Endocrinology - Calcium and Phosphate Regulation

Support me:
🖼️ Buy PDFs: armandoh.org/shop
💵 Patreon: / armando
👕 Buy shirts: teespring.com/stores/ah-7
Social media:
📷 Instagram: / armandohasudungan
🐦 Twitter: / armandohasudung
📔 Facebook: / armandohasudungan
Resources:
📕 Books: armandoh.org/resource
🎞️ Equipment: armandoh.org/armando-faigl
You can send me mail:
📫 PO BOX 166, Randwick NSW 2031, Australia

[@MelbourneMaster]

If you're looking for a few extra steps and more in-dept:
The precursers of vit D comes from foods (like oily fish; D3), plants (D2) and the sun D3. In the skin the suns UV-rays converts 7-dehydrocholesterol into cholecalciferol D3 (done non-enzymatically by heat). Cholecalciferol then moves into the liver (transported from the skin by vitamin D-binding-protein (DBP), and by cholemicrons from the diet) for the first part of its activation. Here it is converted by the enzyme (cytochrome P-450-based enzyme) into 25-hydroxy vit D3 (25-OH-D) (calcidiol) the step is called 25-hydroxylation, it then moves to the kidney for its second and last activation. Here the 25-OH-D/DBP complex is taken up at the surface by renal proximal cells by a specific mechanism involving cell surface receptors; megalin and cubulin. In the kidney 25-OH-D is converted to 1,25 dihydroxy vit D (1,25-(OH)2D) (calcitriol) by renal-1α-hydroxylase - this activation is called 1α-hydroxylation (patients with renal failure therefore cannot perform this step). The 1α-hydroxylase comprises 3 proteins: Cyt P-450, a ferredoxin and a ferredoxin reductase for activity. 1α-hydroxylase is strongly downregulated by 1,25-(OH)2D (calcitriol) and strongly upregulated by PTH as a calcium homeostatic loop.

[@KeirDickson706]

This video just taught me more in 11 minutes than my lecturer has in like 235 powerpoint slides :))))))) ur the best

[@user-dd4vo3ik6n]

Exactly 👌🏻

[@kingbobbie5196]

Asweer chale 😂

[@kingbobbie5196]

U dey UG?

[@KeirDickson706]

@@kingbobbie5196 ye

[@kingbobbie5196]

Oh nice... which year?

[@aboutmedicine]

I think its worth mentioning phosphate doesn't need Vitamin D for uptake from the diet. This is part of the reason why in chronic kidney disease, you have low serum calcium but high serum phosphate. The kidney can't make Vitamin D if its diseased, so calcium uptake is not enough, but phosphate can still get across from the intestines into the blood. Cheers Armando you rock by the way : )

[@samuelbenson1]

CKD - Decreased GFR, Kidney cannot excrete enough phosphate, phosphate increases FGF-23 which blocks 1-alpha-hydoxylase. Decrease Calcitriol, decrease intestinal absorption of ca and phosphate, yet kidney cannot excrete enough phosphate so phosphate remains high and binds free calcium. Decreased calcium stimulates increase in PTH, PTH increases bone turnover, leads to metabolic bone disease, pt over time has bone pain, fractures. PTH normally stimulates kidney to lose phosphate, but decreased GFR and kidney injury causes phosphate to not be excreted.

[@zaman54321]

I was looking for this. Thank you so much.

[@pilatesyogataichifit]

Anything apart from kidney disease that causes low serum calcium and high serum phosphate?

[@kelseymcginnis5673]

ahh thank you!

[@Dandandandandy]

@@samuelbenson1 saved my life thank you!

[@panashechitsike1236]

you are such a lifesaver. this was so clear. cleared a lot of confusion I had on the main hormone that controls bone growth and remodeling. keep up the great work! looking forward to more of your work.

[@sarasultana9804]

You've got some wonderful content in here!!! I discovered this channel a few weeks ago and my whole study game has changed ever since! Thank you so much @armandohasudungan

[@zeynepecearslan4000]

what would i do in med school without your videos

[@lientranthi2261]

Zeynep Ece Arslan Tra

[@aleksandarjoe4290]

There are a few factors in solving sarcoidosis pain naturally. One resource I discovered that succeeds in merging these is the Remission Crusher Tactic (check it out on google) without a doubt the best plan that I've seen. Check out the interesting info .

[@windiandini6919]

trueee

[@obviouslytwo4u]

go vegan and work it out for yourself

[@cristymendez9385]

@@aleksandarjoe4290 unívoca z💗💖😔😁☺👍😅😄😭🐶🐑🐸🐸😰😘😔😗😀🎐🎋📹🖥💻📷🎁🎇🎆🎓🎒💝🎍🎑🎉📼💿🎊🎃👻🔮📀🎈🔮🎅💽💽🏦🏥🏣🏢🏫🏡🏡🏤🏬⛪💒🏯🏩🏪🗼🏭🏭🏭⛺🏤🏬⛪🏨🏨🏩🏪🗻🌆🏯⛺⛺🏭🎠🌉🗽🌃🌅🌄🗻🔠🔣🔢🔡🔄↕↪ℹ◀↗⬆⬅⬇▶↖↘🔼⏫⏩⏪⤵⏬🔽↙↘↖⤵↩🐸🐸🐰🐹🐭🐢🐱🐺🐶🐔🐯🐶🐯🐯🐦🐵🐤🐤🐨🐱🐺🐥🐴🐱🐣🐑🐭🐭⛺⛪🐔🐔🐢🐗🐸🐍

[@Nina21_]

this is truly an amazing explanation in a short amount of time compared to long complicated lectures ! thank you so much sir

[@adnanbashi9793]

You forgot to mention that PTH reduces the reabsorption of phosphate from the proximal tubule of the kidney, which means more phosphate is excreted through the urine!

[@nurkoleptik_art]

Adnan Bashi I think he included that in one of his older videos which is the "bonehomeostasis (calcium phosphate) hormones" video :D

[@bihishtasozan1903]

exactly what i was confused about okay so i did understand the concept

[@nellyhoffman6194]

Thanks adnan

[@cescrosado]

Adnan Bashi that's the fosfaturic action of PTH, exactly!! On the other hand, calcitriol does not do that treating equally calcium and phosphate (reabsobring both of them, PTH only reabsorbed calcium) and so, if there's an excess of calcitriol (vit D), they can precipitate.

[@tonyboroni6949]

not true i have both high phosphate and pth with low low t4 wich i take meds for but nothing i can do for my pth issues so im fct, this condition was missed for years now i have perment bone and liver problems now and heart racing issues.

[@dominiquelee3923]

You have a gift of teaching! Your videos are so clear and easy to comprehend! THANK YOU!!!!!!!!

[@chrisland97]

I'm studying this stuff and it's great to see it in easy to see pictures and descriptions/words. And you have pretty impressive hand skills!

[@FlyingPiesOmg]

your endocrinology videos are second to none, great job!

[@iSisiblog]

Thank you so much! Clear and easy to understand - I really loved it!

[@jasminmehrabi4117]

amazingly well explained, thank you!

[@angelarebelo166]

i had an eyegasm while watching this, also your accent is so good!! tysm for this, i search everywhere for a good video about calcium homeostasis and here i am. tysm for explaining it this way. also, the drawings, i loved them!! thank you thank you

[@dennis.zinner]

definitely very helpful for my upcoming nutritional physiology exam!

[@ritikasehrawat4767]

This video is super awesome
And has proved to be so much helpful to me.
Thanks for this video.

[@anaschreiner2568]

Thanks! Great quick review of physiology. Just what I was looking for.

[@fiza5403]

Honestly thought this was animated till looking closer, props to ur drawings and hard work

[@dr-asaa7445]

thanks aloooot ... you always help me on my medical study ..
thanks again

[@hawraaf6634]

THANK YOU for such an organized way
Really helpful!!

[@Partycornchips]

I just love this guys handwriting. It's so regular and consistent.

[@33bien]

yes he is great writer and draws beatifully

[@desifeminism4576]

Truuuuuuuu

[@rajeshreggie2396]

Thank you very much , after i watched this video i felt ur the best teacher who can ever exist. you made it soooooooo easy to understand

[@33bien]

Thank You! Finally a good explanation of the calcium system. I wonder why it is often claimed that one cannot feel when bone is decreasing or osteoporosis sets in. The acid that "eats" the bone due to the osteoclast activity must be painful. Acid/nerves=pain.

[@bushrakhalid7688]

This is so amazing, I don't know why I couldn't find it before, but it's really very helpful , Thank you 😊😊

[@AndiiiMa]

Thank you so much, your video is really helpful...keep up the good work

[@user-ld9dk6nd4m]

Brief, clear, and knowledgeable.
Keep up the good work.

[@annaso6747]

Beyond helpful!! Didn't realize I was a visual learner until I stumbled upon your videos and everything clicked into place! Thank you so much :))

[@ruigomesxp]

I mean, after watching so many of your videos I must thank you for all your effort to put this out there. I know that you get revenue from this and that all video images are outsourced from an artist that works in partnership with you, but that does not take any merit from it. Huge Thank you

[@abrahamkinsmanamoakoh4077]

Thank you so much for the presentation and more importantly having a camera focus on all the drawings and labels at the end of the presentation. It helps a lot

[@ubongumoren1856]

This is just too good! Thank you very much and keep it up!!

[@shivanagpal1163]

Sir no words in your praise....🙏
Thanks a lot😊

[@Unknown-ft6wz]

1 to 2 hours lecture in just 11 minutes...
Thanx a lot....🥰

[@zeshanansari8720]

Possible Correction: I may be wrong about this but after some researching, I found that C-FMS you mentioned on osteoclast is actually the gene that encodes CSFR-1 which is the receptor on osteoclast. If someone else could also research and confirm or deny this, that would be great! Thanks! Your videos are awesome!

[@himanshusisodiya6022]

I just cant tell how happy i m to find ur channel

[@suzieajayi8424]

Excellently put together.Well done

[@mahbubulalam2067]

U r just soo talented! I like your vedios very much. God bless u.

[@4488Elizabeth]

that was amazing. thanks so much for sharing.

[@Jjtt7]

just great work . thanks very much

[@leak7161]

Great video Armando, love your drawings as well !

[@danielcastilo1840]

great video ,thank you Armando.

[@alishka0109]

thank you for ur efforts

[@Lostpanda123]

Thank you sooo much for this great channel!!!

[@maisoonazzam8830]

Amazing diagram and explanation. Bless you 🙏

[@yogeshgondalia5676]

This video is a great way to recap physiology of Ca2+. Pictures help alot. Thanks!

[@johndytiapco7817]

OH MY GOD, I LOVE YOU DUDE, U MADE THIS CONCEPT SO EASY TO LEARN

[@lenepilegaard5132]

Thanks - again!!!! very good explanation

[@tilak231]

Came here for Rank Ligand actvt and did a quick review of The 3 hormones!! Thanks a lot! ✊

[@ibrahimjouni3458]

thanks, very informative. PTH also reduces phosphate reabsorption by the proximal tubule, resulting in an enhanced excretion of phosphate in urine.

[@jothikhanna7666]

good explanation...thank you armando

[@nisakutluay4931]

It could not be explained better than this 👏🏻

[@ravulanikhileshwari2204]

This video helped me a lot,thank you very much.

[@langeo.2383]

when he is more of an artist and a scientist combined in one human entity... Respect Boss...

[@titilayooluwatosin5891]

Thank you so much.

[@Ali_r1999]

Brilliant, that's very helpful. I appreciate you

[@khayyam3000]

Really enjoyed this video

[@LilibethPinto]

Excellent!! thanks!!

[@barbrauwaifo6941]

Everything about your videos are perfect

[@sarajohn1215]

Thank you for this video😭🙏🏻

[@ridaasif6324]

Great! :) Please explain rapid and slow action of calcium homeostasis as well

[@annamarie6712]

That was great!!! Thank you!

[@samuelbenson1]

Awesome! Better than any class in Medical School.

[@marwaalayoubi9370]

Thanks a bunch 🌷🌷 it helped a lot

[@__h629]

videos like this in youtube became my teachers in online class.. I shouldn't enroll in school 😂.. I should enroll in youtube😂

[@skyassil7689]

although my studies are in French but this explanation was very helpful.. Thank U Mr. Armando /big hi from Algeria :)/

[@Mohamed.Mahran2123]

thank you very much

[@christinakakoulli1783]

Thank you soo much, that was incredibly helpful

[@fatimamb6499]

So helpful ❤
Thank you so much .

[@mayo2708]

Buena clase, rápido y al grano

[@Deepaksharma-zu4tj]

GREAT WORK !!

[@vinysharma9597]

thank you so much sir... very helpful for me...

[@Mpf1012]

Great lecture!

[@BenjaminMoetlediwa]

Thank you sir

[@ademanou4708]

thank you man !
your videos are really helpful for us med students
keep up the good work 😁😁

[@aimz_med]

Thanks ... that was very clear

[@jtan1486]

very helpful ! thank you!

[@mohamadtarq1800]

this is so helpful man, thanks

[@ashitabhasin8434]

This video is amazing...i mean i was about to spend 3 hrs on this metabolism now with this video in just 20 min i gain all concept regarding ca metabolism ...thanks...thanks alot

[@anamikakumar4814]

this was soooo helpful thank you so much!!

[@cansuucar7898]

I can understand whats actually happening thanks to you. please upload more and more vidss

[@shahmirkhan8200]

Continue ur great work sir 🙂👍ur the best

[@5holycows]

Great video, thanks

[@sarahbrandao6028]

Perfect as usual.

[@nkalyankar5975]

you are simply superb !!!

[@emanhtth9830]

thanks soo much,am realy enjoyed

[@lauralucy1]

Absolutely fantastic! I get it!
Big thanks from Ireland ☘️👍🏻☘️

[@hannashapriyadarshini4893]

Awesome video!Thank you!!!!!

[@bunyigechacha5280]

A lot of Love from Kenya♥️🇰🇪

[@pippysmusic]

Thank you.

[@ManpreetKaur-wh6rw]

Tanks sir...without this vedio i can't to do anything....in my endocrinlogy thanks

[@pushkarnigupta9609]

Explanation was awesome along with drawing 👍👌

[@krutisavani4328]

thankyou so much man

[@mich12346]

You help me pass nursing school! Thank you

[@jlee9852]

WAHT AMAZING!THANKS!YOU ARE SO KNID!

[@farheenarifarif6784]

Great teacher

[@user-hy6xw4zi5k]

thank you

[@user-ld9dk6nd4m]

Nice work.
Keep on going.

[@Alhoussien_]

Thanks so much 💓

[@dorosfelix8369]

Thanks you so much

[@User-to7nb]

We owe you so much man

[@ramakrishnamurthyp2842]

Nice video ..thaku