Symmetric Bradykinesia, Rigidity, and Hypomimia in Patient With Early-Onset Progressive Parkinsonism

A 44-year-old man with a history of unexplained sensory hearing loss, cataracts, dyslipidemia, and osteoarthritis presented with progressive parkinsonism and poor levodopa response. Neurological examination showed a masked face as well as symmetric slowness and stiffness. Genetic testing confirmed a variant in the DJ-1 gene (PARK7), which is a form of genetic Parkinson disease.
Click ja.ma/3sw8Aeb for full case details.

[@JAMANetwork]

Click ja.ma/3sw8Aeb to read "Progressive Parkinsonism With Features of Mitochondrial Disease" in JAMA Neurology.

[@8v8i]

When the indirect pathway overcomes the direct pathway

[@princeorakzai2784]

Please help me im 31 years old parkinson's disease

[@erickalvarado7676]

How does one get tested for genetic Parkinson’s ?

[@jamesparsley1259]

I have left foot drop and when i raise my left foot to stretch those muscles, it makes my left arm start jerking alot. What could this be?

[@thesciencesamurai7648]

that sounds like clonus, which is indicative of an upper motor neuron lesion. Do you have any problems with sensation on the right side of your body? Have you had head trauma or any history of stroke?