The Body After Eating Several Pounds Licorice Candy
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- Опубликовано: 4 окт 2020
- Patient VP portrayed by John Posner
@chubbyemu version • A Man Ate 2 Pounds Lic...
Based on N Engl J Med 2020; 383:1263-1275. Link below.
Audio-only version: anchor.fm/chubbyemu
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Licorice candy has glycyrrhizin which increases cortisol (stress hormone) levels in the body. This causes hypokalemia. Hypo- low. Kal- kalium (potassium). emia- presence in blood. Potassium signals muscle relaxation. Low potassium, low relaxation. Heart can't relax, then it stops.
Real licorice candy is not easy to get in the United States. It's not at big chain grocery stores. Most of what you can buy from the big brands is licorice flavored, and won't do this.
These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
References:
A 54-Year-Old Man with Sudden Cardiac Arrest. N Engl J Med 2020; 383:1263-1275. www.nejm.org/doi/full/10.1056...
The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid. Sweeteners. 2018 : 245-261. www.ncbi.nlm.nih.gov/pmc/arti...
Sustained Leukocyte Count during Rising Cortisol Level. Acta Haematologica 118(2):73-6. www.researchgate.net/publicat...
www.nobelprize.org/prizes/med...
Licorice-Induced Hypermineralocorticoidism. N Engl J Med 1991; 325:1223-1227. www.nejm.org/doi/full/10.1056...
Young WF, et. al. Apparent mineralocorticoid excess syndromes (including chronic licorice ingestion). In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2019.
Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003; 88:2384.
Funder JW. Apparent mineralocorticoid excess. J Steroid Biochem Mol Biol 2017; 165:151.
Funder JW. 11 beta-Hydroxysteroid dehydrogenase: new answers, new questions. Eur J Endocrinol 1996; 134:267. 
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Hello! Welcome to Chubbyemu's (is mine!) second channel! This is a more in-depth version of the case in my video!
Could you do a video on how snake venom harms the human body at the cellular and molecular level and why it’s harmless if instead it is swallowed and not bitten/infected into the bloodstream?
And also why/how mongoose’s have there immunity to it and how that immunity works at the molecular level, I know it’s because of an evolutionary arms race vs venomous snakes that they have the immunity which is so cool!
Chubbyemu i thought someone stole your ideas lol
Thank you for doing these in depth looks at the cases. I watch both videos and love them!
Ok that is why the content is longer here
FINALLY IVE BEEN WAITING FOR THIS MORE CHUBBYEMU VIDEOS
I ate a whole bag of licorice candy in college once. Don't remember any symptoms other than that my poop was neon green the next day.
TierZoo I watched you video on fish earlier!
What's the next tier?
Even if it WAS real licorice, it was once, and not daily, neon green poop is weird though, you might have been abducted by aliens ;)
I did as well, but not a whole bag, it frankly made me feel bad and I hated the taste. I love sugar but there are limits.
@Dcard Dcardian yankland !!!!! LOL!!!
This is the other video except it's in "hard" mode
Good one
As a lover of licorice, I wondered a couple things:
1. If he's American, where in God's name did he find enough of the real stuff to eat a couple pounds of it a day, and how did he afford to do so? It's expensive as hell here!
2. How did he not have explosive diarrhea after the first pound or so?
can u have explosive diarrhoea by consuming licorice tea?
@@blepblep7245 I dunno about the tea, but there was this one time I did eat nearly an entire tin of licorice hard candy in an afternoon.
Says in the beginning he's British. There is a dividing line in Europe though - south of it, no liquorice for you, especially none salted. It doesn't follow national borders, e.g. Northern and especially Northwestern Germany's crazy for it while in the rest you're only getting the boring sweet stuff. Unfortunately, I'm living in that rest now :/ When visiting the family I'd help myself to two or three kg. The kilo's 7,50€, so price isn't an issue, really (and that wonderful Dutch lady at the market usually gives you twice the amount you've asked for with the price unchanged, so …)
Popular in Scandinavia as well and Finland even more so.
@@lautreamontg i seee
The actor does a great job with the I’m seizing like a bomb look
I know right! Lmfaoo
@@faithinstinctgaming3759 I love destiny
@@jimothygilbertson9431 destiny is depresstiny. But I'm addicted to getting frozen, lol.
That what i thought when i watched the video on his other channel.
@@faithinstinctgaming3759 hyped for next season looks really fun
My parents are physicians and I'm a biochemistry Master student. We love to watch your videos together. Thanks you for putting so much effort into your great videos : )
Dr. Bernie could make a living making RUclips videos. He makes top flight products.
Do you guys react like you're on gogglebox or predict why things went wrong and the cause/results before it is said in the video?
Haha, I'd actually like to watch that. You should record the viewing
Damn, that explains why you're doing biochem lol
Also, are you the guy every student is warned about when introducing the centrifuge?
I've seen tons of them. Even if he made several daily it wouldn't be enough.
Darn electrically neutral urine. I wish I could piss lightning :(
You probably could, but then you might end up featuring on this channel😂
Toastwhispererr A Man Attached Electrodes to His Body. This is What Happened to His Testicles.
@@ToddHowar.d Brilliant 🤣🤣🤣🤣
Have you tried UTIs? I don't know about lightning, but you'll piss fire 🤣
The dark side is a pathway to many abilities some consider to be...unnatural.
Almost every case that I’ve heard of in which somebody’s pupils are different sizes, has ended in brain death. A very disturbing pattern.
By the time the pupils are different sizes, usually there is a lot of damage. It’s usually a sign of too late treatment I think
@@eerielconstantine5051 Is there a typical underlying cause? I'm curious.
@@eerielconstantine5051 Not really always true, depends on the reason. It indicates some braindamage/bleeding, but if you catch and treat it patients could be fine, such as with a chronic subdural hematoma
@@michellejirak9945 The pupils are controlled from nuclei of the 3,4 and 6th cranial nerve. these nuclei are located in the brainstem (midbrain). So when brain damage reaches these nuclei, other functions of the brainstem are likely compromised, because basic vital functions are regulated here like breathing, bloodpressure and such. I think this is the reason, but a lot of different things can cause aniscorie so be carefull
Sensi Star my pupils are different sizes lol but my optic nerve in one eye is not fully developed
Huh. I suddenly have a much better understanding as to why I had to get regular blood tests to check my potassium levels when I was taking spironolactone for my acne
"for my acne"
Yeah... for my "acne" too. ^_~
Cookie's House Cannabis Co is that another variant of acutane?
That stuff works like a charm for cystic acne!
Spironolactone is a testosterone blocker of sorts. It's used in higher doses by transwomen for their transition as part of hormone replacement therapy. Mentionned in the video is its similar structure to testosterone.
It can also treat acne. But I find it to be quite a dangerous drug to treat "just" acne. That's just my opinion though.
@@claye_l463 that was one of the reasons I stopped taking it. The other being it was honestly bothering me to be essentially taking hrt for women when I am an afab trans non binary person. Also, everytime I wanted to check if my hormones had calmed down and the acne had stopped I'd have to wait 3 to 4 months for it to come back and then another 3 to 4 months for the medicine to start working again and in the meantime I'd break out bad enough to add more scars to my face.
And now, 8 months after quitting the pills, I'm really glad masks are required in public spaces because my chin is just kind of disgusting - even if I'm lucky enough to only get nodules and not cysts. I get tiny pimples all over my chest and back that itch sometimes, too. And I've definitely added to the scarring on my face. I'm going to go to a dermatologist soon to see if there's something else I can do. I'd really like to know what my hormones are actually doing instead of just treating the symptoms
I have a theory of where he got his licorice. My guess is that the patient might have had some connection to the Nordic countries (Scandinavia). Licorice candy is very abudant here and is frequently enjoyed throughout the population. As a Med student in Sweden, or profs have told us many times about the picture: Young patient, hypokalemia, hypertension, syndrome of apparent mineralcorticoid excess -> Licorice fanatic, most likely.
Licorice from Iceland specifically has alot of glycyrric acid. My prof actually had a patient who ate a ton of licorice, got a headace (likely because she got hypertension from the licorice) and then took ibuprofen (COX-inhibition in the kidneys gives more hypertension) and she almost developed malignant hypertension from this cocktail. Yeah.
Some popularity in the Netherlands too, but less.
Also question
HOW DOES ONE EAT THAT MUCH LIQUORICE
Like damn. I love Liquorice myself but goodness. There are limits
@@elvingearmasterirma7241 Easy, it's tasty candy and if hungry, eating a whole meal volume is easy, and somewhat pleasant.
Holy moly, I just ate like 200 grams of licorice and took 400mg of ibuprofen cause i had a headache from getting covid vaccine, i guess i better take some potassium supplements :0
licorice is sold in ikeas to my knoledge
This is a biiittt more advanced than your other account, but I think I’m following
Banana by Mouth - All I see is me shoveling banana into a passed out man surrounded by gross candy - LIVE DAMN YOU!!
This made me burst out laughing, because in his dumber down video on this get said it would take 100+ bananas to normalize his potassium.
I'm gonna be honest, most of the extra info in these videos goes completely over my head but I just like watching you talk, and I think you're doing incredibly important work here.
same
Oh, I like the scientific version!
I'm so glad that Heme Review is a page now. I love the science breakdowns of these case studies. Shame there isn't something akin to this for neurochemistry/pharmacology. Cheers all!
i second this pharmacology
Hemp Wick you know it! Better living through chemistry 🖤
Ooh that would be interesting. I'm a pharm tech so I perk up whenever I hear drug names. I mainly deal with geriatric patients, and now I'm wondering if the average age of my patients is the reason why I don't see spironolactone prescribed as often as I did when I served the general population in retail. Could it have to do with generally higher incidences of hypokalemia as well as heart issues in the geriatric population?
Mint Macaron sounds like a question for r/pharmacy .
@@mintmacaron561 Spironolactone is pretty hard to deal with, in general it's hard to prescribe to geriatric patients. It's a risk for patients with some heart conditions and with kidney problems too. It may cause hyperkalemia which is as bad as hypokalemia and other hormonal changes
I’m an OR RN and we had a lady that got a bowel obstruction from eating so many gummy bears at once….it was over a pound😱😳…..that said, it barely even registers on the scale of the bizarre things I’ve seen at work in 21 years of nursing….it gets way crazier than this by far😬✌️
How many courics was the shit?
We need deets!
Plz tell us more!
Dutch liquorice contians a significant amount of Glycyrrhizin! This kind of case is actually one we get taught in a lot of dutch medical schools as it is a rare-but-possible case in especially pediatrics, as sometimes children get access to liquorice with high amounts of Glycyrrhizin and consume far too much. Also a very good case for Dutch people to understand symptoms associated with mineralocorticoid syndromes, as it is very relatable to dutch people. It could also come from Scandinavia or other nordic countries, as another guy already commented a very similar thing but in Swedish medical school. Considering the fact that there are a few communities that are still very in touch with the Dutch culture, the patient could have Dutch heritage and maybe buying "Dutch liquorice" from a Dutch specialty store could be the origin.
It’s lamentable that I (a Dutch person), have only been educated on the dangers of licorice by chubbyemu. I feel like I should’ve known about this before.
@dutchpropaganda558 I'm just amazed that there is a nordo-germanic licorice overdose problem.
🍬
🍵
What does "emia" mean?
I wonder if Dutch licorice is okay?🤔 I had that occasion as a child. Taste way better than the American kind. There was one called dubbelzout (double salted ) licorice . There is one that is shaped like 🐈. That has a sweeter taste. I miss it. I haven't had licorice in a while, but never would doesn't that guy did.
Heme Review candy!
yäm
I about collapsed a few months ago due to hyponatremia, but once I started eating regularly again, it all went back to normal.
What's the cause?
You must be the best prof because you explain things in the most understandable way. I'm not a medical person- I'm a writer who has written on some medical topics- and I really learn from how you present things. Both this and your Chubby Emu channel are my fave on youtube. :)
I am soooo happy with this deep dive format to the cliff notes version on Chubby Emu. The two together are perfect - because you can start from the macro view and go to the micro view.
The only thing I wish was the key words spelled out so people who aren’t good with medical terminology would know the words like ischemia - which doesn’t look like it sounds and it might help lay people put things better together when they advocate for their own care.
Such excellence is so refreshing!
Hey Chubby, i am a 3rd year medstudent and love watching your videos.
I really enjoy heme review .. in-depth
damn, they really did review his hemes with those blood tests
Any other laypeople here watching this and hearing a lot of new words?
🙋 i dont understand almost all the words, but felt like super genius watching this. Love it!
My mum has a few years of experience working in a medical office, and she began the video nodding her head at all the terminology before finally shaking her head and saying "Nope, to dry for me!" lol.
Ah, so I found the doctor's club. I actually had to listen actively for this unlike chubbyemu where passively listening is adequate
I love this shit bro. Thank you for this content it genuinely improves my life
This is gold.
I remember reading in my textbooks that too much liquorice could cause hypokalaemia but I never knew the mechanism until now.
I tried some powdered licourice root once at a gin distillery tour, and you're damn right it's sweeter than succrose. It didn't taste much of licourice at all, it was like powdered honey.
Thanks so much for these videos - this might sound far-fetched, but this particular video prompted me to my GP a few weeks back, and I was hypokalemic. My son and I are seeing a nephrologist, who mentioned (but not yet diagnosed) bartter syndrome as a probable cause. So yea, informative videos indeed :)
Hey, did you get a diagnosis yet?
HEME👏REVIEW👏IS👏THE👏BEST👏
I love the level of clarity, progression of the analysis, and the detail of explanation! Bravo!
Thanks for going out of your way to post a more in depth version. It helps a lot to reinforce ideas I'm learning in my college biology classes!
We Dutch eat a lot of Licorice candy, and I believe we also export quite a bit to the United States and Canada.
I know I'm 4 months out but yea, in Canada I eat a ton. Dutch background, been to Holland, I bought so much at the gas station. It ain't fresh when it gets here hahah, it's hard.
@@Milkmoney606 noord of zuid holland? (:p)
I don't get half of what you're saying on Heme Review but I understand more with every video. This stuff is so fascinating... kinda makes me regret not taking any natural sciences in high school.
It's amazing how fragile our bodies are makes you think of every bad choice health wise or socially that you have made.
As someone with congenital adrenal hyperplasia 17a hydroxylase deficiency, thank you for being the first person to actually break down what stage of hormone production my adrenal glands stop working right. This info is really helpful to my understanding of my body, and also of my intersex identity
He Looks so satisfied while eating his licorice though so at least He lived his last days hapily.
These are some of the highest quality videos in youtube, they’re like little documentaries. Keep up the good work!
I'm currently studying for the license exam in nursing and your videos are very interesting, informative and helpful! Thank you for putting so much effort into making them, they're the treat of the day!!
I took the first day of the bar exam today and getting a new Chubbyemu and heme review video is a great reminder that I love medical vids but am really glad I’m not being tested on it. Great video as always, thank you!!
As always I really enjoy your case studies. Thanks
Thank you for sharing!!!
I feel like most of these videos are a cautionary tale of "never have too much of anything or you'll get sick."
Not too much or too little or non consumables and not off food
Who else didn’t know this is chubbyemu other channel
All my Swede / German / Euro friends I've known love eating crap loads of salted black fish shaped licorice - you can get it at any importer or high end candy place. I remember them even listing how potent the shaped candies/soft ropes contained for the very broken pleasure of it's nasty taste. At least that's how I read it, I'm a sensitive taster so those "candy/lollies/treats??????" don't even register to me as food - they're so black and gray and plastic caustic smelling and this is from someone who can eat food dyed black or with squid ink without the visceral reaction. Candy importers sell in bulk - he probably caught onto the fact that he could buy direct or from an importer the big bags since he was chewing/stimulating his senses being as he had a history of problematic drug use and now several years sober. We're creatures of habits and rituals - all the people I've known who were users were rail thin and now are either average to very obese very quickly after quitting hard party life.
You mainly talked about the effects of Glycyrrhizin, but I know that licorice also contains some alkaloids which are also found in Belladone and Datura, pretty toxic plants. Could those alkaloids have a significant effect on the body too and add to the damage ? Or are the effects of glyccyrrhizin too important for the alkaloids to do anything remarkable ?
Wait, was the grandpa who drank licorice tea okay??
no
@@HemeReview is that seriously all you’re gonna give us?
@@thedocmain3591 ok
@@HemeReview Oh. Sorry to hear that. Esp given the personal connection
@@thedocmain3591 Just three of 'em? ...ok
I know the amount of work that's needed in just a simple video for my channel but Doctor what you are doing to put this together honestly that's another level of respect for you and to find time as a doctor. Tells me I cannot make an excuse and must work harder with each second given to us is such a gift.. Love all your videos. Your Videos are like the MCU of youtube medical field, movies installment :-).
God bless.
Thank You ChubbyEmu! It's appalling what just a little one time binge can cause, to say nothing about fads and habits! Your explanations are certainly giving me incentive to moderate.
Great job! Excellent video 😊
As a 4th year Pharmacy student, Heme👏 Review👏 is greatly appreciated 😩
Fascinating and well presented. Thank you.
WOW.. These videos are amazing. Keep up the good work.
Thanks for posting all of these. I work in nephrology so your renal insights are helpful.
You are amazing! Genius and so😅 handsome .. a great combination! Love your delivery and voice as well as ur fluid expression of thought . Excellent and addictive to watch u
Oh my gosh I love your videos I love your teaching I love your breakdown I love everything that you do I’m addicted to your videos I’ve binge watched you even the same ones over and over and you’re just so amazing everything about you is awesome thank you so much for making these videos and posting them on RUclips it is the best educational knowledgeable inspiring entertainment That is honest and real that I can respect and admire and appreciate. I believe you inspire people especially the youth to grow up and be doctors just like you thank you from the bottom of my heart I hope you never stop but I understand they must get complicated and not easy to make sometimes. Also I love your personality with your presentation, And I believe some of your videos could actually be life-saving to the public and people who save lives are often Underappreciated but not here in my household we adore you
Dr Bernard, a Heme Review version of your latest Chubbyemu video would be amazing!
I can't wait to graduate from medical school so I can understand Heme Review
So, liquorice is a really common type of sweet here in the Netherlands. We call it drop and its the real stuff, not the flavoured gum stuff (you can easily tell the difference by taste and look when you pull one apart).
You say he didn't have any laxatives that you knew of, but if it was real drop he was eating, then even after eating more than a couple of hands full, it may have some explosive results.
Liquorice extract is also used as a common type of sweetener. I know that because a family member who had run away blood pressure issues and now has been instructed by his doctor to avoid the stuff like the plague.
I'm surprised i understand all of this.
My Pharmacology and Pharmacognosy classes summarized in a 18 minute video
your videos (all of which I binged) made me want to go back to school to pursue my dream to become a doctor so thanks for that
I ate an entire box of tic tacs in 20 minutes. This is how my body bled from 6 different orifices
ive done the same w no issues
Hehe, this video is the hard mode of the ChubbyEmu video. Great stuff!
i like your funny words, magic man
this just shows how clever doctors are and how hard they work for anothers life.
Came here for the med facts, and didn't expect to hear anything about Spironolactone that helps explain why it's prescribed to trans women. Always nice to see how medical science and biochemistry tie into different fields of medicine!
Ever think about making an education channel? videos that introduce laymen and students to medical and bio concepts. Your way of talking about these topics is really accessible without dumbing things down, I think a lot of people would enjoy it.
You do a great job explaining the chemistry aspect of this. I can understand it and I failed AP chem in high school :')
Man, licorice is just so good. No matter the side effects, I'll continue to eat it. Salmiakki as well.
I saw the heme review named somewhere in a video of chubbyemu I laughed and forgot about and now it's a real thing u-u BTW big fan
I love listening to these whilst doing chores, almost like a criminal investigation movie
In Italy and The Netherlands they also eat a lot of licorice aka Drop!
And I Know because I eat killograms of the stuff a year!!! And I am dutch! 🇳🇱 😉🍬
We even chew on the roots! 🌿🌱 🖤
They are sold in dutch candy stores!
I can send you some if you want! ☺️
One of my cats is ill. She is more stable now, but still not 100%. She’s taking two eye drops and two pills, one of which is Enalapril.
I know that all of the medications are to help with her viral infection and high blood-pressure and kidney issues. It’s really interesting to know the mechanism of action of the medications, and where on the line of biochemistry scientists found the issue and created a solution.
This video is great, as they always are. Thank you for being you. Cheers!
I was surprised at the comment that real licorice is rare in the US. I have found it, usually labeled as "Australian licorice" regardless of brand, in local Walgreen's, The Fresh Market and possibly Publix and Whole Foods. Those last two I'm not certain about since I don't recall buying it there. At any rate, for me here in the Southeastern US it's not that difficult to find actual licorice candy.
Thank you Doc
I love this guy, I wish he was my doctor especially since I now have type 2 Diabetes and Leukaemia to deal with.
Wish you the best luck!
The phrase:
'too much of a good thing' works here.
I was missing your videos, from both channels haha
Ah I love the in depth explanation of this video but can see why it wouldn't be for everyone. Thank you for making 2 videos! Isn't real liquorish used a kind natural laxative? I wonder if this guy had bowel problems from the previous poor diet of gummy candy, or perhaps he just REALLY liked liquorish?
real licorice could be found as "pontefract cakes", or maybe as the nicer "australian" licorice, which is becoming more popular in stores
You need your own Netflix series
Thank goodness I’ve always despised licorice! This channel is superb! I need you to be MY doctor!!!
This channel is grossly underrated!
Not me getting a Twizzler ad on this🤣🤣 Ironic much
I watched this and I have no clue what you said but I still enjoyed it none the less
*Sees new Heme Review video*
*Sighs...*
*Opens twenty tabs*
P.S. Absolutely love it. I'm an addict when it comes to in-depth case reviews like this.
Why not post on both as many don't know about your other channel. We APPRECIATE in depth videos very much. You're good at it. Medicine for dummies.....💛💚 ya thanks alot.
It's so crazy how we figured all this out.
The classic board question on primary hyperaldosteronism.
Dr Bernard: Sciencey words
Me: I like your funny words, magic man
Licorice makes me not almost pass out every time I stand up. I quite enjoy that effect.
really?
POTS?
You might have ADDISON'S DISEASE if that is so.
I have an epileptic brother and can say that that seizure at the beginning is really similar to what an actual seizure looks like
This is the normal Chubbyemu channel but on expert difficulty
I love this channel
Licorice is quite a common candy here in the UK, Bassetts , now Maynards, Licoice Allsorts were a firm favourite when I was growing up
Panda is a very common brand of licorice candy, fairly easy to find in chain grocery stores where I live in California, and it's made with actual licorice extract. (Despite the name which might make you think of China, it's made by a Finnish company.)
0:56 i like your funny word magic man
He could have imported it from Europe. Liquorice is very popular here in the Netherlands.
I live in a place where licorice candy is easy to get and I'm glad I only eat licorice once in a while now.