Understanding Blood Sugar Levels, INSULIN RESISTANCE & Impact on Chronic Diseases | Dr. Rob Lustig
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- Опубликовано: 24 июн 2023
- Dr. Robert Lustig delves into the complex topic of insulin resistance and its profound impact on chronic diseases. He explores the mechanisms behind insulin resistance, its manifestations in different tissues, and the role it plays in conditions like Type 2 diabetes, polycystic ovary syndrome, cardiovascular disease, and Alzheimer’s disease.
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Key Points:
Insulin Resistance: Unraveling the Mechanisms:
- Insulin receptors on cells become down-regulated, leading to reduced insulin function.
- Dysfunctional signaling beyond the receptors contributes to insulin resistance.
- Understanding the underlying mechanisms is crucial to addressing this phenomenon.
Insulin Resistance in Different Tissues:
- Insulin resistance manifests in various tissues, resulting in different chronic diseases.
- Type 2 diabetes: Insulin resistance at the liver level.
- Polycystic ovarian syndrome: Insulin resistance at the ovary.
- Cardiovascular disease: Insulin resistance at the heart.
- Alzheimer's disease: Insulin resistance in the brain.
Factors Contributing to Insulin Resistance:
- Subcutaneous fat: High levels can lead to insulin resistance, but not necessarily in all cases.
- Stress: Cortisol and altered sympathetic nervous system output play a role, independent of energy and food intake.
- Fatty liver disease: The liver accumulates fat, impairing its function and necessitating higher insulin production, contributing to insulin resistance.
Challenging the Calorie Paradigm:
- Obesity and diabetes don’t always correlate, with some countries experiencing one without the other.
- The obesity rate is increasing slower than diabetes, suggesting other factors at play.
- Fat distribution and specific diseases influence insulin resistance, not just calorie intake.
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Dr. Lustig is one of the BEST physicians I follow on RUclips. After watching his videos, I feel like I just graduated from medical school..lol..his videos are extremely educational 😊
Prof Lustig has provided one of the most if not the most significant health information that could change our lives to get out of chronic diseases! I’ve learned and applied this piece of information and had heal my families from diabetes, heart problems, fatty liver, etc. thanks a million times to Dr Lustig
hard to overstate the value of this discussion. I am a doc and I never learned this in medical school. Hearing these two go at it is like standing next to them at a party after a medical conference evesdropping on their insights. Most docs do not know this and the subject is difficult enough that most people will struggle to understand it. Thank you guys for trying to bring light into the darkness.
You must have gone to clown college then
Short, sweet, and direct to the point. Thank you.
Well explained Prof Lustig. Love your work.
I always learn something new from Dr. Lustig. I never thought about these chronic conditions as having the same underlying etiology of insulin resistance, just with different targets in the body. I hope more medical professionals learn from Dr. Lustig; we need a paradigm shift in how we think about insulin resistance, obesity, and chronic disease.
brilliant funny patient Robert Lustig, a hero for our time!
❤❤❤ would love to hear more about mental health and insulin resistance.
Best damn physician in the world. Brilliant!
As always a pleasure to listen to Robert, sharing all his knowledge about metabolic decises. It would be a great interview if you could invite Ben Bikman to talk with Robert.
Dr.Robert Lusting: Doctor Lusting, you are a true crusader and a real & compassionate Doctor who has launched a crusade to convince people ailing from chronic health conditions such as diabetes to change their diets and lifestyle to get rid of these debilitating diseases without suffering from severe side effects of allopathic medicines.
All your videos reflect deep research you have done to arrive at such objective and scientific conclusions.
Prof.Lustig's valuable warnings are very significant, but despite this, malicious doctors under the control of WHO never inform people about insulin resistance and obesity, and do not mention the dangers of sugar! Thanks Dr.Lustig.🙏
Thank you Dr Lustig for pointing out the stress insulin connection. Please continue to enlighten you're uneducated medical colleagues many of whom would totally ignore this fact. For many years people with bad experiences whose mental health has been medicated and not actually addressed have been blamed for the obesity that comes from stress overload. Thought of as gluttonous sloths who should just eat less and move more. There needs to be a real big shake up on tooling kids up with skills to help them learn to deal with dreadful upbringing by people who also are under social and economic stress. Example I am just in of night shift I get my children up for school, there is barely time for food its cereal rubbish when they should be getting a hot breakfast. But I am so tired I am on my feet running after dementia elders all night. Who have a dreadful quality of life Kept alive barely by pharmaceutical drugs.
My husband has had the homework duty and taking them to sports and collecting my kids from their friends. He can't wait to escape to work when I come in.
My Doctor can give me an antidepressant it will make me zombified unable to do work. It will most definitely make me crave carbs and gain weight. My Doctor will check me for high blood pressure and he will give me a station. I will go to bed exhausted depressed and then get up and repeat. My Doctor will look at me and tell me I have to give medicine time to work. He will tell me I must make time to relax and to exercise. I'm on my feet all day I say .He just says eat less move more. 😊
your doctor is not God and cannot help you unless you take responsibility for your life and change your lifestyle.
Never learned so much in just a short ten minutes. Thank you for that valuable information😊
Thank you Dr. Lustig! It seems you are one of the few doctors that know about the stress/insulin resistance connection. I don't know if other doctors deliberately down play this connection for what ever reason(s) or they truly aren't aware of it's impact.
K9 they are not aware. Ignorant if you will. Ted Williams the slugger said: Life is hard but it's a lot harder if you're stupid."
I love listening to Dr Lustig, I learn so much! So grateful for the sharing.
Thanks For All The Help My Own Insulin Forever. 🙏🏾
Great interview. Right to the point.
This should have millions of views.
I’m reading Metabolical and watching this video and yet I’m surprised how much more I must absorb.
Thank you.
There's one bit I don't understand. How come people become insulin resistant because their cells become non responsive to insulin yet when they turn diabetic they inject insulin which seems to work. How come? Is anyone able to answer this question please? Thanks
More insulin ( injections) is using a bigger hammer to drive energy into cells.
The patient is full of stored energy. We store energy as fat. You can have perfect insulin production as a type 2 diabetic and have high blood sugar levels.
When you don’t intake food insulin drops over 24 -48 hours. If you have insulin resistance your body will release stored energy into your bloodstream. You then begin to clear this energy ( triglycerides) from you blood. Other cells just consume their stored energy.
There are a calculated excess of 7000 calories in a pound of body fat. You can see how many 2,000 calories of body fat you have. So starvation is going to take a lot of time.
I love this doctor but, does he have a part 2 with a specific dietary recommendations that have proven to be able to put t2 into remission or a cure? I bet there is but his profession would lose 1/2 their income if it was exposed… or he should explain why t2 is “ chronic” which to me is a giving up… and doesn’t offer any hope to cure this thing… he should speak about how he is close to solving and curing the problem… that’s the essence of what we need… I do however appreciate his info and efforts
I just want to know how to reverse it, thanks
@@johntiller605
and GETTING OUTSIDE
Before the early 80s, most were
To get fresh air , away from the
🚬🚬🚬🚬🚬2nd hand smoke
What is Insulin Resistance at the cell level? What is wrong(changed) in cell?
There's multiple mechanisms that have been suggested. I believe toxic levels of energy in the form of calories for the cell cause increased intracellular lipid accumulation and ROS formation and inflammation. Through multiple cellular pathways this leads to insulin resistance however these are beyond me currently haha. Some nutrients are worse for this e.g fructose
@@conradcreate Dr. Lustig also don't know what is IR.
Mitochondria distinction.
So where are we with an insulin level test??? Is blood glucose level a reliable marker?
Blood glucose is a trailing indicator. Look up the HOMA-IR test.
My theory, is, people need to get outside more...
Up until the 1980s, they WERE
People hated to be in smoky rooms
🚬🚬🚬🚬🚬🚬🚬
Don't start smoking or vaping though
How do you know if you have insulin resistance?
Fasting insulin test-it is mentioned in the video-also, if you have some metabolic diseases like fatty liver, it means you have insulin resistance..this was also mentioned indirectly in the video
Also, under the video, in the description box, there are notes related to this video kind of the most mportant points that were discussed
Have your doc draw three fasting tests: an ALT, fasting glucose and fasting insulin. That is a start.
It’s kinda the Randle cycle
🙏❤️
I am no expert but seems to me he is just making excuses for Ansell Keys - eg" Well all science has holes in it" , and spends too much tme just criticising low carbers and what they say. I dont care what low carbers, or carnivore deters, or vegans etc or any other group say, I care what the science says.
What causes this condition I got diagnosed at 27 I was completely normal weight then all off a sudden I became obese activity and diet the same out of nowhere I started tanning massive amounts of weight what is the causes ? And treatment