Endocrinology | Synthesis of Thyroid Hormone

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  • Опубликовано: 5 окт 2024

Комментарии • 558

  • @fadihamati10
    @fadihamati10 5 лет назад +803

    18 dislikes are the school professors who are losing students to this guy... Your work is incredible man.

  • @LaurenLi
    @LaurenLi 3 года назад +486

    you've helped so many med students become doctors

  • @TheKristanoelle
    @TheKristanoelle 4 года назад +88

    when he explained t3 and t4 my head exploded. I literally yelled. I think all this studying is getting to me.

    • @AnjorinOmotola
      @AnjorinOmotola 3 года назад

      Me too!

    • @ferrislkpokpa7867
      @ferrislkpokpa7867 3 года назад

      You are right, that was my first time to understand that part of thyroid physiology. Wonderful Teacher!!!

  • @shreyaray5500
    @shreyaray5500 4 года назад +94

    Endocrinology used to be my least favorite part of physiology until I watched your videos. Thank you for everything!!

    • @timetraveler2yearsago758
      @timetraveler2yearsago758 4 года назад +4

      Do you know if a thyroid issue could be mistaken as diabetes? Type1.. some of the symptoms seem to be about the same for both.

    • @NanditaJali
      @NanditaJali 3 года назад +3

      OMG SAME! After learning from these, I topped my class

    • @aryan7767
      @aryan7767 2 года назад +1

      @@NanditaJali i want to quit

    • @NanditaJali
      @NanditaJali 2 года назад +1

      @@aryan7767 you wanna talk about it?

    • @aryan7767
      @aryan7767 2 года назад +1

      @@NanditaJali im so sorry for concerning you. no its my own laziness pls ignore me haha

  • @rpersonalemail9068
    @rpersonalemail9068 7 лет назад +136

    Once again the man delivers! You certainly put a magnifying glass and expound on it where textbooks and standard learning tools just gloss over it. Thank you very much Ninja Nerd

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  7 лет назад +37

      +Reynaldo PersonalEmail we are so happy to help! I am so glad that these videos are helping! It is our goal to help in anyway possible!

  • @lonelywanderer2467
    @lonelywanderer2467 6 лет назад +426

    Table of Contents
    0:00 Intro - Hypothalamic-Hypophyseal System.
    3:46 - TSH Effects & Thyroglobulin Synthesis.
    7:30 - Thyroglobulin and Iodide/Iodine.
    12:10 - Iodination Process.
    14:18 - Formation of T4 and T3.
    19:26 - Transportation of thyroid hormones.
    20:50 - Recap.

  • @mariya5480
    @mariya5480 Год назад +5

    Your ability to read complicated info, understand it, remember it and then explain it so well is beyond imaginable!!!! Amazing

  • @karansharma2449
    @karansharma2449 6 лет назад +203

    Nerd ninja you are God to Indian medical students
    Big love from India !!
    I personally want to meet you some day sir

    • @med8615
      @med8615 5 лет назад +50

      I guess 10 millions gods werent enough for yall

    • @pavankumaraakash
      @pavankumaraakash 5 лет назад +8

      @@med8615 yet following any gods would give the same vision! : Do justice nd u'll get the same !

    • @aquarius19.99
      @aquarius19.99 5 лет назад +6

      I get it you apreciate him hes really good at wht he does but he doesnt replace god and he is not a god he is just human

    • @sureshpottimurthy1421
      @sureshpottimurthy1421 5 лет назад +5

      God is there with in every creature

    • @mannasharma8220
      @mannasharma8220 4 года назад +4

      Usama N
      A man with a name OSAMA shouldn’t talk about god atleast😂

  • @joshuaospina5968
    @joshuaospina5968 6 лет назад +81

    Your videos are PHENOMENAL! You've got a great teaching style, keep the videos coming!

  • @shariffakassam3773
    @shariffakassam3773 5 лет назад +55

    Seriously, you do not understand how many times you've saved me and I'm only halfway through my degree....

  • @vinayakkapatral4246
    @vinayakkapatral4246 3 года назад +13

    Zach you are making me go to medical school..... as a genomics scientist and ever wanting to learn, I am so happy to have found your incredible lectures!!!
    Simply the best!

  • @brendoncollins5887
    @brendoncollins5887 3 года назад +5

    A Young man, who really knows his subject, I am a therapist, and live to study this stuff, but, this guy is incredible, what a brain he has, live people like him who know their subject.

  • @ramlaabucar5790
    @ramlaabucar5790 5 лет назад +187

    "T peroxidase kicks iodine so hard it knocks an electron out of him" lol that's a good way to remember it

    • @afaqniaz5740
      @afaqniaz5740 4 года назад +7

      He is an amazing teacher genius

    • @shanks7522
      @shanks7522 4 года назад +2

      Lmao yesss

    • @ofennwu
      @ofennwu 2 года назад

      Dude, thats literally the golden commentary ever

    • @asiakhatoon1079
      @asiakhatoon1079 2 года назад

      🤣🤣🤣

    • @alexhema9147
      @alexhema9147 Год назад

      😂😂😂😂😂😂😂

  • @emmazblewski7837
    @emmazblewski7837 Год назад +4

    honestly can't emphasize enough how much I appreciate your work

  • @niteshsah7259
    @niteshsah7259 4 года назад +9

    How many times are you going to win the only heart I have. This guy is really a god gift for medical students around the globe. Huge Respect and love from Germany :)

  • @VivekSingh-nc4px
    @VivekSingh-nc4px 5 лет назад +21

    Much love and respect to you. Thank you. I feel like crying right now because you explained it so well!

  • @debbiejacobs5678
    @debbiejacobs5678 4 года назад +9

    Thank you so much for taking dry, complicated subjects and bringing them to life so that they are understandable! I'm so glad I found your channel!

  • @skhan5086
    @skhan5086 2 года назад +5

    Thank you so much sir........you did help me to score the highest marks ❤️❤️❤️❤️

  • @luziqa4046
    @luziqa4046 6 лет назад +29

    you are so power brooooooo!!! this video is very very helpful ! i'm so glad that i found it .

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  6 лет назад +7

      Thank you so much! And if you could share with friends that would be appreciated!

  • @meronwoldu6711
    @meronwoldu6711 6 лет назад +7

    my GOD!!you have no idea how much i love you! you always save my grades!! good job and i hope you never stop teaching us!!

  • @sanchitasharma272
    @sanchitasharma272 2 года назад +2

    My sir taught me this 3 times but still i used to forget this concept and you taught me only once and now i remember forever 🙏 Thankyou

  • @janaabhilash4577
    @janaabhilash4577 5 месяцев назад +1

    Sir.... actually you are the world's best teacher i had ever seen....thank you sooo much sir❤lots of love from india 🇮🇳

  • @noonereallymattersbutcats9674
    @noonereallymattersbutcats9674 5 лет назад +4

    I just survived thyroid storm, I'm still at home recovering from it, after being the hospital for a long time... enjoying watching your videos so I can understand this better.. I had no idea I even had a overactive thyroid and I go to docs , they just never tested it..

  • @victoriarahbine583
    @victoriarahbine583 6 лет назад +27

    You seriously deserve so much more credit then you are given! I love your videos please don't stop making them lol

  • @KathrynFeatherston
    @KathrynFeatherston Год назад +2

    I’m relatively new on this channel and I’m finding it a terrific resource in learning the things I need to know. I have Panhypopituitarism, have had it for over twenty years but I’m still learning all of the factors involved in maintaining one’s life when one’s pituitary gland is basically nonexistent. Thank you so much for helping me to understand as much as possible regarding my medical plight! Best regards from Kathryn Featherston 😊🎓☺️🧠

  • @roua11
    @roua11 2 года назад +1

    You are seriously the BEST to ever exist and to ever TEACH, not one university professor compares. Lots of love!!!!!🙌🏽

  • @Frankincense_
    @Frankincense_ 2 года назад +2

    The most amazing RUclips video I've seen all year. Thankyou for producing it. It's most helpful in explaining and incredibly complex.

  • @TheCKTom
    @TheCKTom 5 лет назад +7

    The numbered recap at the end was super helpful in organizing the main bullet points. Thanks for all your amazing work! Because of you, medical school isn't just about memorizing anymore. You're the man! Also I saw you wear some UH gear in one of your videos, go Warriors!!

  • @LAisyourgirl
    @LAisyourgirl 5 лет назад +3

    This video is so amazing!! You go into all the wonderful details without making it overwhelming. I’m currently reviewing for my vet school finals and this was pure perfection.

  • @texasgirl519
    @texasgirl519 5 лет назад +1

    This video was AMAZING. My professor's notes are so scattered, we never know where he stops one section and begins the next. THANK YOU for putting this together so well!!!

  • @hoolia4987
    @hoolia4987 4 года назад +4

    15:33 I literally gasped 😲
    Understanding T3 & T4 🤓
    Thank you ☺

    • @carolynreynolds4999
      @carolynreynolds4999 3 года назад

      Me too! Not where I was expecting things to go. So cool!!

  • @juancamposolcina5430
    @juancamposolcina5430 3 года назад +1

    You are a life saver! The way my lecturers explained it never seemed to make sense to me. The way you go through the whole process step by step is super helpful. Now I now how to T4 and T3 are synthesised and I'm confident for my exam. Thank you!

  • @deziangel91
    @deziangel91 4 года назад +5

    When you came to the coupling part, I died, this is gold. THANK YOU!

  • @vusalaliyev5880
    @vusalaliyev5880 Год назад +1

    Dear Dr Zach, your teaching styles are so awesome! I’d already wacthed entire of Biochemistry, Microbiology, İmmunology, Cell Biology sections, and currently on in Physology. You and your team doing a great job! Keep going on!

  • @kittylove199
    @kittylove199 5 лет назад +3

    oh my god, you are AMAZING. I'm new to your channel. I am currently studying endocrinology for my physiology class, and you are a lifesaver! My prof's notes are so vague, and he talks so fast during lectures that it is hard to write down all the extra information he says to clarify the notes. But your videos, really help to fill in those missing gaps that are in the notes my prof posted. I am officially not scared of my final exam anymore. I subscribed. Thank you so much, you have made my day!!

  • @dalyaaldalawii6586
    @dalyaaldalawii6586 6 лет назад +3

    BIG thanks from iraq 🇮🇶 you really help me in my post graduate medical career , keep going on dear and may God bless you dear.

    • @alexhema9147
      @alexhema9147 3 месяца назад

      انشالله تخرجتي ؟

  • @agarcia3017
    @agarcia3017 4 месяца назад

    Sir, you deserve a medal of honor. I'm screaming thank you!!!!

  • @iandavedelgado3322
    @iandavedelgado3322 4 года назад +1

    This man explained his topic passionately with humility. Thank you so much for creating good techniques. 👏

  • @malikalihaider2696
    @malikalihaider2696 3 года назад +2

    I have no words how to appreciate your effort.Really mind blowing Sir.Thank You so Much.

  • @WelshwildGem
    @WelshwildGem 3 года назад

    Literally every topic I start I come here for your video’s, reading alone I can’t absorb but I watch your videos and it all clicks into place, thank you for helping me pass my degree, I don’t think I could do it without you💓

  • @123wingtsun
    @123wingtsun 3 года назад

    This is pure gold - Read my physiology book and didn´t understand much - untill i watched this video. Now the books is easily understood!
    Thank you very much - and please - please - never stop making these videos!

  • @katelyncomella4541
    @katelyncomella4541 3 года назад +1

    currently in an accelerated program and your 30 minute lesson is 10000000x better than the doctor's 3 hr lecture.

  • @monicapuentes9258
    @monicapuentes9258 2 года назад +1

    I love your videos!! I appreciate them so much!! Thank you so much !! YOU ARE SAVING MY LIFE !!

  • @ferrislkpokpa7867
    @ferrislkpokpa7867 3 года назад

    This guy is just unique in his explanations. He is a professor of the age! No match yet!!

  • @hellomonday4427
    @hellomonday4427 Год назад +2

    What an amazing lecture! Thank you so much Ninja Nerd ❤ You help me a lot

  • @jesserios861
    @jesserios861 Год назад +1

    For those wondering what the Transcription Factor protein is at 5:04 , its Thyroid Specific Transcription Factor-1 (TTF-1)

  • @lucasmofokeng6670
    @lucasmofokeng6670 5 лет назад +4

    @ Ninja Nerd Science, during coupling process of iodothyronine residues @ 16:15.. MIT+DIT is a reverse T3 of which is biologically inactive. The only Active T3 (Triiodothyronine) coupling residues is DIT+MIT. Thank You.

    • @KingRockets
      @KingRockets 5 лет назад

      DIT can bind to MIT or DIT, but can you get MIT binding with another MIT? T2 hormone?

  • @anandsingh4071
    @anandsingh4071 6 лет назад +5

    excellent video...u forgot to mention endocytosis of colloid is done by megalin protien...

  • @mohammadjibawi1216
    @mohammadjibawi1216 4 года назад +5

    Is it possible to upload a photo of the board with all of the drawings? you guys are amazing, I appreciate all of the work you put

  • @garygu7999
    @garygu7999 2 года назад

    You are the best medicine teacher in the world! I'm a med student from China. You are my superman!!!🥰😍😍

  • @vngfmcgvnb
    @vngfmcgvnb 10 месяцев назад

    Every time I watch a video of this guy, I thank God for making me learn English (I'm from Brazil)

  • @2YKSS2N
    @2YKSS2N 7 месяцев назад

    thank you for sticking through the whole process of making this video

  • @teambahaymanila5014
    @teambahaymanila5014 4 года назад

    Thank you for these videos. You don't know how many times your videos actually saved me from flunking my previous semester, I have seen your videos from biochemistry up to here. Thank you for your hard work!
    Sincerely,
    A Struggling Med Student.

  • @christianeseemann6123
    @christianeseemann6123 3 года назад +2

    This was very satisfying to watch to re-run-through in a more focused break-down

  • @sephieliz9110
    @sephieliz9110 5 лет назад

    This makes studying Pharmacology easy! I'm currently cramming for a big presentation and don't know what I would do without your videos.

  • @MyNameisDianaa
    @MyNameisDianaa 4 года назад +1

    i cannot believe how amazing this is! Thank you Sir! Incredible work!!

  • @me..7885
    @me..7885 2 года назад

    You have alot in the ball ...I can't get over how much your vedioes are helping me ...

  • @JasonfromEarth
    @JasonfromEarth 4 года назад +1

    I have Panhypopituitarism. I've always seen T4 on my bloodwork but never knew what it really meant. This video was incredibly informative!

  • @drewzzyd
    @drewzzyd 9 месяцев назад +7

    i have endocrinology exam in 2 days. I'll come back here to check my score goddawnnmmm

    • @aleenakhalid1183
      @aleenakhalid1183 3 месяца назад

      How did it gooo

    • @drewzzyd
      @drewzzyd 3 месяца назад

      @@aleenakhalid1183 oh i totally forgot about this it wasn't so good :// i got 58%

    • @aleenakhalid1183
      @aleenakhalid1183 3 месяца назад

      @@drewzzyd that's okey buddy. U did well:>

  • @Arunverma-rb1ci
    @Arunverma-rb1ci 2 года назад +1

    Absolutely awesome man... Huge respect for you man the way you teach is just amazing..... Lots of love to you from India🇮🇳

  • @amindz5592
    @amindz5592 4 года назад

    Tanks from algeria eventhough our médical studies are done with french language
    Your lessons are much better realy you are a great men

  • @josezavaley7684
    @josezavaley7684 11 месяцев назад

    props for the camera guy who always follows your movements! love u guys

  • @austinguria5349
    @austinguria5349 3 года назад

    Nerd Ninja you're absolutely a blessing to Med students . Fan here from Papua New Guinea 🇵🇬

  • @Redheadedlady55
    @Redheadedlady55 3 года назад

    ~You are amazing...getting your point across in the simplest way possible....YOU should or maybe you already are an instructor....thank you sooooo-much for everything young man. Teaching is your gift.

  • @kandacepereira795
    @kandacepereira795 2 года назад

    so good thank you ....saving my life as a pharmacy student.. honestly professors do not even explain they just sent a crap ppt and called it a day

  • @marionleprieur9332
    @marionleprieur9332 2 года назад

    I just discover this channel and I am so grateful for this quality content and those brilliant mind ! Thank you !

  • @alinazary20
    @alinazary20 4 года назад +1

    thanks for your complete explanation, I wish if it's possible for you when you finish explaining to let the camera guy to film only the whiteboard you explained on, so we can take a screenshot and use it to revise later, thank you so much

  • @kalyan5612
    @kalyan5612 Год назад

    Pharmacy student here, great video thanks for the help Ninja Nerds.

  • @trendfansclub4341
    @trendfansclub4341 Год назад

    You deserve an award for helping many medical students 🙌🏻 excellent

  • @gammmm6814
    @gammmm6814 2 года назад +1

    Omg you’re amazing. I was about to give up on endocrine

  • @sudheekshag8257
    @sudheekshag8257 Год назад

    If not you some of us would have really failed to become good doctors, you really doing a great job!!!

  • @maureengreer543
    @maureengreer543 4 года назад

    Sir, you my respect. I hope your personal life and character are as excellent as your teaching ability and knowledge. Good work

  • @budoor-km7jk
    @budoor-km7jk Год назад

    I repeated the video twice to stuck the information ,huge thinks for your effort 💜💜الله يجزاك خيررر

  • @kpezo
    @kpezo 6 лет назад +3

    I am in love with your videos!!! You are magnificent!!! Thank you so much for helping me understand better all these topics!!! Your the man!!!

  • @mansirajyaguru9478
    @mansirajyaguru9478 2 года назад

    Sir, I am a fan of your teaching...You explain complex things so simply it's amazing...Thanks for making these videos, please make more of these videos.

  • @mehedihasanakib3489
    @mehedihasanakib3489 Год назад

    i just understood it within 10 min after watching THIS my whole conception got cleared

  • @viratkohli5367
    @viratkohli5367 2 года назад

    Thanks Zach,u are helping millions of mbbs students to get graduated easily.

  • @rabiyatariq4533
    @rabiyatariq4533 3 года назад

    You are certainly teh best teacher of Biology... I always get here when something irks :) God Bless You

  • @josetrujillo738
    @josetrujillo738 3 года назад +1

    Thank You Zach! Thank You Ninja Nerd Science!

  • @okikagu553
    @okikagu553 3 года назад

    Don't stop teaching please huhu I love your methods of putting things to perspective. Superb. Thank you

  • @michaelaorincakova5392
    @michaelaorincakova5392 5 лет назад +6

    you're soooo talented, I'm in love with your videos, thank you so much for them !! :)

  • @zarafindlay2488
    @zarafindlay2488 3 года назад

    was so confused by my lectures but this is so clear and I'm actually interested!! thank you so much cant wait to watch more in the future!

  • @summergirl198
    @summergirl198 2 года назад

    Wow, you are amazingly smart. Thank you for teaching this. You make it so much easier to understand

  • @MukashfiNaiemAbdAllah
    @MukashfiNaiemAbdAllah 6 лет назад +2

    This channel is a treasure

  • @ayeshapatel461
    @ayeshapatel461 2 года назад +2

    That's a great experience! Feels like really synthesizing such hormone! 😄💫

  • @kevinhall2722
    @kevinhall2722 Год назад

    My continued survival of med school is dependent on these videos. Thank you

  • @nehalfarid7375
    @nehalfarid7375 4 года назад

    you made that complicated mechanism perfectly EASY! Thank you

  • @trianasalgadom5210
    @trianasalgadom5210 10 месяцев назад

    Your videos are awesome, you just make things so clear and easy to understand, Thaaank you!!

  • @perrykay353
    @perrykay353 2 года назад

    The smile that lit up my face when it all made sense. What a beautiful romance between T3 & T4, I guess the T.P.O is the matchmaker.

  • @kcruales9888
    @kcruales9888 3 года назад

    I can listen to these discussions all day even i don't remember anything

  • @sonjaelyandouzi5824
    @sonjaelyandouzi5824 3 года назад

    My students have told me about your lectures today. Wow this is inspiring!

  • @abdullahibrahim8938
    @abdullahibrahim8938 5 лет назад

    I have a small correction for a very small mistake in the video
    After the cleavage of T4 and T3 from thyroglobulin, T4 and T3 won't have a vesicle around them, because they actually lipid soluble, so they will just diffuse from the thyroglobulin vesicle (which is made primarily from lipid) to the cytosol, then they will diffuse also through the cell membrane to the bloodstream.
    Thanks so much for your videos they are really helpful.

  • @mycah1993
    @mycah1993 4 года назад

    I am starting to love endocrinology because of you. Thank you so much!!!!

  • @jaimaheshwari7980
    @jaimaheshwari7980 3 года назад

    You are really the coolest teacher ever. Thanks for making medicine so much fun. So much love and best wishes.

  • @kidneyking7109
    @kidneyking7109 2 года назад

    You are a true KING of biochemistry, thanks so much !!! you make med school more fun ;-)

  • @mybookismylife.2798
    @mybookismylife.2798 3 года назад +1

    U r amazing...very talented smart guy..lots of love n blessings to you from Nepal 👍🙏

  • @توكلتعلىالله-ك7ي

    Your explanation is incredible man...I need you in my college😢 .. all respect to you❤❤

  • @dborisov23
    @dborisov23 8 месяцев назад

    Man I wish RUclips and this guy was available when I went to nursing school in 2011…

  • @oneaboveall5357
    @oneaboveall5357 3 года назад +1

    But great man....u really are awesome.....these diagramatic study is really helpful for revision and learning

  • @stewste4316
    @stewste4316 3 года назад

    This channel is the best one ever !! You explain it so clearly, drawing it all is so helpful too