The 'Microclot' Pathology of Long Covid | With Dr Jaco Laubscher
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- Опубликовано: 10 июн 2024
- This is the first of a series of films looking at the issue of abnormal clotting pathology in Long Covid - yes, the notorious micro clots. In this episode, Dr Asad Khan and I talk to internal medicine specialist Dr Jaco Laubscher about his take on the pathophysiology at play, from endothelial damage, the mechanism of PEM, and how a simple non-invasive test can diagnose endothelial dysfunction.
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The Long Covid Handbook (Oct 2022), by Gez Medinger and Professor Danny Altmann and published by Penguin Books is now available in paperback, ebook and audiobook. A singular resource that brings together everything patients, clinicians and academics have learnt about the condition since early 2020, as well as lessons from sufferers and researchers of ME/CFS and other chronic conditions. It offers world leading expert advice on understanding, managing and treating Long Covid. It is available from the following links.
US: a.co/d/0gvkJCU
UK: amzn.eu/d/9KjurGb
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Contents:
0:00 Introduction
1:05 About Dr Laubscher
1:42 Endothelial disease
5:04 Symptom Clusters
7:19 PoTS or no PoTS?
9:24 Endothelial function test
11:35 Outro
References:
Episode 1: The Microclot Pathology of Long Covid (Dr Laubscher)
• The 'Microclot' Pathol...
Episode 2: The Research with Profs Pretorius and Kell:
• 'Microclots' in Long C...
Episode 3: The Big Picture with Professors Pretorius and Kell:
• How 'Microclots' Fit I...
Episode 4: How to Treat Microclots with Dr Jaco Laubscher
• How To Treat 'Microclo...
Episode 5: Can Nattokinase Break Down Microclots? With Profs Pretorius and Kell:
• Can Nattokinase Help B...
cardiab.biomedcentral.com/art...
www.nature.com/articles/d4158...
www.resiapretorius.net/resear... 
Наука
Thank you Gez for your dedication to raising awareness and providing us with the latest information that no one else is reporting on. Your channel is one of the only things that gives me hope. We appreciate it.
Thank you! Wishing you the best in your recovery
@@RUNDMC1 Thank you, Gez for all this info. I've been trying to get the endothelial function test here in Uk, and haven't suceeded yet. any recommendations for someone who might be willing to do it?
@@FilmVisionProduction I’m afraid not - sorry!!
Thanks! Although lots of us will not be able to ever get tested decently, your research is so important for those who have access to good doctors and for the future as well!🙏
I've been dealing with docter Laubscher for a couple of months now, he's very good!
He's the first docter that took me seriously and didn't write me off with anxiety.
I've been making progress with the anti coagulation meds, bloods back to normal for now, but ANYTHING I basically do that stretches them veins puts me back to start line. - stress, excersise, bad food.
It's like trying to overhaul your car engine while u on holiday with screaming kids in the backseat,the best thing to do is give them your credit card and send them to Los Vagas so you have peace to figure out what to do next. Then you pick up the tab later.
Same for LC, remove all the stress, excersise, etc a'd get the body to stay constant and in the calmest state possible while it recovers. Then u can deal with what it let you.
I've got a new game plan going forward.
Your analogy made me laugh so hard about the car and Vegas. My parents home recently flooded and they’re in their 80s. My brother is trying to recover the home and remodel, yet him and my mom don’t get on too well in same space and I’m like send her to Las Vegas with some cronies and I’ll fund the adventure and just get it done ASAP! He recently threw shade she has a gambling problem, he didn’t like my solution suggestion much🤣. But it would work!
Yes, I'm doing IV ozone, IV chelation, HBOT, etc...original March 2020, severe toxicity/disease and left for dead when I refused the vent, then I was refused. And yes, nitric oxide helps the endothelium.
@Marky rest for a year
@@vanjacalantropo the boredom would kill me......
@@marky5493 I get it but doesn’t seem like there is much of a choice here. How long are you prescribed blood thinners?
Thank you - there have been so many theories and explanations put forward for long covid, but this is the single most coherent and clinically persuasive explanation I've found yet, not least because of its simplicity.
I sent my paperwork to the UCLA Long Haul Clinic back in August. As of today they have dragged their feet on getting me in. They treat long haul covid as it it isn't serious. I have talked to others who have had a similar experience with UCLA. Way too many doctors here in the states that treat long haul covid like a joke
I really enjoyed this Vlog. As a nurse I have seen young healthy men with CVAs and patients of all ages with new onset labile blood pressure. When they are supine their BP is WNL or hypertensive. When they stand up their BP drops precipitously & the pulse races. Midodrine is an RX that I dispensed rarely prior to the past year. A bolus of NS has a short term positive effect on stabilizing the BP. Now I understand why.
What is a bolus of NS…? Thank you for the insights 🤩
@@gaelmclaughlin767 normal saline. inject in one go.
So many tests are not difficult the difficult part is actually getting someone to write the script for that specific test so often there is criteria that has to be met before that can be written in the medical establishments. This is great information it is good to know what test to pursue and what doctors to pursue that through and then the Hertel
Been using the Chinese herb Danshen in a tea with hawthorn to thin the blood and improve endothelial function along with nattokinase for clot removal for over a year, made a big difference . Veins have went for a dark blue almost black to a lighter blue, took several months but improving all the time.
Did you take any test?
Cam you tell me dosage you are taking? I'm 3 years out. Long covid. Lung issues and dizziness ate my biggest problem. No scar tissue found, but treating me as asthmatic since covid March 2020
@@oliviaelliott4623 you might like to try crushing a clove of garlic, leave it for 15mins then swoosh it down with some water in one go, do that 2-3 /day, this should help the lungs, a rosemary extract 500mg twice daily too. When you start to see improvements lower the dose, you can get a bit wiffy 😊
Omega 3 50mg a day and a handful of walnuts if you can should help with the headaches. Dr Mobeen has a vid on it, the blood vessels become leaky, omega 3 helps them seal up. A lymph massage from the back of the ears to the base of the neck will help any excess fluid drain away.
The danshen I got from china as actual root, was adding a chopped segment about the size of two m and m’s to a generic herbal tea that contained hawthorn, dandelion and habiscus (heather and heath is the brand).
I hope you get some relief
@@oliviaelliott4623 nattokinase 2000 fibronic units two to three times a day
@@vikuly8 wee bits , but the hands did feel puffed up, I put that down to leaky endothelial cells. Have a search in pub med for herbs that improve their function. That’s what I do whenever I’ve deduced the cause of a symptom, either through Gezs’ work or other yt docs.
There is always something herbal that helps I’ve found.
I had long covid and then had a stroke. Turns out it was a microclot that crossed through an open PFO hole in my heart and into my brain. During my hospital stay I caught covid again. This time I was on clopidogrel anti platelets meds as secondary stroke prevention. I didn’t get the same covid issues as last time and my long covid disappeared. I haven’t used my asthma inhaler for months since starting blood thinners. I’m now on aspirin as I needed to swap meds. My breathing is perfect. My breathing was a mess until my stroke. So I think the microclots were hitting my lungs pre meds. If I miss my blood thinner meds now I notice my breathing issues come back. Before the stroke I was running 13K a week and medically classed as very healthy at athlete level. However I always felt tired and breathless with watery dry eyes and all over body pain from the long covid.
Fantastic to hear about your recovery!
you took paxlovid ?
@@mathieusynnott8915 no I took clopidigrel aka plavix in the US.
You got the vaccine? Because two persons I know got long haul covid and injury after vaccine.
@@mariaannafarrugia5374 heck no. There was no way I was putting the vaccine into my body. Never. I’ve see too much damage bring do e to people I know who trusted ‘the science’ that never existed. 😢
I’ve had apheresis, did the triple anticoagulant therapy (not easy!). Months of high dose niacin. Now totally vegan (whole foods) with massive amounts of leafy greens to promote nitric oxide. Plus a multitude of other stuff along the way. Over a year now and I’m starting to feel better. No where near 100% but improving. Keep going people.
Glad to hear you’re improving Jamie! Notice much of a difference with the diet?
@@RUNDMC1 I think it’s definitely helping. Hard to assess/gauge the benefits objectively as I have tried so many things (and usually several things at once). Not very scientific I know! But I’ve been consuming lots of nitrate rich veggies since the summer and i’ve turned a corner since then. That said I also got lots of sun, took a shit load of peptides, and actually managed to relax just a little bit. I think it all helped.
@@jamiesmith4141 hi, curious how you’re doing now?
@@ChristyCollins was much better but I got reinfected four weeks ago. It was horrendous (couldn’t get out bed for 5 days). Slowly feeling better again but a few new symptoms to deal with.
As a GP in a functional medicine practice in South Africa, thank you for all you do and share on this channel! Your interviews offer so much helpful insight Gez and are a great springboard into topics at the forefront of the challenge that is long COVID. I'm also so proud of my colleagues for all the amazing work and research they are doing... Grateful to be able to refer some of my patients here to Jaco!
I just love your videos. They are the most helpful resource I have found during my covid and long covid ordeal. I'm going on a year. I had covid pneumonia that produced pulmonary fibrosis so every time I get sick, it goes right to my lungs. I had covid again last month & it has set me back considerably. It's horribly shocking to me that "LC centers" know little to nothing about LC & how it affects the body and therefore, cannot effectively treat patients. This was my experience in my home state of New Mexico & in Colorado.
I have all the symptoms that Dr. L mentioned. I'm an occupational therapist and a health writer & I can't do either job now because of cognitive & physical issues.
Thank you for all you're doing for this community.
Wishing you the best in your recovery Jeanne
Thank you Gez, really good subject and I'm looking forward to the series. Brilliant as always!
So glad I'm still in the control group.
Thank you som mutch for this series Gez!
Thank you for another wonderful presentation. Every little bit of information helps.
Hey Gez!! Words escape me as I try to appropriately thank you for all of this empowering info! I have been watching and sometimes rewatching your videos for about 1 week as, I too, have long Covid. I am a hospice nurse living in Massachusetts, US. I was approaching my limits with caregiver burnout when COVID 19 brought me down a second time (last was Feb. 2020 - not formally diagnosed of course). This time it has brought to my attention the distinct possibility that I may have been suffering from “manageable long Covid symptoms” for months to a year or even more since that first bout. I have had varied degrees of skin itching/hives for over a year, worsening ADHD symptoms, off and on progressive worsening fatigue, muscle/joint aches, stress headaches and when I coincidentally said to my mother one night during our acute phase of Covid. “Mom I know this is hard but honestly, it is just an exacerbation of how I have been feeling for months or even more maybe”. That was when it clicked that I may have long Covid. Currently home on sick leave, about a month after initial infection. I am able to manage day-to-day Activities of daily living and caring for my 4 year old daughter with the help of my family and friends, but cannot do much more than that. If I go shopping and slowly stroll through a store for an hour or 2 I am ok and can manage. However, the next day my energy is sacked and I end up in bed most of the day unmotivated to do anything but watch RUclips and color! Tasks like crafting or painting which I enjoyed in my limited spare time in the past is too taxing for me as well, which, any avid creative will tell you, means something is not right! I thought I would share this as I feel it may be an interesting topic to delve into possibly if subsequent infection can set back any progress or insight onset of long Covid itself. My employer has been extremely supportive and I am grateful for that but eager to figure out how to move forward. Your videos have been, in short, priceless to me on my road to recovery. Grateful for all you are sharing with the world! Happy to offer more insight if you would like. Who knows, I may write a book someday too!
Thanks so much for your support Jessica - wishing you the best with your recovery!
I have discovered your shows about 3 months ago you have helped me tremendously I have long covid and lyme disease the work you do gez is a godsend to all of us suffering souls THANK THANK YOU FRO THE BOTTOM OF MY HEART
And thank you both for your incredible work!
Thanks Tanja!
Thanks so much for this interview, Gez!
Thanks Danielle!
Thank you; greatly appreciated. A very interesting and informative interview.
Thank you for this video and all the other videos you already published. This channel is an important source of information for me.
Thanks Surfguard!
Massive thank you for the super thanks! Very much appreciated :)
Thank you for your continued hard work, research 🙏 and putting most of your findings/comments into layman's terms 👏👏👏👏👏
Thanks Dee!
Thank you so much Gez for another great video, it is soooo appreciated. I'm going to ask my Cardiologist for this test. Since June I've been doing Suzy Bolts long covid (rest, repair, recover RRR) online classes and also working with a local yoga teacher who is teaching me different breathing exercises to increase nitric oxide (I read in the comments here, it may help endothelium). Thanks again
There's a lot of confidence that 'in the end' it's an endothelial disease. But just last week there was a paper about Viral Persistence in organs of patients up to 380 days after initial infection. Will be interesting to see if there's overlap between the two (in some patients) rather than a singular issue.
Agreed, it’s a very complex and variable
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yes I found he was discarding other hypotheses while they might also be correct as we saw long covid could be different for each patient and might not be explained by one single thing.
@@timmy34400 agree, spike protein and gain of function are still in our systems and very difficult to eliminate alongside already pre existing conditions such as arthritis, Lyme disease which I had in remission.
@@MaryinOmshanti I was diagnosed positive with IGg Borrelia just a couple weeks after Omicron infection...Omicron for me was more like Encephalitis...🤔 What are you doing for this Covid/Lyme complication? I feel like it has caused me nerve damage like MS...
@@tigerspiritjourney You may have had latent undetected Lyme Borrellia which gets exacerbated by contracting Covid, however the "cocktail" contained in both the virus which was merely a carrier for spike and GOF and the injection (same thing) contain any number of parasites and pathogens. I don't have answers as yet but have tried a few things. To eliminate pathogens and parasites I'm taking what is known as The Terry Protocol, Praziquantel, Ivermectin and Panacur alongside an H1 blocker (antihistamine) desloratadine at Full Moon each month when eggs hatch. I tried physiotherapy to assist loss of pelvic function and got a brace fitted which helps me do more. I have to pace myself and check out my Garmin when my heart rate gets too high. I try to swim and take cold showers, I've tried stimulating the vagus nerve. I do some easy stretches to keep circulation in my feet going. It's hard when getting on and off a toilet means holding onto karate belts tied around a towel rail 😂 I am supposed to use my Rife equipment but setting up a biofeedback to run the results needs focus. I also have a HeaWea (also Rife) to run a specific blood cleansing program. With Dysautonomia or POTS or whatever the heck it is, I have found that a solution of an isotonic powder, a quarter teaspoon of salt, 4 tsp sugar (6 is recommended), a pinch of cream of tartar for potassium, 2 tspns vit C powder in 1 litre of RO water alongside a daily intake of min 2 litres of water assists with the crazy disconnected dizziness I'm experiencing. The salt intake also help with frequent trips to the loo but loss of pelvic function also plays a role here. Julie, rest is so important and due to high overall bodily pain is not easy to achieve. My Garmin records my sleep patterns and they're weird and in the main I get very little deep sleep, minimal REM and mainly light sleep and wakeful periods. I was taking a painkiller at night but stopped doing it because I'm not going to mess up the one system (my stomach and digestion) which is not giving problems and I don't like pharma meds with awful side effects. Breathing and relaxation are powerful because our central nervous system which I believe has been tampered with, puts us on high alert and produces inordinate anxiety.
I also take cardio aspirin am and pm as I had raised D-Dimers and am now taking desloratadine morning and evening too. Not happy with taking aspirin and would prefer doing Vit C infusions rather than take aspirin. Cardiologist put me on aspirin and statin but I refuse point blank taking statins due to one higher cholesterol reading.
Inflammation is raised and will need to give this some attention. I take quite a few vitamins, minerals and aminos. Vit B12 is a must for peripheral neuropathy.
Gez, thank you for another great video. Very interesting and I look forward to the rest of the series. And I have finished the Long Covid Handbook, Which I recommend to everybody here. I appreciated all the information on causes and treatment, but I especially appreciated your courage in sharing your personal journey with long Covid. I cried through a lot of it, it was very meaningful.
Wow - I’m so glad it resonated. And thanks so much for the support Lynn.
Where can we obtain the Long Covid Handbook, please?
@@pamelajones9734 available on Amazon! Link in the description
Artist can't paint...ceramic workers can't design....yeah, welcome to my world. I've made my living going in and redoing women's homes by moving around furniture and their paintings, rugs, vases, mirrors, lighting- it's been a living I've loved and gotten so much satisfaction from....especially when the women come home so excited about how more beautiful their homes are, even more relaxing with their own beautiful things they have bought!...ALL OF THAT I HAVE LOST....I can't design the room w their beautiful things anymore. So horribly sad....The one thing I was so good at, IS GONE.
I'm working on it to try my damnest to get it back. ITS SO FREAKIN SAD. But.....I aim to fight it.
I'm going to WAR. I want my life BACK!!!!!!!!
🙏😢😭 I know how it feels to lose your life to health issues. 🙏
@@Portia620 Anitra, Whats happening with you?...Please let me know...
Try ketogenic / carnivore diet. Look at Dr. Ken Berry MD's videos for guidance as a starter. Give it a try regardless of how silly you think it is. It has made myself 100% again after about 30 months of being unwell. Good luck!
Same!
Very interesting and useful. Thank you
Spot on! I finally feel understood and that there is a light at the end of this dark tunnel 🙏🏻
Wishing you the best Kate!
For those who have not tried it yet, a diet of fatty meat, butter and eggs has done wonders for me. For those that at this point are too sceptic to read on (I would have been in this group in the past), PLEASE LOOK INTO THIS SERIOUSLY! Getting back to good health would certainly worth be it, don't you think?
After endless experiments with my diet since my health went off the rails in March 2020, about 5 months ago I started doing a diet of eggs and cheese mostly, with considerable improvements, but still nowhere near my prior normal.
Now, over the past 2 months I have been on this meat-heavy diet and while I keep to it strictly, I would say that I am even better than I was pre-covid. If I stray and eat for example a couple of potatoes, my digestion issues, racing heart and other bad symptoms still resurface. After such ocurrances, within another 2-3 days of getting back on the straight and narrow path of strictly meat, butter and eggs in addition to taking anti-histamines (which I have otherwise stopped taking) I seem to get back to feeling awesome.
The other day I had an emergency with flooding risk to my house and had to dig a trench by hand quickly to divert the water away. I noticed after a while that I was not getting exhausted...could have gone on for hours and hours, which would not even have been close to normal pre-covid.
My day to day work sometimes involves quite a bit of manual labour. Over the past 30 months my ability to carry out such work, has been severely reduced, often to the point of being impossible. Now I seem to be able to run around all day, lift heavy things etc., with no bad consequences - as long as I stick to this diet. Some call it 'carnivore diet' and if you care to try, a good starting source for guidance are Ken Berry MD's videos on RUclips. If you dig into it (which I suspect you will, if at all interested), you will come across many others with good info. No information that I have seen so far has mentioned relief from longhauler's, but several other health problems. I am sure this sounds nutty to most people, as it did to me (especially as I have been a big believer in a mostly vegetable-based diet over the past 10 years and VERY reluctant to accept that it could be problematic)....but wow, the results blow me away! If you have pretty much any health issues, I'd say you would be making a big mistake not trying it out, but please don't do it without soaking up some further information on it first. If you decide to try it, preferably give it 2-3 months before making conclusions as the improvements seem to be subtle and gradual. You have to try it thoroughly before deciding it does not work. I would (and have started doing so with RL friends and family) even recommend this to people who are in perferctly good health, as there seem to be significant benefits for a lot of people.
Good luck to you all!
Hi there, thanks for your experience. There seems to be a growing body of evidence that keto and low carb diets are the way to go. The stricter end of that spectrum is the diet you described. There are many talks from all around the world on the RUclips channel LOW CARB DOWN UNDER. Recent talks have been on very low carb diets and yes, the Carnivore Diet.
I too have suffered with LC for 1 year. I had to quit my job due to it being too physical in this LC state. I began Carnivore about 1 month ago, it’s a healing diet. Although it’s still early in this journey, my energy has increased, & I’m starting to feel better all over. I know people think this is a crazy way of eating, but do the research on Carnivore, watch Dr. Ken Berry on RUclips. You will change your life!
The most recent podcast by Andrew Huberman was with Chris Palmer who has used a low carb diet to treat a number of disorders. I'm just about to try a transition to this to see what happens...
Very excited to see the next videos, great work as always Gez. You should do a patreon so we can buy you a virtual coffee /decaff low histamine drink :D
Makes perfect sense to me. I keep saying it feels like my cells are not able to store or use energy efficiently. A drained battery feeling.
My Delta break through infection last July set my hypermobile Ehler Danlos syndrome a Genetic Connective tissue disorder into overdrive
And my vertigo Blackouts and Dizziness are from Ménière's disease.
Before Covid19 I had been able to find a way to work in Hospice and Dementia specialist care.
One on one patient advocate and Death Doula. After I have not been able to walk up a flight of stairs without effort.
My Spinal Cord is suspected to be Tethered at the base as a hEDS complication.. Delta made it worse. Extreme spasms, nerve shock pain so excruciating that it's like having a ball peen hammer dropped on my feet. Or vise grips crushing my toes. My partner had to wrap his body around mine to keep the seizure type movements from further injuring my hypermobile fragile joints.
Got to keep moving even if its slowly bed will kill you faster. I am lucky to stand up and walk each day I make it to my balcony to watch the sky is a good one now
. I am off all medications but BP, a muscle relaxant and anti histamine.
Nothing helps and I have already tested everything recommended much the same as hEDS. Gluten free low inflammatory diet. I am mentally very strong.
And more prepared by years of Chronic illness than many others. My partner is a caregiver too. So I am Blessed in this way and very loved.
Thanks Gez, I'm convinced it's a clotting issue. I'm in the middle of treatment with Dr Patterson & it's beginning to help. I'm very keen to see what treatment he recommends. If it's similar or the same as what I'm already on. Vascular inflammation is the problem, the symptoms feel like this too, pressure, oxygen bit travelling correctly etc. I'm going to get this test asap and I look forward to hearing more from this gentleman. This video I know is bang on point ❤
what treatment are you in?
@@jhonybraavo the one recommended after having the long hauler blood test from Dr Patterson. Few of my cytokine markers were up to 10x higher than they should be
@@castlesmadeofsand I see. What are your symptoms? Are you better now? All the best mate
@@jhonybraavo all typical LC: breathlessness, fatigue, headaches, gut issues, inflammation everywhere etc. I'm better than I was, but caught couple colds recently which has set me back. I don't think it's Covid.
I noticed an improvement after month 1 of treatment, then I've had problems with a couple of these colds. So it's blurring the waters to how I'm really doing with treatment. I'm convinced it's clotting tho so will be continuing with month 3 of treatment very soon. Looking forward to watching this series
Very interesting. Thank you.
Thank you so much, Gez
Thanks Erika!
So helpful and just my experience
Makes all the sense in the world based on my symptoms
This video was so helpful! Thank you :)
Helpful, thanks.
Thanks you very much for your work
Very interesting - waiting for more! Many thanks
Thanks Jane!
Thank you for this. Blood thinner triple therapy regimen suggested by Dr Jaco has significantly improved my symptoms. I sincerely hope more clinicians globally listen to this video
Where can we get the triple therapy?
Massive thank you for the super thanks! Very much appreciated Sonali :) So glad to hear that you’ve improved on the treatment.
Hi Gez, what does the treatment consist of?
@@matthewws5694 Dr L will describe it better than me in the next episode, but it’s aspirin, Clopidogrel and apixaban. It’s indirect treatment though, if that makes sense
@@RUNDMC1 Not really. But I'm going to his practice tomorrow for blood tests. Genuinely hope they can help
I, like Dr Asad, have terribly disabling POTS but I’m not precious where it originates, whether my damaged blood vessels or nervous system are to blame I still have the symptoms! That said, I have very clotty blood, oxygen issues nearly every day and dysautonomia-so there are quite apparently a whole host of things going on.
I’m now fascinated by the success some of Dr Sanjay Gupta’s patients are having with IV saline-wondering whether bumping the system pressure massively and temporarily up gives both relief from the postural issues and may also ‘dilute’ clotting and give the endothelium a break. Might be talking out of my elbow here, but it’s given me a bit of hope that we’re getting closer!
You managed to get a decent amount of magnesium into you? How is your vitamin C intake too? Both essential for endothelial function FYI.
Thanks for this one and especially for asking how to get endothelial function testing done. So important to know who to ask but still takes luck. I've had no luck getting a venous blood gas test done from 2 pulmonologists. Maybe will have better luck with this test.
But what is the treatment after that....as he is saying there's no treatment for that
This guy is a genius...I never believed the story about POTS. Thank you, Gez!!
(I am not the log in name). Dr Laubscher, and Gez Medinger, as a 20+ year veteran of Microvascular Dysfunction (CMVD, #INOCA), and as part of some long term and now, incoming post covid patients, we are familiar with all of this. Your explanation is great. My concern is the EndoPat test. So far, EndoPat has not reached true diagnostic reliability and it does not have the requisite validity in the expert cardiology practices we get diagnosed through (US and UK and others, internationally). We patients, generally have gone through every cardiac test imaginable, many times over. (This all started many years ago with "Syndrome X", considered a women's, "anxiety" problem.) Ultimately, we end up with Provocative Challenge Catheterization, a challenge test with Acetycholine and other substances, to determine if the dysfunction occurs at the Pre-arteriole, Arteriole or Capillary level. It looks at paradoxical vasoconstriction. If the vessel constricts or spasms under chemical duress, we see that abnormal oxygen flow results, whether due to vasoconstriction or lack of NO perfusion. We also need to establish if spasm (sometimes a different etiology and treatment), is the situation, a different diagnostic result from CMVD (Coronary Microvascular Dysfunction.). Rarely, a structural anomaly is discovered that can cause alternation/impairment in blood flow.
The centers of excellence who have adequately served these patients include Mayo, Emory (the expert is now near to Emory, at neighboring hospital), Stanford, Cedars-Sinai and other specific entities. These specialists have usually devoted significant career time with this disorder. We are not usually seen by vascular surgeons unless there is established (>70% vaso-occlusive disease for stent justification), but often Interventional Cardiologists, and those with a specific interest in this aspect. There are several patient advocacy entities. The issue of micro-clots via capillaries is concerning and the hypothesis sounds right to me.
Generally, the treatments for this condition (NOT microclots) are oriented toward nitro (long and short acting) and it's related medications and cardiac meds. I think the apheresis-like treatments sound logical and worth the effort. Anything (eating, exertion, emotion, heat) that stresses the endothelium and blood flow has effects on many of us. (Eating low carb, low sugar, low sat fat food in small portions, avoiding alcohol, caffeine or provocations helps. Pacing is critical. If there is undiagnosed sleep apnea/hypopnea, it is crucial to get on CPAP to support sleep and airflow impairments to have restorative sleep). Understanding of CP/SOB microvascular damage due to a viral or infectious agent is known in Lyme, ME/CFS, inflammation due to pericarditis, etc. Separating the wide variety of reasons for chest pain (occlusion, inflammation, viral agent, even thyroid (and the ever reliable anxiety, etc) is a difficult and expensive task. With our granular Descartes model of health care, history taking is ever so important, as well as eliminating gender bias. I am happy to refer names, but in general, the widespread awareness of Covid-19 issues is propelling our understanding at warp speed. Check out videos #INOCA & web. message me @mbaglg on Twitter
Thanks Gez for all that you are doing for long covid.
I have been treated by Dr Jaco Laubscher for the past 10 weeks and feel that I am fully recovered. ( Covid Christmas 2021 - long Covid symptoms of fatigue / pots (like ) symptoms / breathlessness / spiking heart rate / PEM … all now gone ! )
What protocol did he give you please and how can we contact him?
@@thetruth1734 They tested my blood first and found that there were micro clots and hyper active platelet formations. I then went on a protocol of 5g apixiban /eliquis a day and one 75mg clopidogrel a day, (which has two anticoagulants ), plus a proton pump inhibitor to protect the stomach against gastric bleeding. The Apixiban was reduced in the second month as I responded well to the anti-coagulants and symptoms started lifting (and second blood test revealed improvement ). If you google Dr J Laubscher, and Prof R Pretorius and Douglas Kell, you will find their published research papers which outline the protocols and findings more fully. Best wishes
I do know people who have not got better on the treatment however! Especially those who have more neurological symptoms of Long Covid.
Fantastic news!
Glad to hear of your success
Well done Gez!!!
Thanks Kelly!
@@RUNDMC1 Keep on keeping on Gez!!!! We appreciate you!!!
Great content! Agree 100 % that endothelial disease is at the root of long covid. Glad to know how to definitely diagnose thru ultrasound. Thanks for sharing.
I look forward to the followup videos. The info in this video must be correct. It was early with long COVID that I started taking two adult aspirin to thin the blood and felt better. My primary warned against the damage the extended dosage of aspirin might cause the lining of my stomach, but I got my endurance back, while some of the other annoyances such as dry eyes and runny nose remain.
What were your symptoms? how long did you take aspirin?
Thank you!!!!!!
I like his theory. Addressing clots helped me a lot and it makes all sense. Would be interesting to know what role mast cells play. They release heparin (among others). Somehow it fits into the puzzle…
Some interesting research out there on effects of Curcumin on endothelial cells that might be worth looking at.
I am the person that got long Covid from the vaccine. Interestingly, prior to IVIg therapy I would clot at a ridiculously high rate, yet had extra large bruises at injection sites. After, I clot at an acceptable rate and have minimal bruising at injection site. I’m also part of a clinical study at NIH.
Thank you for this video! Would love to find a doctor willing to do the test.
Hey Gez, are you considering any videos about thrombosis as part of your series? As someone that's had a blood clot during Long Covid, it would be great to get more information on how this might tie into things, as the haematologists I've spoken to seem unclear about the potential mechanisms at work and where microclots might fit in in relation to it.
Part of the issue is finding some haematologists to speak to who can link it all together - and aren’t snooty about the microclots research!
@@RUNDMC1 My current haematologist is of the opinion that microclots may play a role in thrombosis but that haematologists are discouraged from entertaining this due to a prevalence of poor research that has jumped to conclusions regarding microclots. I'm not sure if that's her being a bit snooty herself or if there's some truth to it.
@@RUNDMC1 Hematologist Lawrence Afrin might be helpful. He speaks about MCAS, but he seemed anything but snooty in the video presentation that I saw.
@@beckygee1233 he’s an MCAS specialist, I interviewed him on the channel
I had an appt with a LC specialist, I made it to 8 months of waiting, out of a 9 month wait, then their office called and canceled my appt because they no longer take my Ins. They said that now the wait is over a year.
I think he is right on as it ties together what I have been experiencing. Since I can't sleep I did a sleep study and they diagnosed me with CPAP and prescribed me a machine. When I tried it the first time, it triggered my PEM and caused me to not sleep. I tried it again and with in about 10 breaths the same thing happened. I again tried it only this time just while I was sitting up on the computer and again within 10 breaths it was triggering my PEM. The doctors don't believe it and say I just have to get used to it. I disagreed as I believe there is more to it than that and it is long haul related.
Following that experience I got a CO2 body bag and started doing CO2 treatments. It is supposed to relax you and help you sleep, but for me it gave me energy and made me very alert. Instead of at night, I starting using it in the mornings and OMG, it is working. After 3 times, my head cleared almost to the point of pre-covid (27 months) and I no longer have to take naps during the day. Have not tried exercising yet as I want to take it slow. The idea of the CO2 bag is that the CO2 causes your blood to give up oxygen to your cells (Bohr effect) and as he mentioned your brain needs plenty. I have only had the bag for only a few weeks, so time will tell if it continues to help, but out of all of the tings I have tried, this is the only thing that has actually done something.
That said, this fits right into what he is saying. The CO2 is forcing my blood to give up the O2 to the cells. After this experience, I now believe the CPAP machine was hyperventilating me robing me of CO2 as my clotted blood isn't giving up the oxygen and doesn't need any more.
Where do I find a CO2 bag, please?
@@MaryinOmshanti The one I am using is called Bodystream-see link. To me, the website makes it seem like a gimmick and it is expensive, but after suffering for over two years I am getting desperate so I decided to give it a try. I have tried many things but nothing has worked or had any affect. I don't know if it will actually heal me, but at least I can make it through a day at work without feeling like crap. Time will tell if it does more than that I.e. allow me to get back on the bike without suffering terribly from PEM. Seeing this video seems to tie it in as to why the CO2 is working.
www.consciousbreathing.com/product/bodystream/
Thank you so much for this one Gez! I’ve been intrigued by the microclotting theory since you first brought it up, but it’s great to finally hear the mechanism for the microclots explained in detail.
This endothelial disease angle feels sort of subjectively true to me based on what has worked and what hasn’t for me. I’m thinking especially of the way I often have the longest stamina when I’m running in power saver mode, for lack of a better description, with minimal movement, minimal concentrated thought, etc. Like the waking dream version of meditating almost? Hard to describe. But it makes sense why that would work if the endothelial angle is correct-I’m minimizing the amount and pace of oxygen depletion in cells in a way that generic resting doesn’t really (…well maybe it does if you don’t have ADHD and resting is more stationary).
I’m rambling now but all that to say this is interesting, and I’m curious to see it continue to be tested.
Thanks Rachel!
Rachel I also have ADHD and long Covid, can I ask if you know of any contraindications with stimulants meds and micro clots?
@@lauramullen2202 Oh gosh, I have no idea. Pharmaceutical interactions are pretty far outside my wheelhouse. I haven't heard of any data either way, but I also haven't looked for any. I also don't take stimulants myself because my brain chemistry doesn't love them.
I'm not sure where the best place to look would be. Maybe Gez knows of something?
Endothelial dysfunction! That's a phrase I hadn't heard until now. This sounds very important. I wonder if our NHS cardiologists are aware of this? They might be very soon!
I’m all-in with the endothelium and microclot hypotheses, but I don’t see why we should preclude other causes. For example, Dr. Laubscher says that the POTS-like symptoms won’t be affected by water, because it’s not true POTS. But why do most people’s POTS symptoms get better as the day progresses, even as their fatigue may worsen? I think there must be other things going on as well
Agreed, it’s a complex picture
There are many reasons why certain things may work. Drinking water for example also thins the blood. Just one possible explanation and there may be many
I think for people with Long Covid who fit the ME/CFS Canadian Consensus Criteria which includes ‘Post Exertional Malaise’ PEM (MedScape recently published a paper that stated approx half of Long Covid patients fit this ME/CFS criteria.
So for those with PEM, this endothelial hypothesis isn’t the full story. I believe it’s a factor but there’s more going on.
Because in an ME/CFS study several years ago, when Professor Ronald Davis of the Stanford School of Medicine and his team stressed ME/CFS patients cells in vitro they found they quickly ran out if energy, pooping out, and entering a hibernation type state. This was compared to stressed healthy control cells that remained able to produce energy. Note: In this situation there is no endothelium interfering with the test. Yet still a cellular energy issue
I believe that the endothelium isn’t functioning properly because the endothelial cells are also pooping out of energy, so not enough energy to contract veins when needed to boost blood pressure when upright, hence they mimic the POTS like symptoms. But it’s not just the endothelial cells lacking cellular endurance, it’s every cell in the body with this extreme energy deficiency issue. Including neurones (brain cells) causing brain fog, and immune cells, T cells etc (NK cells are known to be underperforming)
Some good news though, when they put ME/CFS cells into the serum of healthy controls the cells woke up and functioned normally. So that means the mitochondria isn’t damaged. As that was the big concern for decades.
I highly suspect Long Covid (with PEM) will be ME/CFS, and those same issues will be present.
Also interesting when healthy controls cells were put into ME/CFS patients serum, the healthy cells shut down into a similar hibernation type state. (also in vitro)
This test needs to be done for Long Covid. I think Professor Davis must have done this test because he and his team had also looking at Long Covid since the outbreak began.
Mammals cells go into the hibernation type state when sick, that was named the 'Cellular Defence Response' CDR, a sluggish anaerobic state as apposed to the normal aerobic state.
CDR is a hypothesis by Dr Robert Naviaux. And is well known in ME/CFS research community.
CDR happens to healthy people when the body gets sick or injured. It’s natures way of conserving energy for the organs while the body recovers, as during this period a mammal normally is restricted in gathering food. After the virus or injury has healed, a healthy body soon recovers and the CDR turns off.
But in Long Covid and ME/CFS the CDR stays locked on indefinitely. The big question is why???
Professor Ronald Davis believes it’s a metabolic trap, in which tryptophan levels get too high they shut the cells down, and due to a faulty gene the tryptophan can’t be cleared.
I myself suspect the reason why Long Covid (with PEM) and ME/CFS cells aren’t turning off CDR is because of an autoimmune response that develops when the immune system is under a huge stress from an infection like Glandular Fever, influenza or Covid. This causes ‘molecular mimicry’ which mistakenly starts targeting a human produced antigen that’s related to cellular exertion. Because cellular exertion makes Long Covid and ME/CFS worse resulting in PEM. Which to me feels exactly like a horrible immune response. Possibly targeting an antigen on on a receptor or metabolite that becomes more plentiful or during cellular exertion. Even when resting cells exert energy, and therefore are possibly being targeted by a lower level autoimmune response
Researchers have searched for autoantibodies, which is being done now in Long Covid and they have indeed started finding them. The same autoantibodies were found in ME/CFS but researchers were never given enough funding to look for more (which is appallingI. Chances are they exist like in Long Covid
Lastly I think there’s been a lot of good research over the years into ME/CFS often funded by patient groups, especially in the last 5 years. Yet many Long Covid researchers are repeating old mistakes that have already been eliminated. It’s a shame they aren’t digging into the wealth of existing knowledge in the ME/CFS literature.
Damnnn its make sense
Great comment! Thanks B
True really
@@RUNDMC1What is a real tragedy for Long Covid is that had ME/CFS been believed and it got the same level of funding to disease burden of comparable diseases, it would have had much more research done by now, most likely some drug therapies, that could have been ready and waiting for Long Covid patients at the start of the pandemic. Making people with Long Covid, especially those with PEM are also victims of this medical travesty. Unnecessarily suffering.
And all because there’s a small bunch of prominent psychiatrists are to blame, because they produced a fraudulent study called the PACE trail, a study so bad that they also included people with just long term fatigue who didn’t even fit the ME/CFS criteria. Those participants were put with actual ME/CFS patients.
The study wasn’t blinded either, as patients were told that the therapy which was Graded Exercise Therapy GET and Cognitive Behavioural Therapy CBT would help them. Also because many patients weren’t recovering the authors changed the exit criteria, but it matched the entry criteria. Meaning someone who hadn’t improved was deemed to have successfully improved! Yet these patients only had the physical ability of someone in their 80s
The authors failed to tell the patients that they also ran their own private Pacing clinics that used CBT and GET.
In a couple of US universities the PACE Trial is now taught to students in “How not to do a study”
Yet that study was believed by the medical community, it stopped most funding for ME/CFS and caused a decade of hell on earth for patients that worsened an weren’t believed. It caused forced admissions of patients (especially teenagers) into psychiatric facilities that forced them to do Graded exercises. Many patients worsened.
Another appalling issue is the Authors of the study failed to declare to patients in the trial that they worked for the medical insurance industry, as with their ‘expert opinion’ able to deny medical insurance to ME/CFS patients because they said the disease was just a patient in denial that they could recover and were incorrectly afraid of exercise, therefore had deconditioned (this has since been proven to be false as the 2 day CPET (exercise test) shows patients are worse off after exercise.
Note: many Long Covid patients have identical results on the CPET
(See exercise and cardiopulmonary researcher Dr David Systrom’s work on both Long Covid and ME/CFS at Brigham and Women’s Hospital and Harvard University)
Anyway this Long Covid issue is so far behind because the authors of the PACE Trial change the entire world view on post viral illness over a decade ago. That’s why we all remain sick to this day.
To read about this medical travesty go to the reputable TWIV ’Virology Blog’ to read ‘Trial By Error’ by Prof David Tuller
Tuller has written multiple blogs on this subject, and to this day is still battling the same narrative from these dodgy psychiatrists, who are publicly now pushing that GET and CBT be used for Long Covid.
They even accused award winning journalist George Monbiot of causing Long Covid hysteria by merely writing an article about his own Long Covid experience.
Monbiot’s article is in the Guardian under the heading
“Apparently just by talking about it, I’m super-spreading long Covid”
In the article Monbiot wrote “as I began to investigate, I stumbled into one of the most astonishing scientific stories I’ve ever encountered”
It would be well worth interviewing Monbiot and David Tuller, as your jaw will drop at what they have to say about the carnage the authors of the PACE Trial caused to both Long Covid and ME/CFS
Note: Pacing is not to be confused with the PACE Trial. As for anyone with PEM, pacing works, but Graded Exercise therapy will quickly worsen a patient.
@@brobinson8614 I interviewed David Tuller for my book - completely on the same page as you on all this!
Wow, thank you. I’ve got two appointments at the cardiologist next month. I’ve written down this outline for the test. Next thing is what’s the treatment, I guess that’s coming in this series.
Hi Ian that 's great I hope you'll manage to get the test done! Can you share how the test is called/what the outline is exactly? I somehow can't manage to construct the info from the video (brain fog...). Have an appointment with the cardiologist too next month, fingers crossed.
@@maloustoekenbroek9172 hi it’s called flow mediated dilation and is a non invasive rest done on your arm using an ultrasound device. Bit of a techy video for medics but it explains it: ruclips.net/video/YlFvcp65cwE/видео.html
(Aka FMD)
@@gaelmclaughlin767 Thank you!🙏
Can you explain the impacts on the cranial nerves? Vagus, gloss o pharyngeal trigeminal nerve impacts?
Very interesting . A cardiologist told me she didn't think l had POTS , per se , but problems with the Baro receptor feed back loop, due to a collagen disorder . On having my latest covid booster a month ago l experienced the usual feelings of unwellness but also what l would describe as POTS- like symptoms for a f week or so ( never had that with any of the other vaccines ) . Did the vaccine affect vascular epithelim mildly, and it's now repaired itself, as symptoms have resolved? I do a lot of saunas and reportedly they repair vascular epithelium.
No more boosters! They only cause harm (delivering toxic spike protein to you) and don't even prevent transmission.
Will you also talk to the pharmacist who's collecting data on twitter of LC sufferers trying enzyme supplements? It looks exciting. Would be fascinating to hear you and the Dr interview her!
Good suggestion!
What enzyme supplements are they using? Thanks
The bit about the POTS makes sense to me, but mine is from ME/CFS probably from the EBV or similar and surely by his definition half the people with POTS don't really have POTS 😆
I have been able to improve the orthostatic issues through gradually sitting up more and more after my usual crash symptoms have massively stabilised and I've started POTS lifestyle changes and meds, but I have become very deconditioned while having to lie down and trying to figure it all out.
So, maybe I'm just restrengthening my recently underchallenged blood vessels and will reach a point at which I cease to improve, who knows?
Gez, thank you so much for your work.
I'm on ASS and Rivaroxaban for 3 weeks now (off label). Long Hauler (with ME/CFS diagnosis) since 03/2020. Not every symptom is better, but my breathing improves (before, it feels constantly heavy to breath in, like there's something stopping the air), musclepain raises a little bit later under "activity" (basic daily life things) AND most, the brainfog/headaches are less serious.
I think clotting is only one part of the pathogenesis, but I hope adress this issue could help my body selfregulate step by step a little bit better.
(english is not my first language, so be kind :-))
Edit: I have GPCR-autoantibodys and HHV7 PCR +, too. If there's one underlying course or a addition of problems I don't know... We hopefully will see....
How did you get these medications prescribed? Did your doctor recommend them? If so, what kind of doctor did you see?
what is ASS? Aspirin ?
Such a great video! I wish all LC clinics were testing for these things vs. selling deconditioning/ anxiety theories
Good video, I hope this leads to some treatments. I'm not sure about Dr. Laubscher's comments saying it is endothelial damage, not POTS due to covid. It can be endothelial damage AND POTS. In this case a vasoconstrictor such as midodrine can be used to compensate for the poor peripheral vasoconstriction. Midodrine is a common POTS medication and can help in this situation. Worked for me.
What were the symptoms this medication helped with? Did it take long to see improvement?
Is it okay to take Midodrene if you have very low BP. So reluctant to take drugs with side effects.
Yes, midodrine will raise blood pressure if anything. It kicks in within an hour and lasts only a few hours. Helps with lightheadedness and allows me to be more functional when standing up. For side effects I get goose bumps and tingly scalp, but it affects everyone a little differently. It seems like finding medication to treat POTS requires some experimentation.
I want to add a postscript to the comment I made 4 months ago. In January, after 3 months of the triple blood thinners I was told that my blood was clear of micro-clots and the platelets had calmed down. I was thrilled and thought I was better. (when I wrote the comment earlier)
It has been false hope. I am back to where I was right at the beginning!! Complete inablity to exert myself (heart rate spikes madly with slightest exertion) and concommitant after effects - fatigue mainly. On top of that there is also another issue with my heart (goes into fibrillation which now needs medication). The cardiologist I now see believes that the autonomic nervous system has been damaged as well as damage to the heart from covid. Neither of which has been caused by micro clots or I would be better! Micro clots/platelet activity is in my experience a piece of the puzzle but getting rid of them has not returned me to health.
( The treatment is also very risky. A friend of mine on the treatment had internal bleeding as a result of the meds and had to have a blood transfusion as she lost litres of blood! She is still not well as a result of the bleeding and now needs iron infusions as she has anaemia )
So sorry to hear this. Wishing you the best in your recovery!
It could very well be that a mechanism - be it vir pers, autoimm or persistent production of spi pro inside of cells because of a dysfunct va - is driving the mechanisms which the tripl antico ther is fixing. So you may need to do this every once in a while. You can also try less risky combos of these medicns (eg two instead of three) and lower dos for longer periods of time
What were the tests we should ask for? I re-wound a few times to try and write them down but couldn't quite catch them and having them written down so that I can know that I'm asking for the right thing will help a lot :-) thanks :-). Fab interview, makes so much sense to me given my symptoms! 🙂
Dr L mentions the brachial artery flow mediated dilatation (and the fancy Endopat test)
Thank you again Gez. I'm finding your videos really useful.
Dr Laubscher tells a very compelling story, making it sound quite simple and like he totally understands the disease. I'm guessing that the full picture (which you obviously have a great overview of!) isn't quite as simple as "damaged endothelium causes micro clots, causes restricted oxygen transport, causes everything else"? Also he's the first person I've heard to say that long covid POTS is not actually POTS. Is that, and his other claims, supported by other sources?
No I don’t think it’s quite that simple :) Re POTS - not heard it elsewhere but it does make some sense
I appreciate the pov and would not be surprised if there weren't multiple types of failures in long covid. All I can say is that I'm on the dietary/gut repair and mastocytosis bus and I've finally found the right combo of diet and supplements and now making progress. All I can say is it's working for me; may not work for you. Let me also say that I've yet to find a single doctor who knows anything about food intolerances and the complexities of gut dysfunction and how to fix it. That includes top gut specialists. I've done better the last decade self diagnosing and treating multiple genetic defects and gut work than I have all of the first sixty. This is old teachings and the way of the future. If you can't get well, look at the gut. If the gut is broken it will load the blood stream with toxins that will further interfere with issues throughout the body. With my own eyes I've seen improvement over the entire body from gut work... literally Everything.
What exactly did you do to improve?
@@thetruth1734 I already replied... did you not get my message?
@@thetruth1734 Hi there! Can you message me also as to how you healed your gut. Omicron decimated mine and I believe it's the first step for me. Cheers, from Sweden!
Gez, thank you for your continued efforts on this channel. I am thankfully probably about 80% recovered now after 2 and half years. I only started to feel a consistent improvement at the start of this year when I started taking NAC. I am really curious to know if this readily available supplement fits with this microclot theory.
Glutathione is the king of anti oxidants, there's quite a few studies that show that it benifits healing arteries. I think it's converted from NAC if I remember correctly.
What were your symptoms?
@@jhonybraavo Brain fog, fatigue and breathlessness
Great to hear of your improvement John!
I started to immediately feel better after starting LDN and my energy levels are returning to normal since also starting a supplement called Sublyme essential. It has quercetin and NAC in it
He doesn’t come across as open minded in any way and seems completely disinterested in any other pathology. Clotting is clearly at play but with so many other scientists pointing at viral persistance it is strange he is so certain.
Having had HELP apheresis then his triple therapy and seen zero improvement along with many others I don’t think it is that simple.
I’ve also heard feedback from his direct patients that he is close minded and dismissive of them if his treatment doesn’t help…
Thanks for the video Gez, looking forward to the next ones
That is not true. I’m a patient of his & prof Resia’s micro clotting tests
I’m starting my 3 treatment tonight 20-05-2024. I have some progress already
He is polite & listens to his patients, intently I must add
Looking forward to future videos on the subject. I tried taking Nattokinase which is a natural blood thinner for a couple months with no results :(
how are you doing now?
Yes, yes, yes!!! This is the problem for us! Microclothing! Thank you so much, Gez, for sharing this! Looking forward to see treatment. Some sugestions: nattokinase, lumbrokinase, serrapeptase???
These are the ones the community is trying but I can’t explicitly endorse them!
It is probably not funny, but 'microclothing' made me visualise a bunch of longhaulers wearing obsurdly undersized, tight clothes, as a potential remedy.
If only!!
@@RUNDMC1 Thank you again, for confirming that these are true "bullets". I am taking these, but still struggling sometimes. Like now, for example. My husband vad cv again, and it seemed I didn't, but I have breathing troubles... When I take blood thinning - some herbal extracts, like curcumin and resveratrol, and enzimes, I am breathing ok, but I have to keep taking it.
Thx so much for your great work Gez. It's amazing. I'd like to ask you, when would it be safe to fly...? Are there any sort of timing when you would say its safe, in the process of LC? Thanks for your time and help:).
Flying is a relatively high reinfection risk, but aside from that - any time that you can manage the associated walking / travel / energy burden without inducing too much PEM
Thank you for this video, Gez. i forwarded this to a cardiologist for feedback and to ask about the endothelium test. Does this resolve itself over time without intervention?
For some it seems to, but not all
The late Mary Fowkes did autopsies in 2020 showing. Micro blood clotting thrombosis in brain, kidneys liver and lungs. Scientist Tim x showed that people with mercury build up were higher risk of cytokine.
Very interesting video. Thank you
I'm in the UK. Would be very interested to try and get this test. Is it purely an ultrasound? Is it invasive at all, or do you need to be injected with anything?
Here’s a description of endothelial function tests from a piece about a potential treatment (currently researching it!)
Endothelial function was assessed with two methods:
The flow-mediated vasodilation of the brachial artery is an established noninvasive technique to assess endothelial function. A brachial cuff is placed on the arm of the patient. Following release of the cuff, the artery size increases as a normal reaction. The more it increases the better is the endothelial function. After 3 months, the endothelial function (flow-mediated vasodilation) was significantly improved by 189% in the Pycnogenol group compared to the beginning of the study and only by 22% in the control group.
Reactive hyperemia is another noninvasive assessment of endothelial function and microcirculation. Finger skin flow is measured with a laser Doppler flowmeter following brachial cuff release. Pycnogenol increased reactive hyperemia by 116% compared to the start of the study.
wholefoodsmagazine.com/columns/vitamin-connection/preventing-post-covid-symptoms-with-pycnogenol-a-new-clinical-study/
I immediately started to feel better since starting LDN
what is LDN?
@@kyak938 low dose naltrexone. Start at 1.5mg a day and over time build up to 4.5mg
Ketogenic diet and a 5 day water fast are the key to heal the" disautonomia"
Sp: dysautonomia
After Covid, left skull swollen needs daily massage. Had dizziness and loss of balance. Will it heal ever? Does this affect motivation in clinical sense like AHD?
I believe that LC/ME are an umbrella term. For some people it would be viral persistence/debris, for others microclots, etc. If these diseases had only one cause, they 'd have been cured long ago. A lot of people take blood thinners, some feel relief, and some don't. The same is with plasmapheresis, HBOT, niacin, steroids etc.
I had COVID in August 2022. Second day after I tested positive I noticed numbness in my left leg and tingling in my foot. Then a week later my left arm felt the same. Pins and needles. Once I tested negative I went to my Dr. He didn’t think it was a big deal and scheduled me for a CT. at that point still having symptoms. I few blood test showed low level of B12. So he recommended supplement. Still awaiting the CT in October I started getting numbness in my left part of Ny face. This time I went to the ER. They put me through the Stroke protocol CT with & without contrast, MRI more then 24 hours past the “event” suspension of a TIA but nothing showed. They discharged me with a prescription for a statin, 20 mg and a baby aspirin. Throughout all this, I kept asking if it could be Covid long haulers and they wouldn’t even listen to me. I then saw neurologist again, asking if it was long hauler again no direct answer. Ordered an echocardiogram where they push IV fluid through your heart. Everything pretty much came up negative there also went back to my primary doctor and he pretty much looked me in the face and told me I just have to live with it because they have done all the test. I again asked about LH. He told me to stay off google. Today still have body tingles, dull headaches daily, tired easily. I just don’t feel normal nor know where to turn or what to do. This is great education but I can’t seem to find answers. Does anyone else have body numbing and tingling? I forgot to mention that it’s mostly all over now.
Me. Started in the feet- hideous burning and tingling. Moved to include the arms and face. I too thought I was having a stroke! I’ve been out on gabapentin and pregabalin and Lyrica… NOTHING HELPS. I’m exhausted from this and after nearly a year, no answers and I’m afraid now I have to live with this and I don’t know how.
Thanks Gez for another informative video. Does Dr. Laubscher have patients who are improving with the anti coagulant and anti platelet treatments? Would like to know if this is something you or your Dr. friend Asad have tried?
Yes he does - will talk to Dr Khan about this in a future video
Wonderful video Gez! What are the top 3 foods you're eating for calories? My gut is very limited and rice noodles and tortillas seem to be my staples unfortunately 😕
Lots of rice for me!
Fantastic Gez, thanks a lot for your work.
Moonraker, and every other Bond shown on ITV in the 90s, are canon in my family--my grandad taped them all, with dodgy stella artois adverts an everything.
Dr Laubscher seems very set on endothelial damage being the driver of all LC pathology, but I don't understand how MCAS, returning microclots, immune system dysregulation and damage, herpesvirus reactivations necessarily follow. Really glad that he is pursuing this work and hope more gets done in this area. Looking forward to future films.
Agreed Rob, think there’s more to it than just microclots.
And yes - finally someone appreciating the original Moonraker poster!
@@RUNDMC1 ahh an original, nice.
You just got a mention in the House of Lords by the way!
@@allTheRobs What?! By name?!
I spotted it too-was a projectionist at the student cinema in Sheffield in the early 90s-have some loose frames I cut out of various films (intentionally) that I’ll test your knowledge on one day…when this is all over..blah blah. We used to show Bond on Sunday afternoons sometimes!
@@berenairstone7202 that’s awesome!!
Is the work by Caldwell Esselstyn of the Cleveland Clinic of any help?
RN here, seeing clots in patients who had the vaccines. We're talking about legs and lungs FULL of clots, not just ONE clot...
What about non vaccinated individuals?
This is very eye opening. I’m wondering how this endothelial damage can heal? For those who have recovered from LC, why could their bodies do this? What helps?
Would love to know how to heal this
Until doctors in my area accept this test dr Jaco talks about I will die three times
This is so interesting. Thank you so much for raising awareness it was a fascinating discussion . My symptoms started within an hour or so of my first and only vaccine - is this possible? I have been told that this is purely conincidental by some medical professionals. It improves sometimes and then all returns with force. I will see if I can get any doctor to listen and perhaps ask for the tests suggested.
Yes it is possible - and you’re not the only one!
@@RUNDMC1Thank you. It is good to hear someone confirm this. The doctors i have seen at my gps seem to say it is just coincidental and even at A & E they seem sceptical. I am currently waiting to get an appointment with a chest pain clinic that I am supposed to have been referred to. I have been waiting about 5 weeks so far and am totally exhausted so just spending most of my time in bed. Hoping to hear before too long.
Thank you again
Thank you for everything you do, Gez. I have a question. If I got sick 2.5 years ago, is there more ongoing damage to the endothelium in addition to the original damage or am I dealing with the original damage only? If yes, then what's causing ongoing endothelial damage?
Re original vs ongoing - we don’t know.
What might be causing ongoing damage? Vicious cycle involving the hyperactivated platelets, systemic inflammation and poss viral debris or persistence
@@RUNDMC1 If it is viral debris, I wonder if an extended water fast would help?
I would be interested to know why, after all the clots are removed- the dysfunction continues. I’m guessing because the damage is still there. But what exactly is causing the damage - if there are no reservoirs then wouldn’t they endothelial start to heal? Especially after two years! Thanks so much, Gez and Dr. Laubscher!
Good questions and my thoughts too
Maybe some things can’t be fixed like autoimmune. We only get a little better. 😢
I mean...I had a positive ANA that is no longer positive...my dr. Said I tested positive for Lupus but she expected it to go away and saw a lot of that with LC
@@kayceekrieg6064 you can also get a positive ANA depending on where you are in your menstrual cycle
Gez thank you so much for all of the work you’re doing on this devastating and underestimated topic.
I have had covid symptoms for 5 months but recently had a huge breakthrough after taking protein shakes twice daily. Can any of your research explain this? My symptoms are 90% improved. Thank you
Not immediately! But fantastic to hear of your improvement.
@@RUNDMC1 thanks so much 👍
Thank you for your work on lc. I have it, them on Sept 9th I woke up completely healed (after lots of supplements/diet) then about Nov. 1 I started a descent again to derealization..no drive, no motivation, it's all gone again. Ideas? I have mcas so b3 is a trigger I can't afford
Hi, I have LC and also was recovery from derealisation after an emergency operation. This happened 2 years before getting LC. For DR, search for 'the depersonalisation manual' which is a very helpful short & practical course. Effectively it's a subset of of anxiety and it's a thought habit you need to break. It will take some time, the trick is to not focus on it, as difficult that can be at times. The course is also audiobook
P.S. derealisation gradually seems to fade. It's now maybe 25% of what it was, so making progress, still some time to fully go. LC not making it easier for sure
what were your LC symptoms? And what supplements did you take?
Try ketogenic / carnivore diet. Look at Dr. Ken Berry MD's videos for guidance as a starter. Give it a try regardless of how silly you think it is, it is worh it! After about 2 months of this diet, It has made myself 100% again after about 30 months of being unwell. Good luck!