The Best Type of Vitamin B12: Cyanocobalamin or Methylcobalamin?
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- Опубликовано: 3 ноя 2020
- Cyanocobalamin versus methylcobalamin: For prevention and treatment of vitamin B12 deficiency, cyanocobalamin in chewable, sublingual, or liquid forms (rather than in a multivitamin) is best under most circumstances.
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Whoa, that video was packed to the hilt. The dosage needed to treat B12 deficiency, how oral is better than injectable, why the cheaper form (cyanocobalamin) is superior to the more expensive form (methylcobalamin), why you can’t just take it in a multivitamin because of the analogs, and you shouldn’t just take it in a pill you just swallow (because it needs to mix with that saliva protein), and then with the toothpaste thing totally coming out of left field.
I mentioned my book, How Not to Diet, which you can find out more about here (nutritionfacts.... It’s funny how I said it was my “last” book, not aware at the time I recorded it that little did I know I’d have a whole new book out by then out of nowhere. How to Survive a Pandemic (nutritionfacts..., out now in softcover, audiobook (read by me), and e-book form.
This is the last in a 5-video series on B12. You can find all of these videos in a digital download here (drgreger.org/c..., along with two additional videos that will be coming out in a few months the potential for B12 side-effects.
If you missed any in this series, check out:
• The Symptoms of Vitamin B21 Deficiency (nutritionfacts....)
• The Optimal Vitamin B12 Dosage for Adults (nutritionfacts....)
• Healthiest Food Sources of Vitamin B12 (nutritionfacts....)
• The Optimal Vitamin B12 Dosage for Kids, Pregnancy, and Seniors (nutritionfacts....)
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-Michael Greger, MD FACLM
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Methylcobalamin is the active form that the body can metabolize more easily. Cyanocobalamin does not take my pins and needles away and gives me heachaches. The methyl form takes pins and needles away with a few hours. I will always use Methylcobalamin until the deficiency is corrected..
You are correct , cyanocobalamin is the cheapest and the worst of b12 , there are 2 other versions of b12 hydroxocoblalamin and adenosylcobalamin, you need to get your Intrinsic factor checked and folate , not folic ,hope this helps
Cyanocobalamin is equivalent to CYANIDE!
Omg it doesn’t take my pins and needles away and it gives me headaches too. We are obviously being slowly poisoned by it. Now to eliminate it from the body and chuck out those tablets.
He gets things wrong often and I believe him to either be a Big Pharma shill, intentionally ignorant, or believing obvious misinformation.
@@Rebecca-ys3cbu cute
Supplement B12 and #BoycottMeat and all other animal products, cruelty and exploitation in any way possible!
Anything you can do to bring the prices down is appreciated!
(Seriously people, factory farmed meat or veg are equally abhorrent, buy local and sustainable. Switching from one kind of factory to another is not progress, and is not helping animals, much less humans.)
@@outspokeninsider752 Less bloodshed when eating plantbased anyway www.animalvisuals.org/projects/data/1mc
Should there be any concern for those supplementing with cyanocobalamin who may unknowingly have a methylation disorder (MTHFR)?
Thank you Dr. Greger for giving us pure information without the bs
But with the head wagging.
He's all BS
@@Akul1324 that about sums it up.
At 5:02 he's wrong though, they start to give 500ug instead of 100ug thats also why you see the increase... Maybe not because they chew it?
At 4:26 Just before they mention 2 studies that show there is no difference of absorption between chewing and sublingual. Therefore this is 100% speculation, its certainly better but there's no actual proof.
Edit: I think that Greger is right. Mixing b12 with saliva allows it to bind to the saliva's R protein, which theoretically allows a better absorption in your body.
lol, you realize he is sponsored by all vegan companies in America, right?? He is the most unethical doctor ever. Never ever trust this guy.
Eric berg says otherwise: methylcobalamine is best. Who is correct?
Another exception to using Methylcobalamin form instead of Cyanocobalamin is folks who have MTHFR gene mutations can't convert Cyanocobalamin to Methylated form. Hence Methylcobalamin, the active form must only be taken
I'm a chemist who had been developing medicines. Any drug that is synthetically made is NOT good for human consumption: in this case cyanocobalamin is made synthetically, while methyl cobalamin is naturally made.(more expensive). Even medical professionals don't know is the side effect caused when it is used for long term. Human body is not evolved but designed so magnificently that human brain can not wholly understand the whole chains of chemical reactions in your body, even with the aid of A.I. It is mind-bogglingly complex multi-dimensional chemical reactions is in your body. Don't experiment your precious body with the puny human theory which is completely not proven!!!
Yeah, either you're not really a chemist or you are lying for some reason. You should know that synthetic molecules are the exact same as natural ones. And what about all of the not naturally occurring medicines we have? Is aspirin not good for human consumption? No, it's fine, else we wouldn't take it if it was very bad. You also say the human body is not evolved, but it is. I'm a Christian but even I know that is a scientific fact. And you're wrong that we cannot understand chemical reactions in our bodies. If that was the case, why do we have gigantic maps of metabolic pathways? We know enough to actually do science, man. Please stop spreading misinformation.
@@discerningacumen such a childish view there is no absolutes in medicine or chemistry. oh I just read the last part and realized you were a creationist. you just believe whatever you want to believe it don't pass it off as medical knowledge though
Thanks for the awesome comment. Common sense to me.
can u make an update on the subject, it seems that there are a lot more new studys since the one from 2015 u are referring to
best greetings
Thank you very much Dr. Greger for this informative video! I was confused as some said that cyanide occurs when using cyanocobalamin which is unhealthy & not safe for us to use. This video removes the question marks in my head.
you are right to question this
I read somewhere methylcobalamin absorbs better and stays in our body longer than cyanocobalamin. Is this a correct info?
yes
I wonder why that is, if it stays in the body longer. Interesting.
1:47 McDonald's hamburgers are also stable... for years. Cyanocobalamin contains cyanide, and is an unnatural form.
The cyanide contained is minute it is incredibly small. By the way, lots of vegetables also have teeny weeny amounts. Your body can handle it,
@@panes840 Yes but these vegetables are good for our health. Cyanide can be found in tobacco, I dont want more in my body even if its a bit more (I dont smoke but passive smoking happens). Of course eating animal products is even worse but I'm comparing to hydroxo for example which is stable and works great
@@panes840 sounds like a tobacco giant answer. Remember people who are low in B12 are taking it so it becomes their major source - open wide for cyanide !
@suzanneatkin5672 bollocks! I am a scientist graduate and you should not be spreading misinformation.
I read that Methylcobalamin B12 is the form existing in nature while Cyna-type is synthetic.. Has this point been discussed earlier ?
Which form is "natural" and which form is "synthetic" is beside the point. It's about which form is best for preventing the horrible disease of B12 deficiency. And Cyanocobalamin is much better for doing that, and has no downsides for people without kidney failure.
@Paul_K_ that's not entirely true considering the "cyan" in cyanocobalamin is a cyanide compound which taken over long periods is not good for you. It may metabolize more than methylcobalamin, but the methyl version has better absorbation rates oh and you aren't taking any amount of cyanide...
This is great news!!!!!! I had always assumed that methycobalmain was superior and it worked really well in giving me focus, mental clarity and executive function. HOWEVER it breaks me out so bad I can’t leave the house. I’m talking big, swollen, painful boils all over the face. I will try cynocobalmain
where is the video you promised discussing moringa?
looking forward to it :D
Yes anxiously (not really) waiting for it! I haven't touched my moringa since.
@@deb_is_here1425 there is only 1 moringa video on his website, it is 3 years old and it does not talk about moringa..... it talks about lead poisoning. I will continue to wait for the video on moringa safety thx. that video was not helpful.
@@deb_is_here1425 he said there would be a video in the future about it..... so far nothing
If there's not a real research paper on it, he pretty much goes with the Rockefeller method.
He does not recommend. Eat kale etc. instead doc says
I've been watching and enjoying your talks for some years now. There only one area I'm confused with. I have been iron deficient and didn't realize till recently have pernicious anemia and for many years according to previous tests results.. I had been taking B12 methylcobalamin sublingually yet appearant not helping much.. I had bad neuropathy, serious balance problems and many more terrible side effects. After discovery of pernicious anemia I started getting B12 Cyanocobalamin injections that did NOT help in fact I continued to get worst. After I received Methylcobalamin injections I started feeling some relief.
I found out through literature that if taking B12 sublingually for pernicious anemia the dose needs to be 20X what is recommended on the bottle to meet what is equal to an injection. I do believe that the UK recommends only Methylcobalamin for injections and not cyanocobalamin injections. I know everyone situation is different but taking synthetic cyanocobalamin would have been deadly for me. I know non synthetic B12 cost a little more yet when it comes to life or the alternative I'll take life.
Decided to go almost entirely plant based recently and this answered a big question, thx
Yay
With either cyanocobalamin or methyl- form, you should be OK. What concerns Dr. Greger are the people who do not take the trouble to read about B12, itself, so they have no idea they need B12 regularly, on even a whole-food, plant-based diet. It is not a crisis if you miss a day or two, but making B12 a daily habit is a better approach. And make sure the young children, especially toddlers, get their B12 supplement daily.
Yaay!! 😁
Please read the book "Becoming Vegan: The Complete Reference to Plant-Based Nutrition (Comprehensive Edition)" by Brenda Davis, RD and Vesanto Melina, MS RD for proper vegan nutrition guidance before becoming a vegan. Happy vegan journey!
I have the Becoming Vegan Express Edition and it recommends 25-mcg-100 mcg for those over 14 yrs. I am 72, so this is quite different from Dr. Greger's recommendation. I am getting more confused lol.@@ponnamy
I thought it was better to get the methylated version, and that the cyano version could create cyanide when metabolized?
Not more cyanide than eating a peach
@@ooo789456123 I thought the cyanide from a peach is in the pit? Not the flesh?
@@lesliesmith7312 actually in many foods, from almonds to peach and apricot juice, cherry juice, Apple or pear seeds etc.
www.researchgate.net/figure/Total-cyanide-contents-in-food-commodities-containing-cyanogenic-glycosides-a_tbl9_332347963
Those beginning B-12 supplements should be aware that some people are allergic to cyanocobalamin ("CCB" for short), myself being one of them. I began taking the supplement at the recommended dosage (well within the limits of what's considered safe) and I began to get a pretty nasty case of hives. It took me a couple of days to become suspicious about the supplement but I finally learned about CCB allergies online. I stopped taking it and within a couple of days the rashes cleared up. I'm not suggesting people not use CCB, but just that they be aware that it could cause a reaction. if it does, there's always nutritional yeast and fortified cereals, although I imagine the amount of B-12 these have isn't enough to correct deficiencies.
EDIT: I just learned from another of Dr. Greger's videos that not all nutritional yeast has B-12.
I've been told methycobabmin is the best.
My nutritional yeast has CCB, haven't eaten any chocolate for a week and now I have more acne.
It's my understanding that some of CCB breaks down to cyanide, hence the name cyanocobalamin.
Some say that unless you are a smoker or otherwise unhealthy, it shouldn't be enough to hurt you, but for me, I think I'll pass on the CCB and choose methylcobalmin instead.
@@Raw_Roots I agree. Me too
@@Raw_Roots it is! Its the best version of B12 as its the more expensive form of B12 and it also mimics the bodies B12 as well. This B12 gets into your body system FASTER than Hydrox and Cyano!
So exactly which vitamins/minerals inhibit the uptake of B12? I take a multi with B12 as well as a B12 supplement.
Vitamin C, and it's worse when there are also thiamine (b1) and copper. But it's only for cyano apparently and under certain circumstances...
I dont think that thiamine and copper alone would destroy b12, especially in the hydroxo, adeno and methyl forms since these vitamins/mineral are found in animal products.
What about cynaide being released from the cheaper type?
great info, as always Dr. Greger! Thanks so much. However, I think you made an error at 2:46. The screenshot of the article you show says 1200ug of methyl is comparable to 1000ug of cyano, so cyano is only about 20% more efficacious, assuming that the methyl is not photo-depleted, which is unlikely since it is so photounstable.
Nice catch. The numbers did not add up.
3:40 why getting it as part of a multivitamin can be counterproductive
What about methylcobalamin for those with an MTHFR gene mutation? I have it and need to take methylfolate; I thought B12 was better for me as methyl, too.
Emily, Methyl doesn't always work. I have had it fail twice. But you can always take Methyl and then eat fortified foods which have Cyano in them or take Methyl plus Adenosyl or Cyano or Hydroxo. Cyano tested best. But they did test combinations of the others taken together. Methyl fails and I have seen so many people have a Methyl fail that I would never again just take that alone.
This is also my concern. I not only have MTHFR transcription errors, but also MTRR, CBS, COMT and MAOa. *sigh* I have experimented. I tend to over and under methylate. I have found adeno-cobalamin to be the safest for me. I absolutely cannot take cyano-cobalamin bc I get tremors and heart palpitations.
@@mesmire The over and under Methylating is a problem. Glad you found something that worked for you. Do you get palpitations from fortified foods?
@@mesmire I got the tremors on Methyl B12 but that was because it failed. Vitamin B12 deficiency causes tremors, too.
@@mesmire Heart palpitations can be caused from B12 deficiency, too. But cyano rarely fails. It has the best record other than IV B12 or taking more than one type together for reversing deficiency.
I had a level of 260, and after i found out that was too low I started supplementing daily with 1000mcg methylcobalamin sublingual. However after 10 months of this suppmementation, I tested again. And my b12 has gone down to 230. I'm very confused.
how is that possible ?
I have no idea, that's why I'm asking,@@mtvnbp
Increase your Folate....avoid anything with folic acid in it. Folate good, folic acid-bad.
Are you on cyanocobalamin?
@@mtvnbp yes now i am after understanding its more shelf stable. I take b-comp and 1 mg cyanocobalamin per day. Last time i tested it was 400, and that's when I had been supplement 1-3 mg per day for A YEAR of either methyl, adenosyl, or cyanocobalamin + b-comp and some other cofactors. I don't know why it won't increase more.
We wanted to know about adenosylcobalamin though!?
I read a PubMed article a while ago and Methyl and Adenosyl can be taken together if you don't want to take Cyano. He said that he didn't consider Methyl or Adenosyl complete but when taken together it is more successful than just taking Methyl. I have failed with Methyl alone a few times.
Is there a good brand of adenosyl?
Sooo wrong. Cyno may be more stable, but so what if it is so poorly absorbed. The two coenzymed forms methylcobalimin and dibencozide are much better absorbed. The reason so many coenzymed forms suggest you dissolve on or underneath your tongue is because the more highly absorbed coenzymed form gets absorbed by passive diffusion bypassing the need for intrinsic factor further on the digestive tract. Small wonder then, when I took oral cyno my B-12 levels would hardly budge. However, after taking methyl B-12 after some time my levels were raised to high levels followed by very high levels given further / enough time.
Hi Dr Greger, how about supplementing with a vege called Duckweed? Heard that its packed with B12. Will be great if your could cover this in your future videos. Thanks.
Plants can have B12 if they are grown in soil or water that is organically bacteria rich. ( b12 is only made by bacteria ) The duckweed experiments proved if b12 is present in the water plants will absorb it as a nutrient. Problem is b12 is not in any of the common chemical fertilizers that the plants tested are grown in at the testing labs. Fungi are absolutely full of bacteria produced b12. Especially in the common grocery store white mushrooms because those are grown in bacteria rich compost and horse manure. Most vegetables are grown in poor dead soil full of toxic herbicides to kill weeds and synthetic Fertilizers containing only N.P.K. B12 producing bacteria are not present in these soils especially not in synthetic fertilized hydroponic greenhouse grown food plants. Eat mushrooms, organic plants, kombucha tea, etc. My advice as a perfectly healthy 58 year vegan from birth never took ANY supplements nor needed to ate a stinking dead corpse for b12. There is a meat lobby pushing this b12 nonsense.
Then should i take it on an empty stomach in the morning, or before i sleep after digesting dinner?
I normally take it after breakfast, so in the morning but not on an empty stomach. They recommend taking it with food on my bottle of b12
4:28 - So I should chew my B12 (methylcobalamin) pill rather than just swallow it?
Tastes so bad though 😖
@@user-ef1uc2vw9k I have a cyanocobalamin B12 that is quite tasty. From Nature's Aid.
They use to be sub-lingual. I didn't know why, but now I know :)
Sublinguals pills are optimal for absorption and it doesnt involve no digestive process.
@@hikhuhvhh7883 Well, non sublingual pills are meant to be swallowed.
Oh, crap, I am taking methyl... wasting time and money.
Awesome channel, worth every second watching!
You're not. Methylcobalamin is retained better in the body. And about the stability, it's not like you're gonna be like "oh I'm gonna expose my methylcobalamin to light before taking it". Lol
Took methylcobalamin since 2011, once a week and got B12 deficient (MMA tested) with severe nerve problems in my left leg, switched to cyanocobalamin and after 1 month the problems went away. My own experience with N=1 🤔
@@ooo789456123 Wait a little and you'll be deficient again. Cause none of these supplement forms is like the natural B12. Also, check if you're taking other vitamins in a methylated form.
@@ooo789456123 Was the amount of B12 the same in both? Didn't you up the dose? Didn't you increase the frequency of the supplement?
@@jackal7905 Sorry but do you have any evidence and studies to prove those claims or are you just making stuff up? I take B12 every Sunday morning and with cyanocobalamin I'm no longer deficient, this is a fact.
Can you recommend a few specific B12 supplements? There’s so many.
And for people without intrinsic factor? They wrote that the combination of b12 and b7 might help. B7 is biotin.
Dr Gregor, you are a gentleman and a scholar! Thank you for improving the lives of tens of millions of Americans!
ok awesome i like it. K now but what a specifically formulated b-complex vitamin pill with all the b vitamins in it? Will any of those cancel each other out like he said some did or do?
Big like for the speech mode of this video, I like the concise and more focused manner. Of course the information itself is exceptional. I just thought it would be helpful to mention this too.
What an engaging Dr.! Thank you for this video. I've been looking for a way to supplement my TRT and my Peptides. It would be a pleasure to see you venture into that territory if you haven't. Kudos!
Finally... after all the B-12 marketing misinformation... a good video.
what marketing misinformation?? Only marketed B12 is what was made in a lab by big pharma=Cyanocobalamin synthetic B12, NOT real, clone, forgery, not organic.Only misleading info is from the Dr's mouth.
Not everything agrees with this information.
What if a product doesn't specify which type of cobalamin it has? But is cheaper than both methylcobalamin and cyanocobalamin? (From the same brand)
You’re always a blessing! Thank Hod for the work you do!❤️🙏🏾
Thanks - I'm taking methylcobalamin and adenosylcobalamin, which are the products of cyanocobalamin breakdown. These are available in sublingual form, but their formula weight is too great to be absorbed by the mucous membranes, so I simply swallow them. What's the bioavailability after they get to the liver?
should i delay brushing my teeth after using a sublingual b12 supplement? thanks.
My doctor told me to take hydroxocobalamin b12 sublingual. Is this the superior to just cyanocobalamin?
Nevermind! Caught what you said 😁😋 I'm not a smoker and never have been so I guess I dont have to look for that specifically.
Hydroxy gives me headaches and does not deal with neuropathy for me.
Very thorough. Thank you.
Man I am so grateful for you! You have helped so much. I know you will prolly never see this, but thank you!
What about B12 Complex vitamins, does having them all in one pill destroy the efficacy of any of the B vitamins in the pill? Thanks, love your work.
I just saw in another video on b12 from PlantChompers that taking b12 with b6 can actually increase risks if hip fractures among other things. So, yes, the b12 will not be effective but can also cause problems when taken alongside other vitamins.
I just wish I knew how far apart to wait between other b vitamins and the b12.
@@tnijoo5109 No it's only because in these studies the amount of vitamin b6 was way too high (like 20-25x the RDI)
@@botzer8817 I take b12 in the morning because it wakes me up more and the rest of the b vitamins in the evening because they totally put me to sleep. The b12 I take is a sublingual liquid methylcobalamine. I don’t take it every day, usually once every 4 days. I think this is better than in a pill. I did a bunch of research at the time to figure this out. Can I remember any of the reasons now? No. I just know I came to the conclusion it was better this way. Idk.
The problem is that the other splits off into Cyanide. And there's no way, because they say it's a safe amount, I'd go that route.
So the cyanide is perfectly safe in those dosages?
Yes.
_"Yes, it contains cyanide molecule which separates from the cobalamin and is excreted in your urine. Note though that each 1000mcg cyanocobalamin tablet contains only 20 micrograms of cyanide. This is far less than you consume in almonds, millet sprouts, lima beans, soy, spinach, bamboo shoots, or tapioca. Should you accidentally chewed one apple pip you’ll swallow roughly 490 milligrams of cyanide. That’s almost twenty-five times more than one 1000mcg cyanocobalamin tablet."_
Flaxseed has thousands of times more cyanide than B12 and Dr. Greger has a video on how much flaxseed you could eat before toxicity and it is quite a bit.
@@adiohead Thanks! what source is your citation?
Look up cynide so that you know for yourself what it is
flax seeds contain more than 120 mcg of cyanide per gram ! So yes its perfectly safe, but hydroxyl could also have positive effects
Having a hard time finding that form. Any suggestions. Yes you are a really valuable resource so thank you for all you do.
Inessa advanced multiple has it best multi I’ve used im a competitive power lifter over 40 it has really helped me
Garden of Life whole food gummies on Amazon. It has methylocobalamin.
Cyanocobalamin makes my ears ring...exacerbates my tinnitus. I noticed it without looking for it and since then I've experimented a number of times and it correlates. I've switched back to methylcobalamin.
There is no physiological pathway by which cyanocobalamin supplements can exacerbate tinnitus. You are describing a nocebo effect. No shame in that-your brain is just so powerful that its beliefs alter the way it processes physical sensations. If you have the budget to afford the extreme doses of methylcobalamin needed to prevent B12 deficiency after taking the instability of the chemical compound into account, then go with that. But in general, people with tinnitus will do fine with cyanocobalamin as long as they aren't convinced cyanocobalamin is harmful for people with tinnitus (it's not).
Sounds like somatic
Methyl dealt with neuropathy and tinnitus was greatly reduced for me only after the first injection. But I need another one. I must be quite deficient. I have been using hydroxy but it gives me headaches and the pins and needles are still present. Methyl for me.
Oh wow! This is really good to know!! I have tinnitus so I’ll experiment as you did. Grateful for your comment.
@@jbeauty4150 The first part of this video is about answering that exact question... 1000mcg/day
I have been dizzy lately and fighting a rather new potassium deficiency. This could be caused by keto dieting, so I am making more recipes with kale from now on. But I switched away from cyano to the methyl version to see how it works out, then I will switch back to the cyanide version to see if the dizziness and Charlie horses return. I am concerned about absorption because I had dangerously high levels of homocysteine. And I have swelling conditioning still one year after my DVT. So I don’t want a potassium deficiency to last any longer. I feel screwed on both sides of the equation
But the other form has cyanide I just saw another doctor state this I’d say do your research and do what’s best for you or ask your doctor or not because it depends if the doctor is actually looking out for your best interest
There’s less cyanide in 1000 mcg b12 than in a handful of almonds. That level of cyanide is not an issue. Dr. Berg just gets confused (assuming he was the one raising the cyanide concern).
Cyancured me at 250 ljg, I recovered and now feel like I'm deficient again so taking methyl high dose 100ljg and it's taking ages to do anything, very little difference
Has anyone tried Hydroxocobalamin B12 and how did they react to it?
It's natural so there should not be any issue. Also its more stable than methyl and adeno.
Awesome video series, very useful and detailed! Please make more :)
Also about omega-3 (dosage, ratio, recommendations for kids etc), zinc (I personally find it quite challenging to reach the RDA, especially if remembering that we need more zinc than RDA from plants) and calcium (also not so easy on a daily basis, even with leafy greens and tahini, if I'm not craving them). Calcium supplements are sooo controversial...
And what does cyano imply?
Why does my liquid B-12 recommend taking 5000 mcg a day?
Probably cause they'll make more money selling you more bottles. Then again it could be to cover all bases, like older folks who don't absorb it as well, so they might need more to get there levels on par.
@@eelkeaptroot1393 Thank you. I had been getting my B-12 with nutritional yeast, about 50 mcg a day. I'm older so I thought I'd give it a boost with the liquid, under the tongue method.
@@flapjackid Sounds like a clever solution!
Isnt Methylcobalamin also the type needed for people with MTHFR
As a senior, thank you! Will be upping my dosage.
fantastic information thank you!
5:03
we increased the dose from 100ug/week to 500ug/day and b12 levels increased then how that is connected to chewing?
THIS !!! It is misinformation!! Lots of studies show that chewing does not change anything... This is the first time Greger made a big mistake
EDIT: R-protein from saliva allows better absorption when bound to b12. So even if the study doesn't prove anything, its better to chew/mix with saliva.
This video is the most brillant and objective thought about B12 deficienv. MR Gerger pointing his different point of view. Gracefull and thanks...
I have a Methylcobolamine supplement that I swallow whole. Can I chew it instead of swallowing it? It’s 100 micrograms
Maybe ask the pharmacist and if they say you can’t, get a form that you can.
What about the issue of having normal test results for cobalamin, homocysteine, MMA, but still have symptoms of defiency?
1. Talk to your doctor. 2. Take a B12 supplement.
@Steven L. I mean that the symptoms go away upon supplementing with a form of B12 different than the form that was already being taken. (Lot of people anecdotally complain of this issue)
Read an article by a swedish professor saying that cyanocobalamin raised blood levels but didnt function to relieve symptoms. And he recommended the methyl variant only haha. Sure is a confusing jungle of information.
@@ZenDao_85 THANK YOU name?
Take methylcobalamin. Avoid cyanocobalamin.
Is it a good idea for me to start chewing my 100mg b12 tablet I take daily, despite it not being purposed for chewing? This study didn't explicitly say what the participants were chewing?
Tablet I would say yes, but capsules I dont think it's needed
Thanks. I almost freaked out and bought the more expensive B.
Also cyanocobalamin can be made into both methylcobalamin and adenosylcobalamin.
Cyanocobalamin is a chemically made b12. Methylcobalamin and adenosylcobalamin are natural , there is also hydroxocoblalamin
@@alec1113
Reread my comment. It can be made into these two in your body.
Here after JRE with Gary Brecka, interesting to hear no mention of cyanocobalamin being toxic
I have been consuming 2500 mcg of cyano for almost 4 years but suddenly there is not that form all the supplements company only distributed the other form ( metho) is there any new studies i can't able to find the cyno form any more
So you talked later about chewing the B12 tablet to get the full benefit. So, as a 72 year old, I have been taking the reco dosage of 1000 a day. No problems for the past 4 years. So should I start chewing it now?
Amamzing! Thank you for talking about the kidney!
Question for you more knowledgeable peeps....I take a weekly sublingual B12 supplement like Dr Gregger mentions and separately I also take a Multivitamin, it has methylcobalamin but I take it more for the iodine and iron. It sounds like I should take them at different times, but maybe should I not take it at all?
Watch Morley Robins about iron danger.
That's well and good, but I can't find a chewable cyanocobalamin vitamin that doesn't have several additives I would not wish to take all the time! It's so frustrating for me, as I have been looking for weeks now. :-( Having Ankylosing Spondylitis, I react to the most unexpected things. So taking in obscure additives can be dangerous for me. Does anyone have an answer? Please?
Forget about cyanocobalamin. Toxic. Choose Methylcobalamin. Used to treat many serious disorders.
Buy those with capsules and chew them. Or take adeno+hydroxo+methyl combination if you dont find it
Great content, thanks!!! 👏🏼👏🏼👏🏼
Can I ingest an injectable version of the Cyanocobalamin? Like put it in water?
What about the Mthfr gene mutation?
Hey
No swearing
That is a good topic. Methyl fails but it gives a Methyl donor and you want a Methyl donor (but not too many because that causes problems) but you can combine Methyl with the other types and I have personally had Methyl fail twice but I briefly used a Methyl/Adenosyl combination and that worked better than Methyl by itself. I don't have the gene mutation and Cyano works better and is cheaper so I am taking that now. But Methyl can be used as a combination and if you eat fortified Nutritional Yeast or fortified Plant Milk those can help. A few of the people I have interacted with who had Methyl fails didn't know it until they stopped using fortified foods and that is what happened with me. I thought Methyl was fine until I went off fortified foods.
Continue to tell us the thruth thanks
Is there any impact on methyl vs cyan when you have MTHFR?
Great question, I’ve been trying to find the answer to that
Not really. MTHFR is just one SNP in the folate cycle and it affects conversion folates to methyl folates. Processing of cyanocobalamin occurs through MMACHC enzyme. This is the step of concern when discussing cyanocobalamin.
Would B12 in a vitamin fortified cereal suffer the same fate as it would in a multi vitamin? I image the same combination of vitamins would be present?
Good question.
Very good question. Still no one has answered.
Does anyone know how to find the list of recommendations on the nutrition facts website?
the easiest way is to use your mouse. what you wanna do is scroll down to the bottom of the website and use the left button to click on it.
Search with the 'Search' area on the top of the NF site for 'optimum Nutrition recommendations' or, you can go to the bottom of the page and click it, the current link for it is nutritionfacts.org/2011/09/12/dr-gregers-2011-optimum-nutrition-recommendations/
Always a pleasure listening to this man
Thank you so much Dr.Greger! You are a god send!
A B12 supplemented toothpaste? Will wonders never cease? TFP : )
I have it now and it is funny
@@Morfeusm Do you feel any different using it, over a B12 supplement, I mean?
@@tamcon72 I am afraid I haven’t taking it too seriously so I didn’t stop supplementing with regular B12 supplement.
@@Morfeusm Does it at least work well as a toothpaste? LOL!
@@tamcon72 haha. It is bright red as some kids paste but it has neutral taste, slightly more gel like texture than paste paste, it is ok, gets job done and it’s vegan but I prefer our local DM drogerie-markt vegan toothpaste to be honest. 😅
Great insight, thanks!
You are incredible as always, Doctor. Thank you for the simplified explanation you presented about an essential topic like this one.
I'm from Indonesia indonesia injection B12 cyanocobalamin 😁 today first injection intravenous
Me: Sees everyone asking for a Cyano vs. Methyl B12 video for the longest time.
Nutritionfacts: Delivers a video about Cyano vs. Methyl B12.
Me: Insert meme *You did it, you crazy son of a ....., you did it!*
Great video as always!
Can't agree
Is there any interference taking B12 at the same time as Vitamin D?
Also, does "chewable" b12 mean it's a gummy or should you simply chew the tablet?
SoUL Under the tongue is a rapidly dissolving tablet, B12 is absorbed directly into the blood stream. Swallowing or chewing first goes to the stomach, digestive system, then gets absorbed into the blood, etc. Direct absorption gets to work faster.
lordofthestrings86. Chewable could be a gummy or a tablet. Sublingual gets into your blood the fastest.
That b12 at same time as vitamin d question is a good one. I hope someone answers.
I am on dialysis with kidney failure so Methylcobalamin would be "better"? for treatment. Why is that? The stability?
There are small trace amounts of cyanide in the other one.
Your kidneys must excrete the cyanide from the cyanocobalamin. It’s a very small amount, but for failing kidneys every little bit of extra work adds up.
I've been waiting for this video for 4 years, it finally came. Thank you!
How about liquid vit B12 that has 1,000 mcg AND 400 mcg folic acid with it? Please! Thank you.
Liposomal B12 brand now
Can we sulbutiamine and pyridoxal 5-phosphate together ?
B12 is best absorbed in low dosages. So why is there not a single doctor recommending 2x a day 10ug oder 3x a day 5ug? I'm taking 2x times a day 10ug (Methylcobalamin) and my blood levels are fine.
Are you eating any B12 fortified foods?
That's a misconception. The percentage you absorb will decrease the higher the dosage, but the total amount absorbed will still be higher. So if you take a tiny dose like 2mcg you might absorb 50-60%, let's say 1mcg but if you take a 1000mcg dose you might absorb "only" 10%, but that's still 10mcg or 10X as much as your 2mcg dose (edit: that's actually a 1% absorption rate, which would be like someone with pernicious anemia, so it may actually be higher). Dr. Greger had tables that showed this in his previous video so just look at that for the exact numbers but the point is that higher dosages will lead to higher amounts absorbed.
@@davidk2187 Just using the formula from ruclips.net/video/oj8qAwgADdM/видео.html (Timestamp: 1:35).
Dr. Gregor recommends an intake of 50ug (once a day). According to this formula your body will then absorb 1.9ug B12. Taking 2x a day 10ug, your body will absorb 2.8ug B12. So now im just wondering why nobody recommends to take 2x a day 10ug.
Hi Dr. Greger, Please address the issue of cyanide in cyanocobalamin; there happens to be another doctor featured at RUclips who, because of the cyanide in cyanocobalamin, recommends avoiding it.
Also, although I don’t know if B-complex would be considered a multi-vitamin, is it alright to get my B12 via that route? Does B12 interact well with other B vitamins? My B-complex happens to include vitamin C (Nature’s Truth brand). Thank you so very much Dr. Greger.
the amount of CN- on CYANOcobalamin is so small, IIRC it's around 1% of total vitamin b12 weight. So it's only 10 mcg of CN on 1,000 mcg cyanocobalamin.
@@magnificentoutcome Thank you so much for your input. The doctor I was referring to, discouraging cyanocobalamin, is one Dr. Eric Berg; here’s the video featuring him commenting on the different forms of B12. What do you think? ruclips.net/video/ATGp0if2314/видео.html
@@OboeDaCaccia if you take natural forms then take a mix of hydroxyl, adenosyl and methyl. Or at least both methyl and adenosyl. Theoretically your body can convert methyl in adenosyl but maybe some people struggle to do it, I dont know. It looks like some people fail with methyl supplementation alone. Cyanocobalamin is not bad, its less natural but has good bioavailability.
@@magnificentoutcomeHow much is in apricot kernels?
Which means I have to see my doctor before getting one
Hello Doc, unfortunately in India I'm only finding Methylcobalamin ones, what to do :(
Order it from iherb cyno hydroxy both available
Methylcobalamin is good. Avoid cyanocobalamin.
Take it with adeno and hydroxyl to make sure you absorb it
It has a cyanide molecule that most likely can be absorbed, however accumulative toxicity is possible when you factor in energy drinks etc. which contain sometimes 1000% of daily. Not to mention that the hydrogen cyanide that they source for the making of cyanocobalamin comes from our sewage plants. enjoy.
B12 is produced by bacteria that make it on plants. An animal or human can eat that same plant and get enough B12 (2.4mcg). More importantly though, B12 deficiency is only a problem if you lack a chemical called the "intrinsic factor," which causers people to be unable to absorb B12. Intrinsic factor production is reduced as dietary fat increases. This is by far the most common cause of B12 deficiency. Doctors can easily test whether a person has a normal ability to absorb B12. For those who do not, NO AMOUNT OF THE VITAMIN IN THE DIET WILL HELP. THUS, ALL OF US, VEGETARIANS AND MEAT EATERS ALIKE, ARE AT RISK OF B12 DEFICIENCY.
A high fat diet increases this risk substantially, for two reasons. First, the colonies of B12 producing bacteria in our intestines utilize carbohydrates for fuel. As the amount of fat in our diets goes up, the amount of carbohydrate goes down, thus reducing the quantity of fuel available to the microbe. Less fuel results in a smaller colony and an overall decrease in B12 production. Second, the B12 uptake sites in our intestines become clogged when there is excess fat in the diet, further reducing B12 absorption When reduced B12 production is couple with impaired absorption, the likelihood of B12 deficiency becomes predictable.
The situation is further complicated by the fact that many refined starchy foods are "enriched" with a synthetic form of vitamin B12. When doctors test for "normal" B12 levels, their results are skewed towards the high end by the fact that most people eat these foods(mostly grain products--cereals, breads, pasta, cookies, cakes, etc) on a daily basis. People who eat a grain-free diet not supplemented by this poor imitation of the natural nutrient often test "low" for B12, even if their levels are healthy and they are totally asymptomatic. This is because their B12 levels are being compared to those of people who are consuming a B12 supplement in their food at almost every meal.
B12 deficiency can cause anemia. Symptoms of this type of anemia include: fatigue and weakness, weight loss, and sore tongue. It can also cause a neurological disorder. Symptoms of this neurological disorder include: numbness and tingling of hands and feet, memory changes, poor balance, and depression. If you don't have all of those symptoms then you don't have B12 deficiency. You have nothing to worry about. If you want to get checked for intrinsic factor levels, that is the only sure fire way to see if you're susceptible to it. As I mentioned, if you don't have enough intrinsic factor, no amount of B12 will help. Intrinsic factor is lowered by the amount of fat eaten, so watch your fat intake and you won't have to worry about B12 and many other diseases.
Yes, but folks lacking that intrinsic factor are a total minority. I thought the B12 in the gut isn't aborped at all, unless of course one has very poor hand hygene... So you're basically saying all keto dieters or even keto lifestylers are at risk of a b12 deficiency? Interesting, I"d like to see studies confirming that, would be funny to rub their noses in.
Please give brands. I can’t find what you recommend.
He can’t give brands. Mine is a prescription, and it’s Nature Made, sold online and in stores. Nature Made has it on their website, often offers buy one get one free of their products.
Pure encapsulations b complex is legit
I take these. www.solgar.com/products/vitamin-b12-1000-mcg-nuggets/
Believe me “Tri-Vita” makes an awesome sublingual cyanocobalamin B-12. It’s also the only one that changed the way I feel not long after taking it.
@@johncharles857 It seems to contain B6 and Folate and is super expensive.
Guy knows what he is talking about 👍👍👍👍
Should the fact that the cyano version contains cyanide be of any concern? There’s another RUclips dr that says only take the methyl. 🤷♂️
Thank you Dr. This is very helpful. 🍁