Minimum fasting length required for autophagy | Guido Kroemer
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- Опубликовано: 5 апр 2019
- A key regulator of the process of autophagy is a drop in cellular levels of acetyl CoA, an end product of nutrient metabolism. As one would expect, fasting - the abstention from all nutrients - is a potent inducer of autophagy. This is especially true in mice, which begin to experience autophagy within a few days of fasting. However, critical metabolic differences between mice and humans make it difficult to extrapolate these findings to humans. In this clip, Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.
This clip was taken from the FoundMyFitness interview with Dr. Guido Kroemer found at • Dr. Guido Kroemer on A...
Original episode published on July 31, 2017 ⏳ #aging #autophagy #cancer 🧫
About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.
It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com
About Guido Kroemer: Guido Kroemer, MD, PhD, is a professor at the Faculty of Medicine of the University of Paris Descartes. He serves in a leadership capacity at multiple research and medical institutes in Paris, including the Medical Research Council (INSERM), the Gustave Roussy Comprehensive Cancer Center, the Cordeliers Research Center, and the Hôpital Européen George Pompidou. He is also an adjunct professor at the Karolinska Institute, Stockholm, Sweden. Learn more about Guido Kroemer at www.kroemerlab.com/ 
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Watch the full episode:
ruclips.net/video/Gm626MgpveI/видео.html
FoundMyFitness episode page:
www.foundmyfitness.com/episodes/guido-kroemer
More clips from this guest:
ruclips.net/p/PLrGxo-5Uw8gJJa4R_-vlojMyq0GJK6xkn
how about full fasting, no food or drink, when does autophagy kick in ? does it kick in at the same as ketosis ?
Why does he mention Craig Thomson and not Uma?
Got a summary anyone?
Rhonda is so cute
Unfortunately I came down with stage 4 metastatic prostate cancer acouple of years ago that has spread throughout my bones. Hormonecdeprevation therapy and radiation only hurt me so I refused continued treatments. I'm Canadian so the doctors now suggest suicide.
F' that! I did a 21 day water fast in January and feel the best I've felt in two years. I'm following an intermittent fasting schedule and do a 4 day fast each month. I've beat their odds and I'm still alive!
You rock!!Wow, So awesome and inspiring!!!!!!
God bless you! Don't give up!
check out peter attia on cancer. he talks of a friend who used combination of hard core leto and some drug and who reverse stage 4
Are you cured
Rick Simpson Oil cures cancer, consider adding it to your regimen.
Please keep in mind that fasting isn't just about weight loss. I did a 3-day fast that cleared up months of atopic dermatitis on my face. Nothing helped before that. I encourage you to try it, but keep it to yourself. Friends and family are skeptical, and worry needlessly.
I did the same thing. Wasn’t expecting that outcome but it’s gone!
@@aubreyj.tennant1123 Congratulations! The relief is indescribable, no? I fasted for my face, hoping against hope, and it worked. : )
My symptoms were not as bad as I’ve seen in some pictures but definitely there around and in my ears, eyes and fingers. I was not on any prescription medication ever for it. It started about 3 years ago I think. I wish I had taken pictures before. I’m new to fasting - 67 1/2 years young.
@@aubreyj.tennant1123 I'm 63, and mine started at 61. Maybe it took years or decades for something to build up or atrophy. Now I avoid all sugar and cow dairy just in case those are triggers. It's hard to tease apart all the sources!
Really happy for you. I got atopic dermititis after a well known, experienced skin doctor in Mumbai, where i live gave me some medicine for heat rash. Later he couldn't explain why i developed atopic dermitiis but obviously he gave me a new batch of medicines which i never took. Instead i continued Ayurveda medicines & now my skin has healed but not like it was before atopic dermititis.
My question is did continue your fasting without food & water or just food, is it okay to consume water ?
Because in Mumbai the weather is always hot.
Family members who love you are the biggest drawback when fasting. They will discourage you out of fear of you suffering
My mother hates it and always wants to feed me especially when I'm fasting as she assumes I'm dying of hunger
I was lucky my dad introduced my to IF but it took a while for my wife to get on board.
Good point!
Maybe same
You are SOOOOO RIGHT. Its a pain in the backside explaining myself all the time. Makes me look like a freak.
Been eating OMAD for two months now. Am in ketosis constantly. Only drink salted water during fasting. All my health problems have gone. No more pain. Dropped 18 kilos so far and had my first training session at the gym today. Feeling like a new man. I am 51. Oh yeh I also quit smokes and alcohol was a heavy user of both.
Congrats, Dan, on enjoying the benefits of your new lifestyle!
Congratulations keep it up👍🏾👏🏽👏🏽👏🏽
Make a RUclips video to encourage others 👌
Beast mode!
good for you Dan
Respect on the learned who say ‘I don’t know’
But zero respect for people posting videos that say, "we don't know". I came here because I was seriously interested in the answer.
@@johnterpack3940 everybody’s body is different
He is just neglecting the wisdom of for example the science of Ayurveda which goes back thousands of years, it's dumb and perhaps the color of skin........
agreed! too few are unwilling to be that honest
And the unlearned.
The fact that his first response was "we don't know" makes me think this guy is worth listening to, he shows some honesty.
Then how come that Japanese scientist won a nobel prize for discovering autophogy? Shouldn't the answer be in his discovered research?
@@peterbulloch4328they cant tell you what temp to cook pork to safely bud its an evolving process, but one that changes the food pyramid
Not necessarily. I believe he discovered the fact that autophogy occurs, but others probably then went on to study how and when it works.
@@peterbulloch4328 Yoshinori Ohsumi described autophagy in yeast. In humans there's no test that can tell for sure the level of autophagy. But Thomas Seyfried came up with GKI (Glucose to ketone index) parameter that gives you some estimate. GKI 1-3 is very good, less than 1 is even better. I get to 1-3 GKI with 48h water fast.
@@peterbulloch4328there's a difference in discovering something and discovering how trigger something. If I had to guess the amount of time it takes for the body to go into autophagy is going to vary from person to person. Not everybody has the same metabolism.
Best answer ever, "We dont know".
yeah lol like many health gurus do the eat once a day "fast" thats total shit etc the only compass is history how ancients did it but you have no history lol
@@sumerbabylon7069 By ancient method do you mean regular prolonged fasting as in hunter-gatherer groups going long periods without food? Or occasional but similarly extended fasting like in Abrahamic and Buddhist faiths? It's interesting that all the great religions emphasize prolonged fasts, and that they came about after we achieved the means to eat constantly with agriculture! Also, what do you mean by no history?
No I am talking about how ancients lived 100+ years like Psamtik and such so what diet they followed and how they fasted. No hunter gatherers didnt live long so pointless to copy those idiots lol.
So I meant those who gave you all civlizations in return via overpopulation you wiped them all out. The history you have is troll you appeared when? lol. like in China 98% is superior Han lol so its nationalistic shit show.All religions and occult info stolen from Sumer..
Like Sumerian-Christianing is a symbolic cleaning ritual but the fake judeo christian who stole this custom doesnt know and thinks cross symbol is because Jesus died on a cross omg lol
So its all lost what we have is troll religions troll cultures with minimal correct info.
Why they should admit that we can heal ourselfs?
@@sumerbabylon7069 Your username relates to Iraq today. How are you related to those ancient lands ?
I do 16:8 IF for 3 years now and I not only lost 65 pounds, but it fixed ALL of my health problems (hypertension, cholesterol, etc). I also do strength training for 60-90 min 3x per week. At 53, I am now in the best overall health and fitness of my entire life. My next step is to extend my daily fast to 18 hours and eventually incorporate a 48-72 hour fast once per month, for additional longevity benefits. I wish I'd learned sooner that fasting really is the key.
What do you do for your diet? Low carb, keto or just anything you’d like? Curious bc I wasn’t sure if fasting, in and of itself, can heal your body regardless of what you eat when you’re not fasting
@@adubs1985 I did dramatically reduce sugar, carbs and processed foods, but I don't believe in all these extreme fad diets. I focus on eating a balanced diet of whole foods, but I'm not above the occasional cheat treat. Personally, I think a lot of people go way too far with these extreme diets that ignore the need for balanced nutrition. It's just not necessary in my opinion. All I do is fast regularly, eat mostly whole foods, exercise regularly and take a few high quality supplements to optimize my body's systems (multivitamin, CoQ10, omega3, magnesium complex, vitamin D3/K2, vitamin C, niacin).
@@adubs1985fasting its self will no matter what you diet is because you're giving your body a break where it can clean up and uses the storage and ofc for attaining optimal result a healthy diet must be included
I just completed a 48 hour water fast this week, I researched so much on the fast, where I should have researched more on the refeed process…the fast was great no issues, but the refeed did not go well for a day. Please do your research on refeed, it can be very dangerous, important to avoid refeed Syndrom
@@adubs1985 I don't believe in fad diets. I eat what I like, but I try to maintain balance between plants, meat, fat, fiber, protein, etc. The only thing I'm pretty strict about is putting a hard limit on sugar/carb intake, but that's it.
Finished a 72 hour fast Wednesday. (Second one I’ve ever done).
I always feel worse on the first day, which I think is more to do with cravings as opposed to actual hunger. Days 2 I woke up full of energy, went crazy clearing out the kitchen cupboards and went to bed that night with my body singing. Day 3 I was much more tired, and fantasising about my first meal later in the day, but it was manageable as I wasn’t having hunger pains.
I didn’t weigh before or after, I did it purely to eradicate the inflammation issues that had cropped back up since the first fast at the beginning of 2019. It worked, as I knew it would. My glands went down, knee, ankle, lower back pain all gone. I had also been suffering with acne on my neck, which all disappeared.
Wow! I'm planning to do my first 3 day fast in a couple of days. The longest I've ever done was 40 hours. If I may ask, do you feel any difference between a 48hr fast and a 72hr fast? Do you think that you get better results with the 72hr fast?
@@freepatriot9070 I’ll be honest I’ve never done a 48, but I always find on day 2 that I feel the best, so I have no desire to stop at that point. It’s more mind over matter.
I’ve also read/watched that it’s best to do more than 48 hours for a higher autophagy benefit. I always feel better afterwards. It’s definitely worth doing. ☺️
Did it really heal your knee pain ? I would like that and maybe will consider a 72 hours fast !
@@indiea5588 yes it really did. If your knees are inflamed, fasting for 72 hours will definitely reduce inflammation.
I get shaky and start having hypoglycemia issues around hour 40-42. Never made it longer than that. Would love to break through that point and get to 72 hours. I’m pretty lean to begin with so maybe that’s my problem?
I fast for 84 hours (3.5 days) once per month. The first day is easy, after that each day gets progressively less fun.
Fasting and the CDED diet keeps my Crohn's in complete remission without any medicine.
I've been doing it for over a year.
Do you eat wheat or hydrogenated oils? both are very bad for Chrohn's. What is the CDED diet?
@@datsuntoyy You will have to google the CDED diet but it does not include wheat or hydrogenated oils. It is a very restrictive diet but it was clinically proven in a double blind placebo study. I eat cold potatoes, Avacados, eggs, bananas, chicken breast. It's very plain food with no additives whatsoever.
After the full 3rd to 4th day, all hunger ceases. I was able to do a 9 day water fast and intended to do 2 weeks, but I had a candida yeast outbreak in my mouth that was so extreme I had to stop. Try pushing through to day four to see if a longer fast fewer times a year works for you. It does sound like you are doing great with the Crohn's though!
@@threeone6012 add nofap to your routine follow it up to two years not a drop of life energy should be lost.Absolute zero erection,absolute zero sexual thoughts.Observe fasting.Your entire body will clean up and the disease will be gone forever
I am having another Crohns flare up right now and don’t want anything to do with Humira or steroids anymore. Did your Crohns stop after your first fast? Or did it take a few months? Thank u so much. I’ll look into the CDED diet. Never heard of it.
When you fast really keep it to yourself, because then people try shoving food down your throat coming up with myths about “you’re going to get sick” or “god made 3 meals you shouldn’t be ungrateful for having that privilege” blah blah blah.
God invented fasting
Right. Great advice
On point
God also gave his Son Jesus Christ for our sins. If we confess our sins to him he is faithful and just to forgive us of our sins and cleanse us from all unrighteousness. Praise Jesus Christ for his death burial and resurrection and his coming back to us in the near future. Holy Holy Holy is our Lord God Almighty who was and is to come.
Easy response: Jesus fasted for 40 days in the wilderness. Checkmate.
I am 71 years old female. I just came off 91 hours fast today. This is my 6th Fast this year. Usually I break it off at 85 and 87 hours but this time I broke it off at 91 hours. My plans were to stop at 72 hours,. but since I were feeling good I did not want to stop. Fasting is my health benefit program. I did have problems with joint pains lower extremities 2 years ago. But not anymore since I been Fasting the last 2 years . I also uses it to lose wt, but I only lost 5-6 pounds this time . The last 2 days I had the same wt. So I decided to break the fast . I'm a carb sugar eater but my fast has been really helping me. Whenever I notice I have start eating that stuff heavy again I would jump on the Fast to reset. Thank Goodness for this Fasting Thing! PS the 2nd day i'm hungry a lot. I try to drink lots of water. I never experience the headaches, but I do be tired so I can rest. I only did H-salt once , it made me nauseous, I did gatoraide zero once, I didnt like the taste. So I just trys to get through it the best I can to get my benefits. Fasting is my Friend. lmbo
This lady is scary smart. I can attest though to fasting and autophagy. Years ago I suffered a severe wound on my forehead from falling off of a house. When everything was healed and I was well, I still had a growth of scar tissue or some hard fibrous material just above my right eye and just under the skin. It was larger than a dime but smaller than a nickel. It was there for about 5 years. Then I started fasting. usually intermittent 16/8.But a 48 hour fast once a week. My growth thing just simply wasted away. There is a tiny remnant left, that is about the size of a pinhead, that I expect to completely disappear as I began fasting again.
i totally agree with the sentiment about if you are fasting to keep it from people close as they will pressure you to stop. i did a 21 day fast. im no one special, just an average guy. up to day 5 was hard but after that was super easy going. after i had loads of energy, my eyesight had improved. i had also successfully killed the carb crash rollercoaster of emotions that many get throughout the day. the world record for longest fast though is a scottish guy in the 1950s who fasted for 380+ days.
Your eyesight improving is fascinating! When did you notice the improvement? Do you know how much it improved? I’m interested in any details you care to share about it!
Thank you DR RORPOPOR HERBAL on RUclips I was seriously diagnosed with Ovarian cyst for like 10years now, after 17days of using DR RORPOPOR HERBAL medicine on RUclips I was revived back, now I'm 3weeks pregnant,God bless your so much..❣️
Maybe in the western 'world'!
Yogis in India fast for years and have been doing so for centuries.
Its interesting how the west constantly repackages, renames and takes credit for centuries old eastern practices and ideas.
@@feralkat9370 contact DR RORPOPOR HERBAL he's natural remedies are the best ❣️
That makes as much sense as for us to accuse non-Western peoples of ‘taking credit’ for technologies such as musical instruments and recording and amplification equipment that originated in Europe. It’s not an either/or. We could play tit for tat all day to the credit of no one but detriment of all.
Love seeing these comments on peoples stories. I too have a very positive reaction to longer fasts. More energy, skin clears up, chronic inflammation goes away, etc.
How long did it take before you started seeing results?
@@ellennaj3382 the energy is right away. The chronic inflammation goes away in a few days. And a few weeks for skin. Started with 4 days, then from there just did patterns. Eat, fast, eat, fast two days, eat, juice, etc. stuff like that. Taking a different approach now though where I focus on abundance (protein, exercise, strength, etc) but my body did like fasting patterns. There are pros and cons. Now what I would do regarding fasting is OMAD, or include 1-2 full fasting days per week, then the rest of the time just trying to take that approach of abundance.
Done 3 day and 2 day. It gets easier. Key, stay busy. Hoping for internal benefits. My age 70.
Hope you too are well and strong, take care
I have been fasting for 18 hrs daily and have my lunch after 12 noon and dinner before 6pm in the evening. I was able to achieve my ideal body weight by doing strength training once in three days. I feel very relaxed and healthy.
I am doing exactly this. And I am feeling so much better!
Seems that's great
Fasting+exercise is the recipe.
Hi Keerthi, I am currently doing the same fasting (at 12:00 and 18:00)
How long did you continue to this discipline ? How much weight did you lose totally? Thanks
@@Kemal_KARAYILAN It is entirely possible that someone who does this constantly is not concerned about his/her weight. I'd know, because I'm one of those. I don't weigh myself before or after, because weight is not an issue. Staying healthy and fit would be the goal.
At 76 I wanted to lose the final 5 lbs. to reach my goal of 175 lbs. Nothing was working. I went on a keto regimen and now have stabilized my weight at 165! I am never hungry. Have an eating window daily of 6-8 hours and a 24 hour fast is no problem. I feel great, play pickleball 3-4 hours 5 days a week. The physical energy and mental acuity I am experiencing has caused me to get annoyed at my peers physical and mental slowness. I thank God and ask for His help dealing with this newfound personality defect.
Just on hour 36 here. Yes, I forgot the mental clarity it gives and also the spiritual strength too. Its the poor mans ritalin :)
What's pickleball?
God bless 🤣💕
What time do eat start and end?
Im trying to think of a schedule...
@@ronananderson I just finished up a 44 hr fast ... which I only intended to be a 36 hr fast, but kept stretching it since I wasn't that hungry. Just in the last 16 months I have tried to go on an extended fast (30 hrs +) at least once a month ... and have been very pleased and surprised by how the mental acuity that I normally feel when I hit the 20 hr mark on a regular fasting day .... seems to have a much longer impact on my mental alertness for weeks and sometimes months after the prolonged Fast.
Another unexpected benefit from prolonged fasting - was sustained weight loss - something that came as a surprise since losing weight was not my top priority - but I have lost so much weight these past 10 mos, that I am wearing clothes several sizes smaller that I was a year ago - clothes I was going to donate - and it has seemed almost effortless. Those longer stretches of not eating - seem to have jump started my weight loss in a way the shorter fasts didn't.
I have always Fasted for the health benefits of feeling better and having more hours everyday where sugar and insulin levels remain low and stable. I have fasted about 18 hrs a day since college - long before these IF studies came out, because even back in college, I knew I felt more energetic when not metabolizing food constantly. Years later, when the book The ZONE came out .... it confirmed how unhealthy it was to have one's insulin levels continually swing up and down throughout every single day - and for me, the easiest way to control that, was going long stretches during the day without consuming any calories - and only eating in the evening so I could share a meal with my family - and as a bonus - that evening meal, also gave me something to look forward to after a long day.
I am 68, began 16/8 sprinkled with 20/4 and OMAD at age 62. Have completed 8 5-day fasts during the past 6 years. Many benefits perceived by doing this, including better overall health, weight loss and body transformation, I.e., prolonged fasting can lessen or even remove old fat in places ordinary diet and even exercise cannot reach. Rhonda has been an absolutely fantastic resource throughout my journey.
One thing I think we need to consider when comparing mouse to human models is the much shorter lifespan of mice. I’m sure it’s not a simple straight line comparison but it’s vital to understand and I appreciate the questions Rhonda poses to Guido along this line.
I fasted 11 days. Best thing for body, soul and spirit ever!!!
how to you know?
You actually end up losing muscle, which’s very bad for the body.
Still doing?
@@CrystallyLavender Not a significant amount and the HCG from the fasting helps you recover it quickly upon refeed.
Me too
at 43, i have been doing IF with my 5 hour eating window from 3pm to 8pm. outside of this im only drinking water with lemon, salt and ACV. so far my belly is flattening out slighty. about an hour after eating my last possible meal ill fall asleep no problem. ill wake up real early almost too early but with that im totally awake feeling. its totally worth the try if your tired of feeling and looking like crap as i was. plus its the cheapest diet on the planet (please dont fact check). Think about it, you really dont have to eat so much AND eat all the time. you save money, food tastes better, you start getting attention i think there is some truth the idea that IF makes you smarter (dont judge, this is such a rough draft). peace!
should stop eating 3 hrs before bed
It does make you smarter Alzheimer’s is type 3 diabetes basically brain cells become insulin resistant and die other things contribute but yea
I also experienced the high alert-awake feeling despite being less slept, in the beginning of my intermittent fasting plan
How do you build up to 3 days? I have only ever fasted for 30 hours...how do you deal with the lethargy especially if you have work?
@Maxwell Might have an electrolyte mineral deficiency.
Folks looking to fast for a prolonged duration (2+ days) for the 1st time, just know that the 1st 24 hours are the worst. You are fighting your body's subconscious habbit of stuffing ur mouth every chance it gets. You will not realise how STRONG that urge is until you experience it yourself. But keep drinking water. Water weighs ur stomach and temporarily releaves your urge to eat. You wont die, trust me, your body is just a spoilt lil' brat. Keep going past the 24hr mark, it gets easier from there.
Next time would be easier bcz know you know you can do it. Might even encourage some to try a bit longer 36-48hr
Only advice, have water ALWAYS around you.
Start small. You got this.😊
Started at age 60 fasting Mondays and Thursdays. Dry fast for 16 hours each. Had stents placed in my heart and was on a heavy medication. Given up all medicine and it's my tenth year without any problems. Moderate exercise and heart healthy diet is also part of my life.
What's a heart healthy diet?
@@Kitiwake In general terms it is a plant based diet. The only animal protein sources are fish (mostly salmon) eggs and bone broth. More important in this dietary regime is giving at least 12 hours break between meals.
To each his/her own. You found your bodies perfect rhythm. Good long healthy life for you🎉
@@AthariAcademy These days are recommended by the research team of scientists from Edinburgh based on their research and findings.
Wow. That is the sunnah ( prophetic teachings of prophet Mohamed ) fasting Mondays / Thursdays and also 3 days of each month in the Islamic calendar (13,14 and 15) are common practice for Muslims
I had fasted once straight for 14 days. One thing I have noticed is that after 3 days you don't feel the hunger pain.
Dry fast? I guess not, I think one will die after three days without water. Good on you 👍
I wish that was my experience as well. It's always after day 3 that I feel like I'm starving and I don't feel well. The longest I've been able to do so far is 4 days. Trying to work my way up to 7 days to reduce inflammation and help with MCAS.
@@stoptheinsanity Can fasting for 3 days help with MCAS?
You're right! I'm on day five of a twenty one day fast! Hunger left after day two I feel great! I don't even think about food! I watch lots of fasting videos and read comments for motivation!😃😃😃
I get the benefits of IF but at what point does fasting become anorexia? 🤔 14 days sounds a bit extreme 😅
I did IF 18/6 for three months & it healed the terrible psoriasis on my scalp in three months, amazing. I am now doing IF with Keto to get off BP meds & build muscle. I feel fantastic at age 65. I look 40, no face wrinkles or saggy arm or belly skin from weight loss. Thanks autophagy!
I did a 5 day fast mimicking diet and on day 4
The eyesight was noticeably better! I was shocked!
Yeah cause your body was looking for food 😂
Dr Berg says that when he does 20:4 fasting consistently he also notices improved eyesight. Fascinating!
Currently, I am on Day-One of a planned 5-day water fast. Will find out tomorrow if I am a rodent. If I don't update this comment in a couple of days, you would all know that I was indeed a rodent. 🐀 Back soon. 😛
Weight on Day 0: 78KGs.
Day 1: Intense cravings between 22 and 24 hours after last meal. Managed to continue fast. Drank enough water to stay hydrated.
Day 2: Woke up in cold sweat, feeling weak, felt ok after a few minutes of breathing exercises. Feeling energised later during the day. 👍😁
Day 3: Woke up full of energy, feeling great today with very little cravings for anything. Exercised as usual and still energetic throughout the day. 👍
Day 4: Very little hunger pangs. Light exercise. No fatigue. Feeling good. 💪One more day to go!
Day 5: Had some trouble with acid reflux. Bit of searching on the net revealed that even if a person watches videos on food and eating, gastric juices are released in the stomach. So, while lying down, I experienced some unpleasant sensation with acidity. All good otherwise. Feeling great. 👍💪😁
Weight at finish of fast: 75Kgs.
I'm on hour 36 ( out of 54) of a water fast. Just went for a 40 min walk and was wishing I was home. I think for the remainder of the fast, I'll just chill at home.
@@danielw.7705 Good on ya, mate. 👍
Admire your dedication, I struggle with more than 1 day, not really due to hunger, more to boredom, lack of energy and, mostly, discipline.
@@adespade119 Very true! That's why I made sure I would be occupied with lots of things to do during my fast. Usually, the beginning is the hardest. It gets easier after day 2. Wishing you the best with your fasting, mate. 👍
@@danielw.7705 Do consider that exercise brings autophagy on faster than being sedentary.
I've been doing intermittent fasting for at least six months(probably longer) where I typically don't eat for 16 hours or more (but not usually more than 20) and have noticed a lot of improvement with some of my issues. I don't know if 16 is the magic number but I will say fasting can help heal your body. The weird thing is longer dry fasting ( I did a few 1 and 2 days of it and 2 four days of it) didn't seem to do much for me. Everyone is different though and needs to experiment and find out what works best for them.For me, long termintermittent fasting has worked the best for me so far.
You won’t see much autophagy wffects at this stage of fasting, it will definitely help and is very good that you’re doing that but typically peak autophagy levels start at 48 hours, with this ramp up beginning at 18
High intensity Health did a video on how regular exercise helps you get into autophagy easier. When your sedentary and eat poorly your body is less efficent at switching into autophagy.
Yah I also did this fasting thing and it made me sleep better, i feel lighter, I move quicker than before I just do the 18:6 sometimes 20:4 fasting ratio, I feel hungry but the pains in my body gradually disappeares.
I think it depends on many things besides just the time in the fasting state. You have to take in to consideration lots of variables such as activity levels (exercise or stagnant), what was consumed prior to beginning the fast (carb heavy or not), environment itself (temperature in particular, causing more or less metabolism to cool or heat the body), stress (heavy stress vs relaxed state)... etc.
With that being said, there will never be an exact answer that works for all, since no one can ever share the exact same circumstances. I personally feel that by 48 hours of a fast, my body has begun autophagy. How far along, I couldn’t say. But I also work out very hard, lots of cardio, hot saunas, cold showers, black coffee, and sometimes green tea while fasting, so I know I enter autophagy much quicker that way.
what is the purpose of your fasting?
@@FedeRhodes thankyou thats very inspiring I fasted this morning into autophagy (or fat/protiein burning- perhaps it was gluconeogenesis) though I don´t think ketosis & then ate palm dates with water & grapes :D the sun give alot of energy unfortunately it was raining today :)
holy shit you're Batman.
You typically enter autophagy around the 22-24hr mark. You’re definitely already in it by 48hours.
If you're exercising like that, I thought your body starts autophagy even before 24 hours especially if you're already on a low carb diet.
Don't forget that fat loss is also a form of Autophagy...self eating so to speak. If you are overweight and losing weight from fasting...then some autophagy has a occurred. If no weight loss has occurred, then no autophagy has happened, but it has to done over at least a week period as weight can easily go up and down depending on water and food in the body.
No, it's not. When the body switches to using fat as an energy source when it runs out of glycogen, it consumes/burns fat. But Autophagy is the process in which damaged/mutant cells are turned off/killed, consumed, and replaced w/ new cells. Burning fat is not autophagy.
You had me at we don't know.
Help me help u
End the video.
@@dwmy3825 Kitridge, you've never seen me very upset!
Thrilling revelation! Congrats,Rhonda!
What is?
I love this reaction vid, thank you! I watched this concert when it was released but i keep coming back to her performances especially this one. All these songs are just so special to her you could feel all the emotions in ber voice. Just WOW!
richsalvador, are you sure your comment wasn't meant to go on a different post??
I fast for 21 hrs daily with a eating window of 3 hours and usually between the hours of around 9pm - 12am. Not sure if that’s a good thing, but it seems to help maintain longer deeper sleeps! Maybe I’m a rodent! 😂
The only thing I consume during the fasting window is Lemon Water and Plant Based Teas, some carrot juice.. And.. During the 3 hours refeeding window, I consume Coconut Water, 3 Exotic Fruits, Nuts and Oily Fish, Prebiotic Fermented Foods such as Kimchi, Sauerkraut and Organic Biotic Yoghurt and occasionally a little Rice or Potatoes!
Prolonged fasting I’ve achieved 3 days easily and have done it a few times now, however I am now looking to extend from 3 to 5 days in a row soon!
This has been my way of life for a while now, and really changed my life forever, by reducing inflammation, weight loss from 75kg to 60kg and my vascularity returned which I hadn’t seen in ages!
Couple of months back i had started to cut carb to minimum + eliminate sugar on my diet, I initially doing 3 light meal a day and after 1 month 2 meal a day, i had also started to do exercise during that time while making sure my calorie intake is less than what i burn. I am now ready to do omad starting next week. My goal is to fast for at least 3 days once i got comfortable with omad. Btw i lose 12 kg since, and my back pain, knots and constant migraine 24/7 is now just memory, i had multiple doctors and medication for that. i also think i am sharper now specially during reasoning and my stress level had gone down significantly. People around me is seeing the effect but they dont believe me when i say that all they need to do is just not eat at all. 😅 but some of them are now cutting carb a bit, while some are joining me during exercise, Well i am.happy with my accomplishments so far and determined to reach my goal to fast for days soon!
For those who only looking for weight loss, it's actually just an extra benefit!
The real or main benefits are improvements in your overall body condition.
I've experimented with various 'rhythms' of calorie intake over the last few years, also thinking about the type of food I'm taking, also keeping in mind simply ways of getting used to the process (I hit on the idea of using nuts for high calories to get used to small meals, for instance) and it's ended up with me being on OMAD pretty much all the time for about 4 years, a period of one meal every 2 days, gradually getting used to fasting and going from just a couple of days a few times, then 3, then up to 4 or 5 a few times, then 6 a couple of times, then 10 twice, 11 once, then 14 twice, with a month or two at least between each. The key seemed to be getting used to it psychologically, also understanding it (knowing I was feeding myself all the same; also being very aware that getting into the full autophagy and fat burning would be set back to zero if I consumed any food), making sure I was getting the necessary electrolytes for cell function, i.e. sodium, magnesium and potassium, consuming it all the time with water, and just leading normal days that take my mind off of food, that I enjoy, but relaxing. I did it in the summer mainly, and also during holidays, and also while living alone, so that made it much easier. The worst thing is temptation. It's amazing how easy it can get when your body adjusts to it, but the psychological aspect is a big one. I actually would walk past the grocery store nearby all the time and not feel tempted to go in, and even went around the supermarket buying cleaning stuff, but also checking out what best to buy later to finish my fast later, and still not tempted. Results are enlightening. Once fully into it, over the hurdle of the first stages (worst generally is the fourth, I found), better mood, more energy, sharper thinking, better sleep, incredible weight loss (about 4kg per week once properly into it). I lost more than 15kg with this approach. Though, it's true, it made me more relaxed about eating between fasts, so I could have kept more weight off (slow creep sometimes, especially over Christmas). It's true also that doing it with others around, and doing it while working makes it a lot harder. I did it during breaks, long weekends, holidays, and generally alone, keeping the apartment clear of food, of course. I also should add that this developed out of a combination of health problems I was having, plus weight gain, so developed over time and experimentation, so doing it suddenly is maybe not doable. Also I had experimented a lot with low carbs and ketogenic diets, so had gotten used to being in ketosis too, so that maybe made fasting easier for me as well. Also, the fact that I had these reasons and did this experimentation, taking it quite far, is kind of out of some level of desperation, and I can't be sure that the more extreme things I did, the fasts of 10 days and more, etc., do not have some harmful effect, at least in the long term. Short term benefits, weight loss, fine, but I'm still not sure that there might not turn out to be good reason to not take it as far as I did, so 'beware', I'm no expert. Learn about it. Stuff on the channel 'what i've learned' helped a lot in understanding the processes. I think there's more for me to learn, for example what better to eat in the days before it, and how best to come out of it.
That was very indepth and in detail and very honest.. thanks 👍
My first fast ( about four years ago ),I was an alcoholic with a shit ton of skin problems and allergies, so I went 21 days and drank only soda water ( for the extra salt and fiz ) Earth shattering results ! last November I went 32 days , its all in the mind about what you can and can't do !!!!
@@herbetrono4373 you rock
@AngloSaks Can you share the brand of electrolyte supplements you use with the fasting. I wish I knew a powdered product that had all of it (no added sugars).
I've been fasting for 200 years now. Starting to see the benefits.
Hauskaa
Don't forget, breaking the fast is important. So they say.
Well, you look fantastic Teemu! -Keep it up. But be aware when you begin re-feeding again, your diet and the chemicals in the food (mostly excluding GMO) will be very toxic compared to your last meal in 1821.
What benefits are you seeing?
You probably had 200 years worth of glycogen stores. Can't wait for your next update in 2221.
He was very honest about not knowing the minimum about of time for autophagy to begin. But fasting has great benefits with or without autophagy.
Started doing 24 hr fasts a few times/week.Did my first 48hr water fast 2 weeks ago.Will be attempting my first 72 hr water fast next week.
👍🇮🇪🇯🇴🇷🇺🇷🇺
I'm doing 4:20, eating within 4 hours window n fasting for 20 hours ...I've noticed over the last week some small changes already happening...I've been losing a pound of weight every two days and my skin full of blemishes is clearing up, my big toe nails were starting to raise out of shape and they have gone back to a healthy normal...I can't wait to see how much difference it starts to make to my Fibromyalgia and Arthritis symptoms 🤗
I've been doing 20/4 intermediate fasting since September 2022. Couple times was 24 hour fasting, like OMAD, now at the end of March 2023, went from 89kg 109cm weist to 69kg 81cm weist. It could be better, but I have some loose skin at lower abdominal part. But I've notised some improvment in last 7-10 days. If not loose skin, I could say, that I'm completely happy with the result, but even now I'm preetty much got what I wanted. Would try 2 day fasting in some time this spring.
Every second fasted is more autophagy and you always have autophagy going on. It will take 3-4 days to get into maximum autophagy however, which is much more dramatic than what most people experience day to day.
normal autophagy will not reset the immune system or do a good job of cleaning stuff up
hence the attractiveness of fasts > 3 days.
@@DS-eu2ww So you and science say that minimum 72h from last meal to start cleaning cells ?
Everyone else is so confusing 🤣
@@strpljenspasen991 That is when stem cell production has been measured. Maybe it happens otherwise but it is proven there.
@@strpljenspasen991 Alo bem li ti sunce.. hahaha
Besides the hours fasted, would the amount of food and calories intake a make difference in getting toward autophagy? I would think a person with 1200 calories instead of 2000 calories intake before fasting for 20 hours would have better results? And the amount of energy expended during the day.
Surely there is a significant difference if you exercise in the fasted state. I do IF 8 16, but most mornings I run for an hour or so. I have noticed that on long runs at a certain point I can feel my body starting to use fat when glucose has run out. I also notice I feel quite different in other ways. I know if I just sit around I have to fast much longer to get those feelings.
I know exactly what you mean here. I used to get really weak out on the bike due to hunger, and the last 10 miles or so home was always miserable. Now after OMAD keto, it's like the reserves never run out. It's fantastic!
You can’t feel it, give us a break. lmao
Who calles 16-8 fasting? Comeon.. 16 hours is no fast
i rarely brake eating window over 7-9 hours.. And that just means i dont eat before bed ~5 hours, but before that i have a big meal, so i just dont want anything besides mint tea after that. I wouldnt call it ever fasting, id call it " not eating late"
Completely normal to go ketones/fat burning in long workout after depleting glucogen
I combined apple cider vinegar with my 16-8 fasting. Just a table spoon mixed with a glass of water. It seems to work. I lost 30 lbs in three months. I weighted 190 before that.
My pre-hypertension is gone too!
Did you drink ACV during fasting window?
@@akshatak7206 I drink it to break my fast.
I fasted for 45 hours I felt like a new person. I once did a 33 hours fast that gave me a headache.... I am usually not eating for 12-20 hours each day. Eating window of 4-12 hours. Most days 8 hours... But sometimes I am changing because of family dinners etc... My new try is no carbs for one week.
For fasting headaches water with salt did Wonders for me
@@karolworkowski3261 Thank you I do it every once a while when I do longer fasts.
Has there been any recent studies since this clip with more evidence of autophagy? I try to do approx 16 hrs fasting. I can lift more weights in the gym so I suspect my testosterone level is higher. I'm in my mid 50's and I see no drop off at all in my strength. I would say my libido is also higher. Which I could do without if I'm perfectly honest :-)
According to Yoshinori Ohsumi (the 2016 Nobel Prize) it’s 24 hour fast triggers autophagy
Wow! Big difference between mice and humans. Going to have to do some prolonged fasts, not just intermittent or OMAD. :P
Buckle up! It's pretty tough
Don't go extreme. So far three day fast has been the best duration as per studies.
Go big or go home! A week is easy. It's the first two days that are a little bit tough.
From what I collected of all the information provided by Drs. A three day fasting is optimal. Anything longer than that and you start losing muscle.
Cycle your fasts. Start on different days and stop at different times.
@@danielw.7705 After 3 days is when the fun begins. The first 72 hours are the hardest. After that, it's easy and you feel great. No point in quitting after only three days.
Started fasting two days a week (Mondays and Fridays) and eating enough calories on the other days to make up for it. My injuries are healing to the point I can start exercising again. I'm off kinesiotape and I look years younger, lighter than I've been in years!
Praise God for this discovery and for the gift of fasting and prayer, and prayer walking!
What are the needed mg dosages per day for sodium, potassium, magnesium, chloride, calcium, and phosphorus? Long term fast for 3-5 days?
I eat breakfast at 1 pm
I eat dinner before 6pm
I fast 19hrs a day
me too
me too
My (repeated) experience of water fasting is, past the initial stronger loss due to water loss, a loss of 2lbs/day. That's 1.25% of my body mass per day, making the 4-day loss about 5%. I don't know where the number of 2% comes from, it should be revised.
the figure should be revised based just on your weight loss alone ?
@@spongebobsquaretits Experiment trumps theory every turn of science :) Yes, everybody's biology is different but 2% instead of 5% that's not realistic.
there are probably varying factors that influence the onset of autophagy
Three years later, is there any data or new research to extrapolate minimum fasting length for autophagy in other organs, other than le liver mentioned in this video? Thanks! Ciao from Italy, L
boa pergunta
I think intermittent fasting does to your body what high amounts of exercise does, and works so well because we're so sedentary. When I intermittently fast as an office worker who works out once a day, I start to feel like I did as a cross country runner in high school (two workouts a day, plus PE, and a ton of food small meals that fly in the face of intermittent fasting, OMAD programs). I think we all need more exercise and accompanying good sleep and nutritious food, and when we can't get it, less calories and less time processing calories.
Yup....the military can feed you like a hog and offset it with activity. Pick your poison.
Only 1-2% of body weight lose in 4-5 days? On my 4 day fast I lost 15 lbs which represented almost 9% of my body weight. I’ve done this twice with nearly identical results so what gives with his numbers/percentages?
A lot of weight loss early on is due to water loss because of the burning of glycogen and protein. When the body settles into using fat for fuel, weight loss lessens.
Would it be true that, because you're effectively starving yourself, the body becomes far more alert and agile? Like in preparation to go out and catch your next meal? Giving you the energy and alertness to find/kill your prey?
Just a thought i had whilst hungry.
Idk, I wake up on the next day after fasting absolutely helpless, lol. Maybe the reason is because I always did workout in my fasting days
!!!
Yeah, fasting increases norepinephrine in the brain if I remember correctly and it makes us more alert to go out and hunt our next meal at the supermarket
( I'm not quite sure why, but the supermaket doesn't want me to to dress as a caveman with a spear when I go shop there, I had a blue medical mask and dissinfected my hands and all that, so what gives?)
@@Zeon7510 @Byebyebadman's explanation seems like a promising possibility.
Dr looking gorgeous on this interview, just glowing.
once in autophagy how long should you remain in it before you get diminishing returns on your health?
I did 16/8 IF for a few months and my cholesterol went from 204 to 178. It's been 200 for twenty years and IF is the only thing that brought it down. Will keep going and can't wait for what other benefits I get. 8)))
So we’d be wise to conclude that the mouse fasting regimen that produced autophagy and renewal was nothing like a human 3-4 day fast, due to the vastly different weight losses?
I think a better conclusion is that something like 16:8 may not be tapping into the full spectra of effects. What's interesting is that many of the well-known names in the field seem to do something more extreme every six months or so.
See this article, which describes some of their personal habits: www.the-scientist.com/features/running-on-empty-31436
At longer fasts like you mentioned, especially 4 days, which I think most would agree fully qualifies as prolonged fasting, there's definitely evidence, even in humans, that some of the housecleaning processes are beginning to kick in at full swing. Even if what these rodents are going through is even more extreme. See the interviews with Dr. Valter Longo.
Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
www.foundmyfitness.com/episodes/valter-longo
Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD
www.foundmyfitness.com/episodes/valter-longo-2
@@FoundMyFitnessClips Does this mean water only or adding coffee etc?
@@dinner-at-the-diner : Fasting is mostly done with water.
So it seems that a long fast once in awhile is more important than fine restricted eating
Great info! I'm going to get my pet mice on this program right away.
can i ask a question? i've heard that long term fasts are hard on your heart, and the body breaks down heart tissue which can lead to heart palpitations. Is this true? what do i need to do to have a safe long term fast?
Couldn't I just have a shot which puts me to sleep for 4 days.
Lol u genius
😂😂😂
Ikr
I fast primarily for autophagy. If I am not getting that benefit then I see no reason to do intermittent fasting anymore
exactly!
Spreading eating over 10 hrs doesn’t really seem like intermittent fasting to me that could literally be breakfast at 7 am, lunch at noon, and dinner at 5
What a great voice he has
Is that what makes you watch this video?
Fasting for 14hrs overnight is pretty effortless
With little benefit.
The results come when you push your comfort zone.
Not eating for 14 hrs is considered as 'fasting' as well?? 😳.. I though it has to be 16 hrs or longer... 🤔
Tobeon2 technically it starts around 12 hours, but yeah, the greaaaaat benefits usually start at 16 hrs
its 16 hours or dont fast at all. 16 is minimum
Personally I do the 16/8
Besides weight loss the benefit of fasting that I noticed is my skin become softer... Even im a male
Wow, what a big benefit that is lol
@@teddybearroosevelt1847 yes and now i became celebrity and married to kim kardashian
Normally could do a 4 day fast no problem, but picked up scary symptoms recently after 2 days - short of breath, pale, sweating excessively, dizzy, waves of nausea and tingling down to my hands, with any form of exertion, including a short walk, had to lie down to prevent passing out. Will try again to see if it was just a once off.
Would check blood pressure, hydration and blood sugar levels. Good luck and be safe.
Agreed ! Check BP sugar levels pulse
I've been doing 18-6 for some time now and feel great with it.
What I don't understand about 20-4 or longer is this: how do you get all the daily nutrients your body needs, protein, calcium, iron vitamins etc. You can't get the amount you need in one meal surely?
I have been running mostly on ketones for the last eight days dropped 6 pounds and my heart rate is way down to the upper 60s at times when I had to fight sometimes to get it below 100 with medication. just checked it's 69. Im taking 1/2 the Metoprolol needed. Doctors dont even know this. I eat one time a day, a little on the light side and mostly protein as to not trigger insulin. I have at least a minimum of 30 more pounds to go so I'm nowhere near overdoing this. I eat dry lettuce as a snack food when bored as it has next to no calories and water sometimes lemon juice in it. for bad breath. I feel good but I feel tired still as I always felt tired but this is better tired. i take a b complex and magnesium and extra salt and Vit C. Edit I have now completed 50 days of eating one meal a day, I have lost 27 pounds max. I feel tired my sleep is poor but my atrial fibrillation is still gone heart rate is so great and I no longer feel like I'm dying 20 more pounds to go. I'm looking more youthful in the face, I'm 65 years old. i had sagging jowls. they are rapidly going away I'm spending more of each day sitting and walking rather than lying down. I always ate what i thought was healthy until i realized carbohydrate is sugar and starch and they are the same thing according to science both are sugar. so eating 900 pounds of starch a year will kill you just as fast. it was my wife's birthday and I took her out and ate normal carbs and got a big nauseating stomach ache. i dont do well eating any corn product and it's in everything. The big bottle of Metformin has gone untouched, on this desk i think I keep it as a reminder.
How is it going today?
I've been intermediate fasting couple times a week, 16-18 hours, though I cheat a bit as I drink black coffee in the mornings, not sure if this throws everything off but I've felt amazing. I realized I wasn't eating for 12 hour periods anyway and always though this was unhealthy, so I figured what was a couple more hours, now that I've done it for a couple months I think I can go 24-48 hours.
Black coffee doesn't break a fast.
@@itchyscratch3829 Right
As long as nothing is in the coffee ur fine 😊
What should you eat in the other days when you are not fasting? That is also a question
I don't practice fasting, but I eat all my day's food over a period of about an hour, so I typically go 20-26 hours without eating each day. I've been wondering if this is enough for any autophagy.
There was a time that i was laughed at when i used to fast for ramadan. Even doctors told my parents that it was dangerous😂. Alhamdoulilah. Ramadan is my favorite month
Exactly
It’s the water fasting which can be dangerous in Ramadan, not the fasting of food.
@@roryt1983 a 16 hour dryfast is far from dangerous. Your body is more resilient than we think. I even do some low intensity sports before breaking the fast. Maybe the spiritual side of ramadan gives me some more power to maintain i guess.
@@karim3163 I said it ‘can’ be dangerous. For some individuals. Many professional footballers withdrew from games this year because it would be too dangerous for them to play without water. Unfortunately a lot of ‘ordinary’ workers in conditions of heat don’t have the luxury of just not turning up to work and so they have to persevere without water, which ‘can’ be dangerous.
That's Intermittent fasting. Very different from prolonged fasting. You're not getting the same autophagy benefit, if any at all. Not even close.
Everyday I exercise in fasted state for 45min cardio 15minutes HIIT, Then Steam Sauna for 30minutes then break my fast after 18hrs of fasting.
To me it sounds like too much stress on the body to do every day. Might be bad in the long run as the body needs rest to build itself back up. Probably a good regiment to do every now and then though.
I did this yesterday and every other day, though I only do the HIIT once or twice a week, while the rest of the time I try to stay in Zone 2. I use a dry sauna.
I would like to fast 5 days/month and do IF 18:6 the rest of the days for a year. I am a female 53 and I would need daily support (Facebook, Skype etc...) how can I get help ? thanks.
Fasting has both given me the most gorgeous clear skin I never thought was possible. No expensive creams or any bs
How many days is needed to do fasting for skin recovery? I hane lichen planus and I am thinking that maybe this is my solution
She asks good questions, the whole video was so accurate, answers were straight forward. This is the kind of videos that's needs to encouraged sometimes. Thank you so much.
No. Her question was too long, she was long-winded and tried to interrupt the doctor halfway thru his reply. She spoke for about half of the clip!!
@@skinfx3813 She is pushing him to say something bombastic, so she can use as headline....
I've seen her doing that with other of her guests.
i wasnt impressed with either of them and didnt even perceive an answer
Asking the question has taken 2 minutes of my life. The answer took 1 sec😂😂😂😂
I started IF one month ago at 20/4. It was difficult at first, but now I am doing 22/2 or 23/1 most days. I am completely satisfied with this routine. I get an energy boost at about 0900 every morning that is like taking speed. It's unbelievable. That's when I get my housework done!
What I'm not sure about is how can we do so many fasts if we are a "healthy" weight? Eat in a surplus few days before we fast? I want the health benefits without getting skinny
I just finished a 5 day water fast, and I lost 15 pounds, which is around 10% of my body weight. So how do explain this, as opposed to your 1-2%? Granted, I am a long-time fasting practitioner, so maybe this is a factor.
the first thing that goes away is liquid retention, so most of those lbs were likely water
@@PigeoneerToy I only did one day of dry fasting, others I was hydrating properly. What is your point, even if it was mostly liquids? I still dropped 10 times more then the guy in this video said people usually lose.
@@milanveemiami my point? No, you asked a question and I answered. I've been fasting for about 20 years, I know a thing or two on the subject.
@@milanveemiami hydrating during a fast has nothing to do with liquid retention. Water accounts for about one half to two thirds of an average person’s weight. Any extra water being held in the body is referred to as “water weight.”
One of the biggest influences on water weight is sodium. Fasting is low sodium therefore your hydrating has little impact as it is being used and then flushed out.
Also many doctors I have heard factor in anywhere from 2 to 6lbs for water retention and would not include that in the calculation of lbs lost due to the fact that as soon as you start consuming sodium and foods again your body will start building up those stores of water. So it's not really even weight lost.
Even so you may have lost a little more than 2%. The 2% is most likely just an average and you may just be on the higher end of the spectrum used to calculate that statistical average.
If my explanation is not clear enough give it a Google and you can find out more.
I don’t know how anyone can sit in a bath for 5 days
Autophagy is about energy deficit. Run a marathon on an empty stomach and you can expect at least some autophagy for sure. Spent 3 days in bed fasting and there may be none at all. The problem of course is that we have no means of quantifying it in either case.
People should learn their body in and out. If an individual cant detect the changes happening internal to their body, it means they haven't experimented enough with their diet/nutrition/fitness. Nothing wrong with that... but once someone reaches a certain level of experience, they can 10000% quantify those factors you brought up and understand what stage of fasting/autophagy they're in.
3 days in bed while not eating creates a energy deficit. You still burn like 1500 calories a day being sedentary
Anyone know why somebody with insulin resistance like myself who is ridding of it slowly fast 20 hours a day and a couple of 24-hour fast per week has a heart rate that used to be resting in the upper 90s and now low 70s. Anybody know?
How about the starving malnourished people in Ethiopia, are they on autophagy all the time?
I've been trying to do 5 days each month. As suggested by Dr. Longo as a possibility for people with a chronic illness such as autoimmune. In my case, RA. Hoping to help control/treat my condition, as well as all the desired general autophagy benefits. Who can say for certain at this point? I say based on research so far- worth the effort. Time will tell.
How did it go?
@@wmrajput I can't say I've had any significant results so far. But I think as I said, time will tell. The potential, and likely benefits over time are considerable
Mina Irfan on youtube speaks how she cured her RA.
@@annita_dance thank you, Anna. I'll check that out.
Five 24 hour days in a row?
My assumption is, as the body becomes adapted to fasting, fat burning and autophagy it will take longer to reach optimal autophagy.. I make this assumption because it keeps getting easier for me to fast over time.
wrong
its about the same
its based on how much glucose exists in your stores of tissues and organs
if you are doing a 3+ day fast, you will not do this immediately again
if you wait a few weeks before doing it again, these tissue and organ stores are filled back up
except if you are obese and lost body fat. Im not fat, so my fasting cycles feels the same.
@@DS-eu2ww that means if we check insulin level in blood during fasting, we come to know if sugar goes down autiphagy can start?
I think the opposite. I'm thinking that the more you fast the body can turn on autophagy easier... sort of like exercising that function you're training the body to do that. It shifts into getting the energy from storage and that's why it becomes easier to fast and keep up energy levels because the body knows what to do.
It gets easier because you are becomeing more fat adapted. Your body more easily makes the transition to burning fat once glucose stores are depleted. You also become more efficient on utilizing ketones
I think it depends on the person and activity levels
How long do autophagy last when it reaches the peak before it goes back to the normal level?
This has been a challenging time, and I appreciate you so much Dr Igudia, you have created a life that I thought was lost, thank you so much for curing my type 2 Diabetes
Oh I’m so late to this video! Dr. Rhonda had a baby??!! CONGRATULATIONS. You look adorable pregnant. Blessings!
I'm on a 3 day fast now just completed my 1st day I've done 48 hour fast very easily and omad majority of the time every month do 2mad.
Plus walk over 20.000 steps per day whilst carrying heavy items daily
I'm on medication for diabetes & high blood pressure: is it advisible for me to do intermittent fasting? If yes, shall I take my medication as normal? I would appreciate an answer.