I was able to do a quick search and found that there are a ton of successful human trials that where done with this over the past two decades, so I'm really confused as to why you keep saying that there are no human trials... It's really misleading and inaccurate.
Isn’t it sad that the two oldest drugs(fin & min) are still the most effective on the market. Basically scientists could come up with nothing, that could cure balding for decades now. As far as topicals are concerned the only acceptable choice seems to be Fluridil, which has at least a clinical research backing up its safety and efficacy.
Doctors don't even completely understand how hair loss works, people on forums are trying fanatic anti androgen treatments and still don't get to see results. I think docs should start being more open to ideas other than androgenic hairloss
@@Teo_liveyes but it’s when that promotion masquerades as impartial clinical advice that it becomes shady. There’s a big difference between a standard flashy TV commercial and a guy in a white coat telling you something is medically safe
I partly agree with you. It may not have been approved by the FDA but we both know very well how finasteride has an economic monopoly on baldness. and where one company has more money it also makes more market and boycotts the market of others. There is not a single video about finasteride where I do not read negative experiences in the comments regarding libido, gynecomastia, etc.. unlike RU58841 which I am sorry to say I have only ever heard good things about.
The first couple of days I took RU I had a HEAVY chest and shortnessnof breathe and heart palpitations. I've continued taking it and the symptoms have gone away significantly, but the shortness of breath is still there. I was so scared I stopped it initially but it really works but I feel like I'm gambling stupid here. That's ny two cents
I had higher BP and heart pulse in my ears while trying to sleep. Used a month nothing happened but I couldn’t take the heart pounding in my ears so I stopped.
At 9:22 he literally says “ in 2008 ru58841 was used in a study in france that was used on grafted hair from balding men” and you ignored what he said completely and told us it was an animal study even thought he clearly says it was used in humans lol
This Doctor seems to be very pro establishment (FDA) and therefore pro finasteride. He also MISTAKENLY notes that RU has never been tested on humans which is FALSE. There was a study that made it to phase 2 clinical trials in the late 90s but was never continued due to the company disbanding. Do your research and do not simply listen to people in the establishment.
@@schmingusss No, someone reached out to the PM for the trial, they said that safety wasn't an issue. The patent for the molecule had expired and they weren't willing to spend millions on phase 2/3 for a compound that generics could produce
This video even says In France in 2008 it was also tested on grafted hair from balding men and this dude pauses the video and blatantly ignores it and tells us “he was talking about animals” even though the first study he says it was used on a primate and the 2nd he clearly says human hair
That study was never even released to the public which should raise some alarm bells. So he is correct that we have absolutely zero public human studies on RU 54881 to evaluate, and just a single study on its own is already extremely weak evidence in the grand scheme of things to determine whether or not a drug is safe and effective enough to recommend for human use. Evaluating safety in particular can often require multiple high quality good methodology randomised controlled trials in humans and thousands of people to use the drug in order to try and catch those potentially more rare side effects.
Luckily we will have Breezula coming soon which I might plan on using as an adjunct with Finasteride. Is it true that Dutasteride is prescribed in countries like South Korea and Japan? If so does anyone know why the U.S. doesn't prescribe it as often?
Breezula is weaker than minoxidil man. Its basicaly useless if i am to belive their phase 2 data. I think they will never release that one, eventualy they will just remove it from their site like Biosplice did with Samumed.
yes regenrx used RU which is a research compound and hasn't been approved by FDA...so we don't really know the long-term side effects to human as well.
Hello Isaac , I am sure that my experience is worth talking about. It's over a year and my hair is still falling out I've used literally everything and every day and I still use them I take finasteride 2.5 with Avodart Dutasteride 0.5 and use minoxidil mixed with finasteride, bicalutamide and cyproterone, RU58841(from china),and in the morning I use Stemoxdil mixed with dutasteride and spirolactone, and finasteride then put it on my head after using the microneedling 3ml I also do a daily head massage with a powerful vibrator. I also use ketoconazole shampoo every day. All this and my hair is still falling out and it is now worse than before. Greetings to you, and I hope that you will answer me. Why didn't all of this work for me
Hello! Very sorry to hear about your situation. It sounds like you are doing everything possible to preserve your hair but despite your best efforts your hair is continuing to shed. I imagine that this is extremely frustrating for you. To be completely honest, I wouldn't be able to provide you with a concrete answer as to why your hair is continuing to shed. My advice would be to see a physician (preferably a dermatologist) for a full assessment including bloodwork to rule out other causes of hairloss and to confirm male pattern hairloss as your primary diagnosis. I would also recommend speaking with a pharmacist or doctor about your current medication regimen - I am concerned for your safety here. The regimen that you are describing is excessive and I would be concerned about systemic side effects from all the topical anti androgens that you are using (bicalutamide, cyproterone, RU58841, spironolactone). In addition, it seems redundant to take oral finasteride with dutasteride - since you are most concerned about efficacy, you could probably discontinue the finasteride and have similar reductions in DHT with dutasteride alone. I would also check how you are microneedling (length of the needle, frequency, and the force that you are applying). Excessive microneedling can lead to poor hair outcomes from my understanding. I also don't believe there is much data to support head messages as an effective treatment for hairloss.
Also, try and source your meds from a legitimate pharmacy - otherwise, impurities may harm your hair. But again and most importantly, make sure you see a doctor. If your hairloss is being caused by some other condition, all of the hairloss meds in the world will not save your hair. You would need to treat the underlying condition. And lastly, it's possible that you lost the genetic lottery and are destined to be bald. In that case, I would consider using a hair system or coming to terms with being bald. The potential damage that you could do to your health through these excessive regimens of experimental treatments is really not worth the risk in my opinion. Your physical health is so much more important. Hope this answer is helpful! All the best, Isaac
@@isaacwadepharmd3969 thank u so much brother .You are really a helpful man with a wonderful personality. I believe that the pharmacist has more knowledge than the doctor about how the medicine works. So I want to ask you why does the body not respond to medication sometimes? And does the drug sometimes take more than a year to work?
@@engyousif4383 Thank you my friend! That is the 1 million dollar question. If you look at any clinical study, there's always a group of individuals that do not respond to the treatment. Why is this the case? A lot of the time, we honestly don't know. Everyone has a different set of genetic and environmental factors that influence whether or not a particular drug will work for them. Sometimes we can figure out the reason for this, other times we can't. When it comes to male pattern hairloss, my understanding is that we really don't know why some people don't respond to treatment. All we know is that that the vast majority of men (greater or the same as 90%) will respond to finasteride or finasteride + minoxidil so these are typically the treatments that we recommend.
I'm currently doing quite a bit to get my optimal hair. 1. Fin 1mg 2. Minoxidil 3.Microneedle 4. ketoconazole 5. Scalp rubbing wooden hair brush I might try this from this company because it doesn't have to be refrigerated. I am only going to apply it to the front of my head. Since other places seem to be responding quicker.
What blood tests would you recommend? I've already had iron/ferritin tests, as well as full thyroid panel + autoimmune. B vitamins and D3 should be fine as I take B-complex, D3, and multi-vitamin.
WHAT ARE U DOING ????.....................If your worried about Hairloss, its the hair folicle becoming more sensitive to DHT, and miniaturizing......bang Your BALD.....nothing to do with vitamins !
@YRFMHNWWFTMBBIA yeah I had all of that tested, was much cheaper paying cash w no insurance. Idk about the sensitivity. They were all the standard tests. Everything optimal.
That’s what I said too lol, the guy said it was used on human hair and he freezes the video and say “okay he gave us clinical studies of animals” when it clearly says humans
@@joeymcdavid3287 They grafted the hair from balding men onto rodents for the test. A human study refers to when you do the study directly on the humans themselves.
I think you need to educate yourself more on post finasteride syndrome. Patients describe a very similar pathway in onset of symptoms. After stopping or during use of the drug, a "crash" happens where their previous symptoms of low libido, ED, insomnia, depression/anxiety, shortness of breathe, muscle wastage, fatigue, etc. all become noticeably worse very fast. People describe being unable to sleep and feeling like the body is in fight or flight mode all the time. The milder form of post finasteride syndrome is just the persistence of common finasteride side effects like low libido, ED, brain fog, and a few others.
Im losing hair by the time lets say 10 years but only on the front side left, i trued minoxidl and nothing, do u recommend me to start using finasteride? And how can i buy it, i only know that "keeps" is selling finasteride...
18 years old i would say since that s the youngest age it was studied in clinical trials and i dont personally belive any developmental side effects ( such as external genital development) would be clinically significant aside from maybe less beard and body hair.
@@isaacwadepharmd3969 Thank you very much! If you had to guess about the side effects of ru what would you say (besides gyno, heart/lung issues)? Could it cause fatigue?
Also could topical minoxidil cause fatigue and what are some blood markers/vitamins you would get checked in order to make sure male pattern baldness is the cause of your hairloss?
@@kungfu_kenny63 Yes, dizziness and fatigue are reported side effects, although rare. Probably a consequence of systemic absorption since these side effects are more frequently reported with oral minoxidil secondary to low blood pressure I believe. Topical minoxidil solution has a systemic absorption of roughly 1-2%. That means that if you are applying 1 ml of 5% solution twice daily, that is a 100 mg topical dose and as much as 2 mg may be absorbed into your bloodstream each day. For reference, oral minoxidil, which is essentially 100% systemically absorbed, is typically dosed at 10-40 mg per day. Oral minoxidil gets a bad wrap for causing cardiovascular side effects but it is typically only prescribed to very sick people - with kidney disease, heart disease, very high blood pressure, etc. I would guess that young healthy individuals would be less likely to experience side effects from systemic exposure to minoxidil.
That being said, if you believe you are experiencing systemic side effects from the 5% minoxidil solution, you could try switching to the 5% foam with has half the systemic absorption compared to the solution or decreasing your total exposure to minoxidil by applying 1 ml of the 5% solution only once per day or switching to the 2% solution.
Post Finestride Syndrome is Real.............Finestride affects Brain Nuerosteriods, and these can depending on age may become permanent, thru epigenetic means
This isn’t true. The neurosteroids in the brain are affected by the type 1 5 alpha reductase enzyme and not the type 2 5 alpha reductase enzyme which is what finasteride is inhibiting.
@@mlinger18 creatine isn’t a waste. The issue is most ppl don’t know the science behind it. A simple biochem will teach you that. Creatine isn’t useless due to its ability to readily donate a phosphate to adp, amp cAMP etc so if you can regen energy supply more frequently then you can tech push your workout a little harder and longer Leading to increased skeletal muscle tissue from indirect use
If creatine really increased dht millions of men would use it for sexual performance. Just think about it. Literally noone ever associated creatine with improvements in sexual performance.
Same. I lost almost all my front hair when I stopped RU, even though I continued Minoxidil, Keto shampoo and microneedling. It seems the only highly effective product in my stack was the RU. Ordered 6 bottles of RU just now, hopefully I can regrow all the front hair I lost.
@@Man-u-flex No. Just to name a few reasons: 1. You are confusing slightly systematic (a topical serum) for 100% systematic (oral meds). Magnitude always matters. 2. They function differently 3. Only fin is currently known for having risks of permanent side effects.
@@JoeMoss83 That’s because of the nocebo effect that people give themselves from reading horror stories online and psyching themselves out. There’s a reason you hear all of these horror stories online but the placebo controlled trials show a completely different story.
@@meltedsnowman9637 Hmm I don't know about that. I went on dutasteride because doc told me side effects are less common, and so far so good. Still waiting for some hair growth, but no side effects yet
It is stupid to discuss if a drug can be responsible of certain side effect if you wont believe that this is a side effect that the drug can cause. You are disregarding the evidence because you believe that the drug can't make this. Of course, it is easy to evaluate a side effect like pain or death, but psychological effects, by its nature, is more difficult, there is no analytics, no measure. Also, many idiots think that hormones and chemistry has little to do with emotion and sex. That's the problem of people ignorant who don't Believe in pfs
That human trial on human participants was never released to the public. So we don’t know the results of that study or whether that study had good methodology and was well conducted. Also even one well conducted study on its own isn’t enough to deem a treatment safe and effective enough to recommend to the public. You need at the very least multiple well conducted randomised placebo controlled trials to come to that conclusion.
Yea tons of ppl including me has much success on propecia for hair loss but the side effects where aweful. If Ru goes systematically than it’s just as bad as propecia
The side effects are barely more than placebo. If you read the actual placebo controlled research trials into it, the sexual side effects will often be like 1.3% of placebo users experiencing sexual side effects and 1.8% of Finasteride users experiencing sexual side effects. Whereas antidepressants can have up to a 50% rate of sexual side effects in men.
@@meltedsnowman9637 Well I usually tolerate almost everything very well I don’t have any allergies or anything but that stuff sucks I guess I’m the 1.8%
@@meltedsnowman9637 Even under the assumption that the controlled research is gospel, that is still a 1 in 200 chance of non-placebo sexual sides. I do think that is enough to warrant caution with finesteride.
I was able to do a quick search and found that there are a ton of successful human trials that where done with this over the past two decades, so I'm really confused as to why you keep saying that there are no human trials... It's really misleading and inaccurate.
Because many people are shills for the fda and make no money recommending a research chemical or herb.
where can i find the RU human study?
Isn’t it sad that the two oldest drugs(fin & min) are still the most effective on the market. Basically scientists could come up with nothing, that could cure balding for decades now. As far as topicals are concerned the only acceptable choice seems to be Fluridil, which has at least a clinical research backing up its safety and efficacy.
Doctors don't even completely understand how hair loss works, people on forums are trying fanatic anti androgen treatments and still don't get to see results. I think docs should start being more open to ideas other than androgenic hairloss
Pyrilutamide and GT20029 look like the most promising future drugs in development for the treatment of hair loss within the next few years or so.
He sells RU, thats why he promotes it. Shady business
Agreed! Thanks for commenting!
It was quite obvious he was selling something
Isn't that what every business on the planet does, promote a product they sell?
@@Teo_liveyes but it’s when that promotion masquerades as impartial clinical advice that it becomes shady. There’s a big difference between a standard flashy TV commercial and a guy in a white coat telling you something is medically safe
I partly agree with you. It may not have been approved by the FDA but we both know very well how finasteride has an economic monopoly on baldness. and where one company has more money it also makes more market and boycotts the market of others. There is not a single video about finasteride where I do not read negative experiences in the comments regarding libido, gynecomastia, etc.. unlike RU58841 which I am sorry to say I have only ever heard good things about.
Finasteride is generic, so it’s not made by one company.
The first couple of days I took RU I had a HEAVY chest and shortnessnof breathe and heart palpitations. I've continued taking it and the symptoms have gone away significantly, but the shortness of breath is still there. I was so scared I stopped it initially but it really works but I feel like I'm gambling stupid here. That's ny two cents
I had higher BP and heart pulse in my ears while trying to sleep. Used a month nothing happened but I couldn’t take the heart pounding in my ears so I stopped.
@@kevinoltman9584don't fuck with your heart! If it goes , you are fucked
Any updates I'm considering ru @@kevinoltman9584
At 9:22 he literally says “ in 2008 ru58841 was used in a study in france that was used on grafted hair from balding men” and you ignored what he said completely and told us it was an animal study even thought he clearly says it was used in humans lol
They grafted the hair from balding men onto rodents for the test
This Doctor seems to be very pro establishment (FDA) and therefore pro finasteride. He also MISTAKENLY notes that RU has never been tested on humans which is FALSE. There was a study that made it to phase 2 clinical trials in the late 90s but was never continued due to the company disbanding.
Do your research and do not simply listen to people in the establishment.
Amen
More likely never made it to phase 2 trials due to too many negative side effects. Same reason clinical trials on Dutasteride were abruptly stopped.
@@schmingusss No, someone reached out to the PM for the trial, they said that safety wasn't an issue. The patent for the molecule had expired and they weren't willing to spend millions on phase 2/3 for a compound that generics could produce
This video even says In France in 2008 it was also tested on grafted hair from balding men and this dude pauses the video and blatantly ignores it and tells us “he was talking about animals” even though the first study he says it was used on a primate and the 2nd he clearly says human hair
That study was never even released to the public which should raise some alarm bells. So he is correct that we have absolutely zero public human studies on RU 54881 to evaluate, and just a single study on its own is already extremely weak evidence in the grand scheme of things to determine whether or not a drug is safe and effective enough to recommend for human use. Evaluating safety in particular can often require multiple high quality good methodology randomised controlled trials in humans and thousands of people to use the drug in order to try and catch those potentially more rare side effects.
Hey Isaac, any idea what RU's half life actually is?
Luckily we will have Breezula coming soon which I might plan on using as an adjunct with Finasteride.
Is it true that Dutasteride is prescribed in countries like South Korea and Japan? If so does anyone know why the U.S. doesn't prescribe it as often?
Breezula isn't anywhere near market. Pyrilutamide will be in market way before they ever will.
Breezula is weaker than minoxidil man. Its basicaly useless if i am to belive their phase 2 data. I think they will never release that one, eventualy they will just remove it from their site like Biosplice did with Samumed.
Breezula has weak binding affinity
Yea you guys are right, now looking into it Breezula is weak but I think Pyrilutamide is from Kintor which is showing great promise so there’s a plus.
@@demonslayer-ds9vo yea its used more here in japan than fin
yes regenrx used RU which is a research compound and hasn't been approved by FDA...so we don't really know the long-term side effects to human as well.
It's a peptide.
@@roshay6379 Non sequitur
Hello Isaac , I am sure that my experience is worth talking about. It's over a year and my hair is still falling out I've used literally everything and every day and I still use them I take finasteride 2.5 with Avodart Dutasteride 0.5 and use minoxidil mixed with finasteride, bicalutamide and cyproterone, RU58841(from china),and in the morning I use Stemoxdil mixed with dutasteride and spirolactone, and finasteride then put it on my head after using the microneedling 3ml I also do a daily head massage with a powerful vibrator. I also use ketoconazole shampoo every day. All this and my hair is still falling out and it is now worse than before. Greetings to you, and I hope that you will answer me. Why didn't all of this work for me
Hello! Very sorry to hear about your situation. It sounds like you are doing everything possible to preserve your hair but despite your best efforts your hair is continuing to shed. I imagine that this is extremely frustrating for you. To be completely honest, I wouldn't be able to provide you with a concrete answer as to why your hair is continuing to shed. My advice would be to see a physician (preferably a dermatologist) for a full assessment including bloodwork to rule out other causes of hairloss and to confirm male pattern hairloss as your primary diagnosis. I would also recommend speaking with a pharmacist or doctor about your current medication regimen - I am concerned for your safety here. The regimen that you are describing is excessive and I would be concerned about systemic side effects from all the topical anti androgens that you are using (bicalutamide, cyproterone, RU58841, spironolactone). In addition, it seems redundant to take oral finasteride with dutasteride - since you are most concerned about efficacy, you could probably discontinue the finasteride and have similar reductions in DHT with dutasteride alone. I would also check how you are microneedling (length of the needle, frequency, and the force that you are applying). Excessive microneedling can lead to poor hair outcomes from my understanding. I also don't believe there is much data to support head messages as an effective treatment for hairloss.
Also, try and source your meds from a legitimate pharmacy - otherwise, impurities may harm your hair. But again and most importantly, make sure you see a doctor. If your hairloss is being caused by some other condition, all of the hairloss meds in the world will not save your hair. You would need to treat the underlying condition. And lastly, it's possible that you lost the genetic lottery and are destined to be bald. In that case, I would consider using a hair system or coming to terms with being bald. The potential damage that you could do to your health through these excessive regimens of experimental treatments is really not worth the risk in my opinion. Your physical health is so much more important. Hope this answer is helpful! All the best, Isaac
@@isaacwadepharmd3969 thank u so much brother .You are really a helpful man with a wonderful personality. I believe that the pharmacist has more knowledge than the doctor about how the medicine works. So I want to ask you why does the body not respond to medication sometimes? And does the drug sometimes take more than a year to work?
@@engyousif4383 Thank you my friend! That is the 1 million dollar question. If you look at any clinical study, there's always a group of individuals that do not respond to the treatment. Why is this the case? A lot of the time, we honestly don't know. Everyone has a different set of genetic and environmental factors that influence whether or not a particular drug will work for them. Sometimes we can figure out the reason for this, other times we can't. When it comes to male pattern hairloss, my understanding is that we really don't know why some people don't respond to treatment. All we know is that that the vast majority of men (greater or the same as 90%) will respond to finasteride or finasteride + minoxidil so these are typically the treatments that we recommend.
All the hairloss treatments that I am familiar with should start working within one year. Most take around 3-6 months to kick in. Hope this helps!
Can you please make a video sharing your thoughts and opinions on CB-03-01
I'm currently doing quite a bit to get my optimal hair.
1. Fin 1mg
2. Minoxidil
3.Microneedle
4. ketoconazole
5. Scalp rubbing wooden hair brush
I might try this from this company because it doesn't have to be refrigerated. I am only going to apply it to the front of my head. Since other places seem to be responding quicker.
Update?
Update?
Any update?
What blood tests would you recommend? I've already had iron/ferritin tests, as well as full thyroid panel + autoimmune. B vitamins and D3 should be fine as I take B-complex, D3, and multi-vitamin.
@YRFMHNWWFTMBBIA his shit is way too expensive tbh... I contacted evolve before and their prices were outrageous compared to other options
WHAT ARE U DOING ????.....................If your worried about Hairloss, its the hair folicle becoming more sensitive to DHT, and miniaturizing......bang Your BALD.....nothing to
do with vitamins !
@@agaragar21 there are plenty of conditions that also cause hair loss. But im already treating for androgens
@YRFMHNWWFTMBBIA yeah I had all of that tested, was much cheaper paying cash w no insurance. Idk about the sensitivity. They were all the standard tests. Everything optimal.
@YRFMHNWWFTMBBIA I think my genetics just outweigh the treatments.
After seeing your research hierarchy I’d love to see you do a review on Covid-19 vaccines, bet you won’t lol.
9:17 blatantly ignores the human study lol.
That’s what I said too lol, the guy said it was used on human hair and he freezes the video and say “okay he gave us clinical studies of animals” when it clearly says humans
@@joeymcdavid3287 They grafted the hair from balding men onto rodents for the test. A human study refers to when you do the study directly on the humans themselves.
It's deeply misleading for him to stay it's still being researched. No company will fund it - can't make any money from it
Agreed!
I think you need to educate yourself more on post finasteride syndrome. Patients describe a very similar pathway in onset of symptoms. After stopping or during use of the drug, a "crash" happens where their previous symptoms of low libido, ED, insomnia, depression/anxiety, shortness of breathe, muscle wastage, fatigue, etc. all become noticeably worse very fast. People describe being unable to sleep and feeling like the body is in fight or flight mode all the time. The milder form of post finasteride syndrome is just the persistence of common finasteride side effects like low libido, ED, brain fog, and a few others.
I believe it’s true but there has to be a solution it don’t have to be permanent for those who don’t improve a month after stopping.
Im losing hair by the time lets say 10 years but only on the front side left, i trued minoxidl and nothing, do u recommend me to start using finasteride? And how can i buy it, i only know that "keeps" is selling finasteride...
its in every pharmercy
Hey Isaac, great videos, what's the youngest age you would get on finasteride?
18 years old i would say since that s the youngest age it was studied in clinical trials and i dont personally belive any developmental side effects ( such as external genital development) would be clinically significant aside from maybe less beard and body hair.
@@isaacwadepharmd3969 Thank you very much! If you had to guess about the side effects of ru what would you say (besides gyno, heart/lung issues)? Could it cause fatigue?
Also could topical minoxidil cause fatigue and what are some blood markers/vitamins you would get checked in order to make sure male pattern baldness is the cause of your hairloss?
@@kungfu_kenny63 Yes, dizziness and fatigue are reported side effects, although rare. Probably a consequence of systemic absorption since these side effects are more frequently reported with oral minoxidil secondary to low blood pressure I believe. Topical minoxidil solution has a systemic absorption of roughly 1-2%. That means that if you are applying 1 ml of 5% solution twice daily, that is a 100 mg topical dose and as much as 2 mg may be absorbed into your bloodstream each day. For reference, oral minoxidil, which is essentially 100% systemically absorbed, is typically dosed at 10-40 mg per day. Oral minoxidil gets a bad wrap for causing cardiovascular side effects but it is typically only prescribed to very sick people - with kidney disease, heart disease, very high blood pressure, etc. I would guess that young healthy individuals would be less likely to experience side effects from systemic exposure to minoxidil.
That being said, if you believe you are experiencing systemic side effects from the 5% minoxidil solution, you could try switching to the 5% foam with has half the systemic absorption compared to the solution or decreasing your total exposure to minoxidil by applying 1 ml of the 5% solution only once per day or switching to the 2% solution.
I took acutain and lost my hair. Help
RU gave me heart palpitation and heart problems
Same for me at Finasteride :( Maybe they have changed recipe similar to covid jabs🚨
Post Finestride Syndrome is Real.............Finestride affects Brain Nuerosteriods, and these can depending on age may become permanent, thru epigenetic means
This isn’t true. The neurosteroids in the brain are affected by the type 1 5 alpha reductase enzyme and not the type 2 5 alpha reductase enzyme which is what finasteride is inhibiting.
@@meltedsnowman9637it is true dik smack
Does creatine cause hairloss?
There was a small study in rugby players that demonstrated an increase in dht after using creatine. For this reason, I personally dont use creatine.
No sir creatine is a waste
@@mlinger18 creatine isn’t a waste. The issue is most ppl don’t know the science behind it. A simple biochem will teach you that. Creatine isn’t useless due to its ability to readily donate a phosphate to adp, amp cAMP etc so if you can regen energy supply more frequently then you can tech push your workout a little harder and longer Leading to increased skeletal muscle tissue from indirect use
If creatine really increased dht millions of men would use it for sexual performance. Just think about it. Literally noone ever associated creatine with improvements in sexual performance.
Creatine might be an answer to generate some extra dht so you have some if finasteride gets it out of balance. I take a small amount here and there.
He wrong, the side effects do go away after you stop Fin.
You should invite Derek onto your show, that would be a great debate.
Yesssssss
I stopped using RU and I lost 3cm of my hairline in 4 months
why you quit ru ?? can i ask??
Any sides from uaing it?
Same. I lost almost all my front hair when I stopped RU, even though I continued Minoxidil, Keto shampoo and microneedling. It seems the only highly effective product in my stack was the RU. Ordered 6 bottles of RU just now, hopefully I can regrow all the front hair I lost.
Can I ask where are you getting the RU? Thanks
Why did you stop ? Did you have side effects im assuming yes
RU will 100% go systemic just a matter of if u get sides or not. Risky and dangerous treatment ime
It's a dangerous substance. It gave me tons of life threatening side effects. Don't do ru58841
It cannot work if it is 0% systemic, in saying that is certainly isn't 100% systemic.
@@Teo_liveso then it’s no different then finesteride if it goes systemic bro that’s the whole problem with finesteride so why would anyone use RU
@@Man-u-flex No. Just to name a few reasons:
1. You are confusing slightly systematic (a topical serum) for 100% systematic (oral meds). Magnitude always matters.
2. They function differently
3. Only fin is currently known for having risks of permanent side effects.
非那雄胺虽然会减少DHT,但是并不会减少睾酮,但是睾酮也会导致脱发,所以非那雄胺的效果并不是很明显,大量人甚至觉得非那雄胺没什么作用,至于Ru58841,请拭目以待
Taking finasteride was the worst month and a half of my life. Severe depression, inability to get an erection or orgasm, lethargy.
Did you experience any anxiety or panic attacks?
Same... but had bad heart palpitations and extremely light headed about 1 hr after taking the pill
I hear this way too often for it to be "extremely rare" side effects.
@@JoeMoss83 That’s because of the nocebo effect that people give themselves from reading horror stories online and psyching themselves out. There’s a reason you hear all of these horror stories online but the placebo controlled trials show a completely different story.
@@meltedsnowman9637 Hmm I don't know about that. I went on dutasteride because doc told me side effects are less common, and so far so good. Still waiting for some hair growth, but no side effects yet
Dont think that RU is able to block DHT, mostly only T
It blocks both, dht is an androgen and ru is a topical anti androgen
@@joeymcdavid3287it prob blocks both on the scalp but are you saying systemic as well?
Nice job doing this kind of videos.
I already watched all of them. 👍🏾
It is stupid to discuss if a drug can be responsible of certain side effect if you wont believe that this is a side effect that the drug can cause. You are disregarding the evidence because you believe that the drug can't make this. Of course, it is easy to evaluate a side effect like pain or death, but psychological effects, by its nature, is more difficult, there is no analytics, no measure. Also, many idiots think that hormones and chemistry has little to do with emotion and sex. That's the problem of people ignorant who don't Believe in pfs
this guy is lying ... there was a human trial ..... also tons of people using it successfully over many years
That human trial on human participants was never released to the public. So we don’t know the results of that study or whether that study had good methodology and was well conducted. Also even one well conducted study on its own isn’t enough to deem a treatment safe and effective enough to recommend to the public. You need at the very least multiple well conducted randomised placebo controlled trials to come to that conclusion.
Yea tons of ppl including me has much success on propecia for hair loss but the side effects where aweful. If Ru goes systematically than it’s just as bad as propecia
Very nice. Thank you!
great video, still going to try it but yeah that guy was super shady and unethical misleading watchers. ez sub
Thanks for watching!!
Anyone wearing a lab coat or stethoscope slung over their shoulder while doing a commercial should immediately alert you to some sort of scam.
Hey buddy how were your results?
@@pullmyniblets im on a crazy stack man, dut 2mg ed ru58841 100mg a day and now just added cyproterone acetate 25mg ed
Finasteride Is trash, don’t need hair if you can’t even get it up.
It also has other nasty side effects including depression, anxiety and panic attacks. Not worth it.
You won’t even get women tho if you don’t have hair lol
The side effects are barely more than placebo. If you read the actual placebo controlled research trials into it, the sexual side effects will often be like 1.3% of placebo users experiencing sexual side effects and 1.8% of Finasteride users experiencing sexual side effects. Whereas antidepressants can have up to a 50% rate of sexual side effects in men.
@@meltedsnowman9637 Well I usually tolerate almost everything very well I don’t have any allergies or anything but that stuff sucks I guess I’m the 1.8%
@@meltedsnowman9637 Even under the assumption that the controlled research is gospel, that is still a 1 in 200 chance of non-placebo sexual sides. I do think that is enough to warrant caution with finesteride.
It works for me and many other people
which one are u usin
@@jss.2020 Anageninc
How long have u been using it for
@@jeffbro1021 3 months. My thinning st the temples and above completely reversed but have not re-grown any hair
@@tristanmichael45 to short time to see regrowth. How is it going? Any sides?
you talk like you are using Finasteride oder dutast
Machst du Werbung für finesterid??