Renin production in the kidneys | Renal system physiology | NCLEX-RN | Khan Academy

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  • Опубликовано: 17 сен 2012
  • Learn the three major triggers for Renin production by the Juxtaglomerular cells. Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai.
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Комментарии • 81

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +9

    You're very welcome. Happy new year!

  • @tshoganyetsomotete747
    @tshoganyetsomotete747 4 года назад +3

    8years later I still find the video helpful, thank you very much. Sending love from South Africa

  • @shrey381
    @shrey381 11 лет назад +5

    To reduce the complexity of any problem to the simplest understanding is an art ,thank you so much for the effort you put in these videos

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +8

    Renin is a protein (made of amino acids) and an enzyme (it helps to catalyze reactions such as the cleavage of another protein) and a hormone (it is released from one cell and acts at a distant location). These are all different descriptions that apply to Renin equally well.

  • @youssefrefaat1594
    @youssefrefaat1594 6 лет назад +6

    Finally, I understood it! Thank you very much, sir! I wish you were my teacher

  • @languageandmana9255
    @languageandmana9255 Год назад +2

    Wow! Your voice a is so cool and you teach incredibly well! ✨
    I'm so happy that this amazing channel is free and I can't thank you enough for being here and helping students like me who can't afford even low membership fees.
    Please don't forget people like me and continue to make FREE contents as you are amazing at explaining things and making the most informative short videos! ✨❤🙏

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +2

    Hypervolemia with Hyponatremia sounds like an SIADH type syndrome. In SIADH, GFR is high so there will be a naturesis (ANP plays a role in this). High sodium levels in the filtrate means that the macula densa will not be triggering renin release.

  • @alkanpiano
    @alkanpiano 11 лет назад +2

    What an understandable video this is!! I study physiology of kidney now. Thank you!

  • @carmendupote8333
    @carmendupote8333 8 лет назад

    you are just amazing!!!!!!!
    thank you for all what you do

  • @peenleib
    @peenleib 10 лет назад

    this is brilliant!

  • @nizmiponery8146
    @nizmiponery8146 6 лет назад

    Wonderful detailing. Thank you very much.

  • @hannahwelsh9263
    @hannahwelsh9263 4 года назад

    Thank you, very helpful. Love watching your videos

  • @hlingdh
    @hlingdh 10 лет назад

    love ur videos, thank you ^^

  • @kuckimonster2
    @kuckimonster2 11 лет назад

    EXCELLENT!

  • @zakeriaabdi
    @zakeriaabdi 8 лет назад +8

    In case anyone is wondering the sympathetic receptors are B1 receptors. Rest of the detail in this vid is perfect.

    • @jayraymond9707
      @jayraymond9707 4 года назад

      Zakeria A direct cardiac effects/response is what you’re saying?

  • @HafizahHoshni
    @HafizahHoshni 8 лет назад +1

    thanks!

  • @dr.shaikatroy8651
    @dr.shaikatroy8651 8 лет назад +1

    itz awesome.... thanx :)

  • @saintz2k7
    @saintz2k7 10 лет назад +7

    Amazing video, I wasn't too sure when people other than Sal make khan academy videos, but you nailed it

  • @dhrushyarajput2606
    @dhrushyarajput2606 3 месяца назад

    Thank youuuuu sooo muchhhhhhh

  • @nyawirawaithaka4993
    @nyawirawaithaka4993 5 лет назад

    Thank you!

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +1

    I'm glad you found it helpful!

  • @nellyhoffman6194
    @nellyhoffman6194 8 лет назад

    This is awesome bro

  • @user-mz3dz5ux9h
    @user-mz3dz5ux9h 4 года назад

    Thanks a lot for this clearful explanation but I hope you make 3 separated videos each one is for one trigger of renin release ...thanks again

  • @Elheln
    @Elheln 10 лет назад +4

    Thank you so much!
    Please, do not stop doing this, you are awesome! This was so helpfull!

  • @otakudnp3880
    @otakudnp3880 7 лет назад

    wow awesome man

  • @akashhera
    @akashhera 4 года назад

    The explanation is excellent!

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +2

    The Macula Densa senses LOW sodium levels in the filtrate/urine. Low sodium means low GFR (sodium is being reabsorbed easily with low GFR), and the Macula Densa causes a release in renin to increase blood pressure. I want to do a video to stress this point.

    • @bartosz9174
      @bartosz9174 5 лет назад +1

      In my book it says that it senses high level of sodium which would be accurate because it would indicate that there is a small reabsorption of sodium in the nephrone which causes the release of renin -> angiotensin -> aldosterone which reabsorb sodium back into the blood ;)

  • @robr7200
    @robr7200 2 года назад

    This is such an excellent video.

  • @backstreetfan2887
    @backstreetfan2887 3 года назад

    thank you

  • @srinivasandr.cheema8180
    @srinivasandr.cheema8180 5 лет назад

    Excellent

  • @whitemountainash
    @whitemountainash 11 лет назад

    Thank you, I'm studying Naturopathic Medicine and the basics of the Kidney were not sinking in even after lectures and reading Guyton... and you've done it in two videos :) Keep up the awesome work, thank you so much!

  • @Saiydjama
    @Saiydjama 2 года назад

    Thanks u are life saver

  • @nekomamusheii
    @nekomamusheii 7 лет назад +1

    That was really helpful! Thank you so much :D

  • @vish187
    @vish187 11 лет назад

    Awesome video as usual. Just one thing I'd like to add - apparently renin is pronounced ree-nin, because the reh-nin pronunciation is already "taken" by rennin (aka chymosin),an enzyme some animals have, that induces milk curdling in their stomachs.
    I like saying reh-nin though, and I will rarely if ever talk about chymosin, so I'm gonna keep calling renin reh-nin. Just thought that was cool trivia.
    Thanks again!

  • @asianman103
    @asianman103 3 года назад

    i have no clue why but you teach so well that a 10 year old like me can even understand

  • @lusppr
    @lusppr 9 лет назад +1

    Amazing!!!

  • @roxana4681
    @roxana4681 10 лет назад +1

    I wish words could describe how much you have helped me throughout my anatomy class and now physic!! Thank you sooooo much!!

  • @bobomac2012
    @bobomac2012 11 лет назад

    i have always hated the kidneys, the renal is always the last one i want to learn, i always put it at the end of my study. but not anymore, thank you.

  • @mayzeidan3149
    @mayzeidan3149 10 лет назад

    Can you please explain what is renorenal refles

  • @Oxcilic
    @Oxcilic 11 лет назад

    With diabetic nephropathy, do the macula densa cells also detect high glucose?

  • @khanacademymedicine
    @khanacademymedicine  11 лет назад +1

    I'm glad you liked it... =)

  • @conniecarty5214
    @conniecarty5214 10 лет назад

    Can someone tell me how this video was recorded-black background and added
    notes with markers?? Connie What program???

  • @johnjacobsjr1134
    @johnjacobsjr1134 5 лет назад

    This is an excellent video, so clear, thank you so much!

  • @saumyajose4372
    @saumyajose4372 2 года назад

    will low Na in proximal tubule stimulate renin secretion?

  • @hotmess86
    @hotmess86 11 лет назад +1

    A question about the macula densa: Does the macula densa sense high concentration of Na+ levels in the urine, causing it to believe that enough Na+ is not being reabsorbed to the blood? Which is probably why the blood pressure is low?

  • @headbangaboogie1
    @headbangaboogie1 11 лет назад

    is this process completely unrelated to the feedback loop of macula densa cells that reduce filtration rate in response to increased glomerular filtration rate? because if there was an increase in GFR there would be more Na+ for the macula densa cells so can macula densa cells also go the other way using different paracines/hormones?

  • @michaela9499
    @michaela9499 4 года назад

    will these videos be taken down when the NCLEX course is retired?

  • @alilulu9523
    @alilulu9523 10 лет назад

    I'm really so grateful to you for this wonderful video dear

  • @tonystark-qu7pc
    @tonystark-qu7pc 6 лет назад

    Hey bud what if the BP is high then what does the kidneys use to lower the BP ??

  • @mmaggi05
    @mmaggi05 11 лет назад +1

    Thanks, I feel like I learned something. I have a question about the last info about Renin as a hormone, I read that Renin is an enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down protein and produces a rise in blood pressure. so is Renin a Hormone or an enzyme ?
    Thanks

  • @LostLittleSoul84
    @LostLittleSoul84 9 лет назад +3

    even if renin is an enzyme :D this is awesome :D

  • @dzday6320
    @dzday6320 11 лет назад

    Finally a way I can remember this! THANK YOU!

  • @aguy3203
    @aguy3203 5 лет назад

    Does anyone know any tips to make memorizing this stuff easier?

    • @jayraymond9707
      @jayraymond9707 4 года назад +1

      a guy repetition. Watching these videos, writing it down, drawing it, and explaining it to people when you’re comfortable. That’s why KA’s videos work so well. People connect with illustration and explanation in simple, functional terms.
      During your day, watch these videos and try to “beat the presenter” by explaining what he’s talking about.

  • @888167
    @888167 3 года назад

    Uhm isn't the "messenger" supposed to be Adenosin?

  • @shamsalootah6406
    @shamsalootah6406 8 лет назад

    Doesn't prostaglandin cause vasodilation of the afferent arterioles? Then how is it produced by macula densa cells in response to low Na/low BP?

    • @kingchan69
      @kingchan69 8 лет назад

      low na=lower glomerular filtration rate, so it wants increase this rate which requires vasodilation of the arteriole --> more blood flow into the glomerulus --> increase in blood pressure in the glomerulus --> higher filtration rate --> higher Na concentration in the distal

  • @anshubaid6923
    @anshubaid6923 8 лет назад +1

    how is gfr and bp related?

    • @sarahmuakitangata5795
      @sarahmuakitangata5795 6 лет назад

      Glomerulus Filtration Rate is determined by Blood Pressure. For example, if there is high blood pressure the rate in which the filtrates are travelling through the renal tubules are also high due to the large force exerted into the glomerulus. Here's a link for better understanding ruclips.net/video/SDQ5wrdplSk/видео.html

  • @mayzeidan3149
    @mayzeidan3149 10 лет назад

    Reflex*

  • @napoiskafarming669
    @napoiskafarming669 7 лет назад

    very impressive.
    the book was very confusing with all these words, thanks for the explanation.

  • @Oxcilic
    @Oxcilic 11 лет назад

    Are you left handed?

  • @adityar506
    @adityar506 8 лет назад

    you missed lacis cells. other than that this video is amazing

    • @miguelfurtado791
      @miguelfurtado791 8 лет назад

      the extra glomerular mesengial cells he drew are the lacis cells
      he forgot to mention that their another name for it.

  • @sobster123
    @sobster123 8 лет назад

    mmm imagine him being my personal tutor..;)

  • @ladyinblackb277
    @ladyinblackb277 7 лет назад

    I LOVE THIS!

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    We want arabic translation please?????????????????????

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Arbic

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Want arabic translation pleas???????????????

    • @nadiacharafi8815
      @nadiacharafi8815 5 лет назад

      look it up to see if they translate khan academy to arabic version

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Arabic

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Arabic

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Arabic

  • @user-ei5dn4qr2q
    @user-ei5dn4qr2q 6 лет назад +1

    Arabic