A New Drug to Treat Schizophrenia
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- Опубликовано: 4 май 2024
- In this video, I’m going to walk you through a new drug that is shown to be effective and safe, and that could potentially treat schizophrenia by decreasing the negative side effects.
This video summarises the paper: A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.
By: Kenneth S. Koblan, Ph.D., Justine Kent, M.D., Seth C. Hopkins, Ph.D., John H. Krystal, M.D., Hailong Cheng, Ph.D., Robert Goldman, Ph.D., and Antony Loebel, M.D.
This is a link to where you can find a copy of the article for yourself to read:
www.nejm.org/doi/pdf/10.1056/...
0:00 Introduction
4:42 Importance
6:24 Design of the Clinical Trial
8:59 Results
11:28 Summary & Significance
12:26 Future Directions
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Good informative content for those who wait for new medications.
Well presented!
Your introduction is very detailed and I believe it will play a positive role in the future.
Yes you did a great job and it helped me
Is there a good place for treatment,and do they have exercise programs and nutrition for them and counselors. I feel this is much needed.
Thank you for this insightful presentation !
Important information. All currently available antipsychotic medications cause side effects that make them difficult to take. I believe this is because they all block dopamine, which is involved in feeling pleasure and reward, coordinated movement. Some of the worst side effects are dystonic reactions and akathesia which I would not be able to tolerate long term. All the antipsychotics I have tried dampen my ability to feel motivated, and my ability to enjoy things. I take antidepressants to try to treat these side effects, but they are not effective enough to fully treat the problem. New medications with new mechanisms of action are badly needed
Heh, that not enough, the D2 receptor is a major signaling component in glia cells.
So its blockage leads to the death of astrocytes and microglia.
@@fragileomniscience7647 I'm not surprised to hear that they might be damaging to some parts of the brain
Hi there one last thing, you have been very helpful in describing this medication and creating a small platform to discuss it. I am very hopeful for this medication (maybe overly so) but am trying to piece this in my head as to how it would work. What it would do etc. one question I have is if patients somehow described hypnogogic or hypnopompic feelings, thoughts images, optimism sort of like returning to a younger self and somehow captured that in the medication. Do those buzzwords come up from what you know in patients testimonials? It’s all very interesting and thanks again for being so punctual about responding!
I am uncertain of what exactly the patient testimonials are surrounding this medication, as in the paper all they gave were assessment scores. My apologies on not being able to find exactly what you are looking for.
Dosik drops founded very useful but temporary
Does it work on the positive symptoms too?
doctors and helth care are recommend and pre testing this ?
Would this medication be useful for an otherwise healthy anhedonic person in relation to how physical excercise improves symptoms of general anhedonia?
This is a good question, unfortunately, that is information that I do not have, so I cannot give you a good answer for your question. I think that this question is something that you should bring up with your healthcare provider to help find the best medication for you
What affect does it have for positive symptoms ?
stellar presentation .
Do they do a brain scan first and lab work before they give meds.
nope
help me how by this drug im in very dangerous stuation at sri lanka
Hi again, so after talking with a few people I am kinda getting a picture of what Ulotaront is going to do…is it maybe like an MDMA feeling coupled with a MAOI am I correct? I was sort of thinking it would be more of a “exercise in a pill thing” but that was probably pretty unrealistic of me. Have you heard of KARxt and do you think that would be more effacious? Ulotaront is not demonstrating the strongest numbers as far as PANSS goes. It’s disheartening but wondering if I’m kinda on the right track with that guess? And once again thank you for sticking with this comment 😂section and answering questions it’s very nice of you to do that.
Is this drug available now??? Its heartbreaking my 24 year old son suffers from this illness and hes such a brilliant, beautiful person.
Nop it failed
Good job
My son has this, but he also had trouble sleeping at night.Could this be some of the causes of the mental illness. He doesn't sleep good at all .He is delusional all the time he is awake.
Hello can you help my son with Schizophrenia
Please give a link to the exercise study improving schiz.
Wang et al. 2019 Front Psychiatry www.ncbi.nlm.nih.gov/pmc/articles/PMC5962673/
Very good news sufferers of schrezophenia when it will be available. Is 4weeks sufficient for early. Schrezophenia. While using this can we stop other anti psychotic and anti depressants completely or low dose madam please make a video related to dosage and age wise thanks madam for your wonderful service to mankind.
Thanks. What can be valuable is how SEP 363856 compares to Atypicals, especially in Non-Respondent Patients.
i think this drug is interesting because im sure it will be easier on your body and sideffects then seroquel or clozapine. If you live a healthy lifestyle and do sports u can be on top!
My son has this he isn't on meds yet.
stay strong
is the drug avelaible? in europe?
Where will this medicine find easily
What's the name of the drug
The commercial name of this drug is Ulotaront
I'm sure they'll let you
Sounds good but getting a doc to give it to you is another story.
When it is available for patients
According to Sunovion Pharmaceuticals, the researchers are still comparing the long-term efficacy and safety of Ulotaront (SEP-363856) to existing medications for schizophrenia. This drug is currently in Phase 3 of the clinical trials, which can last for several years. There is progress!
Next year
@@constantinhaller4391 Where did you get the "next year" information. Please let me know.
@@barbaramartinetti3221 because its in end of phase 3 0ktober 2021 and it already has a brand name so it will come out soon. But im sure it will be expensive
Next year means? June 2023?
& it will cost a million dollars a month.
is this drug similar to AMISULPRIDE WHICH IS AVELIBLE OTHER COUNTRIES'
Ulotaront and Amisulpride are two separate drugs that have differing mechanisms of action.
Mindy Mandy molly
Hi there,
My son suffers from Kleine Levin syndrome but he has been treated with clozapine for almost 7 years.
Last year his white cell count were going down. Then he got into episode and found that it was very low and life threatening so they stopped clozapine and put him on amusulpride olanzapine. Still getting episode. Would you advice to try SEP 363856
Please advise.
@@elamenjikolela3980 SEP363856 will not come out
Good job