NeuRA Talks - Freedom from schizophrenia by Professor Cyndi Shannon Weickert
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- Опубликовано: 9 окт 2017
- Professor Cyndi Shannon Weickert discusses her recent breakthrough in schizophrenia research
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We need an alternative to currently available antipsychotics. All existing available antipsychotics block dopamine, and this is part of the reason they all have difficult side effects.
Thank you for researching biology that could lead to new types of medications. New types of medications for psychosis are badly needed.
You forgot to look at your gut health since there is indeed a connection of gut to your brain. Gut-brain is real
Thank you very much Professor. God bless you.
I am so happy that such people like you exist, keep up your important work in improving the suffering of people with schizophrenia and giving them a chance to have a life woth to live. I am so proud of you.
Thanks so much! Words like this inspire me to keeping trying hard.
Idk if that sentence makes sense. --- keep up your important work in improving the suffering of people with schizophrenia. It sound sounds funny. But I get what you're saying
Schizophrenia very care please please my son Dr mbbs 🇮🇳India 🙏🏻 Russian MD study life loss please treatment any schizophrenia🙏🏻🙏🏻🙏🏻
I’m a twin too, thank you for you’re research!
My son is married to a schizophenia lady ; but now he himself is on depression meds as he didnt have enough support from her relatives & his job is very demanding ; we dont have enough counciling support here in our country ; she has been getting the injection treatment & is much calm now ; but my son has a maid not a wife as she dont wants him to touch her or sleep together & that is killing him as loves & cares for her ; he suffers in silent , using his meds for his chest pain & to sleep ; l wish someone can help him
I am praying for him right now. 🙏
My son wife got treatment & is doing better than him , but she not getting work & expect him to pay her bills , including rent because he is married to him , despite during covid lockdown she told him she was in love with her exboyfriend , but as l9ng as she is married to him he has to pay all her bills , l told him he can ask his coworkers , no man dont do such a thing as she wanted to be independant & she left home saying she got a favourable respondance to her pass job , he borrowed $20, 000: from his dad to furnish an apt for her as well , now she wants a divorcee & half of everything he owns , she used to live as a companion with him as she didnt wants to be intemate with him & never worked any where , he had to wash his own cloths & order food most times , while she was his wife , seems she only was married to get what he had or his pocket as my family calls it ; can you imargine to see your grown child in such a condition ; she is good now , she is happy & educating herself to try to get better paying jobs
So glad I saw this.
Wow...this is amazing! I really hope they find out the reason people get schizophrenia soon. My mom and now my older sister has symptoms. My sister hasn't been diagnosed but this is a terrible disease and it affects everyone around the I'll person. I pray there's a cure or the right medicine to help the people improve without such bad side effects. Thank you for what you do and all those really trying to solve this and help. 🙏
The cause is obvious it is stress related
Yes, that is a big influencer on it developing, but there's other things too.
Congratulations Dear Professor Weickert and Team. I want to take the opportunity to congratulate you and your husband both in your truth quest. Well done!! KEEP ON!! Your brief video is encouraging and provides the beginning to so many answers.
It makes sense!!! I honor and salute your work. Such a breakthrough and future improved quality of life and care for those suffering. Please keep up the error free work and authentic life stand.
As the facts unfold I look forward with hope to hearing of improved recovery paths forward. I speak as a mother,( who has the utmost respect for health professionals) ,of one son whose suffering was so great he remains with us as a memory and light and a second high achieving son who is now facing the same challenges. May revelation and truth flood your paths.
(please let me know if if there is some way I can assist you.)
Roslyn, I too have experienced voices in my ears and thoughts that are not mine. But I learned in the Christian Holy Bible that there is an invisible war on Earth involving very evil demonic spirits who can speak into our ears all manner of thoughts. The Lord Jesus Christ helped me in this battle against the schemes and strategies of the enemy and He can Help anyone else who will believe God. Please listen to my story on RUclips at Hearing Voices: Real Help and Understanding
ruclips.net/video/WoGhx-Orflg/видео.html
I'm praying for you all, Carol
Thanks so much Roslyn. Your uplifting words are wonderful to hear.
Amazing work thanks so much
Thanks!
I like such programming about the so called disease schizophrenia. I already study a lot being schizophrenic since 2003.
i had huge ocd, and depression, my blood work always are normal, i went through alot of stress, and traumatic events, so stress is huge factor
Thanks. Have a Great Day. M.
I only recently put two and two together having schizophrenia and anytime I’ve had blood work done from any accident or issue, that my white blood cell count is always very high but I had no infections. I do have fevers, tremors, and pains if my meds wear off.
Thanks you
How far is this research now, six years later? Is there hope? Hope for new medicines with less side effects?
Makes sense inflammation of the brain, the brain on fire. Viruses and cytokines crossing the blood brain barrier. Virus creates a more intense reaction in certain populations as to immune response and overload of cytokines. Lymes to EBV to COVID 19, and genetics that are more sensitive like those with autoimmune disease in tandem immune system response and attacks. I tried to get a Immunologist and Neurogists to evaluate my son 5 years back and was completely ignored. I read that anti inflammatory immunological drug treatments helped save Susan Calahan and others including a young boy in Durham NC. Also a young child afflicted in FL whose parent was aware and brought him to the same doctor in UNC. One question I was asked when my son was in early symptoms and being evaluated for anxiety and erratic behavior..
was "did I ever have a viral infection in my third trimester." Yes I did and apparently it is correlated maybe not causation but often this correlates to children later becoming ill, I had a horrible respiratory flu like infection working in a clinical laboratory several of us got very ill I coughed relentlessly likely RSV or a Corona or Pertussis type infection. Does a virus create these angry glia cells in utero and they eventually calm to be reactivated later?
I so appreciate this research and imagine if these patient could get personalized medicine they could afford like the few teated successfully for recovery we would have less Psychiatrists and drugs, here the reality is the medication straight jackets used today are out of reach of ill patients in the US and most of the world and do not make life easier just keeps then out of the hospital but often on disability. These cytokine dampening drugs may help, the type of medicines will be financially unreachable. 1% of the population in the past, let's realize that was before A Pandemic that affected pregnant women worldwide and young people as a trigger if it is circulating cytokines.
We must be on the offense now with research and treatment or preventions and save future victims and generations of this horrid disease that destroys a normal young person to fall apart and suffer and the family with them often.
Imagine if there was wasn't a huge industry that did not get paid to work with these ill patients and make a living off their disease state would we already have a cure for this and alsl addictions.
Let's be better, fund cures find affordable free medication or preventative care the existing drugs that helped with cytokine storms in COVID 19 would reduce the inflammatory response in angry glial responses.
We need families to speak up and out about this physical illness of the brain organ called schizophrenia and demand attention and research. Interesting the the early research she did was on estrogen and receptors and seemed to help memory and cognition claims. Look at our food industry that pumped hormones into our food supply and how we ended up with a generation suffering from ADHD. If estrogen receptor damage is present and we flood our bodies with hormone pumped foods to make breasts on chickens bigger and chemicals that disrupt our endocrine and hormones it seems to be a perfect storm of the gut brain and head brain.
Thank you Dr. Weikert, what we learn hopefully will rule out and in the facts needed for responsible care. Addiction in the brain also to force someone to take a drug they know may kill them is another need as we are losing a generation to fentanyl and opiod abuse. That may be an inflammatory outcome in the brain trigger also.
As soon as the lady started talking about Brian of the Beach Boys I thought "He likely used drugs and it caused his condition".....then she said that Brian himself said that that is what caused it ...I have seen this happen to others using drugs ...
Thanks a lot Proferssor Cyndi, does this explain somehow onset disorder in early adulthood? (I heard that faulty synaptic pruning hypothesize seems to fit)
I got schizophrenia when I was three and my brain developed normally. Schizophrenia doesn't stop the brain from developing normaly
Fascinating research. Hopeful it leads to breakthroughs in treatment and recovery from schizophrenia. Any consideration to the pathology of schizophrenia developing in early adulthood? Is there something specific about that age group? What about the contribution of drug use to the development? Are there some drugs more likely to induce aa psychotic break and what is the pathophysiology at play?
Would this be considered an autoimmune disease? What a spinal tap help see if the body is attacking itself?
Some forms of schizophrenia have an autoimmune basis. One example is NMDAR autoantibodies. It is believed that this antibodies can also be detected in blood.
Schizophrenia has long been associated with certain autoimmune diseases. When I first started my research there was a big question on whether the autoimmune caused the schizophrenia. The biggest excuse I hear is that the white blood cell count is not elevated, so there is no infection. That does not rule out an autoimmune condition. In my experience I find the antibiotics to be way more effective and immediately. I would be interested in having more data on the temperature of the skull during episodes. I have also understood there to be a link to a decrease of cranial fluid. Possibly linked to a break in the cranial sac located directly behind the sinus cavity that has constant sinusitis. Caffeine is supposed to increase cranial fluid production.
The answers to the questions are in the 20% of patients cured. Their DNA and immune systems need to be rigorously studied. Certainly a new horizon and great hope.
This video is 5 years old. We were told to "stay tuned." What is the update?
the drug, Raloxifene failed
what kibd of tablets are suppose to be taken by patient of this disease
Give us a update
Wow she is so good at explaining. I would like her for my teacher.
That's a very good explanation of why I think antibiotics work better than antipsychotics!
Could you elaborate on that?! My cousin is on day 25 in the ICU after a large overdose of many meds, one which was Clozapine and is quite toxic. He’s on a ventilator and has pneumonia and other infections that many broad-spectrum antibiotics have been used and he’s still on some of the antibiotics. I wanted them to wait to put him back on psych meds to see if he did okay without them. I had found an research article on the gut microbiome of people with schizophrenia that they have 3 distinctive bacteria that most other people do not have. That is why I thought the antibiotics might somehow help his schizophrenic symptoms. But now this idea of immune cells in the brain is very interesting. How would antibiotics work in schizophrenia? I’m interested in your idea. Thank you.
Okay… I just found some stuff that minocycline and doxycycline both have helped with schizophrenia, especially psychotic symptoms and cognition, possibly by inhibiting the microglial activation that causes inflammation. Please let me know if you have any thoughts. So glad I stumbled on your comment because I found a lot of good information. Thank you. 🙏
@tnijoo5109 sounds like you're on the same path I was. All I know is that they have helped me out through my entire life. I have never been on any antipsychotics. But they want to put me on several. I'm not so sure I have schizophrenia, most of my symptoms do indicate that I could be schizoaffective. But vascular dementia runs in my family along with Parkinson's, Alzheimer's and other brain illnesses. That is one of the main reasons I don't want to take any of the antipsychotics because they tend to make those illnesses worse.
@@stoneyvowell1239 yes. Good choice. All the antipsychotic meds are insanely toxic and have many long term health consequences. If you can get by on alternatives, definitely a better way to go.
@tnijoo5109 and of course it does vary from person to person. No two cases are the same or may have the same causality.
Personally I think making a distinction between astrocytes and microglia would have made this talk clearer, partly because of astrocytes' role in regulating glutamate and therefore the excitatory-inhibitory balance, which appears to be more disrupted in individuals with a greater genetic load for schizophrenia and less disrupted when the illness appears to have been more likely to be brought on largely by cannabis (which I believe also interacts with both astrocytes and microglia, at least indirectly...)
PSYC's are till a Pseudo-Science. A real tragedy.
What happened to the Oestrogen Receptor Hypothesis and SERM research trial?
I assume that they couldn't invent any treatment on that research. So, this is a newer hypothesis that they're working on.
@@TheSiddhaartha We found that SERM improved memory and attention. From here another research group in the Netherlands is trying to replicate our findings. It takes quite a bit of evidence to turn a positive finding into an available treatment. We would need substantially more support to do this.
@@cyndishannon4145 thanks for replying. Can't it be instead first simulated on some super computer using available DNA data or something. It sounds very sci-fi but maybe some genes you already know can cause schizophrenia?
Please, you have to hurry up. Thanks for giving hope to such patients.
I read your comment about schizophrenia on RUclips. I too have experienced voices in my ears and thoughts that are not mine. But I learned in the Christian Holy Bible that there is an invisible war on Earth involving very evil demonic spirits who can speak into our ears all manner of thoughts. The Lord Jesus Christ helped me in this battle against the schemes and strategies of the enemy and He can Help anyone else who will believe God. Please listen to my story on RUclips at Hearing Voices: Real Help and Understanding
ruclips.net/video/WoGhx-Orflg/видео.html
Praying for you all, Carol
@@carolbrock5798 I'll listen
@@carolbrock5798 can you tell about your medication and in which age did you diagonsed?
Yes, I agree, the research is too slow! I would like an army of people and tons of money with a sense of urgency that we attacked COVID. Then, we could get some where quick!
@@cyndishannon4145 it's million times tougher than Covid vaccine. Can modern day data Science help? I'm just a software engineer but can I help in some manner? Thanks!
How can I get help for my grandson
At the time when my son was taken to A&E first on set of psychosis he had blood tests done and when asked about his bloods she said his white blood cells were elevated and all I was thinking was there was an infection somewhere and I think in the brain!
Possible.
Thank you for sharing!!. I also started hearing the voices, along with the shadows. I started thinking about my life and memories brought me to the conclusion that I have always heard voices but never paid attention to where they was coming from. I am 31 and noticed the voices big time now. The voices ont feel fake, they even tell me it's nanotechnology and the people. For me it even feels that the whole world is in on this conspiracy that I like to believe schitsofrenia is made up. The voices tell me I'm targeted because I'm perverted and what not. My thoughts are read before I even noticed them. I search nanotechnology and it's a technology that can manipulate your mind and manipulate your feelings. Something positive I can leave you with is, find a way to love music, wear headphones! A good pair. Watch good movies that fill your heart up with happiness and tranquility. . Prepare yourself for one day your love of your life is no longer in your life. Save money for the rainy days. Love you !!
Thank you for your comment. I hope you have a loving mind and life. Listen to happy music. Much love from Sweden.
How are you doing now brother?
Does not mean you are Schizophrenic. Be careful what you want to believe.
I wonder just how many people are working on new treatments based on this discovery. My psychology class is still not updated with this kind of information. Even though this is a relatively new discovery compared to everything else we are taught.
Hi Elijah, thanks for your comment. We're about to host our next NeuRAtalks on schizophrenia in November with Professor Cyndi Shannon Weickert if you'd like to register. talks.neura.edu.au/register. Thanks
All mental illness including schezophrenias has something to do with gut health and the type of food you eat. Brain disorder is not only the brain function in itself. There is a brain-gut axis.
If you have mental disorder like schezoohrenia please consider also the gut health.
that wont fix it, I have been eating healthy all the time.
What do you call healthy? Are you on a Ketogenic diet? Read Dr Georgia Edes book Change your Diet, Change your Mind,just been published. Good luck 👍
People get beat down when they try to get better they still trapped around tge ones who help get them there how u heal from that u putting them right back in the same loop of insanity
I've been on numerous antipsychotics and they either dont make much difference or they do so much that they leave me with debilitating side effects. I don't rate them.
So what’s the cure then ?
A faraday cage and a signal jammer has helped some. That is how you block the weaponised neuroscience, which causes some "schizophrenia".
New medication is badly needed!!!
You are an inspiration. Hope your work translates into better medicines for mental disorders.
These immune system is the no of WBC in our system... And amount of WBC is derived from Lymph in our body
I myśleć suffered from schisoaffectiv / bipolar, i dont care about cells, all i cared for was how to be free of meds and healthy, that is what should you work on, how to free patient from meds and mąkę tchem get back to normal
I am just gonna add that i am healthy now and no doctor or specualist helped me, the only person that brought me back to normal is my husband
Congrats! This is good news. However, I'm wondering how chronic trauma affects the parts of the brain that you are studying? The latest research on trauma shows that it may induce schizophrenia and other mental disorders.
Trauma might create a stress response and stress triggers auto immune disease
Like most American Medicine, very little is used to verify a diagnosis, only pharmaceuticals are used to treat but not focused on healing or repairing. USA still in Dark Ages for Medicine.
My grandson, is schizophrenic, he generalized and recovered, but is disabled tremendously at times but he’s reclusive from being estranged from his effective families. His classmates jeered him and rejected him everyday no one comprehends him like us. He’s off-put and he manages it in relevancy, his republican dad says he’s lazy, he doesn’t know anything, he’s lacking and doesn’t understand his illness and denies it . I beg to differ the disagreement, is he’s a profound difference of his scrupulous views of trumpism, so we’re divided conclusively, the republicans refuse any regards to compute any comprehension or assistance to generalize many reasoning he’s a democratic man progressive and helps his illness he attributes his freedom to view. I don’t concur he’s any differential context but actually excels in music songwriting, & part time singing it’s degenerative to his complexities to complete daily tasks the talk is jaded from seriousness, he’s an attuned to diminishing hes favorable and deserves his degree, He’s a strong man who can write songs preferable in a day when restorative. It puts his mother and me in a bind, he’s an honest man who struggles of statements, his morphia displacement is he’s yet to find love and he’s gay, our family denies him. It’s hectic and struggled and puts an affines the affirmative support. We’re raising, it ends stigmas to disassociate anyone’s differences.
Autoimmune? Then how did drug use set it off. I know of someone who had carbon monoxide poisoning…working in confined space, then roommate cooked meth lit house on fire while she was at work…some drug exposure but negative on tests. How does abilify work then?three days and back to reality. No memory of story. How is memory involved.
"Seeing things are rare"? LOL! I must be a rare individual. I not only
heard voices, I saw, in writing in front of me, what the voice was
saying. I looked in the mirror and the person in the mirror began
yelling at me, literally! He was very angry at me! I thought I was God
and the devil (not at the same time). I had conversations with imaginary
individuals, I had a control panel in front of me for a while. I had a
spider running around in my mind. I heard very loud explosions. I had
dilating pupils. I was poked in the eye so much that it physically hurt!
I could do miracles. I could not only read minds, I could interject
suggestions to people related to what they were thinking.
I recovered from severe schizophrenia without any medication or help
from anyone. I ignored the hallucinations and refused to believe in
them. I changed all of the habits of thought not believing what I was
believing. I had to entirely reprogram my mind and way of thinking. I
just retired from a high security airport job after working for 30
years. I not only beat the illness, I beat those who seek to treat the
illness. The things that we do affect the way that we feel. If there is a
problem with the mind, it could be from the choices that you make that
result in the way that you feel. If you want to know how to treat the
illness, talk to someone who beat it.
Very hopeful comment. Love to hear that someone has changed their way of thinking; realizing and ignoring the lies that this disease can manifest
Amen
Amen to that 🙏
We need to hear more from u ,and how are u doing now it would make a different for so many who are fighting
@@devoniescott-francis7632 Yes, I retired from the airline in 2020 and I’m doing very well, thank you! I no longer become unreasonably suspicious of people, very much : ) I laugh at myself. I’m no longer tormented. No more flashes of light or explosions. No more nonsensical voices wasting valuable time. It’s great!
The reason I got sick in the first place is due to a lot of abuse. I didn't have a prayer in heaven. Oh well, I'm not a loss to humanity, but I enjoy messing around and listening to music, so whatever. One doesn't matter.
Karla, Please listen to my story on RUclips at Hearing Voices: Real Help and Understanding
ruclips.net/video/WoGhx-Orflg/видео.html
I'm praying for you, with compassion, Carol
You do matter! Whoever taught you otherwise was being mean, vicious, and manipulative. Please, please, please believe in yourself. You are special and you matter. Please take excellent care of yourself. :-)
To my opinion schizophrenia doesn't exist but detress yes :)
@ Grey Fox : you are right. But keeping quiet about mistreatment can make you feel crazy & so down.
@@kimlec3592 ????
@@kimlec3592 what do you mean exactly?
@ Grey Fox : am just seeing your comment now, in 2023. It is well recognised that mental symptoms are due to loss & traumatic experiences. Many who are diagnosed suffered much in early life. Please forgive my late reply. As human beings, we all have different levels of ability to tolerate adversity. Wishing you health & strength to withstand the trials of life.
Im trying to Pay attention i'm Schizophrenic. And there is alot going on inside and outside
Study orhomolecular med. For balancing your brain chemistry. Then the meds work better. Neuro. Mag. Will stop the anxiety and panic. Take litium oratate. 5 mg. Twice a day. Us b complex 2 timesa day. And melatonin at night. Also v c