Unlocking immortality: the science of reversing aging
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- Опубликовано: 22 июл 2024
- When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.
This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.
Asking our bodies to heal themselves could be one of the largest medical breakthroughs ever, instead of trying mainly chemical means of medication. And it has significant implications for whether or not we can achieve longevity escape velocity and continue to live more or less indefinitely. This promises to be a very interesting topic.
#aging #longevity #science
The science of super longevity | Dr. Morgan Levine
• The science of super l...
Groundbreaking Research on Anti-Aging: Unlock the Secrets to Longevity | David Sinclair
• Video
Is Aging Reversible? A Scientific Look with David Sinclair | David Sinclair | TEDxBoston
• Is Aging Reversible? A...
Dr. Greg Fahy on advancing the first trial ever to reverse human ageing - Our Longevity Futures, with Chris Curwen | Ep. 2
www.gowinglife.com/dr-greg-fa...
Regenerating The Thymus: Profile Of Greg Fahy
www.forbes.com/sites/calumcha...
0:00 Intro
0:21 Part 1: What is aging?
0:53 Demographics of immortality
1:25 Three paths to immortality
2:13 Observable effects of aging (side effect 1: telemere length)
2:45 Side effect 2: free radical damage
3:08 Side effect 3: unbalanced states
3:27 Side effect 4: epigenetic damage
3:50 Example: Sequoia trees live for centuries
4:20 Beneficial and negative mutations
5:52 Cells are untrustworthy
6:30 Part 2: Overview of epigenetics
6:41 Some history of DNA discovery
7:11 Explanation of how DNA encodes genes
8:28 Explanation of the epigenome
9:13 The effect that mutations will have
9:53 DNA methylation = epigenetic clock
10:49 Example: immortal jellyfish and transdifferentiation
11:42 Reprogramming our software
12:17 Part 3: Reversing the epigenetic clock
12:20 Research from Shinya Yamanaka: artificial stem cells
13:13 Research from David Sinclair: curing blindness in mice
14:19 Holy grail for treating diseases
14:42 Research from Greg Fahy: regenerating the immune system in humans
15:37 Regenerating the thymus
16:44 TRIIM trial, making humans 2.5 years younger
17:44 The path to immortality (advice? :))
18:49 How long we have to wait
19:03 Conclusion
19:50 Nature resets epigenetic clocks too
20:16 Outro 
Наука
I was surprised at how much is out there on the topic of longevity medicine. It's very inspiring. Sorry for the 20+ minute video :)
Thanks to @ginxzypher, @vitzcar6219, @ProbingPolitics, and others for asking about longevity in my comments and inspiring this video. Keep it up. Cheers.
Why not make longer videos, I am sure people that watch your content would like deeper dives into topics. And it's better for the youtube algorithm
@@aymanjaber2585 I have a harder time keeping them organized, 15min is fine but 20min feels like rambling sometimes. It also takes longer to research. But I think I am growing into the longer videos!
Sorry for the long video? Please. Lol... Keep these vids coming. In fact, if you would like a co host, let me know. I'd be honored to do a podcast style vid with you!
#KnowledgeIsPower ✊🏾💪🏾🙌🏾💙
really great!
@@DrWaku hi have you heard about the chemical combos
MY Mother had a stroke in her eye and is blind and to see her feel her way threw life is heart breaking and I would love nothing more than to be able to have her see again, just like the mouse model that was healed of blindness. It’s one thing to live longer, but without being able to hear or see or some other health problems You really do suffer.
I'm sorry your mother has gone through that. Quality of life is so important. It's always seemed strange to me that people sometimes wait until retirement to do what they actually want, because their health might not be good at all by that point. Sensory issues, or motor control issues, are especially problematic IMO and we rely on sight more than any other sense. Let's hope medicine can begin to help with these types of issues more in the future.
Great video like always ! This subject has interested me for several years and it's crazy to see the progress we've made! I think that in the decade 2030 we could already be immortal in theory :)
Yes, especially factoring in AI, I wouldn't be surprised!
@@DrWaku I 100% agree :)
Let's hope that billion times more anti aging reasearch is done in 2030. Serious research can begin.
@@Apjooz there is already serious research in this for decade now, go check the david sinclair’s work etc :)
My guess is that it will be sometime in the 2030's when real anti-aging therapies become available.
This year! One patent application is being allowed in October..
@@roblake602not including that the military has been using it for almost 4 years now on seals and marines or so the news broke from sinclair
@@roblake602finally a man made horror to be both terrified of and excited about.
Anti aging "therapies " are already available to you.:To stop all aging of your skin and eyes keep your face and neck out of the sun 100%.Top stop the aging of your heart don't eat anymore than ten grams of saturated fat and or Trans fat each day or you will be at a higher 48sk of having a heart attack.To stop DNA mutations that may result in cancer: Avoid all serious toxins.
The only reason the guy in this video looks so much younger is that he keeps his neck, face and hands (why is he always wearing those gloves?)out of the sun.Look how pale he is.
Thank you so much for this video. I needed your take on this. I also watch David Sinclair clips and it's astonishing to see all that's been uncovered. He even says that in the long run it wouldn't be very complicated to distribute. Just insane. Looking forward to it! :)
Thank you for your comment! I'm glad you got something out of it despite already following David Sinclair. See you at the next video :)
Dr. Michael Levin’s work is pretty awesome too.
This channel is a gold mine
work by biologist Michael Levin...forgot to mention the promise of Regenerative Medicine through decoding the Bioelectrodynamic system of the human body.😊
I'll check it out! Thanks!
I had so much fun watching your great work again. It seems to me wonderful, though a tad mad science. I would be truly interested in a systems approach towards aging, as we're connected beings. 🙃
Big LIKE!
Thank you! This was a really fun video, I always love learning about cutting edge biology research - it always blows my mind. I would love for you to cover research done by Michael Levin, something like his xenobots or whatever you find most interesting
We live in interesting times. I'd be interested in a follow up video. Cheers.
Love it.! Maybe because I wanted to be a Dr. So clear, & simple even though technical.!! I would listen again,,, and I'll listen others you have in your channel. Thanks 👍
Thank you for your comment! That's a good summary of what I try to do: clear & simple even though technical. Appreciate it.
Just my take - More health related vids would be great. Just found your channel now. 👍 - 👍Rock on
I think the usage of medical nanobots is the most likely evolution of human healthcare. Would love to see a video on that
I always recommend your videos to everyone I know
Thank you very much! :) You gave me the idea to ask about this at the end of the next video... See you around.
@@DrWaku haha happy to hear. Excited for the next one! :)
I feel like everybody with a health problem (including me with my goofy ahh heart) wants the singularity to happen faster so they might get some form of cure or advanced treatment. Seriously hope it does happen soon though, AGI can’t come fast enough.😫
I definitely want to hear your takes on the other paths to immortality as well.
You got it. I'll make another video or two on the subject!
Awesome summary
Thank you!!
I would like for you to post more videos on longevity. There is one more epigenetic approach; you need to have 'students' for your 'teacher'. We currently decline in stem cell reproduction. So to increase the output of new stem cells creates the 'students' for your thymus, 'teacher', to school. The stem cells also repair the thymus. The key is maximizing stem cell reproduction.
I think the solution is a combination of nanobots repairing damage, as well as more straightforward treatments.
Water is the fountain of youth! It is literally that simple. Excellent video by the way.
This was so interesting that I watched the whole thing! Normally I have a horrible attention span issue and can only watch a few minutes of something but this was exciting! Very well made!
I especially enjoyed your line " you're encouraging your body to treat itself by playing piano on the epigenetics of your cells" around 18:40 to 18:50. As a former pianist that one really *struck a chord* with me xD
Do you have any videos on sound frequencies and are there really healing vibrations or how does music work with our bodies?
I once got rid of a persistent headache by listening to a reiki-chant cd with headphones when I was younger and I have no idea how that worked.
Sometimes certain cds felt like they reduced inflammation for me, but maybe it was also because they helped me focus on healing too...
I'm really glad you enjoyed it. I don't know why the piano analogy came to mind, but it seemed appropriate :) I have not done a video on music but I like the idea, I'm adding it to my list. I know that with my fibromyalgia, sensory sensations including light, sound, smell, etc have a dramatic impact on my well-being. So I wouldn't be surprised if some music had a positive effect for you.
Based on your comment, you might want to check out my video on quantum computing, I think it holds attention well. Also I made another medical video recently.
ruclips.net/video/TYNAPof0OqE/видео.html or ruclips.net/video/6MRfmEo4xUU/видео.html
I could've watched for another 30 minutes if he kept going 🤣😎😂✌🏾️
I was at Cambridge about a year and a half ago, and I saw that bar (The Eagle was the name of it, I think), and the plaque as well
Nice! Yeah I was there for a short visit and just had to take some footage :)
Awesome! Thanks for covering the this, it's been such an interesting topic as of late. I would love to see what your thoughts are and what research says about the other two approaches to immortality (Digital uploads and nanobots)
Cool, I'll add it to the list. Your previous comment was one reason I made this video as I mentioned in the pinned comment here :)
@@DrWaku I’m glad! Thanks for that and the work you’re doing, it’s nice to see a creator take their audience’s feedback and wishes into account
The issue with uploading an exact digital copy of one's brain is in the same wheel house as having a working transporter (as seen in Star Trek) in that both result in an end of life for the participant. A digital upload of yourself would have your memories, your personality, your likes/dislikes, and would vehemently defend that they were you. It wouldn't be wrong because it's a perfect copy of you and to itself....it IS you. However, it's not. It's a perfect copy enshrined digitally, but YOU are gone. Unless tech is developed (which I'm positive will happen) to somehow install your physical brain into a system as a form of biological software, any upload achieved will simply be a speaking, thinking, and very expensive Polaroid memorial that you existed.
Nanotech however? Personally I feel nanotech, while progressing very impressively, will be what scifi makes it out to once we can give an AI system that is technically an AGI system (Remember, AGI does not mean sentience. General intelligence is an AI that can utilize it's general knowledge to grasp a problem or concept that is completely unknown to it to understand it.The same way you or I apply knowledge we have to understand something new to us) the computational power of at least a 1,000,000 qubits quantum computer. An AGI AI with access to that computational power along with current data and progress would result in new sciences we honestly can't comprehend.
Would like to see and know more.
The philosophical analyze would be great, thanks.
You got it :) ruclips.net/video/uusuwjOrIKo/видео.html
It really upsets me when people say aging is a natural process and needs to be embraced. Aging is evil, getting old is evil. What is worse about aging, is it makes you look unattractive and then you get this horrific disease or illness such as cancer dementia or alzheimer’s.
According to the younger generation of people, they would rather Die Young than face those fates, and who can blame them. I myself refused to age, get old and get a terminal illness. Just a thought of that makes me wanna die alone, young.
I’ve lost the will to age, get old and get a terminal illness and die just at the thought of it. The cause and effect has shut down my aging process, got killed.and hasand has reversed me mentally and physically 30+ years.
Don’t let society drag you down. Don’t let them tell you that this is something that must happen unless there’s nothing you can do to stop it. You basically look at your eye and you tell them that they’re full of bunk.
The this process is mined over matter and the use of subliminals. Trust in the process and believe that it’s already happened. And yes, do your preventative maintenance.
Just even walking around every so often makes all the big difference. If the weather is too severe outdoors then go to a Walmart or a mall works just as good and walk around that for a while. Also drink a lot of water to keep your body dehydrated and drink green tea as well that is really beneficial.
I've been wondering if there's a pleb's version of thymus re-habilitation I could do: pre-GH peptides, DHEA, and a cocktail of insulin helpers as berberine, ALA, low-carb ?? Any thoughts anyone
Physical immortality is also my interest
Great video. I heard that the people in the TRIIM study also took Vitamin D and Zinc, I'm trying it substiuting berberine for metformin.
You're following the TRIIM study's regimen on your own? Not participating in the new trial or anything? That's brave haha. I hope it works out for you.
Vitamin D is a good idea in general.
Thanks for covering Longevity & Life Extension! You covered many topics and seemed to really do your research. Are you a fan of longevity?
Thank you! I actually didn't know much about longevity before doing some research on medical AI for a previous video. Spend too long in a PhD program and you get good at doing research haha. I do have a strong interest in health and autoimmune conditions though since I am impacted by one. You can check out my video "how to move on..." if you want to learn more about that. And of course, if you want to see another (sub)topic in a video, let me know what it might be. Cheers.
I would suggest a fourth way. I believe we are already immortal, but we don't are fairly well disconnected from our past lives. What if we discovered a way to stay more conscious through the process of dying and being reborn?
There was an article recently in the science section of the NYTimes that caught my interest. Basically, it's being determined that if you're fertile then genetically this works against longevity. Apparently, the genes enhancing your fertility are configured in such a way that while they prime you for children in your younger years those very same genes, longer term, cause you to self-destruct. So to speak. Which makes evolutionary sense. You breed, you pass on your genetic code, you're done so you can die now. Evolutionarily speaking. A bit of Mother Natures wisdom?
Which set me to thinking. Leaving aside the idea of some form of digital immortality I can envision a day where, with a periodic cocktail of medical treatments, you can live forever. But given the above note about evolution this isn't really a good idea without a corresponding change in societal ethos. Evolution is about diversity and creating more of it, not being static with one organism just because it, you, wants to keep living. So, about that cocktail. I can see a day where society will have to come up with a solution. You cannot have a legion of immortal beings all running around merrily breeding, can you? That makes no sense. At least not in the context of the lives we have within this terrarium, Earth. But what does make sense would be this.
You want immortality? Fine, you can have it. But you cannot breed. This will be the choice proffered you. This choice will have to be given you when you enter your prime years and before you inadvertently breed. Choose immortality, then fine. You're rendered sterile. Choose to breed, then you abrogate your right to immortality. From a societal perspective this seems fair to me. In fact, even if you choose immortality at the beginning there's nothing to say you can't choose to change it later. You just give up, in so choosing, access to the treatments to immortality.
Hmmm....I can think of a whole line of stories based on this idea. Can't you?
John!
Do cells make up tissue? Are cells in the inner part of tissue the same as the cells on the outer part of the tissue?
💯💯..
Is there a way to join a new TRIIM trial?
I think in the end humans will transcend their biological bodies and became immortal digitally.
In the meantime, we need to extend our physical body's longevity.
Yes agreed, in the long run it makes the most sense. And it could explain why we don't see much alien life out there!
It’s a population gets over populated we just build higher and higher vertically, and then we spread out for the solar system in the galaxy and beyond.
Sometimes dreams can have desastrous effects If knowledge are less.
,,Not only Univers are infinit,,
Brilliant! I've always held that the body can heal itself and you totally support my theory. Thank you and yes, I'd love to hear speak more on this subject. For me, it's never been about longevity, it's about staying fully functional as long as I'm alive!
Gandalf doesn't need longevity medicine. He's been around since before space and time.
So true. Who needs rejuvenation when you can have a brisk battle with a Balrog every now and then.
I was going for Merlin in the thumbnail because he theoretically experienced time backwards. But it ended up looking a lot like Gandalf and I can't say I disapprove.
I'm not sure I'd really want to live "forever" - whatever that even means! Extended life though, yeah maybe a couple hundred years would be nice. For me, I just want enough time and decent health to actually enjoy life. Travel around, read more books, have new experiences. But then again, if you lived for hundreds of years, you'd probably always need to seek out more experiences and stuff just so you don't get bored. Could keep things interesting but also seem tiring. Anyway, endlessly rambling over here! What do you think - would you wanna live forever or just an extended period? I'm torn. There's definitely perks to having more time, but there's something appealing about life being relatively short too. Makes you appreciate every moment. But who knows! I'm just thinking out loud. This is fun to think about. 😊
I think of it like a TV show that could either end on a high note, perhaps there are ideas you could've explored but everything so far has been good and you can wrap things up nicely. If you continue the show you can explore more ideas, but you risk going on for too long, you'd have to end the show because you've run out of material and it's not entertaining to watch. I wouldn't mind being able to live longer, if I was still capable of doing things without too much aid, but immortality I feel would come back to bite you in the end and it'll ultimately be the reason your life ends, because you wouldn't want to experience life any longer than you have. Also you're challenging this phenomenon that affects all organisms, dictates our lives to such an extent, to reverse aging and live beyond what we're capable of is weird to think about
Universal Basic Income now 🎉
+1
People can still die from accidents and disease, so I am not so sure about full immortality.
Yes, certainly. Full immortality requires some kind of backup mechanism so that accidents and disease can be mitigated. In terms of just longevity and expanding our existence within biological bodies, there's always going to be inherent risk there I think.
@@DrWaku I agree. Thank you for the clarification.
The most exciting news in Age Reversal is the new 101 million dollar X Prize that runs until 2030. It is not a requirement for the participants to wait till 2030 to claim the prize. If someone comes up with a solution to reset lifespan/healthspan by at least 10 years with a hopeful target of 20 years they win. Hypothetically, say they reset our age by 20 years but it in fact takes until 2030. Whoever makes it till 2030 could potentially then make it to 2050. By 2050, we are entering that magical era where those who choose to can become digitally immortal.
Such an amazingly interesting topic. Isn't wonderful to think we could be dawning on an era of immortality?
Yes, it is an amazing and interesting topic. Something along the lines of immortality is coming. One can just feel it in the air.@@YoureSoCreezy
Maybe the thymus treatment could benefit from a special diet to limit the side effects.
I agree, seems likely. Just following the diet of someone who is diabetic would probably be effective.
@@DrWaku I think the best diabetic diet is the Nutritarian Diet by Dr. Joel Fuhrman.
Where is the hd version at?
RUclips is overloaded I think. It reached 100% processed and then "Video processing is taking longer than expected" lol. Maybe give it another hour or something. It's definitely coming though, this was recorded at 1080p as usual.
It's available now, not sure how long it took
@@DrWaku 💗
Must accept reality
Young Forever ?
A dream?
With what cost?
It’s a rare occurrence to see a millennial family in my rural town. So many old people… stealing the housing…
Ah padwan, aging is because, everytime our cells reproduce, they included errors, hence aging. Errors can be corrected dna correction.
Can you do it again without using your hands?
I've heard some feedback that I wave my hands around too much. Other people like the hand gestures though. Can you let me know some parts of the video where the hands were too much? I'll try to improve
1:00 The lower birth rates argument doesn't make sense to me. It makes sense as a temporary thing, like raising interest rates to boost economy. But after a while you'll get crazy inflation. Too many metaphors...
If the birth rate is dropping forever then it doesn't matter how many immortal people there are, humans will eventually succumb to negative birth rates and go extinct. Nobody is truly immortal. An accident in the kitchen and your superior telomeres are useless, for example.
If the birth rate is dropping and immortal people are having more and more babies, then we run out of "space". So which immortal person will kill themselves or choose to stop having kids?
in summary: living forever isn't a fix for low birth rates. You either make too few or too many. Just a tangent to the main point, carry on...
We need to work on regrowing new sets of teeth.
We need to understand muchmore mitochondrial medicine first....😅
So you're saying the boomers might be around forever?
Just to remind people. Be biological immortality will not save us from death FOR EVER anyway. We will still die in some of all the other ways and causes. Sure it would be cool to live longer and healthier. But an end will always come. We just can’t control it. We can only try to postpone it. (=longevity different from IMMORTALITY or defeating death)
you are a prepared person but you have to speak slowly, thank you.
what are the new immortals going to do when an unfortunate car accident happens to a 1000 year old person. death is inevitable and the only way to escape the simulation! No, you won't be transfer consciousness to a digital computer, but a good copy of your likeness will be possible.
Yes, another "you" lives on...
💥 Why we need 8 billion people ? Just imagine a century from now, perhaps 80 billion people. What all these people will do ? AI will do everything. There's no place for too many people. 😮
Carcinoma cells did not age
Death program
The average human lifespan being 40years up till 1850 - this is a myth commonly repeated. Fact is - cavemen could live till 70 quite easily if they reached adulthood. The very high infant and adolescent mortality rates screw the data! This is important - because even today people are dying in their 70's and we must realise how little our lifespans have actually improved. Or rather - how the benefits of modern medicine are simply offset by the damaging effect of the modern lifestyle!
No.
No?
We can’t live forever. God limited us to 120 years.
Can you explain where you got that from?
It actually sounds about right but how did you come to that conclusion?
Have a great day! 😎🙌🏾
@@mailmanphilakagogoandcrank365 Genesis 6:3
@@mailmanphilakagogoandcrank365 no le hagas caso
@@luismiguelmartinezsanchez4069 😂😎🤣 Gotcha! Will do 🫡