A Brief Discussion of Hydroxychloroquine In COVID-19 (March 2020)
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- Опубликовано: 8 апр 2020
- This episode was recorded on and is current up to Friday March 27 2020
Heme Review Podcast (full audio) ▶️anchor.fm/chubbyemu
Understanding COVID-19 From Cases Described By Doctors In China
▶️ • Understanding COVID-19...
Video by @chubbyemu
What (Hydroxy)chloroquine Does To The Body ▶️ • What (Hydroxy)chloroqu...
A Student Ate 5 Day Old Pasta For Lunch. This Is How His Liver Shut Down ▶️ • A Student Ate 5 Day Ol...
A Man Drank 1 Bottle Rubbing Alcohol For COVID-19. This Is What Happened To His Brain ▶️ • A Man Drank 1 Bottle R...
Music by @Lifeformed
Papers described in show:
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial. Gautret et. al. (Google Doc: drive.google.com/file/d/186Be..., version as preprint submission: www.sciencedirect.com/science...)
- Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. zenodo.org/record/3724167#.Xn...
- White NJ. The treatment of malaria. N Engl J Med. 1996;335(11):800.
- Warhurst DC et. al. Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother. 2003;52(2):188. Epub 2003 Jul 1.
- Metal Ionophores- An Emerging Class of Anticancer Drugs. iubmb.onlinelibrary.wiley.com...
- Chloroquine is a Zinc Ionophore. www.ncbi.nlm.nih.gov/pmc/arti...
- Treatment of Severe Chloroquine Poisoning. www.ncbi.nlm.nih.gov/pubmed/1...
#coronavirus #COVID19 #sarscov2 
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Hello! I wasn't sure to make this episode into a video because of the heavy clinical trials part in the second half. But here it is
Hope you learn from and enjoy it, if you haven't heard it yet. New episode in the next few days
I appreciated you going into the minutiæ of the open-label study data. It elucidated why the study was very suspect, because of it's recording issues and methodology issues, and it did this in an understandable way.Thank you.
I suspected that QT prolongation, and G6PD deficiency, would be complicating factors for using it more widely. I was previously studying to be a Medical Laboratory Tech, and remembered from my hematology class, that intravascular hemolysis was a big issue for patients with G6PD, especially since a dosing regimen hasn't been standardized yet.
Hi! Thanks for the detailed review of this study! A quick addition to the rationale of chloroquine helping with the disease: there is a study showing in silico data of chloroquine blocking the active site of the papain like protease of the virus (Arya et al. 2020). Not the most promising thing but it maybe adds up to the picture.
Formoterol showed similar binding and might be worth investigating due to its other properties.
@@breadfish8826 it's protease has activity like papain? So it will react with the epitopes on red blood cells?
Very wel explain, and put some good question on so call French study report, There are very few who openly criticized the wrong claims as there are some big names involved in those studies
Great video... only addition is that the couple who used the fish tank cleaner has a new development.
The woman has been accused of murdering her husband and using the announcement of the HCQ/AZM protocol as a cover for her crime.
So she was not a victim of hype of a drug, but a cynical person who used the hype to cover her motive.
"This is obviously written by somebody who has never cared for patients" what a take down
Dr. Bernard's frustration was palpable in this one, and mirrored in my own mind. I'm not trained in medicine, but my training in chemistry taught me enough to know when a study stinks, and this would be laughable if the implications weren't so problematic. I love this kind of in-depth explanation of things, and look forward to hearing more of it.
As a biophysical chemist, I always look forward to your in depth explanations! 😊😊
Yay, thank you!
Off topic question- im working on a biophysics degree but Im just not sure if I should stick with this major. If I want to help humans or other animals live better lives through development of biological prostheses and things like that, should i switch to biochem? Ive asked some people about this and I still am a bit confused as to the scope and opportunity of my current degree path.
@@SolidSiren Hi Cori! I believe that the field of prostheses is under biomedical engineering rather than biophysics/biochem. If you can, I strongly recommend expressing your interests in detail to the advisors under each degree so that they can tell you whether you are most compatible with them or the other branch.
Hope this helps! :)
As a biochemical factory I'm always fascinated by them!
I’m a 15 year old school girl and I also look forward to it😊😊😉😊😊
When someone on the new says 'potential cure' doesn't mean it actually works. People need to stop taking unnecessary risks, but such people who do will always be there
I also noticed that person who died during trial but was tested negative beforehand. There is no clear correlation to the virus caused illness then, right? But that would mean that the hydroxychloroquine could have done a lot more harm than good. I really do wish journalists would read in deeper than just abstract of a paper that's not even been reviewed yet
@@mobius8407 yeah... It would be nice if they did that, or at the very least, cited the research that they're yammering about. Finding random publications that are being reported on in a negligent manner, is often difficult.
Like the current vaccine hype from Moderna, and when you look into their data, I don't if I laugh or cry.
Not only did media spread Bs on this, it turned out the man's wife is now suspected of trying to murder him.
@@Shyhalu in cases like this, Media should be held accountable. I'm not one to hate the "mainstream" media, but to be completely honest, with how political they have become, they are doing more damage than good to society.
I understand that why you think the second half of the video may scare away some viewers, but that is the most important information the viewers should know about Hydroxychloroquine right now. Thank you for making this into a video.
I appreciate your ability to teach to non physicians. It makes it easier for me, a physician to talk to my family (I am the first physician in my family).
Chubbyemu is the powerhouse of science!
Seriously though, I couldn’t agree more with your critique. This research is an ideal example for us to learn why we need peer reviews no matter how urgent the situation is.
Really sad to see bad science when we need good science so much.
As someone who takes both hydroqxycholorcquine and azithromycin for the past 13years,its scary to think that a little more than my usual dose could kill me in 30 minutes
@@ajasen yea i take 250mg but I take more when I'm sick
Also, the French study treatment was for 5 days.
@@bobn1955 *6 Days
And even then, this is still too short of a time frame to get valid results and inferences from.
If you take too much of any vitamin, it will most likely kill you. Good luck sleeping after reading that.
The 1,061 French treatment by Dr. Raoult gave 200 mg HCQ taken three times per day for 10 days, a total dose of 6,000 mg
Mid-March was absolutely and in all respects life-changing for me. I'm an educator, and my professional life imploded, followed shortly by my personal life when Washington state went into lockdown. I can only imagine what it was like for you as a physician. I hope you're doing as well as can be expected two months on.
Hello, French citizen here. First of all, many thanks for your work: it is one of the most concise I have seen on the subject. Now despite all this number juggling, the doctor Raoult still continues his « trials » and announced on the Marseille IHU youtube channel they are soon to publish a study involving around 1000 cases (although I am not sure we can expect it to be properly randomized / blind). It’s a bit surreal here, our president Macron even visited the guy yesterday (we do not know the details of their discussions).
That experiment was so so poorly designed. No double-blind setup /control group, the inclusion of barely sick/asymptomatic patients, just to name a few. I don’t recommend putting faith in Raoult at all. It’s BS. If there was any truth to his work, do you think the world would still be shutdown? Or is it easier to believe the whole world is conspiring against Raoult; and why - because we’re all suicidal??? 😞
@@elephant_888 First of all, sorry for the long reply.
Mostly, I agree with you here: I am just reporting on it and it is on his team to show whether or not the treatment may or may not work, using randomisation, double blindness and a control group.
However so far the papers that conclude against this treatment, even if some are a bit better made, suffer from the same kind of bias.
We cannot make a real conclusion yet regarding the treatment as a result, which is a shame. What we can say however is people blow out of proportion and polarize the debate fare too much.
Again, the fault is mostly on the people that are advocating for the treatment, of course. It is again, mostly on them to prove their results better, to comply with the standards. That doesn't mean we have to assume everything they say is entirerly right, or emtirerly wrong though.
Regarding the idea that including barely sick or asymptomatic patiens is a bad thing though: Didier Raoult actually advocates for the use of his medicine for such cases, before and only before the symptoms become much worse, because by then, according to him, the viral charge is already low (it is usually a combination of an infection and a bad immune system response from what I understood).
I wouldn't be surprised if that belief lead to actually using the treatment in a bad fashion in a lot of cases, thus leading to worse results (especially for patients that already had hypertension, heart diseases, etc.)
@Jonath Kane - Thanks for the kind response. I was very interested in the paper, so I looked it up and also read through a lot of the peer-review criticisms of the study. Most of his the peer feedback was from people who were sad because of the poor test data and methodology. Others asked a lot of questions because they noticed missing data. I don’t think these people were against him. People are looking for hope in this difficult time. You and I can agree that politics sucks; I won’t even mention those guys!! 😂 But thank you for your response. 🙏🏽
Dr Renault is the same as Dr Fauci here. Do you really think a double blind is ok when that means you are withholding meds in a pandemic! This is an old drug with known side effects. Very safe. Needs to be given earlier.
Jonath Kane So you would withhold HCQ in a pandemic just to do a double blind study
Great video!
If I'm gonna be completely honest, you are my favorite RUclipsr and I love the way you explain these topics
Keep it up!
Love from Texas
Well said. I have been in medicine for 40 years and this article was by far the most ridiculous I ever read.
I have a feeling that everyone else with science education knew, like I did, in January, that this was going to be very very bad and that it would definitely come here. What I didnt anticipate, as an American citizen, was that my federal government would ignore experts, and make policy decisions based on uninformed "gut feelings" when expert opinion was so clearly provided from so many sources.
I knew in January to early February it was coming, what the growth rate appeared to be, and that we needed to do. If we had acted sooner, we may have saved hundreds of thousands of lives. But no one seems to care about anything but money. They refuse to do what is doable and would have saved so many.
Yup
I absolutely love how you explain everything to me! I'm a nurse and I've yet to hear anything clear and concise about these trials!!! Thank you! Keep up the awesome work!!
I was in a tropical country and felt somewhat ill one day. I used one of my unicorn tests and came up positive. I went to a doctor's office and told him I was going to travel to a friend's cabin in the jungle and I would like to get some Hydroxy chlo riqu ine as prophylaxis against malaria. After taking H CQ for a full day I felt completely fine the next day. Just my 2¢! Unlike other treatments, this actually was safe and effective!
Unicorn tests?
"The virus has likely permanently warped the psyche of every human living in a society."
This aged like fine wine.
fr
How can you be so pure hearted and not be a liar as most of the media. Truth... this Nation is hungry for truth tellers.
how did i miss this 17 months ago....god, we needed to hear this then on EVERY news outlet
25:54 I try to be respectful to the hard-working researchers, but like... what in the living actual f**k? They somehow managed to mess up the research ethics 101 principle?
Thank you for this video. It’s very important that serious and honest works like yours are considered in times like this.
Thank you for this!!! During this pandemic I'm noticing a sort of trend happening: people being so desperate for good news that they're willing to accept & spread information from studies that, when you go looking for the peer reviewed published paper, it turns out they've not yet been peer reviewed, not been published & the details given in the paper are suspicious or just missing.
In other words, I'm noticing that people who are usually quite dependable & reliable for this sort of information are starting to grasp at straws and failing to treat each of these trials with the same amount of skepticism they normally would and should, they consequently spread the information to their viewers who then start spreading it as if it's fact based and backed up by peer reviewed studies.
That sort of thing is making this virus even more deadly than it otherwise would have been
Starting my morning off right.
The amount of data manipulation in this study is outrageously stupider than what me and my campus classmates religiously do in the lab lol
they share what they change, not like what student do; change data to make it look nice and telling nobody. So the student is not even a half of integrity as these French researcher is.
"The virus has likely permanently warped the psyche of everybody living in a society." I'm so glad I don't live in a society.
Very minor point: while we're commenting on grammatical errors, "enrolment" is considered the correct spelling in most places outside the United States, so I wouldn't expect to see that changed.
None of those places speak English as their primary language, so they would be incorrect.
@@Shyhalu Yeah, UK, Australia and New Zealand don't speak English as their primary language LOL
@@Shyhalu Yeah sure, the UK, including ENGLAND, doesn’t speak ENGLISH as a primary language. Meanwhile the US which, by the way, has no official language, is correct.
@@Thwack992 Londonistan disagrees.
@@Shyhalu Ah I see how you are. Pretend we never interacted.
As an immunosuppressed patient (and ex-nursing student) it is wild watching this from April 2021 in New Zealand. What has happened and is still happening is just.... so alien. I've lived through two major traumatic times (earthquakes destroying the city & mosque terror attacks) but this whole beer panini is just outside the realms of reality, even though we've been watching it playout for more than a year now
That woman is under investigation for murdering her husband. Only an idiot would INTENTIONALLY take aquarium cleaner internally.
Thank you. Your content on the virus has been so helpful.
You uh.. you got it right on the nose Emu, that shit really did warp our psyches and I still haven't recovered lmfao
Love your videos, law student but this really makes me want to study medicine.
Thank you for always explaining things in a way that is easy to understand!
I think the woman that drank fish tank cleaner ended up being investigated for trying to kill her husband. Not sure where that ended up.
You teach well, Dr Bernard. An exceptionally thorough and competent analysis of the article in question. Strong discussion of research design and methology. Kudos, Dr Bernard!💖
The aquarium cleaner incident turned into a homicide investigation....
Only because it’s believed that the wife gave her husband a much larger dose. The wife also took it herself and ended up in the ICU.
Surreal watching this again, now that I'm working in healthcare myself nearly three years later.
bring back the anime hair!
We'll have to kill Chubby's childhood friend to get him that mad
@@worsethanjoerogan8061 a good hint dude , let's really do it……in games
I'M SO HAPPY & GRATEFUL TO BE ALIVE IN SUCH A TIME WHERE I'M MEDICAL STUDENT AND WATCHING MY FAV DOCTOR / MEMER ALIVE, HAVING A HUGE BRAIN AND A BEAUTIFUL WAY OF EXPLAINING AND EXCITING WAY OF VIEWING VIDEOS
Just over a year on - it's so strange to consume media from this time. How the hell could we have known.
I love the way the tone of this podcast reminded me of the old life videos.
More episodes! Love the heavy detail in the second half
Great video! I like this type of videos! Heme review is most educational podcast that I've seen. I hope you keep it up. Big support from Croatia! 🇭🇷
cutie prolongation uwu
No
UwU
sorry but no
uwu
UWU
Such a gnarly virus, jeez
Thank you for your informative videos, from Sweden. I learn something new everytime 😊
I also thought the trials were done poorly upon reading it and your video confirmed that for me.
It doesn't really help as many have already bought into this Hydroxychloroquine "CURE" hype, it could be dangerous and it's still unproven!
Keep up the work 😉 take great care and stay safe 😊🌷
Interestingly, the non-North American spelling of 'enrollment' is actually 'enrolment,' so that's technically not a typo. I know that's not the point you're making at all, but I learned about this fact recently and found it intriguing.
I can sense the anger when you read how they included those that didn't want to take the treatment in to the control, without specifying if they agreed to the study or not.
Thank you for helping us throught the epidemic Chubbyemu!!!!
Another vote for a revisit for this one. I love the podcast format
As a pharmacy tech we had hydroxychloroquin scripts skyrocket. We now have gotten more ivermectin scripts in the past two months than we have in the past 3 years. It is infuriating.
Snake oil salesmen love a good public health issue.
DUDEEEE YOU ARE SO CORRECT IN EVERY POINTTT! and i’ve NEVER seen you ANGRYYY bbeeffoorreeeeee
3 years later, COVID has done its damage. Is apart of daily life. The Omicron variant is less severe that Delta, and helps generate anti-bodies for most people. Daily life has moved forward, but not forgotten.
Yet my parents keep taking unproven injections, in the face of multiple complications.....because of the fearporn. It's like they're in a cult. 😔
@@patientlywatching7775what injections are they taking?
Daylight Savings is also farmers have more light to farm, too. Thank you for the educational vid!
What do you mean? The day/night cycle doesn't change, the clocks do. Farmers can schedule their activities accordingly. No need for clocks to change.
@@MegaKopfschmerzen Yep and the cows come in for milking when they always do not when it suits the clock.
It was more about reducing the amount of time that farm kids had to take off school, originally.
That's not so much of a concern, anymore, however.
It is still crazy depressing to go to work or school in full black, and, by the time you're finished, it's back to full black, again. Daylight savings can help a tiny bit.
chubby you do an amazing job with these videos. you seem like you know some stuff. thanks for the videos. i am not in any way in any field of medicine but i find these videos very interesting
Viewing in late 2021 (September) ... Wish I had found these absolute gems of videos much earlier. great work mate!
I didn't follow you channel for about two years and found it again recently. I love that you go in depth in a larger variety of subjects and make it understandable for everybody. I am personally a researcher in another field of biology but Raoult's clinical trial has infuriated the Francophone research community. It gives us all a bad name. This study was published in a journal created by people from the same institute as Raoult whih would explain the lack of peer review. Now people are dunking on Raoult daily for his crappy Research practices and his lack of ethics. Sometimes he literally conducted human studies without the approval of an ethics committee. This guy I swear.
BRAVO, SIR!!!
EXCELLENT VIDEO & WELL THOUGHT argument to the idiocies that we find ourselves swimming in throughout this last few months.
God bless you man. I sincerely appreciate & enjoy the content you produce.
Cheers!
all medicine have side-effects, including paracetamol and disprin
I really love every video that is put out by this channel. I always leave feeling more smarter after every video. Thank you for providing such useful information to viewers. Rock on!
What is the damage done to the kidneys? what should I be looking for? I work in Electron Microscope and look at kidneys all day and we have has COVID positive patients, but haven't seen any damage for it yet.
They didn't"bought into the hype".
The wife knowingly poisoned her husband. She's under criminal investigation.
Watching this a year and half later and it's giving me chills ... Not sure we'll ever get over this pandemic and the trauma it caused
Thanks for the indepth explanation! How about an updated video on more recent studies?
Still a fascinating, excellent vid; especially appreciate the astute discussion of data/research: Spot-on!
The woman who drank fish tank cleaner has a charge of domestic assault and is being investigated for murdering her husband.
False. Police have explicitly denied there is any such investigation.
I don't remember anybody saying that 'it won't come here' thing. Most people I talked to feared it would or knew it would come here.
Much respect. I understand why its on a backup channel. Thank you.
You make chemistry looks easy while I can barely remember o-chem (yikes). This vid quality is 💯, as always.
There’s always really good stuff!
Lol 35 cases. Such a distant memory
Dude this is fire content!
Watching this on the same day that I got my first dose of vaccination really hits different.
HCQ requires zinc sulphate for optimal efficacy. And, no, it's not a CURE -- it's treatment therapy that works best when taken at onset of symptoms. If you take it at a late viral stage or without zinc, it won't do much more the patient and could even be detrimental, and sadly that is how the "studies" were run. Taken correctly, it works beautifully.
And yet not a single study shows it works.
You remind me of proponents of perpetual motion devices. No one ever connects up their devices correctly. 😂
@@nosuchthing8 Dr. Pierre Kory, formerly an NYC ICU pulmonary specialist, will tell you as much information about it as you care to know. He personally administered it to thousands and saved thousands. Look up his video testimony before a Covid Congressional committee, if you're brave enough to challenge your assumptions.
This is the stuff _nobody_ reports. Thank you!
Just having tht swine flu reminds me some wht its unbelievable how people are walking around thinking this is a joke! It's not.. thanks for your time God bless you!
Just would like to say that "enrolment" may not be a typo from the Europe background...
the audio analogy was really good dude
02:30 listening again at the end of 2020 and "it" still gets the job done...
Thank you for the video, it's very interesting
Am i only first year medical student trying to make sense of all this chemistry
probably not
I love the chemistry but I’m glad a med student is having as much trouble as me, I was worried lol.
Lol same
The treatment sounds worse than asphyxiation. Im terrified of going into another coma, the last one was like being trapped in many bad dreams.
As of Friday, December 18th, 2020: Hydroxychloroquine is no longer recommended for patients with SARS-CoV-2 disease due to the increased risk of cardiac arrythmias.
There are currently two drugs that are given to patients with this disease: remdesavir, an antiretroviral used for diseases like Ebola and dexamethasone, a corticosteroid.
That coronavirus from flu to death pathology breakdown was brutal bernard damn boi
Thank you.
I hate it when people say that china developed covid19 or that science has failed us :(
I have a question, you hate that people blame China or you hate that they blame science?
@@pictureofacat9525 I hate that they blame china without evidence .. and I hate that they blame science and researchers for not finding a treatment yet
@@k2slab889 China is at fault for the spread of Covid
@@PivotDXer China is not a monolithic entity. There are people at fault around the world, regarding the virus
25:15 "Conformed incent" lol
Can you explain how malaria drugs are that dangerous and yet every time I travel anywhere my doctor gives me a bunch just as a precaution?
It may be because the place where to travel to has such an endemic spread of malaria that the benefit of prevention *grossly* outweighs the risk of side effects for you, and also greatly reduce the costs of your home country to treat you. Also many malaria drugs have been massively studied and proved to benefit for that purpose.
This comment is so dumb.
@@hephaestus9901 can you explain? I am genuinely curious. I don't even care if I'm wrong. I just don't know who to believe. My doctor who says it's fine or this guy
@@opioid01 I went to Peru, Ecuador, Brazil and Ethiopia. About half of those times I never left big cities and still got it prescribed
@@Andy-gq5hb Staying in cities is irrelevant. If it exists in the region, it's worth a small dose to avoid infection *AS LONG AS IT'S TAKEN WITH INSTRUCTIONS FROM YOUR DOCTOR*
Very nice podcast
All the studies on HCQ have been suspect, even the one put in the LANCET! I would love to see your opinion on other trials and drugs for covid19. We need science, not politics in this.
Super real case study about the double blind test.
My bday's 3/10 & I was sounding the alarm w my loved 1s for at least 2 wks before then bc the evidence at that point suggested we had very little time to act effectively. My point: we had plenty of warning but the ball was dropped, unnecessarily.
Man, revisiting this video in 2024.. I didn't understand everything that was being said when i first watched this in 2020. Now, I'm 3 months away from finishing my MPH in Epidemiology and understand way more of the video.... ho boy, how did THIS end up getting so much attention? There are glaring red flags all over the place
Thank you for taking the time to break down the French paper on this subject. I have not read it, but Dr. Raoult has been on national TV in France airing his knowledge of the situation as director of the tropical and emerging disease research unit, and slamming politicians and the ministry of health in the media and in a senate hearing about how they were not listening to the doctors in the field - ending up as a PR war, with journalists often siding with the older hippie looking doctor against the faceless uncaring mandarins in the health ministry in Paris. The truth is somewhere in the middle I guess but the mistakes in the study and the bias and exclusions from the published paper, along with what seems to be misses in analysis (why only the nose? What about the possible cytokine storm that it can cause - and possibly still kill, were people still infected or not as you would not expect a Covid death from a cleared patient...), having a review of the misses in this paper was enlightening and thank you for taking the time to do it!
well i just found this so I ask do you know about the study in New at the hospital St Francis that has others volunteering in other states. Its on now as of 6/1/2020
The French study was retracted, but it didn't get much attention about its retraction.
36:29 “the only good tech analogy I have for this is [awesome analogy that makes total sense]”
im a lot late, but for a trial for this instead of using a potentially harming drug for people, why couldn't we have used it for those who are critically ill, take the statistics of the people who died at the time of this and start using hydrochloriqine for those ICU patients, if death rates undeniably decrease then use it as standard care and if it causes the opposite throw the idea out the window. im 3 years too late but would that have had any kind of validity if we did that instead?
Covid is so painful on some days. It feels like my body is falling apart.
Incubation period is about 14 days I think.
Why are there random cuts of bernard just looking into the distance its kinda creepy