Antisense RNA Technology

Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology.
Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell.
Watch this video lecture to understand the mechanism behind the antisense RNA technology as an genome editing tool.
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Thank you for watching the video lecture on Antisense RNA Technology.

[@hassanbangash3303]

excellent and simplest way of demonstrating. goooooood

[@froglegs4910]

very good lecture ! good work !
thanks Lot !

[@rachanasomaiya8032]

Great video. Thanks

[@rajdeepchakraborty9669]

Wow...!I can't say what I feel after watching this video...Just amazing...

[@shomusbiologyofficial]

Thank you

[@kirancu4713]

Sir thank you very much, I have an exam day after tomorrow it's very informative but I want to know about what the role of this technology in target discovery and target validation and I request you to make a video on this plssss.

[@krishnabaruah7185]

Very useful...thnku sir..

[@varshavarsha1302]

Mind blowing sir , this topic is completely set in my mind

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@amrithacs4708]

excellent sir....

[@jojoyaz90]

Thank youu.

[@mayukhroy5393]

This video was truly helpful Sir.

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@gregorychileshe5955]

Thanks a lot for the lesson. Superb indeed.

[@shomusbiologyofficial]

You're welcome

[@sajalmishra2872]

great video sir
sir plz make a video on C4 cycle

[@voskarin]

thanks for this :)

[@harshalidhaygude1212]

sir plz make video on different models of dissolution kinetics

[@lakshmanchandru6905]

Excellent explanation with clarity👏

[@shomusbiologyofficial]

Thank you

[@ANANDCHOUDHARY143]

Helpful.... thank you sir 😊

[@shomusbiologyofficial]

You're welcome

[@rameshkandagatla738]

I don't understand in every lecture many of them will say excellent, super, very good.
I have a few questions on Gene silencing.
(i) What is the role of retroviruses and transposons and heterochromatin in gene silencing.
(ii) How nematode specific gene is cloned in tobacco plant.
(iii) Would nematode parasite release its m-RNA into host cytoplasm such that host plant with cloned gene produce antisense RNA that base pair with Nematode m - RNA, Explain the process.
(iv) How both sense and antisense RNA are produced in tobacco plant cloned with nematode specific gene.
(v) How cDNA produce antisense RNA.

[@karishmafirdosh8681]

Ur vdeo helped me a lot today in my project

[@shomusbiologyofficial]

You're welcome

[@patelmahira8040]

Thank you so much sir

[@shomusbiologyofficial]

You're welcome

[@pratikshakshirsagar8315]

Sir I am having a doubt in one of the part, where u said RNase H is used to break the mRNA but RNase H is only degrading the RNA which is in hybrid form i.e. with RNA: DNA hybrid.

[@esakkimuthuk4382]

thanks for this video siir

[@shomusbiologyofficial]

You're welcome

[@Sabavaishu]

Thank you Sir 🙏❤️

[@shomusbiologyofficial]

You're welcome

[@srisurya9744]

Super teaching sir....

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@lovlyms6385]

wonderful video , very interesting thank you.................

[@abhijith_jain]

Hi, can Ataxia Telangiectasia be treated with antisense oligonucleotide gene therapy ?

[@syedaafsananushrat2795]

Thanks a lot brother.

[@shomusbiologyofficial]

Thank you

[@avisheksarkar1328]

Sir,Your videos helped me to complete graduation......love and respect from Bangladesh

[@shomusbiologyofficial]

Thabk you. Glad you liked it and

[@rashmiaryabev7504]

sir will you plzzzzz upload the vedio on Ribozymes. its my request sir plzzzzz

[@bharatsahu1050]

Sir pls suggest any book for this topic

[@abdullahyounas3322]

very good explanation but I have a question, as y said that anti scence RNA is complementary to targeted mRNA , then how can this blocked the translation instead of regulating. Is there any special difference between complementary Antiscence and mutated one.

[@Triology003]

According to this simple technique If the complementary RNA attachs on targeted RNA it will take help from RNAse H enzyme and it will break down the Targeted mRNA and we 'll get rid of all mrnase nd there will be no chance of production of protein

[@shravyaburra6262]

I want post transcription modifications detailed plz

[@shomusbiologyofficial]

Will post it soon.

[@jigyasasharma8379]

Why does rnase h does not degrade the antisense RNA and only the targetted RNA?

[@ranujain311]

Sir, dna sequencing antisense ??

[@ankitchauhan3698]

My father is suffering from ALS😞pls pray for him🙏

[@korrabhaskar4723]

Don't worry man he will be fine soon 😊

[@yashisrivastava8833]

Sir your videos are just perfect but there's slight problem with the sound. It's really very low

[@shomusbiologyofficial]

Sound is fixed later

[@sudarshanreddy5115]

Tq sir

[@shomusbiologyofficial]

You're welcome

[@diyanaskar7610]

Khoob bhalo sir

[@shomusbiologyofficial]

Dhonyobaad

[@diyanaskar7610]

@@shomusbiologyofficial sir aapnar video dekhe 11th,12th,Bsc paash korlam or ekhun MSC te oo podchi

[@klam77]

Thank you Shomu. One Question: since the original bad DNA sequence remains in place in the body, it will continue it's propensity to create the "bad" mRNA, so one has to continue to take the anti-sense therapy FOR LIFE?

[@jeffbrannon1757]

While I'm not the gentleman, I know some about this. You are correct. However, there are upsides to short duration therapies. If a mistake is made, or if the side effects are greater than the symptoms of the disease, you can quickly halt the therapy and revert to former physiology. RNA therapy is also very tunable; assuming effective, consistent transport into the cell you will have a predictable, concentration/does based effect.

[@klam77]

@@jeffbrannon1757 it's all very interesting stuff. Some time bakc i was think of the monoclonal antibody market! it's huge. RNA vax technology can 100% disrupt that market! rather than taking antibodies therapeutically, every day, one can get an RNA "vax" to use your body to generate the antibodies! however, covid has shown that even that is not a long term therapy, you need to take it again every 4 months.

[@vijetakatoch54]

🙌

[@ShakespeareCafe]

Morpholinos

[@augustgene5732]

Antisense creates a single strand of DNA. Not RNA, that is how the RNase H works. As it recgonizes the hybrid of DNA & RNA. It does break down the RNA, but it is a single strand of DNA, not RNA.

[@augustgene5732]

I created a new treatment concept for DMD/Beckers, I am presenting it at the NORD Rare Disease Conference in Washington D.C. next week. AON technology is a part of my treatment concept.

[@augustgene5732]

I do love your videos, and have learned a lot from you. So thank you.

[@Sumairah10]

Yes u r absolutely right@August Gene.

[@rishikabudakoti2161]

who is here in 2022?