Excellent! Looking forward to that. I found this video really useful. I have MS and notice that when life is working well so that I feel more positive, I do feel much better. It's nice to see that there's information and data that shows reasons why. It gives me ideas of how to incorporate more good things into my life, little and often and the motivation to do so.
1. Exercise. Both strength training and cardio will help. 2. Fasting (Depends on your diet. All about maintaining 'healthy weight') 3. Be Disciplined about Staying Positive and Express Gratitude. Especially at Night.
I just want to share a book from 2010 by Dr. Terry Wahls who reversed her MS to a great degree by concentrating on the health of her mitochondria as the primary focus: 'Minding My Mitochondria'. Its great that researchers are finally catching up after 14 years.
One of the best and easiest ways to improve mood before bedtime is making a gratitude list - things you're grateful for, whether from that day or further in the past - doesn't matter when. Also doesn't matter whether the list is written or just in your head. The key is lingering in a moment of gratitude. Surprising how many people find it difficult to do at first. It gets way easier with practice, until it's possible to get that warm feeling even when you've had a crap day.
My long covid has given me post exercise flat out exhaustion that can last weeks to months. Infrared light therapy, eating right, water, gratitude, community, anti depressants, doing things I love to do that I can physically do and for me this is painting and getting outside is what is slowly helping me. I am trying to get my mitochondria to heal and increase. AND I’ve detached from the news.
Ray peat baby! Forget low carb. The mitochondria LOVE glucose. The issue never was sugar, if it was our ancestors wouldn’t have sought out honey and fruit. The issue is a mitochondrial one! fix them, fix your disease. ;) Go high carb low low fat. Not forever, for now. We wanna get the body metabolising sugar instead of fat and turn your body in to an energy producing machine so it can heal itself. Kick out PUFAS too.
Bruce Lipton is incredible, I first found him many years ago on a Food Matters or Gerson documentary, not sure now. Resonance is a fundamental force of our reality, intangible but undeniably powerful.
@18:15 This admission alone sets you apart from others on YT and why you’re growing. Humility and curiosity make the best researchers and scientists. Thx Nic!
10:51 very interesting, particularly what you said about mitochondria downsizing in response to a nutrient overload. I've heard people say to continue your supplement regime during fasting - but maybe it would be more beneficial to discontinue the supplements during a 24/48 hour fast to freak the mitochondria out a bit more? rather than keeping them relatively comfortable despite the lack of food intake.
Dealing with severe ME/CFS, these things sadly didn't do anything and that's true for almost everybody with this illness. I hope there's WAY more research coming out in this regard. Desperate to not lose another decade.
Have you tried methylene blue? It’s helps to generate energy in mitochondria cells. Also just now I’m looking into Q10, Ive seems people say they’ve been taking it and it helped them.
Thx Physionic for this another great video. May I ask you what are your thoughts on the impact of metformin on the mitochodria. Some people say it's a mitochondrial poison, but a pretty large number of studies indicate that it increases mitochondrial biogenesis. Other researchers say that even if metformin impacts the mitochondria negatively (but slightly) it's actually a good thing because it triggers the mechanism of hormesis in the body. Excited to see how you could clarify even a litte bit this complex topic.
The issue with PhD scientists is that they take their laboratory subject “mitochondria” and study and make recommendations outside of the rest of the body. If you eat in a way that is a calorie deficit, with many anti-inflammatory compounds, and increase fasting window PLUS move more PLUS sleep enough - that will help a raft of different processes such as hormonal responses to food, your body composition, and your stress pathways, which will sure probably have flow on effects to intercellular organelles including mitochondria. The constructs that focus on one particular aspect of the body are spurious
I grew up in a neighborhood that had large fields behind all of our houses. They grew cotton, soy beans, and corn and rotated each year. As kids we played outside all day and I can still remember the smell of the pesticides and herbicides they sprayed on those fields. Then in 1997 I had a flu shot. It was all downhill after that.
Most subscribers will probably agree with abc - but let me add that apart from informing intelligently and discussing knowledgably, you do it with the most delightful touch of humour. You are to serious information what yeast is to bread - making it lighter and more palatable 😊
Hi, great content as usual. I just watched it during my 20 min morning bike (fasting) exercise to start the day and apparently to multiply my mitochondria. I constantly stumble upon the effect of red/infrared light on the cell even on energy production. Is it something you plan to cover in the future?
Nicolas, please make a video about supplements that really help with mitochondrial health! Such as Q10 as an electron transporter and other interesting things 🙌🏻 Maybe about cellular respiration and overall more basic bioenergetics stuff 🤓 BTW like your work a lot! Keep it going! 🙏🏻
Here are a few more: pqq, d-ribose, creatine, alpha lipoic acid, cumin seeds (you need to grind them or chew on them to have a chemical released that I would have to look up but that supports the mitochondria)
Fred Hatfield's book, Bodybuilding: A Scientific Approach, had a section claiming (and citing studies, if I remember right) that mitochondria increase mainly when you stress muscles with 20+ slow reps... 90+ seconds of continuous tension... IOW, anaerobically (sarcoplasmic reticulum increases with 10-12 reps, actin & myocin increase with 4-6 reps). Has this information been lost among researchers? Was it speculative? IDK
Good work sir. A key takeaway from a latter part of the video, re: sleep, stress, mitochondria...for ⬆️ A.M. ENERGY, optimize stress PRIOR to sleep! Work towards consistently better mental mood prior to sleep time! Makes sense...emotionally better state during sleep onset --> more PNS-activated state during sleep onset --> positive neuro-emotive inertia starting out--> momentum carries through subsequent sleep cycles to some extent, perhaps facilitating (for example) better dreams and so on. Anyway, I'm sure findings in the field of psychoneuroimmunology would agree! Keep it up Physionic, and let's all take care of our emotional, cognitive and overall mental health and resilience, folks!
Conventional agriculture usually uses fertilizers that contain N, P and K; the continuous maintenance of crops deplete soils and the fact that nobody. " makes number 2 " out of a toilet, prevents the recycling of minerals on soils. Is magnesium added to commercial fertilizers? Many enzymes cannot work without enough magnesium intake.
@@DesertDog8989 I know people who take 30 mg or more zinc a day (as they heard that zinc= better immune system), and they don't even care about taking copper and selenium. So yeah I don't expect them to do the same for magnesium
@@DesertDog8989 Does the ingestion of magnesium affect the level of copper in the body? Or do you mean that people should also check for the level of cooper? Thanks.
I wonder how issues such as chronic digestive issues such as IBS, SIBO, leaky gut etc impact mitochondrial health. I am aware these can impact mental health through the gut brain axis.
Looking forward to your “senolytics” video. Please include “Qualia Senolytics” contentions that their 2-day regimen actually cleans out zombie cells. Thank you.
I’ve had a shift in focus: Instead of focusing exclusively on how to lose weight, I’m learning how to improve my mitochondrial function I think that focusing on these practices will improve my overall health and the result will likely be multifactorial
Same here. According to Robert Lustig mitochondrial disfunction is the main factor behind insulin resistance. Although there's a strong overlap and interplay, managing weight or blood glucose feels more like treating symptoms than causes.
15:37 There's a book, Kahneman, D. (2011) *Thinking, fast and slow.* 2nd edn. New York: Farrar, Straus and Giroux. where he says question order is super important; if you ask (1) how happy do you feel? then (2) do you have a girlfriend/boyfriend at the moment? you get _completely_ different scores compared to asking the same questions the other way around. Because "do you have a girlfriend/boyfriend?" gets the subject thinking and sets them up for the next question.
Oxytocin is connected to mitochondria, it helps balance the need for iron in electron transport and OXPHOS. So it makes alot of sense that happiness would be connected to mitochondrial health.
No magic for now... but as always... great job to giving us a real landscape about mit. Just one question, talking about how phisical activity could increat mit. account... is there any study about how "mental activity" could induce similar process about increaing mit. account but in neurons?. Thank you so much for sharing you work. PD. I´m quite interested on PQQ , do you have in mind to do any video about it?.
I feel proud of promoting you, Nicolas and this, your channel in each and every antiaging forum I follow. Hope it helps you and your team to reach your goals in YT. Big Thank You. 🎉
Please make a video about salt (yes, NaCl). It's a very controversial topic. I read "The Salt Fix" and "Salt Your Way to Health" both present a very interesting picture. I wonder what's your take on salt in our diet and also salt as a supplement for endurance exercise and muscle strength.
20:20 what fat source? I feel great with coffe and cocoa butter early in the day, pure fat and the stearic acid is good for mitochondrial fusion as well?
I have a question regarding ME/CFS and the negative effects of exercise on patients with the condition, in relation to mitachondria health, which is known to be affected in these patients. If exercise promotes good mitachondria health in a person without ME/CFS, what effect does it have on the mitachondria of ME/CFS patients, where exercise usually causes a worsening of the condition and can cause relapses that last for days, months, and years? Is diet/fasting alone enough of a way to promote good mitachondrial health in a patient who cannot exercise? I would appreciate any insight into this matter.
Im neither a MD nor a researcher in such a field. But maybe the capability of mitochondrial transcription or translation is in a manner affected that makes it hardly possible for the body to adapt, to the by exercise forced stress, in form of increasing the amount of mitochondria. Meanwhile existing mitochondria might lack under needed substrates to ensure proper balance in the equation of energy needed vs. energy used. Thus the overall burden of stressed mitochondria increases, since the lack of needed substrates, which already is responsible for the lack of needed energy, also leads to the incapability of a proper maintenance of the existing mitochondria. Maybe this will result in apoptosis? What actually also leads to a lower energy-production? But maybe that's completely wrong. Just like a said, im not a specialized person, just a curious & interested guy.
I have CFS and have for decades. It forced me to optimize everything about my life so that I could do more than get out of bed to take a pee. After such optimization exercise became a positive element, and I suffer some relapse if I become too sedentary.
I am also thinking this is a good video for people grappling with ME/CFS. I guess as ever it is a very very gentle increase in movement over many months alongside diet optimisation that will ultimately help.
@@SkyRiver1Really great to hear that exercise has become a positive thing for you, and how you went about making it so. Thank you for your reply. I hope today is a good day.
Very informational video. Would you consider making a video about exercise adaptation and antioxidants? Ubiquinol is an antioxidant yet it increases mitochondrial biogenesis, which is seemingly contradictory. There is not much info on it other than the bro science avoid antioxidants a couple hours before and after exercise.
I have read articles that connect the dots about ME/CFS symptoms being brought about from some mitochondrial dysfunction . It is hard to imagine increased aerobics improving a ME/CFS patient's symptoms when doing so results Post Exertion Malaise (PEM).
19:40 . . . So I suppose I should leave out the organic olive oil that I add to my organic oatmeal groats along with pepprine, so as to more readily assimilate the circumin I put in it. Or maybe just leave them all out and take them separately.
being able to measure mitochonrial health and population is amazing, everyone knows extrinsics like emotion have everything to do with how we feel, now backed by this most fascinating area of research,, thank you for sharing this! you're a good man!!, despite having admittedly commiting murder in your lab
Just a peripheral comment on the importance of neuromuscular junction (NMJ) maintenance in enabling exercise. An NMJ is the synapse between motor neuron and muscle fiber. There are genetic diseases as well as inevitable aging that cause the motor neuron to die back, causing fewer muscle fibres to fire, in turn weakening the muscle. Much remains unknown about this process that leads to sarcopenia (muscle weakness in the aged), but it would come as no surprise to me if mitochondrial health turns out to be one of the players in this process, possibly setting off a vicious cycle of weakness discouraging exercise, in turn leading to more die-back of motor neurons.
It's cool that you're keeping things complicated. Some of the mitochondria people are alluding to or even explicitly stating a level of simple certainty which doesn't seem valid, more like ideology.
Independent of glucose is my conclusion too using a sample size of one. To redress then fasting may improve mitochondrial health in addition to reducing food overload. Thanks.
With the feelings study. I wonder if they took menstrual cycle into account. Like I feel a bit more depro in my luteal phase (2 weeks after ovulation). But like I would think the cocktail of hormone interactions over this cycle has a larger effect than the mood. Like it might be correlation not causation
I take cardiovascular research brand magnesium taurate. I take 4 tabs a day which is 125mgx4 of magnesium. I also supplement separate taurine at 1g. Definitely beneficial.
Is mitochondrial fission inherently bad for energy metabolism? Its function is to only dissipate the excess energy? Can the newly separated mitochondria grow in size to match the previous mitochondria after the fission?
Normal weight but osteoporosis 81 yrs on cane fracture femur stem . Anterior hip replaced 10,000 steps 4 miles today going out once more to get up hill cardio. Was sprinting bf fractured occurred picking up trash. Do weight arms shoulders grip.
Very informative discussion with information I haven't seen anywhere else. Do you think keeping a stiff upper lip through adversity helps mitochondrial function?
Edit: okay I did hear a mention of it. Does “physically active” always imply aerobic exercise? Or does an average walk help? What about weight-bearing exercise? I rarely hear specifics on this.
@@veniqe Pesticides more concentraded in meat, due to bioacumulation. Antinutrients that are antioxidant, anticancer etc that are the very reason plants are healthy.
Omg the very last thing you said is the question I'm spending my life trying to find the answer to! Is keto/carnivore bad because of too much fat the our system?
Is this one way that taurine supplementation/exercise that increases taurine levels might be helpful in mitochondrial health/longevity? "Taurine deficiency and rotenone actions are similar, as both lead to reductions in complex I activity, inhibition of NADH dehydrogenase activity, reductions in respiratory activity and elevations in NADH. Because a primary physiological function of taurine is the maintenance of complex I activity, there is reason to believe that taurine therapy should reduce the severity of Parkinson’s disease (Alkholifi et al., 2015). "
On the optimum diet my view and experience tells me that titrating glucose load against use and the ability to store it as glycogen is a key factor and this declines with age due to the inevitable loss of muscle mass. As a nutritional physiologist I find it a limitation to many of these videos and nutritional papers where they link their results to fat or protein when the cells do not recognize either but rather amino acids and fatty acids and the responses are different depending on which are involved and their ratios. This is especially true for excess omega 6 fatty acids and lack of essential amino acids, especially leucine but also other factors that determine their activity.
Nice! One key concept that is often missing in metabolic vids (keto, ...) is that fasting/hunger (to generate mitochondria) is more than endogenous use of MCT oil (with abundant nutrients).
![Fasting and Overeating - How you Change your Mitochondria. [Study 32]](http://i.ytimg.com/vi/KQBmtzT4VTU/mqdefault.jpg)
Here is the first video in this series: ruclips.net/video/QX9o3G_G9SY/видео.html
FASTING
Excellent! Looking forward to that.
I found this video really useful.
I have MS and notice that when life is working well so that I feel more positive, I do feel much better.
It's nice to see that there's information and data that shows reasons why.
It gives me ideas of how to incorporate more good things into my life, little and often and the motivation to do so.
No interest in E5? Amazing. . .
What about supplements to boost mitochondrial health?
And this is exactly why I haven't owed a TV in years! (And don't even miss it).
Thank you 🙏
Educating entertainment the Physionics way 😊
In the evening, my Kitty sits in my lap and purrs, in order to sooth my Mitochondria. Very intuitive animal.
Cats are tremendously helpful in this way, bless'em!😸
Give that cat a treat
Mitochondrions love Kitties!
Nice
Anyone want to share some pics of their kitty?😎
1. Exercise. Both strength training and cardio will help.
2. Fasting (Depends on your diet. All about maintaining 'healthy weight')
3. Be Disciplined about Staying Positive and Express Gratitude. Especially at Night.
Strength training doesn’t really move the needle on this, steady state cardio however is very effective. Read Inigo San-Millan
Well written
which brand and how much does it cost?
767
Red light
I just want to share a book from 2010 by Dr. Terry Wahls who reversed her MS to a great degree by concentrating on the health of her mitochondria as the primary focus: 'Minding My Mitochondria'. Its great that researchers are finally catching up after 14 years.
Thanks for the referral!
One of the best and easiest ways to improve mood before bedtime is making a gratitude list - things you're grateful for, whether from that day or further in the past - doesn't matter when. Also doesn't matter whether the list is written or just in your head. The key is lingering in a moment of gratitude.
Surprising how many people find it difficult to do at first. It gets way easier with practice, until it's possible to get that warm feeling even when you've had a crap day.
FO.
@@babyboltbark What is that short for?
My long covid has given me post exercise flat out exhaustion that can last weeks to months. Infrared light therapy, eating right, water, gratitude, community, anti depressants, doing things I love to do that I can physically do and for me this is painting and getting outside is what is slowly helping me. I am trying to get my mitochondria to heal and increase. AND I’ve detached from the news.
Ray peat baby! Forget low carb. The mitochondria LOVE glucose. The issue never was sugar, if it was our ancestors wouldn’t have sought out honey and fruit. The issue is a mitochondrial one! fix them, fix your disease. ;)
Go high carb low low fat. Not forever, for now. We wanna get the body metabolising sugar instead of fat and turn your body in to an energy producing machine so it can heal itself. Kick out PUFAS too.
The mood-feeling-mitochondrial relationship makes so much sense! Bruce Lipton talks about this is his studies of cell-environment relationships.
Bruce Lipton is incredible, I first found him many years ago on a Food Matters or Gerson documentary, not sure now. Resonance is a fundamental force of our reality, intangible but undeniably powerful.
@18:15 This admission alone sets you apart from others on YT and why you’re growing. Humility and curiosity make the best researchers and scientists. Thx Nic!
That I'm a murderer? ;-P
Thanks, JMC. Trust me, I never forget I have much to learn.
Oops, well compliment still applies but not that you don’t already have a lot to teach and share. ✌️
Thanks for this information ❤
I'm battling cancer and I need to know more about mitochondria
Study cancer metabolic treatment options, youre mind will be blown
Look into the Joe Tippin's Protocol. I don't know if it works but it sounds like it has real promise.
Check out TED Talks. Eat 3 cups of vegetables a day
What has been your diet for the last 20 years? AVOID bread, carbohydrates and go vegan!
I use your content these days to make my health tips notebook.
Thanks for the immense amount of research you compile.
That's awesome, abc. I'm really glad.
@@Physionic best wishes from now rainy India heading towards autumn soon 🇮🇳
And my name is Sam.
Autumn here, too, Sam. :)
10:51 very interesting, particularly what you said about mitochondria downsizing in response to a nutrient overload. I've heard people say to continue your supplement regime during fasting - but maybe it would be more beneficial to discontinue the supplements during a 24/48 hour fast to freak the mitochondria out a bit more? rather than keeping them relatively comfortable despite the lack of food intake.
That's what I do in my weekly 48 fast. Nothing besides water, black coffee and a bit of water kefir
Dealing with severe ME/CFS, these things sadly didn't do anything and that's true for almost everybody with this illness. I hope there's WAY more research coming out in this regard. Desperate to not lose another decade.
Have you tried methylene blue? It’s helps to generate energy in mitochondria cells. Also just now I’m looking into Q10, Ive seems people say they’ve been taking it and it helped them.
@@Mrskess
I have long covid and Methyleen bleu first gives me energy but makes me crash later
I see a lot of people writing online that they healed because of the carnivore lifestyle.
Thx Physionic for this another great video.
May I ask you what are your thoughts on the impact of metformin on the mitochodria. Some people say it's a mitochondrial poison, but a pretty large number of studies indicate that it increases mitochondrial biogenesis. Other researchers say that even if metformin impacts the mitochondria negatively (but slightly) it's actually a good thing because it triggers the mechanism of hormesis in the body. Excited to see how you could clarify even a litte bit this complex topic.
The issue with PhD scientists is that they take their laboratory subject “mitochondria” and study and make recommendations outside of the rest of the body. If you eat in a way that is a calorie deficit, with many anti-inflammatory compounds, and increase fasting window PLUS move more PLUS sleep enough - that will help a raft of different processes such as hormonal responses to food, your body composition, and your stress pathways, which will sure probably have flow on effects to intercellular organelles including mitochondria. The constructs that focus on one particular aspect of the body are spurious
I grew up in a neighborhood that had large fields behind all of our houses. They grew cotton, soy beans, and corn and rotated each year. As kids we played outside all day and I can still remember the smell of the pesticides and herbicides they sprayed on those fields. Then in 1997 I had a flu shot. It was all downhill after that.
Most subscribers will probably agree with abc - but let me add that apart from informing intelligently and discussing knowledgably, you do it with the most delightful touch of humour. You are to serious information what yeast is to bread - making it lighter and more palatable 😊
Great analogy.
That's really kind of you, Garbielle. Thank you.
It's amazing people like you that make a difference with us humans. Thanks for being a great one. Keep studying and sharing⭐
Hi, great content as usual. I just watched it during my 20 min morning bike (fasting) exercise to start the day and apparently to multiply my mitochondria. I constantly stumble upon the effect of red/infrared light on the cell even on energy production. Is it something you plan to cover in the future?
Nicolas, please make a video about supplements that really help with mitochondrial health! Such as Q10 as an electron transporter and other interesting things 🙌🏻
Maybe about cellular respiration and overall more basic bioenergetics stuff 🤓
BTW like your work a lot! Keep it going! 🙏🏻
Here are a few more: pqq, d-ribose, creatine, alpha lipoic acid, cumin seeds (you need to grind them or chew on them to have a chemical released that I would have to look up but that supports the mitochondria)
Also the UBIQUINOL supplemental form of CoQ10 as well, for adults over 30 years of age! Melville from sunny Malaysia
Can you please share supplement names and brands?
@@bejul2yes, please mention brands as I too suffer chronic fatigue
Bejul mentioned peptides that help cfs
Fred Hatfield's book, Bodybuilding: A Scientific Approach, had a section claiming (and citing studies, if I remember right) that mitochondria increase mainly when you stress muscles with 20+ slow reps... 90+ seconds of continuous tension... IOW, anaerobically (sarcoplasmic reticulum increases with 10-12 reps, actin & myocin increase with 4-6 reps). Has this information been lost among researchers? Was it speculative? IDK
Good work sir.
A key takeaway from a latter part of the video, re: sleep, stress, mitochondria...for ⬆️ A.M. ENERGY, optimize stress PRIOR to sleep!
Work towards consistently better mental mood prior to sleep time! Makes sense...emotionally better state during sleep onset --> more PNS-activated state during sleep onset --> positive neuro-emotive inertia starting out--> momentum carries through subsequent sleep cycles to some extent, perhaps facilitating (for example) better dreams and so on. Anyway, I'm sure findings in the field of psychoneuroimmunology would agree!
Keep it up Physionic, and let's all take care of our emotional, cognitive and overall mental health and resilience, folks!
Id love to hear more about mitochondria in relation to MS and post viral fatigue or fibromyalgia
Mitochondria play a role in almost every disease, as they do much more than just provide the body with energy
Alex Howard in his book Decode Your Fatigue goes into depth on this
Martin is a great guy I've learned so much from him.
I just find myself trusting the way this guy describes things. Subscribed now ✅
Yes this should go out to more people! Been following people talking about mitochondria health! Thank you good sure 👌🏾 😊
Conventional agriculture usually uses fertilizers that contain N, P and K; the continuous maintenance of crops deplete soils and the fact that nobody. " makes number 2 " out of a toilet, prevents the recycling of minerals on soils. Is magnesium added to commercial fertilizers? Many enzymes cannot work without enough magnesium intake.
Well this is the charm of industrial farming which is more and more spread and supported by politicians worldwide.
and many who take magnesium don't check their copper; this balance is critical ❤
@@DesertDog8989 I know people who take 30 mg or more zinc a day (as they heard that zinc= better immune system), and they don't even care about taking copper and selenium. So yeah I don't expect them to do the same for magnesium
@@DesertDog8989 Does the ingestion of magnesium affect the level of copper in the body? Or do you mean that people should also check for the level of cooper? Thanks.
Could you put your analytical expertise into the study of Tinnitus...?
Yes!!
Thank you...@@sncnutrition7118
👍
As soon as you say tinnitus, I hear mine... again 🎉
Relates to insulin resistance if you dig into it
I greatly appreciate what you’re doing. You provide a valuable resource to those of us wishing to learn more.
I wonder how issues such as chronic digestive issues such as IBS, SIBO, leaky gut etc impact mitochondrial health. I am aware these can impact mental health through the gut brain axis.
Looking forward to your “senolytics” video. Please include “Qualia Senolytics” contentions that their 2-day regimen actually cleans out zombie cells. Thank you.
You offer tremendous service to that greater body of knowledge.
Aha! Suspense - more to come in part 2! What a science opera 😁
Amazing work and explanation 👏 thanks ❤️
I’ve had a shift in focus: Instead of focusing exclusively on how to lose weight, I’m learning how to improve my mitochondrial function
I think that focusing on these practices will improve my overall health and the result will likely be multifactorial
Your mitochondria will take care of themselves with regular exercise and a healthy calorie restricted diet.
Same here. According to Robert Lustig mitochondrial disfunction is the main factor behind insulin resistance. Although there's a strong overlap and interplay, managing weight or blood glucose feels more like treating symptoms than causes.
👍
15:37 There's a book, Kahneman, D. (2011) *Thinking, fast and slow.* 2nd edn. New York: Farrar, Straus and Giroux. where he says question order is super important; if you ask (1) how happy do you feel? then (2) do you have a girlfriend/boyfriend at the moment? you get _completely_ different scores compared to asking the same questions the other way around. Because "do you have a girlfriend/boyfriend?" gets the subject thinking and sets them up for the next question.
I find your presentation style engaging and substantive. Subbed 👍
Thanks Mac, kind of you
Oxytocin is connected to mitochondria, it helps balance the need for iron in electron transport and OXPHOS. So it makes alot of sense that happiness would be connected to mitochondrial health.
Thanks for the information on the mitochondria and the references to the studies.
Thanks for highlighting details of our incredible design!
A positive attitude improves your biological function. We know that intuitively but I love to hear it from a scientist in the know....
Sleep good, eat better , fast for 12H every day. Lift some weights and move.
Stay calm and carry on.
Eat plants also or carnivore?
@@Bully-mu1su plants too. Get carbs from plants. Like potatoes , sweet potatoes , etc.
Only ever eat fermented vegetables not starch.@@Bully-mu1su
Meat and vegetables are all you need to improve your health. If you don't like veggies, try saurkraut.
No magic for now... but as always... great job to giving us a real landscape about mit. Just one question, talking about how phisical activity could increat mit. account... is there any study about how "mental activity" could induce similar process about increaing mit. account but in neurons?. Thank you so much for sharing you work. PD. I´m quite interested on PQQ , do you have in mind to do any video about it?.
The interweaving of science and humor in your content is sublime. More? Yes please. ❤
Deal!
Any studies on caffeine’s (ADP receptor blocker) effect on PGC1a to signal for mitochondria synthesis. Might be super relevant to lifters.
I am actually retaining this stuff. Thanks, again!
Great video, as usual. Have you by chance looked into any of the work Cohbar is doing with mitochondrial peptides?
Hey, great content. Please make an analysis of molecular hydrogen!
Thanks for featuring Martin Picard and breaking down and expanding on some of his insights. Great video.
I feel proud of promoting you, Nicolas and this, your channel in each and every antiaging forum I follow. Hope it helps you and your team to reach your goals in YT. Big Thank You. 🎉
Really kind of you. Thank you. :)
Please make a video about salt (yes, NaCl). It's a very controversial topic. I read "The Salt Fix" and "Salt Your Way to Health" both present a very interesting picture. I wonder what's your take on salt in our diet and also salt as a supplement for endurance exercise and muscle strength.
We wish to translate this teacher's channel so that all languages can benefit from it.
Great presentation, love your enthusiasm and sense of humor.
Fascinating information. Thank you.
And what about the additional use of CoQ10?
As often used extra with statins? Do you notice results right away?
20:20 what fat source? I feel great with coffe and cocoa butter early in the day, pure fat and the stearic acid is good for mitochondrial fusion as well?
Thanks!
I have a question regarding ME/CFS and the negative effects of exercise on patients with the condition, in relation to mitachondria health, which is known to be affected in these patients.
If exercise promotes good mitachondria health in a person without ME/CFS, what effect does it have on the mitachondria of ME/CFS patients, where exercise usually causes a worsening of the condition and can cause relapses that last for days, months, and years?
Is diet/fasting alone enough of a way to promote good mitachondrial health in a patient who cannot exercise?
I would appreciate any insight into this matter.
Im neither a MD nor a researcher in such a field. But maybe the capability of mitochondrial transcription or translation is in a manner affected that makes it hardly possible for the body to adapt, to the by exercise forced stress, in form of increasing the amount of mitochondria. Meanwhile existing mitochondria might lack under needed substrates to ensure proper balance in the equation of energy needed vs. energy used. Thus the overall burden of stressed mitochondria increases, since the lack of needed substrates, which already is responsible for the lack of needed energy, also leads to the incapability of a proper maintenance of the existing mitochondria.
Maybe this will result in apoptosis? What actually also leads to a lower energy-production?
But maybe that's completely wrong.
Just like a said, im not a specialized person, just a curious & interested guy.
I have CFS and have for decades. It forced me to optimize everything about my life so that I could do more than get out of bed to take a pee. After such optimization exercise became a positive element, and I suffer some relapse if I become too sedentary.
I am also thinking this is a good video for people grappling with ME/CFS. I guess as ever it is a very very gentle increase in movement over many months alongside diet optimisation that will ultimately help.
@@BllackdogFood for thought indeed. I appreciate the time and effort you put into your reply. Thank you.
@@SkyRiver1Really great to hear that exercise has become a positive thing for you, and how you went about making it so. Thank you for your reply. I hope today is a good day.
What about drugs? Bezafibrate, SR9009, MitoQ, AICAR....?
Very informational video. Would you consider making a video about exercise adaptation and antioxidants? Ubiquinol is an antioxidant yet it increases mitochondrial biogenesis, which is seemingly contradictory. There is not much info on it other than the bro science avoid antioxidants a couple hours before and after exercise.
Thanks for your work!
I have read articles that connect the dots about ME/CFS symptoms being brought about from some mitochondrial dysfunction . It is hard to imagine increased aerobics improving a ME/CFS patient's symptoms when doing so results Post Exertion Malaise (PEM).
Yes, correct... What is the solution?
Ooh, this is going to be good 😊
19:40 . . . So I suppose I should leave out the organic olive oil that I add to my organic oatmeal groats along with pepprine, so as to more readily assimilate the circumin I put in it. Or maybe just leave them all out and take them separately.
I get it!
Have you studied Inigo San Millan’s work? “Maximum mitochondria expression” zone 2 training.
The video was very informative and your humor is so dry, love it.
This is so helpful!
Can tetracyclin affect human mitochondria?
This channel has been a great discovery. Thank you for providing this service.
Thank you so much for your amazing video. Loved every minute and can’t wait for part 2. Have an amazing day 🎁🎁🌟🥁
being able to measure mitochonrial health and population is amazing, everyone knows extrinsics like emotion have everything to do with how we feel, now backed by this most fascinating area of research,, thank you for sharing this! you're a good man!!, despite having admittedly commiting murder in your lab
Just a peripheral comment on the importance of neuromuscular junction (NMJ) maintenance in enabling exercise. An NMJ is the synapse between motor neuron and muscle fiber. There are genetic diseases as well as inevitable aging that cause the motor neuron to die back, causing fewer muscle fibres to fire, in turn weakening the muscle. Much remains unknown about this process that leads to sarcopenia (muscle weakness in the aged), but it would come as no surprise to me if mitochondrial health turns out to be one of the players in this process, possibly setting off a vicious cycle of weakness discouraging exercise, in turn leading to more die-back of motor neurons.
It's cool that you're keeping things complicated. Some of the mitochondria people are alluding to or even explicitly stating a level of simple certainty which doesn't seem valid, more like ideology.
Independent of glucose is my conclusion too using a sample size of one. To redress then fasting may improve mitochondrial health in addition to reducing food overload. Thanks.
With the feelings study. I wonder if they took menstrual cycle into account. Like I feel a bit more depro in my luteal phase (2 weeks after ovulation). But like I would think the cocktail of hormone interactions over this cycle has a larger effect than the mood. Like it might be correlation not causation
You are delightful! Learned so much..thank you sunshine!! Sending love from LivelyLasVegas!!
I take cardiovascular research brand magnesium taurate. I take 4 tabs a day which is 125mgx4 of magnesium. I also supplement separate taurine at 1g. Definitely beneficial.
Is mitochondrial fission inherently bad for energy metabolism? Its function is to only dissipate the excess energy? Can the newly separated mitochondria grow in size to match the previous mitochondria after the fission?
Normal weight but osteoporosis 81 yrs on cane fracture femur stem . Anterior hip replaced 10,000 steps 4 miles today going out once more to get up hill cardio. Was sprinting bf fractured occurred picking up trash. Do weight arms shoulders grip.
Thank you, Nickolas 🌞
Very informative discussion with information I haven't seen anywhere else. Do you think keeping a stiff upper lip through adversity helps mitochondrial function?
Now that's sn amazing video ❤
Don’t worry, be happy!
Great summary - well done
I'm surprised you didn't mention David Bishop's research. He says a lot of interesting things too in podcasts.
Fascinating. Thank you!
My health is outstanding with an alternate days fasting routine (eating 8 hours/ fasting 40 hours) .
Edit: okay I did hear a mention of it.
Does “physically active” always imply aerobic exercise? Or does an average walk help? What about weight-bearing exercise? I rarely hear specifics on this.
Thank you for sharing
Great video thank you
😉 May all your mitochondria be healthy 🙏 ✨️
Moving...then, why do people with ME/CFS experience severe aggravation of their symptoms when they try to do so?
HMMM! Fascinating question.
thank you
Love your info.
How does it effect bone density? Any research?
Move and lift weights improves density of bones!
I wonder how animal consumption (full of hormones' and antibiotics) affects mitochondrial health?
Definitely better than the pesticides and antinutrients from plants.
No meat is much better for all@@rfbead321
@@veniqe Pesticides more concentraded in meat, due to bioacumulation. Antinutrients that are antioxidant, anticancer etc that are the very reason plants are healthy.
Omg the very last thing you said is the question I'm spending my life trying to find the answer to! Is keto/carnivore bad because of too much fat the our system?
Is this one way that taurine supplementation/exercise that increases taurine levels might be helpful in mitochondrial health/longevity? "Taurine deficiency and rotenone actions are similar, as both lead to reductions in complex I activity, inhibition of NADH dehydrogenase activity, reductions in respiratory activity and elevations in NADH. Because a primary physiological function of taurine is the maintenance of complex I activity, there is reason to believe that taurine therapy should reduce the severity of Parkinson’s disease (Alkholifi et al., 2015). "
On the optimum diet my view and experience tells me that titrating glucose load against use and the ability to store it as glycogen is a key factor and this declines with age due to the inevitable loss of muscle mass. As a nutritional physiologist I find it a limitation to many of these videos and nutritional papers where they link their results to fat or protein when the cells do not recognize either but rather amino acids and fatty acids and the responses are different depending on which are involved and their ratios. This is especially true for excess omega 6 fatty acids and lack of essential amino acids, especially leucine but also other factors that determine their activity.
Hi Nick could you please talk about determinants of what constitutes as a healthy weight. Thank you.
Nice! One key concept that is often missing in metabolic vids (keto, ...) is that fasting/hunger (to generate mitochondria) is more than endogenous use of MCT oil (with abundant nutrients).