Finally extracting pure Salvinorin A crystals
HTML-код
- Опубликовано: 14 мар 2023
- The final conclusion of Salvia Divinorum extraction. May my sanity remain intact after doing this so many times. Enjoy!
Sources:
www.iceers.org/salvia-divinor...
www.mdpi.com/1424-8247/14/2/116#
pubs.acs.org/doi/10.1021/acsc...
• Doctor Strange - Open ...
Music: Bensound
License code: ADCOZPT0Q7J3EE4W 
Наука
![XO (Only If You Say Yes) - ENHYPEN エンハイプン 엔하이픈 [Music Bank] | KBS WORLD TV 240712](http://i.ytimg.com/vi/wBT1bKKwPTo/mqdefault.jpg)
You should make a video where you make acid and go through each step for scientific purposes, of course.
Lmao, if only
Uhm... I tried reading a paper on acid synthesis once, and I'm quite confident in stating that, if you're not an expert chemist already, you're not even going to understand what you're looking at, let alone be able to reproduce it.
If only it were that easy...
Frlll
@@remcovanvliet3018 also the precursors, I believe they are called ergotlides, are extremely difficult to get
Yeah lsd requires ridiculous level of talent not only as a chemist but a mycologist.
"Oh good he's wearing gloves"
"Oh he's wearing gloves because his hands are cold..."
What a crossover.
lets uh... get a taste test.
LOL
Exactly what I was thinking.
Getting that on your fingers might be a Hoffman moment.
Hot tip: when doing freeze recrystallization, put the hot container in an extremely well insulated vessel like a thermos or styrofoam box, and put that in the freezer. The slower you cool, the bigger your crystals.
This makes sense to reduce the speed at which it cools.
High pressure should also help.
Very nice tip ! And i can add - put the hot container in an extremely well insulated vessel like a thermos or styrofoam box, and do not put that in the freezer, let it cool slowly to room temperature, then put in fridge and let it cool to fridge temperature, and then put that in freezer. Then you get largest and purest crystals. And use minimum amount of solvent for recrystallization.
@@timkrause1925 good point ! may be do 2 steps recrystallization - first slow, so most impurities go in mother liquor, and second - fast, so no solvent is trapped in crystals ?
@@goiterlanternbase sounds interesting! I’ve never heard of that
I’m deathly afraid of what this vial is capable of.
The secrets of the universe are in that little thing..
😂 facts
I exhaled, blacked out, and apparently said "I'm a traveler of both time and space!", before leaping off the bed and running out of the room
“Steven what are you doing in there??”
“A- Uh... Drugs”
Hahaha
What a wild ride, I wouldn't even want to in the same room as that vial but super glad to see your success, really shows that extractions aren't usually as straight forward as they sound on paper.
Couldn't agree more
I'd eat it ngl
The only way you would trip from it is if you smoked it....I think you would be fine int he same room as itm
Blink in its direction from a few counties away and you are instantly telephoned into the most mind boggling brain fuck trip you've ever experienced
@@M_u_t_e96024 eating it would destroy it but letting it absorb through the mouth or sinuses would work
Thank you for the psychopharmacology intro. This was my favorite part of school, the other stuff was so boring. In fact, my psychopharm professor is the one who awarded me a praticum.
Holy fuck the madman actually managed to pull it off, congratulations! Your channel is fucking incredible❤
This video feels like it could have existed on youtube 15 years ago. Love it, but its only a matter of time until someones mom finds it.
Even the intro is from 15 years ago
🤣 I'm "someone's mom" and found it fascinating!
Yes, I realize and no, I don't care. The more, the merrier!
@°•.Mags.•° hello. How are u doing?
I’m someone’s dad and I love salvia it’s the most based substance in existence
1:55 - Just a _slight_ correction. Although many classical psychedelics are agonists of the 5HT2A receptor, it's actually the 5HT2A-mGluR2 complex, an oligomerized receptor complex consisting of both the 5HT2A receptor and the mGluR2 (metabotropic glutamate receptor 2) receptor that is responsible for psychedelic effects. There are drugs out there like Lisuride which acts as a partial agonist of 5HT2A, but doesn't result in psychedelic effects because it only binds to the uncomplexed 5HT2A receptor. The uncomplexed 5HT2A receptor has a similar, yet distinct, binding pocket when compared to the complexed 5HT2A receptor in the 5HT2A-mGluR2 complex. So, a drug that binds to 5HT2A doesn't necessarily mean that it's a psychedelic drug, but there's a good chance it will be.
pharmacology is so incredibly confusing yet incredibly interesting
@@sciencething1449 Yeah, this whole "it's not the 5HT2A receptor, it's actually a 5HT2A receptor complex" thing confused the fuck out of me when I first heard it. Then, I went to a lecture on receptor dimers at university and it started to make sense. Basically, GPCR's (G-protein coupled receptors), can join with other receptors to make a dimerized receptor i.e. a combination of 2 or more receptors. They can have similar effects to each receptor on it's own, but they can also have effects that are completely different.
It's an emerging field of research. It's so big, and we currently know very little. Like, if activating the 5HT2A-mGluR2 complex can result in psychedelic effects, who knows what effects messing with other dimers can result in?
@@Crowbars2 very interesting i did not know this at all, does the dimerizing happen automatically like how does that work? When do the receptors decide to do that?
@@sciencething1449 I think that the mechanism of how/why GPCR's dimerize is currently unknown for certain, but it's a hot topic of research. Expert opinions range from "omg these particular GPCR's never dimerize" to "Of course all GPCR's function as dimers."
What we do know is that the way that these GPCR's dimerize is through linking of certain domains (extracellular domain, transmembrane domain, c-terminal tail) from each GPCR through disulfide bonding, and non-covalent bonding. This also explains how a dimerized receptor can have different pharmacology. If the binding pocket is located on the extracellular domain in each GPCR, and the receptor dimer involves two extracellular domains linking together, that could change the shape of the binding pocket and mean different ligands can affect the dimerized receptor compared to the undimerized receptor.
The GABA-B receptor is quite interesting in this regard, because it can only function as a heterodimer of GABA-B1 and GABA-B2 receptors, and the mechanism of how this occurs is known. GABA-B1/B2 have minimal function on their own, and they need to dimerize to make the final GABA-B receptor, and there's a very particular mechanism to it's production.
GABA-B1 and GABA-B2 are encoded by two separate genes (the genes are called "GABBR1" and "GABBR2"). When the GABA-B1 mRNA is produced from the gene, the mRNA then enters the endoplasmic reticulum, where it is converted to protein, the GABA-B1 receptor, and inserts itself into the membrane of the endoplasmic reticulum.
But on the GABA-B1 receptor, there's a particular protein sequence which causes it to be retained in the endoplasmic reticulum until a finished GABA-B2 receptor comes along, which causes a conformational change in both receptors. This leads to both receptors subunits linking together through the c-terminus tails, producing the completed GABA-B receptor. The conformational change in the receptor also allows amyloid precursor protein (APP) to bind to it, which causes the finished GABA-B receptor to form a vesicle, releasing the completed GABA-B dimer from the endoplasmic reticulum, and be shuttled to the cell membrane.
Since dimerization is necessary for the function of GABA-B, this could just be a way of ensuring both receptors dimerize into a functional receptor. Maybe other receptors can dimerize just by being close together on the cell membrane. Maybe there are other mechanisms of dimerization with other receptors. Unfortunately, we don't know for certain.
@@Crowbars2 geez thanks for the essay lmao. Im asuming you are studying this? anyway very interesting, this motivates me to look deeper into pharmacology to try and understand half the words you are saying haha
Nile Red has some competition! another great video bruv, Thanks!
Science is so crazy. The mechanics and organic chemistry is fascinating. Even though this is not my type of pace, I can appreciate the beautiful synthesis.
It really is!
@@chemdelic You should take the Salvinorin A and turn it I to Salvinorin B ethoxymethyl ether, it's more potent than Salvinorin A and the effects last for 2 to 3 hours instead of 30 minutes.
@@oitthegroit1297 cursed chemical
I love the *purely informational* video you posted about, how to make salvinorin crystal👍
And your video quality is getting really good👀
i dont know anything about chemistry but you somehow managed to be in the top 2 of my favorite youtube channels (sebastian lague is the other one). you have a unique style and i like that.
Salvinorin A is such an underrated compound. I'm willing to bet that the majority of people who dislike Salvia did so because they did little to no research on the substance. They probably expected a euphoric high similar to cannabis, and I can't even blame them. Due to dumb drug laws, Salvia was marketed as an incense not for human consumption which meant they couldn't list the correct dosages, causing people to fill a whole bowl of the stuff when all they really needed was a small pinch.
I think the best way to use Salvia is as a tool to explore consciousness while letting go of all expectations. The moment you expect an outcome is the moment the drug turns on you.
I'm so glad that when I got into Salvia, there was already a dosing guide on the dmt nexus. Using a scale with a sane level salvia extract (~10x) was a game changer for me. The other game changer was discovering that salvia in a changa mix was amazing. A guaranteed ticket to carnival/circus land.
@@MisterNiles I don't know if Erowid is still a site, but that's what I used to use in my misguided youth for dosage recommendations.
this has been a great experience, i'm glad you brought us along for the whole ride!
Salvia has a bad reputation but I think it's because most people had no idea what they were getting into. It's effects are powerful and peculiar.
Most people didn't even consider using a scale.That may have helped.
I would love to try salvinorin A extract because I hate the smell and tasteof the leaves so much. I have a feeling the trip would be less dysphoric if I didn't have to experience that taste.
It is always fun seeing the iterative process at work.
This channel is so GOOD! Thank you for posting these fun educational videos
i will enjoy this video for the next six weeks that it exists on youtube. best channel ever.
Instant subscription. Salvia was one of my babies. Glad to see them grow.
Thanks for the sub!
Salvia was by far at the top of my favorite trip list. I always explain it as a 5 minute LSD trip, it honestly feels like hours, last time I ended up in a snow bank. Make sure to have a good trip sitter, a lot can happen in 5-10 mins.
you are fn crazy then lol salvia was a horrible horrible experience for me and i love me some L
DMT ?
@@gstein123 I agree, it's a completely different box of frogs to LSD.
@@EddieTheH Box of frogs 🐸 love it
Once had some 5x extract and it made my skin crawl but not much else. Then I won some 60x extract and thought "why not?". Whoosh. I thought I was 6 years old again on my way to school on a snowy day. I could feel the icy cold metal of a lamppost (in reality my glass containing water device). It felt so real. No trace of current reality was left. Then, after an unknown amount of time I was back and totally freaked out by what happened. Not a bad experience but enough to make me NEVER want to try it again.
This was fascinating and so appreciated! I love watching well explained demonstrations - thank you!
Awesome video series bro! Great to see the activated charcoal and methanol recrystallization work so beautifully. That charcoal column had me laughing 😂
Never heard of this crystal yet I'm so proud of you.
Recommendation: flash chromatography column packed with lab grade clean cotton, clean sand, charcoal. Boom. Edit: check out this book: Techniques in Organic Chemistry: Miniscale, Standard Taper Microscale, and Williamson Microscale This is what I used for ochem back in my undergrad program. It's a solid manual on techniques and is cheap now.
Finally! Great job!
congratulations! Your product looks beautiful, and this seems to me like an excellent conclusion to this series.
Conclusion? I'm just getting warmed up to him.
@@freehat2722 I meant to the Salvinorin A series.
i did not expect such a good yield from an extraction with so many potential for loses
This is quickly becoming my favorite RUclips channel
Thank you so much!
Hello dear friend
My main field is electronics technician and graphic design
But due to my interest in chemistry, I am also active in this field
I saw that you used devices and funnels for filtration several times
I don't think there is a need for so much complexity
A 20 ml syringe
Remove the piston
Squeeze a piece of cloud or Kleenex tissue
Push the tissue into the syringe until it reaches the outlet
Press it with a tool that is not sharp
Now pour activated carbon up to 1 cm
And now dissolve the crystal in water
and pour into the syringe
Put the piston in place and press gently
and over
I used it many times in the extraction of ephedrine and so on
The result was excellent
be happy
If you have access to a -80°C freezer or some dry ice it helps tremendously with the wax/chlorophyll issue, extract is light lime instead of dark green. Also just realized it was like 15 years ago that I last did this extraction, damn, time does fly...
Where do you buy liquid nitrogen?
@@lindboknifeandtool uhh... thats something differerent
@@thedude4795 I know but I’m in the right place, and casting a wide net.
@@lindboknifeandtool Check welding supply companies. You need to have a container that's actually rated for it, of course.
very simple and clean video :)
i expected little harder process of extraction but this piece of cake.
but yea as you said this is more like nexus guide than yt video xDDD
and proud to say this year is my 10th year of continuous mimosa extracts :D
deemz?
@@seadffsa yes sir :)
Salvia was the only compound I experimented with as a teenager that would give a very different response per plant. Such a wide array of strengths and effects
just found the channel and im loving it!
The amount of "professionel" lab equipment is really nice to see in a home lab
I feel you so mutch with the aktivated charcole issue, I had the exact same problem with an extraction I did, only difference: I had a Hand crank centrifuge... yeah my arms were unuseable for an houre or so after turning the the centrifuge with my pure muscle power... again and again...
rig up an electric motor to that bitch
I really like the way you narrated this video.
Glad you liked it!
wow! beautiful! fantastic job!
Idea for next video: decarboxylation of tryptophan with spearmint oil
Hey chemdelic! Would you perhaps consider a kratom extraction video? I’d love to see how you tackle that one ! It’s a much less legal grey area for than salvia!
Yes I can
@@chemdelic I'm mildly curious, but this takes the cake. I would certainly watch that.
@@chemdelic yeah if you can get around all the Wax and fats they have and are able to make a pure product that would double your sub count over night lol only time I was able to get a clean product was to use dry acetone and let it soak over night then filter the top clean part it made a brown crystal that looked amazing but sadly every extract I've made or bought isn't as strong as taking the hole powder itself 😔 but finding a way to make it easier on the stomach is my goal because it sits so heavy in my stomach it makes it hard to eat and you just feel like shit when you drink it it's so bitter
Omg this would be amazing
@@SheikhN-bible-syndrome I take the powder with oblate paper (Blate Papes), making there no taste to worry about. I have used them for a few years and use them for all my powder supplements. They are great
I've watched this video at least 4 times already. Please make more videos like this of other medicinal plants
Legend says the table is still high from all the spills
Oh my God it's a Kappa agonist!? Trippy AF for sure
another way you could have done that decanting was by using a funnel with a small size filter fret plugged with diatomaceous earth. another way would be old fashioned filter paper with a slight vacuum pump 2 micron will clean it up nicely.
A had a ton of this stuff back when it was legal. Very, very fun times!
Awesome video again! Keep it going.
a concentrated DMSO solution of this would be terrifying
Ah ha ty. I was thinking menthol as it's much more available (like my front yard). I made a similar post.
Only problem: both are soothing for pain. So is capsaicin, which I would find somewhat necessary for a "banish to hell" effect. Hypothetically speaking. All in good fun.
Chemdelic always posting bangers
I'm proud of you son. Keep up the good work
dad?
I feel each and every person here is so interesting to be a part of this channel.
Thanks for the tutoria-
I mean educational video not meant to be tried at home!
You may want to clarify at the end that the mg scale a lot of people use off amazon isn't good enough. You need like a $10,000 dollar scale to measure safely for sub miligram measurements and it needs to be properly calibrated.
yeah a safer way to dose it would be to measure out like 50 mg with a cheap scale, dissolve that in some quantity of ethanol, and then dose it volumetrically onto blotter paper or some kind of plant matter for smoking. That way if your scale is a little bit off it won't make a big difference.
@@user-ro9md9wp3j That's a good idea!
you know the day is good when new chemdelic video comes out
you are a true legend in my book bro man
10:58 our boy lifts weights
Not only is That Chemist smart, but also very observational!!
@@chemdelic I used to have them on my hands - not anymore lmao
It could also be due excessive masturbation. We just cannot know.
Is the removal of the chlorophyll in rhe latter stages just for aesthetic reasons, or does it mess with the efficacy of the product?
I’m not chemist, but if you don’t get it out, it seems unlikely to crystallize properly. Regardless I’ve performed extractions, and getting chlorophyll out is something you want, it could interfere with the steps after it.
You can smoke the leaves directly and you would have effects from the Salvinorin A. It mainly is an isolation of the psychoactive compound. It just changes the style of consumption as leaves are less concentrated and this is WAY more concentrated. Though mine mainly was for aesthetic reasons. Plus it is much easier to dose when you have the exact isolation of a pure compound rather than an unknown concentration with impurities!
Makes it gunky and gooey and tastes pretty bad chlorophyll kinda sucks for tryna get pure crystals or really anything that doesn't look like black/green tarry paste
Probably don’t want to inhale the vaporized chlorophyll. On the other hand the chance of introducing a more toxic impurity through the extraction seems high for the general caliber of chemists doing this extraction. Most of the videos I’ve seen the product looks more like dried leaves than extract.
Thanks to all, that makes sense, and congratulations @Chemdelic. Been interesting following you on this journey.
I don't envy trying to dose 1mg of yr crystal. ;-) gl.
Thank you! Chemistry is such a beautiful world!
Great 3 episodes excellent results 😊 Thankyou
Did it once....My main trip was awesome. My job in life was to lay on my back in a meadow while stamping out multi-coloured 'crazy paving' slabs out of the gooey stream that was flowing overhead....
However , the off-ramp was so horrifying that I can't bring myself to try it again...I believed I'd being held captive and sedated for 6 months and I 'realised' that the sedation was wearing off giving me a chance to escape. I somehow managed to get up, stagger down some stairs and out into the street. I felt like I was moving through electrified gel.
If you happen to be in a situation where you run out of methanol, you can pick some up at an auto parts store or a truck stop. It's listed as air brakes antifreeze.
It's got shit mixed in it that you can't clean out though
wow i do love some good old chemistry Great work dude!
Awesome work!
This but extracting DMT from mimosa hostilis would be dope AF.
Got some root bark powder I've been meaning to give it a go at . Confident I could it but wouldn't mind some extra references!
I wouldn't admit to that. but, hey I'm not a lawyer. All I can say is good luck... its an intense drug.
@@granderondeproductions3286let me just start with I appreciate you looking out homie, but to your first point,I live without masters. If they want to come lock me in a cage then they will, I will not censor, hide, or change anything about myself to appease some pseudo overlords. I am hurting no one and I am proud of my actions, I will always do them in the light.
To your second point yeah I've done it a handful of times and you're 100% right in that it's intense, words fail to describe what is experienced on the deemz. Last time I did it a voice told me to stop for a while, you'll know when it's time to come back, and its time to come back.
Im a lab tech and a coworker did the extraction for me last time but I think I need to remove the training wheels
cybs tek was super easy
@@charlesalberti563 DEA watching this 👀👀👀👀👀
@@electronium6378 who cares? You go live in fear I'll live without it
7:12 Don't worry. I would do half of the things different🤣
Like not using Aceton, like at all.
Like filtering every pull straight on. Look what you pour out of the bottle and how green it is, after the night. That is caused by all the stuff, you did not filter out straight.
Pull time of 3 times one minute, is 2 times and 57 seconds to long. It's plant material. Just grow/buy 20% more of it, to cover the losses.
Get Salvia leafs, not powder. Powder is only good for a vitamin rich smoothie.
Great video as usual 👍
Holy shit bruh. I thought biochem was useless but i understood the entire intro 😭
Great video.
This is so cool to find
Nice work. There are simpler methods, but given how potent a substance this is, I don’t want to spell out Salvinorin A Extraction for Dummies here. Hint: the easiest, but not most productive, methods I have tried are basically just like recrystallization, but starting with leaf powder. The change in solvent temperature and volume does most of the work. Extract the leaf powder into a solvent that you would use as a solvent for recrystallizing salvinorin A (ethanol works well). Maybe do two 24-hour macerations. Filter the combined extracts, then boil down to concentrate (how much to concentrate here is important, but you’ll have to experiment). Put the concentrate in the fridge for a day or two. Then filter off the crystals. They can then be washed in boiling hexanes. Then in boiling distilled water. They should be quite clean at this point, but you can purify further by recrystallizing in ethanol.
What an ambassador of Her Spirit xD ! Love it : )))
Hey if you could put chemical list and necessary equipment list, that would be helpful 😎🧪
I will put in the comments later!
@@chemdelic lol
Bruh he literally said everything he did in the video
@@SafetyLucas I know it’s just easier for organization and setup purchase
If you use CC option it should help transcribe most of it.
Awesome stuff 🙌
Thank u.
Great Video. 🙏🏻
Holy shit dude, amazing looking end product 👌
excellent video thank you
This is great.
Nice!! Salvia completely tore up my ego, gave me new look and perception to life. Respectfully tried it about 4 times and disrespectfully 1. All it takes is one bad trip to learn to respect salvia and salvia will treat you right.
I just discovered your channel and im in love with you
Do you think a vacuum filter would be efficient at removing the sediments without filtering out the desired chemical?
Would that remove the need to settle 24 hours or centerfuge?
Good work!
Well done ❤
Very cool!
End product: an eternity of nightmares in a grain of sand.
Underrated comment ‼️🤣✌️
I hope there's another more to come. Just found channel. Extremely interesting
Kratom soon
Salvinorin felt for me like my skeleton was jumping out of my skin while a high speed train was rushing through my room. And well, that was far below a real high dose. Such a crazy compound.
Oh and those are some beautiful Crystal's
I am so sensitive to Sally D, that I tend trip HARD on small doses of dried leaf extract. It definitely changed my way of thinking after a few very deep spiritual trips. When you say you will see God, I can back that 100% I can't imagine where pure Salvia would put me. It's my 3rd favorite psychedelic and for me, comes nowhere near the same as shrooms or LSD. Salvia is on it's own plateau. It's get the most respect from me.
Love the video - great stuff!
~New sub 😊👍
Please stop using drugs. It's mat be illegal in your area.
well played sir. well played
The opening clip was a pretty faithful recreation of how I would describe my salvia experience, minus the certainty that I was being pulled into some sort of giant deli slicer.
I have done every substance. And Salvia is the most crazy, Crazier then K. I watched the ceiling of my friend room open up peel down the center and splash down the walls like wabes as I went into another dimension of time and space, thought my whole life before was just a dream and now I was awake.
Oh man how did I not know about this channel.
Haha I love the ending, yeah I was thinking "oh man that's like 100 doses".
can't wait for you to craft Acid !
Your video titles rock
You have the same energy as sam o’nella academy
Someone's doing cool Salvia Science in 2023? Holy moly, bro. I haven't seen anyone do serious work with Salvia for as long as it's bad reputation clouded peoples interest in it. Subbed
omg, this channel HOW DID I MISS YOU?
Boy, every time someone talks Salvia it throws me back to my wildest hallucinations I've ever had, scary shit and you made pure crystals are you mad ??? It's very cool I'm an engineer but I always wanted to be a chemist I want to start doing extractions
wow, you did it!
came hard to this video. thanks