMAZING! I’m 52 & have invested in the Emay Gua Sha Skin Massager, the Nira laser, the Newa RF device, the Dr. Pen Ultima M8, the HOOGA Red Light Therapy Device, a Diamond Microdermabrasion Pen & last, but certainly not least my fave sunscreen of all time-Neutrogena Ultra Sheer Face Mist 55! My sister SUFFERED as a teen w/cystic acne & grew up to become a licensed Esthetician here in Charlotte, NC. If u didn’t know she had bad acne as a teen, u would never be able to tell it from the beautiful skin she has now! Very frequently u 2 share similar info on products & skincare routines so I know I’m getting the BEST knowledge! Thank u for always giving ur honest opinion. That was the reason I bought these devices! EDIT: After reading ur intensive blog post on oneskin, I decided to order it! Can’t wait!!! Thanks for the discount:)
I just Love learning and you sharing What we are wanting 🙋♀️...I'm very intrigued 🙏 and you practice what you preach 😇Penny you have such a sweet spirit and you look fantastic... Now you are talking my language 🤗(Younger) Wow‼ it's in the science department and that's your expertise. Thank you for sharing and going down that rabbit hole for us ...🐇 HAPPY EASTER XOXO 🌷🐇🦋🌷
Thank you for this valuable info!! I definitely will be checking out the blog, btw luv your hair & color... Maybe you could do a hair tutorial on how you get that perfect wave in those beautiful locks! 💁♀️
Great information. You really did dive deep into the subject with explanations we could understand. These women are truly dedicated! Wish I could be one of their subjects. Thank you for this wealth of new information. I always enjoy your desire to teach us the newest science that is being developed and now readily available to us. Seems like you are the first to learn about this science behind the product. Thank you for sharing. PS Your hair looks great!!
Super-excited about this science and products. Loving the face product and excited to try the body product.. can this be used at the same time afterwards that is , as retinoids? Love your new darker hair transformation! Makes your beautiful eyes and skin pop.
Great video, thanks! What’s your understanding of how Oneskin compares to EGF technology like that in BioEffect products? Is there benefit to using both, do you think?
Hi! Quick question…shouldn’t the OS-01 peptide be higher on the list of ingredients? You always say ingredients are listed in order of how much is in the product…this peptide comes in right around the middle of ingredients, so just curious what your thoughts are. Thanks 🙋🏼♀️
Yes - class is in session!!!!! I love this content. I’m curious what you think of this vs. the Photoenzyme MD Youth Recovery Facial Serum for efficacy. 💗
Thank you Penny! Another informative video. I have osteoporosis at 57 and I had hip replacement surgery a month ago. I will look into this product, maybe it will help me 🤗
This is exciting stuff! Penny, where would the face mosturizer fit into my skincare routine? Last step? Or should I use it after serums and before applying sunscreen?
Great information.... i have ben using both products for the last 3 weeks. I heard about it in one of Dr. D. Sinclair Life Span videos. On another note, I wonder if OneSkin will be working on products to reverse hair greying. Wouldn't it be wonderful.!!! Thanks Penn . Martha
I am soon to be 75, yet feel like I'm 57, & would like you maintain that look. Does this skincare still help you if you are mature. Because of you I ordered it! Thank you, Penny!
Great video ! Super informative as usual ! Not a skincare question but would you mind sharing the details about your necklaces ?❤️ I really love the look !!
Hi Penn- What an exciting and incredibly detailed, helpful, promising video! You are so incredible at explaining the complicated to make it so so easy to understand. It brings me back to when you explained some thing like using a recipe that has stains on it and it’s hard to read. I can’t read what you were talking about but it was so helpful. Can’t wait to hear more about this!
Hi friends 🙃
Here’s a link to the blog post, I hope you’ll check it out!
www.pennsmithskincare.com/post/oneskin-slowing-the-velocity-of-skin-aging-really
XXPenn
Thank you so much for all your hard work Penny! This was so fascinating!! Thank you too for getting us a fabulous discount!! I just made my first purchase and I'm hoping this product, along with my tretinoin will help reverse some of the sun damage from my younger sun worshipping days 🙏🏻. Hope you have a Happy Easter 🐇! xo EJ
Just ordered the face and body! You sold me because of the science and brilliant women behind the development! I have high hopes to slow the aging of my 40 yr old skin. Interested in becoming an affiliate once I’ve documented the results! Thanks for the PENN20 code as well🌷🌷🌷
Just ordered the face and body! You sold me because of the science and brilliant women behind the development! I have high hopes to slow the aging of my 40 yr old skin. Interested in becoming an affiliate once I’ve documented the results! Thanks for the PENN20 code as well🌷🌷🌷
@@LeslieDCain I hope you love it!
@@ejhaqqi6480 happy Easter to you too! ❤️
Great video Penny. As someone with an inflammatory auto-immune disorder, this seems like huge news! Love the science behind it.
I love skincare but I’m not a nerd when it come to the science side of it. I would probably not have clicked on it if it was some other person but I just love how you explain things when it comes to the science you make it sound easy. Loving brunette on you ☺️🤎
That is such a huge compliment, thank you so much Shereen ❤️
Penn, I'm waiting in my first order from OneSkin so I'm so relieved you "approve"!!! Keep the skin science coming!! We love it and need it!! thanks for all you do
Penn this was so exciting to watch and incredibly easy to understand. Thank you. Xxx
So glad you did this video! I've been following OneSkin for a while but haven't pulled the trigger on ordering anything! Definitely going to give it a try! Your reviews and videos are always so informative! Thank you!
This is very compelling research, but I wonder, what happens to the cancerous cells that were turned into senescent cells to protect us? What happens to the process? Does os-1 bring the senescent "zombie" cells back to life to create a new "Frankenstein" problem, or will the body be able to discern? ... I have my coffee ready to go, I'm heading over to the blog right now to find out more information. As always, Penny, thank you for being at the forefront of these developments and passing on all of this information to us in a clear and concise way.
Very good question!
Excellent blog. You have a gift my friend. Your voice has an excitement to it. It’s not boring. Also your voice tone, and reflection is fantastic.
Thank you! 💕
Hi Penny, Karla 61 and becoming a skincare junkie. LOL so glad I looked you up and joined your channel. This was so very interesting and makes so much Sence. Thank you. Can’t wait to be able to order the One Skinn as well as the other stars of your skincare routines.
Hi Karla 😊 Thank you so much for joining!
I’ve been a fan of your videos for YEARS, and I’ve learned so much from you.
I noted your tone when you very briefly mentioned using OneSkin with the promise of a full video to follow. That alone lead me to investigate for myself, and I ordered the product that night. I appreciate how your content is evolving, and I benefit tremendously from the knowledge and advice you pass on. Thank you, Penny!
❤️❤️❤️ Thank you Kristen!
Your hair color looks great! Thanks for all the wonderful information you research and share!
Thank you so much!
Awesome and hopeful information!! As someone with multiple autoimmune problems, my skin/body is is in a constant battle! This information is incredible. Since I am 73, I may not have time to benefit from this research, but I sure hope so! P.S. You look great as a brunette- actually you are beautiful in every color!
I love getting nerdy with you! Your rabbit hole discoveries are always helpful and educational. Thank you for taking the time to make this new (seemingly complicated beyond my scope of comprehension) science; both interesting and understandable. Kinda mindblown by all of this new info. It really did make sense. You are a rockstar teacher, Penny! I'm def ordering this. I love supporting a bunch of kickass, brilliant women! BTW, you look sensational as a brunette. Gorgeous! xo
Wow!! Love the hair!! You are gorgeous!
Ahh thank you! So nice of you! 🥰
MIND BLOWN!!! 🤩🤩 if I didn’t like to write so much I would’ve majored in biology. It’s completely fascinating to me. Thank you for this, and now I’m heading over to the blog. But most of all I wanna know when these people are going to come out with their complete line! What amazing, bad ass women!! 😎
This was mind blowing
Just watched every bit if this and loved it. Never thought I'd be a skin need, but hey if the serum fits. Thank you for all your work...as always you are AWESOME. THANK YOU❤️❤️❤️
I LOVE that….”if the serum fits!”
Yes!
That’s a tag line if I ever saw one!
Happy Saturday Lynn, thank you for being here 🥰
@@PENNSMITHSKINCARE .I love being here. Beginning to feel MY normal and just ordered this stuff. I'm very excited. So far, lately, I think I've ordered everything you mention or also everything. Love my RejuvatoneMD., and my myolift mini and my... etc, etc, etc.❤️
Thank you for this incredible review. I am 63, and always have had trouble using retinol/tretinoin...so, I pulled the trigger and purchased this...your code makes it quite affordable!
You are so welcome!
Thank you so much for all your info I ordered one of everything you mentioned. So far I love everything. I also used your codes and mentioned that I heard everything from you. Thanks so much!
Thank you so much! 🥰🥰🥰
I love this whole new scientific approach to skincare, the digitalization and the beauty tech device that are on the rise. I started using this micro current Bear device to firm my skin and facial muscles and I love it. I combine it with the facial yoga exercises . Totally recommend!
Love the Foreo Bear, great device!!! ❤️
i just saw they have great Mothers Day promos , great time to invest! was thinking of getting it for my mom
Drop dead gorgeous, Penny! ❤️ Love the hair color!
Thank you so much Jessica 😀🥰
I am such a nerd!!! I love the science behind skincare. It’s literally the answer to every question. Ugggh, love youuu 😍💖
I love the brown hair! You look great as a blonde and brunette.
Thank you Naomi 😀❤️
That hair looks amazing!!
Ahh thank you so much!
I've been waiting for a "One Skin" review from you. Been using it for a couple months. I'm seeing great results; smoother, firmer, more youthful looking skin, and it appears to gradually fade dark spots as well. I have both the body lotion and facial lotion. I use them judiciously, as the products are very pricey, but worth it. The cheapest, most effective way to induce autophagy (the recycling of damaged or senescent cellular organelles), is by doing a fast. There are different levels of autophagy. The deepest, chaperone-mediated autophagy, can be achieved with a 24-48 fast, not recommended more than once a month, and something one needs to build up to gradually.
I’m so excited that you’re seeing results!
I’m so interested in the lifespan subject-and I’ve been binging David Sinclair (among others). It appears that adversity is key (which I’m sure you already know) and no doubt 24-48 hours of fasting would be adversity for me! 😂
But seriously, I’m going to continue to study this because it’s truly fascinating.
I agree on building up to a fast-I’m going to start with simple intermittent fasting-like 12-12, shooting for 8-16 (I think. I’m definitely not an expert in this in any way).
Thank you for being here ❤️
I love this conversation!
@@PENNSMITHSKINCARE Thanks for the reply! You are right about adversity. They call it the hormesis effect (low to moderate stresses on the body or system, provoking a beneficial response, which ultimately makes the system stronger). Weightlifting would be a good example, where you breakdown muscle, and it rebuilds bigger and stronger. I can definitely say that with intermittent fasting, the more consistently you do it, the easier it becomes. I'm a big Sinclair fan! As I'm over 50, I follow some of his protocols for sirtuin (longevity genes) activation; resveratrol and NAD+ supplementation, low dose metformin( 1 gram) daily to suppress blood glucose levels. My main takeaway from David Sinclair is that you can have growth ( mTor activated, which is just protein synthesis signaling), and you can have longevity ( mTor suppressed and AMPK activated, which is a signaling pathway to suppress cellular growth), but you cannot have both all the time. Solution...cycling periods where you can have the benefits of both.
I ordered before your video ended! Thank you for keeping up with the new discoveries in skincare! I have no doubt that our generation will be the first to be able to trial new formulas that Rapidly reverse the aging process, and I’ll be the first Guinea pig on that list!
LPD15ponce….where can I get this information you are discussing? I would love to learn more about this intermittent fasting! Mostly for weight loss but if it helps with the aging cells…that’s a huge bonus! I just purchased the One Skin line tonight! Super excited! I’m hoping to hear back from you. Thanks ❤️
@@leahgolden7242 Hi, if you're interested in healthy aging and longevity, I would recommend David Sinclair's "Lifespan" podcast series on RUclips (ruclips.net/user/DavidSinclairPodcast). David Sinclair is the Director of the Harvard University Laboratory on Aging Studies. He's a native Australian and one of the unintended benefits of listening to him is his calming, pleasant voice. Another RUclips channel for all things intermittent fasting and keto that I follow is Thomas Delauer. Here's a short video of his titled, "Over Age 50 Intermittent Fasting: Complete Benefits Guide" ruclips.net/video/la1Whdc5EHw/видео.html. There are a lot of sources. Additionally, for books(longevity) I would recommend "The Switch", by James Clement (everything you want to know about mTor), and (for healthy aging, especially for women) "Glow 15", by Naomi Whittel. If you are interested in longevity resources or supplements, two I like, although not cheap, are agelessrx.com and renuebyscience.com. If you're on a tight budget, here's a video by Dr. Michael Lustgarten, P.hD., in which he discusses natural foods which contain different flavonoids that inhibit CD38, a glycoprotein in the body which breaks down NAD+ (you want to preserve NAD+). He gets a little deep in the biochemical weeds, but if you hold out until the last few minutes, he lists those foods( black elderberries, blackberries, dried Mexican oregano, celery seeds, radicchio, Black Sorghum) ruclips.net/video/q-3GmgWO03k/видео.html. Hope this helps!
Great video penn thank u for taking the time to explain the science !
So glad you covered this topical skincare supplement, Pen! I ordered their sample size of the OS-1 Facial Moisturizer and I quite like it so far. It leaves the skin smooth and firm. Would love to see you interview the founders!
As soon as I saw this video I went to their website thinking I might want to buy this product, but afraid it would be like $500 or something. I couldn't believe how affordable it is, considering the expertise and research that went into it! I signed up for autoship 😬 I can't wait to try it
It’s interesting because I agree, it could be a lot more. I know it’s still spendy, but given all the research, the lab, the testing and formulating THEN all the normal stuff (packaging and business) it’s pretty incredible 🙂
And they’re generous (making their molclock available) with their science-truly remarkable women. ❤️
You are amazing! I love how you do your research & really know your stuff on products & devices. Thanks for sharing, I will be going to the blog to check it out!
Thank you so much Penny, very informative video...By the way, love your hair and the new color, looks so beautiful on you 🌸
You look so gorgeous!!
Oh my gosh thank you Sarah! ❤️🥰
OMFG I was senescent glued ( pun intended 😂) to the screen! This information is truly fascinating to me. It's the first time I've heard of these cells. I've got good skin overall for my age. I'm 60 and worked and played outside in the Australian sun most of my life. Definitely all my teenage years and into my 30s. I remember using SPF when I was a teenager because my skin is courtesy of my English heritage so I easily burned. Skin acclimates though and I stopped using it. Growing up in the 70s was all about getting lying on the sand at the beach to get a tan and many of us used oil. It was PROMOTED as was smoking which I did until 3 years ago. My only real problem is lost volume and the lines above the lips and some on the chin. I have good elasticity and no sagging. My neck is still good too. If I could find something to help the lines above my lips I think I'd cry. I spent 5K on fillers in 2015 which worked brilliantly on them. Really softened them and of course my lips looked great too. Thank you for sharing this amazing info. I'm off to read the blog. Cheers Penn x
Pen! Love the hair color and style! You are so pretty that any color looks good!
Thank you so much Andrea 😊❤️
Loving the new hair color 😍 Thanks for continuing to wow us with science-backed skincare goodies 🙏🏻
You are so welcome!
Dear Penny, you brought the gift of explaining science to us. You are a great educator and this science incredible indeed! You truly are pretty as a brunette!! Love it! Kissie from Dutch tulipes, Jolina
Thank you Jolina 😊
Thanks Penny, really appreciate this. Sounds exciting.
Thank you for the easy-to-understand explanation! I’m using the OneSkin face and body products . Love them!
I’m so glad you love them! I do too!
❤️
It also has something to do with the bone structure, the mineralization changes of the bone with age.
Yes, for sure.
You’re explanation is great, thank you. I ordered mine today!
Thank you Julie! I hope you love it! Take pics 😍
excellent! I don't know if you are familiar with the work of Dr. david Sinclair, but he is a researcher at Harvard and is researching the science of aging and is a big proponent of NSM and Reserveratrol. He has a series on You Tube is an excellent teacher...puts things into an easy to understand format. He speaks about senescence and has a protocol of nutrients. He has been taking these for 10 yrs....he's 53 and looks about 40 and has beautiful skin. I think everyone here would enjoy his series as well. PS.......Penn...LOVE the hair!
Yes! I actually referenced him in the blog and shared his lifespan book! He’s an inspiration to say the least….I could listen to his podcast ALL day long’ lol!
And thank you ❤️
Thanks so much for sharing this, Kathleen. I just subscribed to his channel !
@@suzannelevesque8368 ...Enjoy! The science is exciting! Another channel you might like is called The Pulse and is created by a fellow in Germany who has been on the protocol for 3 years and the change in his appearance is dramatic!
@@kathleenb3096 Thanks so much! I will check it out. ;-) Dr Sinclair is awesome!
Wow. The founders of OneSkin are geniuses but so are you for presenting this compelling information in such a succinct blog. Thank you for taking the time to include the Q and A at the end. It would be so cool to have a Molclock like test to monitor progress at home.
Would the OneSkin face product replace growth factor products like DefenAge, Anteage, TNS Recovery for those of us wanting to keep our routine simple? They seem to be all in the same general category but all work a little bit differently. All are pricey but I was pleasantly surprised OneSkin is the least expensive!
Thanks again Penny.
Sounds fascinating Penny. Thank you so much for putting the work to make this video 🙏🏻💗
Been waiting go this review. Just placed my order with your code. Thank you!
Thank you! If you can, check the blog….it’s even more mind blowing than I could fit in this video! ❤️❤️❤️
@@PENNSMITHSKINCARE read your blog and printed it out for my aesthetician! This is huge and your endorsement (and code) make it that much more exciting. Thank you
Fascinating! Thank you for learning all this and posting it. There’s lots more to learn about microcurrent as well. Microcurrent is restorative the to the skin. Microcurrent is healing. I used microcurrent to heal a torn rotator cuff. I had an MRI that showed it. The doctor wantedTo do surgery. I use the microcurrent for six weeks. It was healed completely. I also use it to heal a torn meniscus in my knee. That only took four weeks. There’s so much good about microcurrent! The reason I learned about it is I owned a skincare business that only did microcurrent. I sold that business and I’m retired.
The business I started called supreme skin is thriving! People see results in one session and can purchase a package of treatments. We emphasize that aestheticians know the muscles and how to work them. Even if people do microcurrent at home they will have better results with a well trained aesthetician.
This was fascinating Penn. Aside from your wonderful explanation on senescence, I had no idea Oneskin was headed up by four incredible women. I nearly missed this because I didn't recognise you! Wow, loving the brunette. And love your necklace. xx
I love the video and the blogpost so much! Thanks
Oh yay! Thank you! That means so much to me ❤️
@@PENNSMITHSKINCARE I’ll definitely subscribe to the brand for regular shipping & use your code for sure! Thanks again.
I am so excited about this company product and technology!
For sure I will check it out 😃
Thank you for the information and like always you look amazing! I love that hair color on you 🥰💕
Yay! I’ve been waiting for this video!
Wonderful! Thank you for being here ❤️
@@PENNSMITHSKINCARE I have OneSkin, and I have been using it for months now. But, my confusion is about how to layer it. They say it’s like a moisturizer, but then they say put it on before serum. I’m confused on how to layer this product and I hope I haven’t been using it wrong.
Wow fascinating!! I just purchased both the face and body! Love the science behind it and all the advances that are being made. I hope by the time I’m 45 (preferably sooner) that we can just stop aging all together? Lol
I’ll buy whatever it is!! Hahaha 😝
BTW! I love the new hair color! Makes your eyes pop!! Gorgeous lady as usual!
Oh and the code “Penn20” that you offered us also works on the subscription as well as the one time purchase! I’ve never seen that before. Score!! ❤️🙏🏼
I'm loving One Skin. Started about a month ago.
I absolutely loved this video and the blog post!!
So informative!! The science behind this skincare,
Is amazing!!! Thank you so much for all your hard
work and research!! So we can have this information.
To help us in our skincare journey. It Is truly appreciated.
And I can’t leave without commenting on how absolutely
gorgeous you look my friend !!! Loving that hair color
on you !!! Stunning!!! ❤️❤️
Thank you Blanca, you are always sooo kind!!!! ❤️
Yes! I've been waiting for this video!
Yay!! Happy Saturday! Thank you for being here Tosha! ❤️
I love the hair
Oh thank you! ❤️
Your hair looks amazing! And very informative video!
Love your dark hair!!
Hi Penny! This was SO informative! Wow! Very fascinating and I'm very intrigued. Also, love the hair color. Pretty. It goes beautifully with your skin tone. Thank you! ♥️🙏
Thank you again for all the knowledge! Just ordered🙌🥰
Thank you for being here!
Luv your new hair colour
Penny your hair 😍 it looks so beautiful that color!
Thank you so much!!!
I just love listening to you, you are just down to earth, I'm 64 and trying to keep my face from to many lines. And that saggy stuff. I use the tria and evenskin and it really has helped on my lower face around the mouth.
My lip lines have really improved. Ty❤
Omg- Penny you look amazing as a brunette!! You're beautiful as a blonde but your eyes really pop with that color💖
Astonishing! I'll try to find the blog. Very keen to learn more and thank you for discovering this ❤
Thank you for being here ❤️
Here’s a link to the blog:
www.pennsmithskincare.com/post/oneskin-slowing-the-velocity-of-skin-aging-really
❤️❤️❤️
@@PENNSMITHSKINCARE thanks you fantastic
I now dub thee Professor Penn. You articulated this beautifully.
Great review - I am so pleased that you are covering the science behind OneSkin. You succinctly made understandable the scientific key elements of OneSkin's proven reversal of cellular senescence. I love OneSkin's OS-1 Face Supplement and plan to incorporate their newly released OS-1 Body Supplement into my skincare routine. I'm proud of the truly international female empowered advancement in the longevity sciences. I can't wait for the OneSkin products and scientific findings to become truly mainstream.
Thank you!
I agree, I can’t wait for the science to become more mainstream. It’s revolutionary 🙂❤️
Did you have great results using the OneSkin? May I ask how old you are and what you saw change in your skin?
@@AussieChick48 .. I'm going to but in.. if you go look at this product, their reviews ask that question. That's what sold me, well, that and Penny!
I have no doubt that it works, but my concern is that it targets just one part of ageing - cellular senescence. What about other pathways? If it’s patented and only available in this product that means that most people will still have to use other ingredients and multiple products.
@@AussieChick48 I've only used OS-1 Face for about two (2) months, so I cannot say that I have documented any noticeable changes yet because cellular turnover when in one's late fifties takes about 45 days. However, it's a great light moisturizer and I am excited, based on the proven science, to continue using OneSkin - extend to fully body use - and know that i am reversing cellular senescence. This is just one more thing that I can do, which I know is great for me, even if I cannot yet see the immediate benefits ... similar to using Retinol. 😊
As an esti graduating this month, I loveee your content 💞 i feel extra prepared!
Congratulations on your upcoming graduation! 🎉
Excellent job on this! Thanks for sharing. 😃
Thanks for watching!
Thank you Penny, loved this nerdy info sesh!! I am definitely going to give this range a try. I was also listening to a wonderful podcast on this topic Conversations - living to 120 and beyond with biologist David Sinclair. Feel like you would get a lot out of it and it may even give you some more lines of inquiry into age reversal science! Thanks again for your content I really value your incredible knowledge xx
That hair color on you is 🔥!!
I just received the full size of this product.
Thank you! And yay! Take pics! I really think this is one that subtly improves our skin over time and pics help SO much! ❤️
@@PENNSMITHSKINCARE I will definitely do that thank you for your informative videos!! I will be 50 this week and will do whatever I can for my skin.
So awesome thank you. Also your hair looks fabulous
Thank you Susan ❤️
Happy Sunday 🥰
I ❤️ ur channel & follow ur tips (almost) religiously! U look AMAZING! I’m 52 & have invested in the Emay Gua Sha Skin Massager, the Nira laser, the Newa RF device, the Dr. Pen Ultima M8, the HOOGA Red Light Therapy Device, a Diamond Microdermabrasion Pen & last, but certainly not least my fave sunscreen of all time-Neutrogena Ultra Sheer Face Mist 55! My sister SUFFERED as a teen w/cystic acne & grew up to become a licensed Esthetician here in Charlotte, NC. If u didn’t know she had bad acne as a teen, u would never be able to tell it from the beautiful skin she has now! Very frequently u 2 share similar info on products & skincare routines so I know I’m getting the BEST knowledge! Thank u for always giving ur honest opinion. That was the reason I bought these devices! EDIT: After reading ur intensive blog post on oneskin, I decided to order it! Can’t wait!!! Thanks for the discount:)
I just Love learning and you sharing What we are wanting 🙋♀️...I'm very intrigued 🙏 and you practice what you preach 😇Penny you have such a sweet spirit and you look fantastic... Now you are talking my language 🤗(Younger) Wow‼ it's in the science department and that's your expertise. Thank you for sharing and going down that rabbit hole for us ...🐇
HAPPY EASTER XOXO 🌷🐇🦋🌷
each video, darker hair, younger looking Penny ☺️ I love this color on you, such a beautiful contrast with your gorgeous eyes. Go girl!
Thank you so much 💕
Thank you for this valuable info!! I definitely will be checking out the blog, btw luv your hair & color... Maybe you could do a hair tutorial on how you get that perfect wave in those beautiful locks! 💁♀️
Great information. You really did dive deep into the subject with explanations we could understand. These women are truly dedicated! Wish I could be one of their subjects.
Thank you for this wealth of new information. I always enjoy your desire to teach us the newest science that is being developed and now readily available to us. Seems like you are the first to learn about this science behind the product.
Thank you for sharing.
PS
Your hair looks great!!
They are so dedicated!! Thank you so much Elaine 💕
Thank you once again for an informative video!
Great video!
Super-excited about this science and products. Loving the face product and excited to try the body product.. can this be used at the same time afterwards that is , as retinoids? Love your new darker hair transformation! Makes your beautiful eyes and skin pop.
You can definitely use along with retinoids. Since they can be inflammatory the anti-inflammatory nature of OneSkin is complimentary 😍
And thank you!
Omg your hair color makes your blue eyes POP, wow😳
Great video, thanks! What’s your understanding of how Oneskin compares to EGF technology like that in BioEffect products? Is there benefit to using both, do you think?
Hi! Quick question…shouldn’t the OS-01 peptide be higher on the list of ingredients? You always say ingredients are listed in order of how much is in the product…this peptide comes in right around the middle of ingredients, so just curious what your thoughts are. Thanks 🙋🏼♀️
Try it, Its AMAZING! Best Produ ct on the market for Skin
An ingredient can be lower on the list because it doesn’t need to be a higher amount to work effectively.
Yes - class is in session!!!!! I love this content. I’m curious what you think of this vs. the Photoenzyme MD Youth Recovery Facial Serum for efficacy. 💗
Thank you
Thanks so much Penny. 😘
Thank you for being here Debi ❤️
🤩penny you look gorgeous girl!!! 💃🏽
🥰 thank you so much ❤️
Ordered!! 🙌🏻
OS- 1 , best operating system. great video
Thank you Penny! Another informative video. I have osteoporosis at 57 and I had hip replacement surgery a month ago. I will look into this product, maybe it will help me 🤗
Thank you for this info
Thank you for being here ❤️
Have you heard or do you know if its effective...the oralift device for face toning?
So interesting. Such a help to the viewers 🥰
This is exciting stuff! Penny, where would the face mosturizer fit into my skincare routine? Last step? Or should I use it after serums and before applying sunscreen?
Great information.... i have ben using both products for the last 3 weeks. I heard about it in one of Dr. D. Sinclair Life Span videos. On another note, I wonder if OneSkin will be working on products to reverse hair greying. Wouldn't it be wonderful.!!!
Thanks Penn .
Martha
I am soon to be 75, yet feel like I'm 57, & would like you maintain that look. Does this skincare still help you if you are mature. Because of you I ordered it! Thank you, Penny!
Fascinating. Many thanks.
Thank you for being here 🥰
Hi Penny! ❤
Hi! Happy Saturday ❤️
Great video ! Super informative as usual ! Not a skincare question but would you mind sharing the details about your necklaces ?❤️ I really love the look !!
Hi Penn- What an exciting and incredibly detailed, helpful, promising video! You are so incredible at explaining the complicated to make it so so easy to understand. It brings me back to when you explained some thing like using a recipe that has stains on it and it’s hard to read. I can’t read what you were talking about but it was so helpful. Can’t wait to hear more about this!
One Skin - fascinating!!! Ok are you using it in your daily routine?? 🥰
Loving your makeup, do you have a tutorial on this look?
Hi Penny! What changes have you seen in your skin since using it?