The Future of Medications for Schizophrenia | with Pharmacist Matthew Elswood
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- Опубликовано: 4 май 2024
- We got to sit down with Specialist Mental Health Pharmacist Matthew Elswood to learn about how psychiatric medications are developed and potential new developments in medications for treating schizophrenia. Thank you so much Matthew for chatting with us!
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My poor brother, he has schizoaffective and every time he has a " break," and hospitalized . He is treatment resistant. He has been hospitalized for 15 months. Every anti- psychotic med, combination hasn't worked. Right now he is waiting for a bed to be transferred to a state hospital for another year. Hopefully, they can help him there. Dr. told me last week that he is " literally at a loss," for treating my brother. I am heartbroken. He just turned 47 . Dr. said he is going to continue to decline as the years wear on. I am praying for a new medication to keep my brother stable and out of the hospital. My heart breaks.
Prayers for your bother. Your love for him is apparent. He is lucky up have a sister like you. My daughter lost her life to szhoeffect disorder. Best wishes.
Keep Hope always and for God nothing is impossible 🙏 I will pray for your brother to be happy and joyful again.
I’m so sorry to hear that. I feel for you my wife has been in and out of the hospital and I often feel hopeless. It’s been 9 rough years. At times she goes months with no sleep. We’ve tried just about all meds and the only ones that somewhat helps is Olanzapine.
My sympathies to you.
God bless you and yours ❤️🙏🏼
My heart goes out to you. Stay well yourself, you need your strength.
I love how passionate Matt is about his field and his work. One of my favorite humans has schizophrenia, and I hope medication continues to improve to treat him so he can live the life he wants and deserves
My heart breaks for those who experience akathesia from their meds. I know often others will think they’re faking the side effect in order not to take their meds which sucks so much. Akathesia is the worst mental experience I’ve ever had in my whole life and I would not wish it on my worst enemy. It’s hell.
I would like to know if it’s known that a psychopharmacologist can be more precise prescribing medication than a psychiatrist?
Hang in there. There is a new med that will release this summer in U. S. It is called Kart. at the moment which will take away negative effects of the meds.
How does restless leg differ from akathisia?
@@paulmillich8934 I think it’s because akathisia comes with dysphoria and feelings of doom and dread where as I think RLS is just the physical sensation of restlessness. I really don’t know that much about RLS so I could be wrong.
@@tzippysegal1883 I would definitely believe that especially if said psychiatrist has no first hand experience with taking psychotropic meds. Most seem to (at least the psychs I’ve had) just read from the DSM and prescribe without fully understanding the patient’s full situation.
Hi all. I'm based in South Africa. Look mental health care facilities here are a nightmare. I've been reading up on new trials and diets etc as my husband has schizophrenia and dyslexia. He is in and out of work, his family don't really fully understand him or the dynamics of our marriage and the love we have for each other.
Lack of empathy and understanding has had it's strains but we strong together.
My husband takes serenace and is on 5mg now and doing well. In 10 years he's only relapsed twice.
I keep him calm as much as possible and I am over protective of him and his wellbeing.
Chris is 55 and coping okay sometimes better than me. Thank you for the program and history lesson. Extremely interesting. Blessings to you all. 🦋🌻
Bless you! He sure is lucky that he has a wonderful partner!!
Oh, thank you for this. I need information from older people with schizophrenia, who have marriages and careers. When you say relapse, how does this happen...is it because he stopped taking his meds, or did his meds stop working. I hope my son stays well, he has been good for a year.
@@freethinkingMILF He needs to taka his meds just like antibiotics! Same time every day! I know that it is very hard, but he has to eliminate sugar at all! He needs to eat a lot of yogurt with a little garlic. Nuts are excellent Omega 3 sources especially for negative effects for schizophrenia! I know that it is very hard, but at least 30 minutes walking outside is extremely necessary for this hard illness. Do also you can for the gut! It is the second brain! Hang in there from a mother that dealing with this illness for 14 years!!!
@@ashleyriblet2326 Thank you so much, he is a vegan, and he doesn't like sweets, so this is good. He is slowly getting back to exercising. He used to exercise and play basketball daily, but then he got ill, and went on Zyprexa, which worked, but he gained 90 pounds in 6 months, so he went on Latuda, which is working just as good, and he lost 40 pounds in a month. He's in college and wants to be a Physical Therapist...I want his dreams to come true and to live as much as a normal life as he can. I just don't see any stories about people with schizophrenia holding jobs as medical providers, nor holding down a job for years. I just hope my baby stays well...he suffered for months before he told me, and that's only because the voices came. His delusions made him not trust me...he thought I was dead and had been cloned. So, I am desperate for him to be well, at least for ten years without relapse like the op said her husband. I will stay vigilant, and make sure he takes his meds.
@@ashleyriblet2326 Thank you so much, he is a vegan, and he doesn't like sweets, so this is good. He is slowly getting back to exercising. He used to exercise and play basketball daily, but then he got ill, and went on Zyprexa, which worked, but he gained 90 pounds in 6 months, so he went on Latuda, which is working just as good, and he lost 40 pounds in a month. He's in college and wants to be a Physical Therapist...I want his dreams to come true and to live as much as a normal life as he can. I just don't see any stories about people with schizophrenia holding jobs as medical providers, nor holding down a job for years. I just hope my baby stays well...he suffered for months before he told me, and that's only because the voices came. His delusions made him not trust me...he thought I was dead and had been cloned. So, I am desperate for him to be well, at least for ten years without relapse like the op said her husband. I will stay vigilant, and make sure he takes his meds.
Has anyone heard of Xanomeline-trospium, or KarXT?
This is a fairly recent article about this drug saying its likely to be released in late 2025 in the U.S. It's still a frustratingly long way off, but looks promising.
May be it would approved in mid 2024
Likely submission in 4q2023 based on positive Phase 3 studies. This NDA will likely get priority review- 8 months so approval summer of 2024.
I am having a nervous breakdown right now as a schizophrenic person that gets manic off and on in the first place. No fun!!!
Hey, hope you're okay, please stay calm and get some rest
Looking forward to this one to give me hope. My son had a psychotic breakdown at 22 and is now 29. No insight into being ill. High functioning. Sectioned in hospital for over a year now and he’s just getting worse. He has paranoid schizophrenia and they believe it’s treatment resistant. He’s never had a period of stability since and none of the medicines or doses work. It’s heart breaking knowing there is a chance that this will be his life forever. I have hope that things will happen in this field of medicine over the next 5-10 years.
As a mother, it is very hard to see that your child suffers. I urge you to talk with her Dr and get him on Clonex! Clonex is for resistant patients and it works wonders. Dr's give this med reluctantly, because patients must do a blood work every week for 16 weeks at the beginning.
My daughter is also very resistant to meds. Her body gets used to meds then they do not work on her.
He also must quit anything that has sugar in it. He also should take extra omega 3,eat a lot of nuts, beans(not green beans). I also found that homemade yogurt is also very good for the gut. Hang in there.
@@ashleyriblet2326 thank you. He refuses any medical intervention from being weighed to bloods taken. He’s vegan and has to have additional supplements when possible but he thinks we are doctoring them so he won’t take them often. He is so gaunt now but we can’t do anything due to his current paranoid state. I will talk to his team about Clonex though thank you again.
Thank you for giving me hope in new medication deveopment! I am stuck with a medication that makes it hard for me to function in the every day life. Trying to switch medication or reduce my dosage had me relapse. I never really thought that there might come a medication down the line that will make it better. I always thought age will make it all worse. So this is giving me hope that one day I might have a better medication.
I’m in the same boat. The one I’m on has the least side effects but I’m still so tired, but it could also be chronic fatigue syndrome
@@mushroommellowYeah it can be rough sometimes. I hope that you will find some solution that works for you, may it be medically or otherwise.
@@fraurosenthal2958 thanks! You too!
I got off all meds after 6 years, 8 for the benzo and anti depressant with 4 hospitalizations. As time goes on, it gets easier to deal with. As you said.
I spent a week hospitalized before xmas ‘21, after most of the year spent in an ‘episode.’ my stay was enough for some clarity to come through, but it soon became fully clear that my medicine simply wasn’t working.
i can’t work due to lupus so I stayed at home in 2022, trying a few medications over the span of about nine months. then i said, ‘can i try X medication again bc it’s been a few years and it really worked in the past?’
well, it worked when i was ‘bipolar I, w/o psychotic symptoms’ … it was MORE than clear that THAT was no longer the dx (& had been clear for almost all of 2021, but it was unclear to me bc the mixed manic episode and psychosis together didn’t allow me to see any of it).
my primary, though, he saw it within three seconds (said he could feel it all bouncing around the room) and he called my psychiatrist, who shoved me in for a quick in between appts type of appt in two days.
i’m about to be 44 and have an 18 yo graduating a month after that. it’s just us and i know it’s tough on her. i seem to be treatment resistant to anything but clozapine so I wonder what fun will occur if I have to dip into the original antipsychotics the next time around.
I am STILL struggling and have only been on the clozapine 3-4 months, if that. with awesome weekly blood tests. there’s so much memory loss, and then cognitive impairment, in general.
I look back and it’s so awful, what i don’t recall correctly (and what i do…).
I went from a bipolar II dx 20 years ago, when i was first hospitalized, to now having schizoaffective disorder. how 15:47 else will it progress….?? ugh. it’s scary but we’ve gotta keep moving forward.
I hope that all made sense…
I’m really interested in how AI will help drug discovery.
Matt is so knowledgeable, what a great guest, thank you Lauren, looking forward to your next guest!
I really like Lauren! She’s smart!
Thank you for doing these videos. It’s so informative!
I experienced akathesia and it is a hell. I'm glad that I didn't have to experience it for long, just a long long weekend. My moms a nurse, and thought that I wouldn't be able to contact them on Sunday. I cried and pleaded with her to call them, and hearing that I could go to the pharmacy and pick up a medication, made me cry. I needed to move so badly that we picked up a gym membership that weekend to immediately get me in the pool, and that worked for one day, and I was able to sleep after working myself to exhaustion, but it was terrible because I couldn't work hard enough the next day to pass out. I called extended family to see if I could lay down on an air conditioned floor to try to sooth aches. Its a hellish situation when you don't know if its normal or not.
having guess is super. Thank you xx
Such an interesting interview, thanks for this!
Thanks!
Thank you. That was a great discussion - I learnt a lot.
that was really interesting thanks lauren and matt
thank you Lauren & Matthew.
My brother and I are both diagnosed as schizoaffective. Thankfully antipsychotic medication works for me, though it does have some unwanted side effects such as anhedonia and weight gain. Unfortunately for my brother he is constantly experimenting with illicit drugs on top of his medication so he tends to relapse.
I hope we can develop better treatment that can remediate a lot of these side effects so people with any type of mental disorder can live as normally as possible.
Thank you for your videos 🖤
Interesting video.
I just want to say , thank you Lauren , for educating people on schizophrenia and giving advice and hope , for people suffering with this cruel disease.I've been diagnosed with schizoaffective disorder , a few years ago and I am currently taking fluoxetine and olanzapine.Hopefully new meds will be created , in the future , that doesnt cause as many side effects.I am staying hopeful.Wishing you all the best for the future , Lauren.May each day , get a little bit easier for you.
Thank you God for these passionate doctors, nurses and scientists for helping people with mental illness such as schizophrenia find coping med hopefully we can cure it. I'm watching as I learn about the future of medication for schizophrenia.
Thank you so much for such an interesting and informative video. informing people about mental health is the first door that needs to be opened. I can't wait to see more of your videos. Bravissima!
good video lauren!
I Love You!
I would like to see you interview older schizophrenics in professional jobs (my son is in college now, and he wants to be a PT), I just want to know that he can follow his dreams, and grow old, not in a hospital, but his own home.
I’m 33, I don’t know if I’m older like you would want. But I was diagnosed with schizoaffective disorder. I went to college and the first couple years were rough. It was very stressful for me. But staying on medications and having my support group in my family and friends I did finish college. I became a respiratory therapist and worked in the field for 6 years. I only stopped because I got pregnant and wanted to be a stay at home mom. I’ve been doing that for 4 years no with two kiddos and it’s my favorite job so far. So thankful to have my hubby being able to work and me stay at home. But all this to say is you can lead a normal happy fulfilling life with schizophrenia/schizoaffective disorder. I have been hospitalized while medications needed to be adjusted and relapsed but I still finished and worked and was successful. My dream now is taking care of my kids and homeschooling them. I start this year and I am very excited. I also have a huge support system in my faith. Keeping strong in my Bible readings and going to church helps in myself staying healthy and taking care of myself. I hope this gives you hope. God is good and I’ll be praying for your sons journey and you being right there with him through it.
@@Lela419bg Thank you so much, this helps a lot, even though you are not that old, lol.
Hi Lauren, hope you're doing well 🧠🌺
Hi Lauren. I am so grateful to you for sharing all you experiences with the illness. You are helping so many people!I was wondering if you have looked into Ketamine infusions for depression? Or even if you know anything about its use for schizophrenia.
Thank you SO much for this video. :) It's hugely informative and hope giving!
Amazing video idea! Would love to know the same thing (what future pharmacotherapy might look like for depression and anxiety)
That's hopeful that your mentioning diet. I think chris Palmer said that everyone he has treated with the Keto diet had responded positively. Some more than others. That is the direction i would like to move in to eventually come off my medications.
I tried a relatively new antipsychotic called cariprazine 3mg along with 400mg of clozapine tbh I don’t think it did anything but I was told it would help alleviate the negative symptoms it did help slightly but not enough
Hi there, thank you for your videos.
My son did GeneSight because after trying several antipsychotic medication and not getting better, one psychiatrist finally decided to test him. Although Clozapine was not indicated for his genetic type, psychiatrist took a chance a md prescribed a combination of Clozapine and Lithium and responded very well. He is doing great now, and being monitored for low levels of Vitamin D, supplements are necessary.
Understanding there is no sure process, we have to try to see how the patient reacts to medications and swiftly change it.
I’m on clozapine an lithium it’s a very good combination for me I have paranoid schizophrenia an general anxiety disorder
the key question that was not asked is ;
" how do you deal with patients and the phenomenon called ;
" ANOSOGNOSIA" ????
If the patient would not have an insight to his or her illness, how can one get the necessary cooperation from him or her to take the treatment , and monitor what works and what does not work????
I want to start this off by saying this is not a particular jab at Lauren or Matt, but im very sad that this talk was very nothing burger.
I was hoping this woild be about the severe lack of insight/care of the negative symptoms os schizophrenia. Almost all Antipsychotics are dopamine antagonists, meaning they target dopamine receptors and block most of the dopamine to be recieved, which is very helpful if your struggle with schizophrenia is hallucinations, delusions, and or paranoia. This does not help with ANY of the negative symptoms, and it actually worsens them. I know this from my own experience.
We need to do better. We can't just sit here and act like the medications we have are good. They are failing a great chunk of people, and its sad how im almost forced to keep taking antipsychs due to their own irrational fears abput schizophrenic people, without looking at me as a specific person. I do not display textbook schizophrenia, though i have been diagnosed, it doesnt mean i dont have it, its just in a way not really seen much in the population.
Very dissapointed no one brought negative symptoms being treated at all when that is an obviously huge problem in schizophrenia treatment, because there is nothing for it right now.
interesting and some good news there, i hadn't heard that genetics could be applied to drug design and prescription.
yea it's cool right? :D i remember writing an essay on this for my genomics class a few years ago and like the interviewee said the whole field is in its very early stages, we still have a LOT to learn etc etc
something that i personally found very interesting regarding all this stuff is that this field isn't able to look at just medicine but also for example diet, so basically looking into the question of how everyone's individual bodies respond to certain parts of their diet, do some people for example respond better to an increase of carbohydrates in their diet than others? (not sure if ppl are actually researching this carbs question exactly, i'm just spitballing hahah)
but yea it's all very exciting but still *very* early stages (and there's for example ethical issues involved as well, for example privacy issues concerning the sequencing of people's whole genome etc.)
if you want to learn more about it i think looking up "personalized medicine" (or "precision medicine") would be a good keyword to use :)
My aunt is suffering for schizophrenia for very long. She lives with us (family) when Grandma died and aunt has not married. I understand how schizophrenia affects and also how meds affect them but we are all tired because of how her meds make her lazy sleepy and careless 😢
Lyme disease gave me psyche issues,
I lost a cousin to schizophrenia he committed suicide at the age of 27 in 2002.miss you so much Eric.xo
Hi
Could you please tell me if a psycopharmacologist can be more precise in prescribing the medication than a psychiatrist?
👍
Histamine were the first meds used for psychosis
What about Invega sustenna (I believe it was approved in 2021)? Twice annually; could this be the future of meds for schizophrenia/schizoaffective disorder? Thanks.
In teory Risperidone is better. For bipolar, Risperidone pills are probably better for home usage than injection. Risperidone fix maniacal psychosis. Just mine opinion...
Invega gave me dystonia which is incurable and horrible to live with
My grandmother on my mother's side had schizophrenia and my mother had bipolar disorder and I also have bipolar disorder. I've come to realize that schizoaffective disorder is essentially bipolar disorder with schizophrenia? I'm just curious on that because looking at my family tree if my grandmother didn't just have schizophrenia but indeed she had schizoaffective disorder then that would kind of make a bit more sense why my mother myself some of my aunts and cousins have been diagnosed with bipolar disorder.
Yes it’s schizophrenia with bi polar
@@connieperkins5135 thx ✌️
Doctors want to put my 28 year old son on Clozapine? What do y’all think? He’s been on a lot of different medications and nothing has changed
@@connieperkins5135 thx ✌️
YES SCHIZOAFFECTIVE DISORDER IS USUALLY BIPOLAR DISORDER with Symptoms of Schizophrenia.
Sadly all too late for my daughter.
So sorry for you also for your daughter
It kinda feels like Lauren was trying to end the interview asap 🤭
I heard that ziprasidone doesn’t cause weight gain. Is this true?
No..I am having ziprasidone..have to put up a lot with the side effects,weight gain being one of them
We had the genetic testing and the meds that should help did the opposite reaction. A lot of restlessness insomnia and even suicidal thoughts. Not trusting it anymore
I have schizophrenia 😢.
What about CRISPR? Is this nothing that might be helpful in the future for schizophrenic people?
Antibiotics because it's often caused by misdigonosed infection s
time is running out..
Xanomeline is future
It would be a huge innovation if they stopped forcing their shit upon people that ain't interested.
First
heek hook
what😂
Drug nerdyness is so fucking hawt. Im not gay, I just know good looks when I see them. Thanks fore this vid!
We want to know causes.nobody gives right answer
Yahshua - you know Him as Jesus - was born to a virgin, turned water to wine, taught, healed the sick, raised the dead, casted out demons, walked on water, calmed the storm, and fed a crowd of thousands with a few fish and a few loaves of bread on two separate occasions, among many other things. He was killed on the cross as payment for the sins of all mankind, three days later He rose from the dead. Forty days later He ascended into heaven where He sits at the right hand of the Father. He is returning very soon, but before He does, Satan, the devil, is coming to pretend to be Jesus/God (2 Thessalonians 2:1-4 and Revelation 2:10). Satan is an angel, and he will have certain supernatural powers with which to try to fool everyone. He will, for example, be able to make fire come down from heaven in the sight of men. He will only be on earth a short time before the real King of Kings, Jesus Christ, God in the flesh, returns. When the real Jesus comes we will all be transformed into our spiritual bodies at the same moment. Jesus came in the flesh to offer forgiveness of sins and eternal life to anyone who believes and calls on His precious name!
if thou shalt confess with thy mouth the Lord Jesus, and shalt believe in thine heart that God hath raised him from the dead, thou shalt be saved. - Romans 10:9
Now when Jesus was in Bethany, in the house of Simon the leper, There came unto him a woman having an alabaster box of very precious ointment, and poured it on his head, as he sat at meat. But when his disciples saw it, they had indignation, saying, To what purpose is this waste? For this ointment might have been sold for much, and given to the poor. When Jesus understood it, he said unto them, Why trouble ye the woman? for she hath wrought a good work upon me. For ye have the poor always with you; but me ye have not always. For in that she hath poured this ointment on my body, she did it for my burial. Verily I say unto you, Wheresoever this gospel shall be preached in the whole world, there shall also this, that this woman hath done, be told for a memorial of her. - Matthew 26:6-13
Seek ye the LORD while he may be found, call ye upon him while he is near: Let the wicked forsake his way, and the unrighteous man his thoughts: and let him return unto the LORD, and he will have mercy upon him; and to our God, for he will abundantly pardon.
Be ye also patient; stablish your hearts: for the coming of the Lord draweth nigh..
To anoint your self, the sick, or a building for spiritual protection:
Get a small bottle of olive oil and pour off a small amount into a smaller vessel like a vial or baby food jar. Use the rest of the bottle for cooking. Ask the Lord to bless your vial of oil in Jesus name. Anoint yourself with the oil by placing a dab of oil on tip of finger and touch it to your forehead, and ask the Lord to bless you/heal you. To anoint your home or other building: place a dab of oil on your finger and anoint the door posts and order all negativity and evil out of the house, and order that nothing negative or evil can enter into your home including piggybacking on a person entering, order it to be so in the name of Jesus. Anoint all potential entrances to your home. To anoint the sick: place oil on tip of finger and touch it to the head of the sick and say a prayer of healing over them in Jesus name. See James Chapter 5:14-15.
Amen, Gloria a Dios!
Amen Jesus is the great healer and
stabilizes my life
Amen, the Lord Jesus I'd the great healer
and stables
Please, spare us the religion. This video is about science not superstition.
Do you recommend mushrooms
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