You always think ahead in your teaching in a way that both reinforces the material but also makes it matter conceptually. For that, you are the best teacher I have ever had
I SO wish youtube was a thing when i was in undergrad for biochem. This would have been SO helpful. Your michaelis menten videos would have been nirvana when we were deriving it in biophysics in grad school. Its obvious that u love this 👍🏻 but i still want to thank you for all your hard work.
I have watched these from step 1 and i must say- you are gifted!!!!!!!! thank you so much. Your way of explaining will help me understand and remember it quicker!
wow..... simply amazing! I hear you are in Med School now-- the best of luck to you! You have helped out so many students- you truly are a gift. You are going to be an incredible doctor.
The best and most efficient lecturer out of all professors on planet earth. Thank you for existing. I love you ; the only time I'll ever say I love you to a stranger.
Thank you so much, you're a great teacher I've been watching your videos for 3 years now and I found them more and more helpful every single time!! God bless you
I think he made a slight mistake at 6:43 when he was comparing the reactivity between the reactants and the substrate. I believe he meant to say that the question we need to ask ourselves is: "Why is 2-phosphoglycerate more reactive than 3-phosphoglycerate?"; which I believe he answers correctly (the two negative charges are closer on the 3-phosphoglycerate than the 2-phosphoglycerate thereby rendering repulsion and increased in reactivity. Please correct me if I'm wrong.
thanks, its really great and helpful, is it possible to have a file or picture of the white board? i mean the notes which yhave wrote in board? thanks again
I always wait for the moment in which he moves to the right (his left) because he does not appear in the video. Then I take a screenshot. It always works for me, maybe it could help you :)
although this part of the reaction is endergonic. what makes the reaction move forward? is It because of the tautomerization? when the enol transforms to the ketone?
THANK YOU! i just want to make sure. In step 10 where PEP is transformed into pyruvate my text book says its an irreversible reaction where in this video its says otherwise? why so?
Why does adding a double bond to 2-phosphoglycerate (forming phosphoenolpyruvate) make the molecule more unstable and thus more likely to donate the phosphoryl group to ADP? Is it because the increased steric hinderance of a double bond?
if 2pg is less stable than 3pg, then why (or how) does the reaction take place... i mean, i get it that we need a less stable molecule for the next step but energeticly how does this leas favorite reaction takes place
video 6/57, 6:45 it kind a confuse me, when you asked the question you said " why is 3, phosphoglyercerate is high energy"? then you proved 2, phosphoglycerate is high energy and more reactive. thank you for these videos
You have replaced khan academy for me. I can't stand the way Sal Khan talks, or how messy his illustrations are. Your boards make my little type A heart sing
YOU ARE LITERALLY MY SAVIOR!!!😭😭 thank you for existing! Medschool wouldn’t be the same without you!! Now everything finally makes sense
I love how you just get straight to the point. No cute analogies or metaphors.
I made an account just to thank you. Videos are amazing.
I think I love you. I have been learning this in some class or another for 6 years now and it has never made so much sense!
Though it’s out of the scope I need, I think your explanation of 2,3-BPG’s purpose is the most clear I have ever heard it. Thank you for this!
You always think ahead in your teaching in a way that both reinforces the material but also makes it matter conceptually. For that, you are the best teacher I have ever had
I SO wish youtube was a thing when i was in undergrad for biochem. This would have been SO helpful. Your michaelis menten videos would have been nirvana when we were deriving it in biophysics in grad school. Its obvious that u love this 👍🏻 but i still want to thank you for all your hard work.
I love you. You make so much more sense and thank you for a thorough explanation!
I have watched these from step 1 and i must say- you are gifted!!!!!!!! thank you so much. Your way of explaining will help me understand and remember it quicker!
wow..... simply amazing! I hear you are in Med School now-- the best of luck to you! You have helped out so many students- you truly are a gift. You are going to be an incredible doctor.
The best and most efficient lecturer out of all professors on planet earth. Thank you for existing. I love you ; the only time I'll ever say I love you to a stranger.
Thank you so much, you're a great teacher I've been watching your videos for 3 years now and I found them more and more helpful every single time!! God bless you
I think he made a slight mistake at 6:43 when he was comparing the reactivity between the reactants and the substrate. I believe he meant to say that the question we need to ask ourselves is: "Why is 2-phosphoglycerate more reactive than 3-phosphoglycerate?"; which I believe he answers correctly (the two negative charges are closer on the 3-phosphoglycerate than the 2-phosphoglycerate thereby rendering repulsion and increased in reactivity. Please correct me if I'm wrong.
yep, I noticed that as well
thank you for your detailed explanation!!!!! i really hope that you are really my lecturer!!!
Thank you. This is amazing.
u r amazing!!u saved my life!!
Thank you. This video helps a lot your videos are amazing.
You are an amazing teacher.
Excellent 👌 presentation
This channel is fantastic
Fantastic explanations thank you
YOU. ARE. THE. BEST.
Thank you so much sir you are beyond amazing
U are really great ❤
you're my hero
big WoW, you are an amazing guy
BEAST!
you are amazingly excelent
thank you so much
thanks, its really great and helpful, is it possible to have a file or picture of the white board? i mean the notes which yhave wrote in board? thanks again
I always wait for the moment in which he moves to the right (his left) because he does not appear in the video. Then I take a screenshot. It always works for me, maybe it could help you :)
although this part of the reaction is endergonic. what makes the reaction move forward?
is It because of the tautomerization? when the enol transforms to the ketone?
Hello! Wanted to say something..."the substance is awesome". I also want to know any technique you use before a lecture of that magnitude.
THANK YOU! i just want to make sure.
In step 10 where PEP is transformed into pyruvate my text book says its an irreversible reaction where in this video its says otherwise? why so?
thank you sir.
merci bien. your lectures are amazing
+Peter Ridge thanks again!
Well explained
the best
Thanks dad
I don't understand which can be called phosphoglycerate mutase. Is it enzyme-his-phosphate or 2,3 BPG?
Why does adding a double bond to 2-phosphoglycerate (forming phosphoenolpyruvate) make the molecule more unstable and thus more likely to donate the phosphoryl group to ADP? Is it because the increased steric hinderance of a double bond?
Isn't pyruvate kinase catalyzed reaction irreversible?
how does the 2,3-BPG exit the cell to allosterically inhibit hemoglobin in the blood vessles?
+vikipoyta 2,3-BPG stabilizes the tense state of Hemoglobin and therefore decreases Hemoglobin's affinity for Oxygen
If all my university professors taught like this, I could finish med school in 3 years instead of 6
In last step H+ from where it comes
you are a fucking god mate
if 2pg is less stable than 3pg, then why (or how) does the reaction take place...
i mean, i get it that we need a less stable molecule for the next step but energeticly how does this leas favorite reaction takes place
2pg is rapidly removed fr the next step of glycolysis which keeps the product conc less and hence mass action ration drives the reaction forword
video 6/57, 6:45 it kind a confuse me, when you asked the question you said " why is 3, phosphoglyercerate is high energy"? then you proved 2, phosphoglycerate is high energy and more reactive. thank you for these videos
Haha, probably didnt notice it but he tells you why its more reactive, so he accidently said that.
so 2-phosphoglycerate is the more reactive right? because the repulsion makes it unstable and high in energy
yes, that is what i see. good luck with biochemistry
حدا بعرف متى كويز مامون
Meanwhile, fatty acid metabolism rides by (right to left) on its bicycle.
And this all happens billions of times throughout your body in a fraction of a second. So don't waste it, use it.
hi, i love you, bye.
You have replaced khan academy for me. I can't stand the way Sal Khan talks, or how messy his illustrations are. Your boards make my little type A heart sing
thank you for your detailed explanation!!!!! i really hope that you are really my lecturer!!!
thank you for your detailed explanation!!!!! i really hope that you are really my lecturer!!!
thank you for your detailed explanation!!!!! i really hope that you are really my lecturer!!!