Homology-dependent double strand break repair

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  • Опубликовано: 11 авг 2014
  • In this animation, we explore how a transposon moves as a consequence of DNA cut-and-paste transposition.
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Комментарии • 55

  • @reeseymeimei
    @reeseymeimei 8 лет назад +785

    I will take my genetics exam and remember this man whispering about double strand break repairs.

  • @gingerrmoe
    @gingerrmoe 7 лет назад +405

    Snape, you gotta move away from the microphone when you breathe.

    • @Ethentent
      @Ethentent 7 лет назад +6

      I thought the same thing! But yeah, it sounds like he's trying to make an ASMR video xD

  • @uneloutredeuxloutres
    @uneloutredeuxloutres 6 лет назад +230

    Is this oxford press ASMR?

    • @leenasa2286
      @leenasa2286 5 лет назад

      Lise Rose MAURIN 😭😭😭😭

  • @taylorbrady4213
    @taylorbrady4213 9 лет назад +149

    This guy should be a Bond villain.

    • @k.j.b.h5245
      @k.j.b.h5245 8 лет назад +1

      +Taylor Brady Jajaja i thought the same when first listened his voice.

  • @daniellaschaening4470
    @daniellaschaening4470 6 лет назад +48

    Wow! I didn't know I could speak parseltongue, but I understood everything this guy just said!

  • @karstenlane6864
    @karstenlane6864 9 лет назад +39

    This was incredibly helpful. To see this animation done with DNA looking structures, as oppose to just lines, made a world of difference. Thank you millions :D

  • @misterphuzz
    @misterphuzz 7 лет назад +53

    I don't care about the voice. At least I can understand the words he speaks, unlike many other big-time science video producers. And the visuals were so helpful.

  • @omrisinder5602
    @omrisinder5602 8 лет назад +207

    whats going on with that man voice??
    does anyone else feel discomfort with that??

    • @Kjonesa
      @Kjonesa 7 лет назад +33

      literally only went to the comments section to see if anyone else noticed that, lol.

    • @skarpengland
      @skarpengland 5 лет назад +1

      his voice is awesome. Funny part of learning for oncology.

  • @simonbaker9909
    @simonbaker9909 9 лет назад +9

    Valuable animation, but could use some more explanation, such as: 1) under what conditions is the homologous dsDNA conveniently located nearby, and how is the physical coordination/matching of regions initiated; 2) other references (wikipedia) mention two different paths to resolving the bubble, one involving cross-over, the other not -- is this true, or is this video more accurate information showing only the non-crossover way; 3) how does the bubble know when it has synthesized enough new DNA on the invading strand to match the other hanging end of the broken DNA?
    Why is the description of the video seemingly wrong ("Published on Aug 12, 2014
    In this animation, we explore how a transposon moves as a consequence of DNA cut-and-paste transposition. ")?

  • @adrianbulfon8430
    @adrianbulfon8430 9 лет назад +8

    One of the best videos Ive seen to date!

  • @kufuffin47
    @kufuffin47 5 лет назад +1

    Amazingly helpful animation. Thank you!

  • @ImperialGoldfish
    @ImperialGoldfish 6 лет назад +3

    Incredibly helpful explanation, thank you

  • @moonju0116
    @moonju0116 9 лет назад +49

    Why is this guy whispering?

  • @karenn.8810
    @karenn.8810 8 лет назад +13

    good animation and well explained ! this was very helpful

  • @xx8113
    @xx8113 6 лет назад

    brilliant video---!love the animation!

  • @MrCharanthej
    @MrCharanthej 5 лет назад +1

    Great video.....Both videos on Homologous repair and Non homologous repair are nice...Thankyou.....

  • @anubhavdas2095
    @anubhavdas2095 5 лет назад +8

    Really nice video, I got goosebumps

  • @sym2988
    @sym2988 6 лет назад +1

    even though you whispered through this whole thing this was a great visualization aid, thank you

  • @dinosaursgorawrish
    @dinosaursgorawrish 8 лет назад +61

    its worse because when you turn up the volume you can hear his heavy gasp for air in between sentences

  • @turma85medicinaepm7
    @turma85medicinaepm7 6 лет назад

    very comprehensive, thank you.

  • @roveradamus
    @roveradamus 9 лет назад +66

    Good video. But the narration made me uncomfortable. Please record the audio away from the microphone please!

  • @Dornatum
    @Dornatum 8 лет назад +1

    I don't understand how the C region is entirely newly synthesized DNA. I thought the endonucleases only removed one strand of DNA from the site of damage. At 0:36, I still see a single strand of C. How is that removed later on?

  • @DeemahAd
    @DeemahAd 9 лет назад

    Did you mention that the nuclease digests 5' ends???

  • @AMillionOs
    @AMillionOs 7 лет назад +5

    His voice makes you automatically think he knows what he's doing

  • @murg526
    @murg526 6 лет назад +3

    That voice will be haunting me

  • @oglow100
    @oglow100 9 лет назад +7

    Thuderf00t is that you?

  • @sebastianaguiarbrunemeier9192
    @sebastianaguiarbrunemeier9192 6 лет назад

    Well explained

  • @hazemelnahrawy2715
    @hazemelnahrawy2715 7 лет назад

    great

  • @peishitan2519
    @peishitan2519 9 лет назад +1

    Hmmmmmm Where did the homologous strand come from? Did it come from its sister chromatid?

  • @goldenyuusha
    @goldenyuusha 7 лет назад +2

    this was like asmr

  • @SrirachaPilsner
    @SrirachaPilsner 6 лет назад +1

    why is werner herzog explaining homologous repair to me rn

  • @MrMetalHead1100
    @MrMetalHead1100 6 лет назад

    it looks like it created a repeat in the DNA

  • @bongwhanyeon9584
    @bongwhanyeon9584 8 лет назад +2

    It sounds like Jigsaw

  • @NH-px6vj
    @NH-px6vj 5 лет назад +3

    This boy seriously needs to learn how to use his voice effectively when presenting something to people. I can’t focus at all because his voice is like a noise. He’s gotta speak clearly

  • @zackfairthepuppy
    @zackfairthepuppy 7 лет назад +4

    Bio ASMR

  • @Sannoon93
    @Sannoon93 6 лет назад

    am i color blind or the "pink" strand is actually purple hahaha men! just kidding :P very useful video narrated by the a guy who is extremely dehydrated yet congested and should narrate the villain in a movie or something!!

  • @ldnt1698
    @ldnt1698 7 лет назад

    This is probably a really stupid question but the other name for this method of repair is Homologous Recombination, Right?

    • @ldnt1698
      @ldnt1698 7 лет назад

      and micro homology - mediated end joining is the other video, the Holliday junction resolution.

  • @omerfaruksimitcioglu3190
    @omerfaruksimitcioglu3190 9 лет назад

    içinden konuşuyo sanırım

  • @maria11135
    @maria11135 8 лет назад +5

    With this voice. NO!!!

  • @jschoong94
    @jschoong94 9 лет назад

    Narration can be improved.

  • @rakeshbam9883
    @rakeshbam9883 9 лет назад +7

    confusing as heck

  • @isabelshelton07
    @isabelshelton07 6 лет назад

    thanks for the video but creepy voice

  • @00the00virus00
    @00the00virus00 8 лет назад +3

    Horrible voiceover.