Osteoporosis pharmacology, prevention and treatment (bisphosphonates, denosumab, SERMs)

"There are medications available to prevent and treat osteoporosis. Medications to prevent osteoporosis are only for those at high risk of osteoporosis, this includes those taking high dose of steroids for a long duration. If someone old has a fracture then usually they are started on medications for osteoporosis regardless of T score. Or if they are diagnosed with osteoporosis on with a T score less than 2.5.
Medications include: bisphosphonates, denosumab, SERMS, PTH analogs and sclerosting inhibitors"
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[@bjalexandria1]

Confirms why I'll never, ever take any of these drugs!

[@Dr.DiyarHamid]

Because of your videos we all benefit from them thank you so much. I'm from Kurdistan/Iraq

[@spaghettidem0n]

just a correction to the video and description, if you are going to make a diagnosis of OP off of a T score, it includes a T score of -2.5 . in your video you say the T score must be less than -2.5 (should be less than or equal to)=

[@anmato11]

Is it worth it?

[@robertbrooks6167]

Calcium hydroxyapatite (Ca5(PO4)3(OH)) can reduce bisphosphonate concentrations and protect the oral mucosa by exploiting bisphosphonate’s calcium binding affinity.

[@dawncarrasco8320]

No way am I getting those meds or shots. Sounds deadly pics stopped.

[@tameramares5785]

Thank you. I just got diagnosed with osteoporosis at age 59.

[@anmato11]

This is a teal concern for me. Started with Actonel but didn’t improve much. 8 years of Prolia and then given Iv infusion of Aclasta. Was very ill and vomiting, passed out and went to ER. ER didn’t seem to know what happened. Endocronologist wants another iv infusion in 6 months time. Not likely to try it again. Help! May be best to leave them all alone.

[@richardworker9280]

Hypothyroidism?

[@karlint39]

Great video with lots of information. I was hoping you would go into more detail about the mechanism by which denosumab discontinuation results in rebound and rapid bone density reduction and increase in fracture risk. Why would that be an issue with denosumab but not with other medications such as the bisphosphonates?

[@bojjavijay3836]

Thank u so much sir,in just 15mins got the full knowledge about osteoporosis,very helpful

[@iWillLuvYouForeva]

This is perfect. Thank you so much for the details and terms.

[@gauravsharma-st6ex]

Kudos .. to your efforts . Making many lives easier !

[@lucuu6543]

Kudos to the man himself!!

[@amandarossell5167]

Thank you! Just when I needed this!

[@dhabsheeg36]

Thank you for your mening full lecture

[@jstroudfit]

Thank you very much you make this information very understandable extremely helpful thanks

[@billytheweasel]

Great vids here, thanks.

[@wafaztaha]

Very useful, thank you

[@AnsariyatAhmed]

Very useful. Thank you!