NHEJ | Non-homologous end joining | What proteins are involved in non-homologous end joining?
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- Опубликовано: 31 июл 2024
- This video talks about NHEJ orNon-homologous end joining. We will talk about what proteins are involved in non-homologous end joining.
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nicely explained sir...thank u😊
I haven't known NHEJ's mechanism how many times I googled.... but I could understand it's mechanism by your video!!!!!!! thanks!!!!!
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Thanks a ton. This was so helpful for me💕💕
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here DNA polymerase micro and Lamda work as replicative DNA polymerase
What was your font in the powerpoint presentation?
Kristin itc
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does this introduce mutation every time as some of the nucleotide sequences are removed
yes
So the lost basepairs are just lost? And we just hope they weren't important?
Good question. In NHEJ there is some mutation because of the loss of these basepairs. But faulty dna is still better than double strand break.
NHEJ is used in gene technology too, also in replacing entire segments, so in short, not all lost basepairs are that important (depends on the organism what the statistical chance of "being important" is). For example the majority of human genome is non-coding, many transposons and old viruses(' components). On the other hand, most viruses have no extra DNA (or RNA for RNA viruses), many viruses even have multiple overlapping genes in the same sequence, making them many x as important, so to say c: (but of course, viruses don't have NHEJ in the first place)
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No it is wrong probably, we cannot use faulty dna, it would be catastrophic. The ends are repaired in a particular manner
1. If 5'end has hydroxyl group, it would be changed to phosphate by PNKB. And vice versa for 3' phosphate.
2. If gaps are present, they are filled by special dna polymerases like mu and lambda, which are very specialised.
3. The first step of ku 70/80 binds to ends spontaneously and prevents any kind of nonspecific processing at dna ends as soon as damage occurs. Present in both NHEJ and HR mechanisms.
So, the mutation is not as common as you might think.
This repair mechanism causes frameshift mutations?
yes it can lead to deletion and frameshift
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