Hello Dr. Ben Lynch, in what cases do you recommend Hydroxy Cobalamin Injections and what to do if B12 serum gets above 2000 pg/mL after only two Hydroxy Cobalamin injections? The dose was 1 mg per injection and spaced 1 week apart. The blood 🩸 test was done ✅ 2 months and 11 days after the first Hydroxy Cobalamin shot and I suspect it is possibly one of several reasons for daily Headaches and feeling of pressure inside of the skull 💀 What do I need to do to lower that level? Is this considered to be toxic? My PCP is just going to make me wait till my next appointment on June 30th. and I am still getting Headaches and weird feelings inside of my head... I hope Excedrin Tension Headache 🤕 would alleviate the pain! Than You!
I knew it my doctor gave me trash ,she gave me cyanocobalamin, and I was felling the same way , tired ,pain, memory loss ,and i decided to do a research about B12 and I decided do try Metylcobalamin sublingual 5000mcg ,and I feel great and alive again it was unbelievable!my levels on B12 right now is 180 of/mL and my vitamin D is 10 ng/mL she prescribed me the right amount I think 50000IU but I think 🤔 I may. Need the vitamin K2 to give a little help too! Great video doctor , I wish you could help me with the vitamin D 50000 how to take it , because I think taking the vitamin D this high alone don’t make sense for me! Thank you!
Great video! Looks like I will be getting the one that starts with an A because I have high MMA which means my mitochondria needs a little help. Thank you. very much!!!
Thank you very much for this video, one of the useful on the internet. Could you please tell me if and how the hydroxocobalamin could help improve Methylation?
If methycobalamin needs stomach acid to absorb, than why sublingual tablets and injection methycobalamin is sold? As it does not pass through stomach.😶
Harilal Patel I take vitamin B12 Kirkland brand they are dissolvable vitamins 5000mcg mythycobalamin and it works. It did for me my lab results show that when I went to my doctors they said my B 12 levels were too high. So yeah but don't know if it's a good thing or not that's why I'm searching here. K bye.
@@hiraymondduarte9176 Please don't believe those blood tests They will always show high while you're using vitamins you have to not take them for at least three weeks to a month before you get somewhat accurate Test please do more research don't let that stop you if you have symptoms keep using them I'm doing injectables and mine always show super high but as long as you have symptoms do not back off
@@sergeygayvoronskiy4753 absolutely right, it's a wastage of money to test again and again when we know improvement in symptoms are the real indicators of recovery.
I''m confused too. different doctors say different things. CVS carries mostly Cyanocobalamin. I had hard time finding methylcobalamin. I recently turned vegan and took cynaocobalamin but it kept giving me acne and I am afraid to try methylcobalamin because it can be more absorbant causing more acne? It's real confusing with different information on internet.....
Nitric Oxide is high in Multiple Chemical Sensitivity too,right? How accurate are the saliva nitric oxide test strips to determine if someones NO levels are too high ?
On my 23andme Report regarding All b12 factors I had homozygous variants on the MTRR A66G, GIF, TNC1 and a single on the TNC2. Thankfully nothing on the FUT & MTR. Also many variants on the NOS2 & NOS3 genes for converting L-Arginine into Nitric Oxide. Hydroxocabalamin B12 has recommended, BUT I have many variants on the MAT gene, resulting in excess Methionine and B12 will convert homocysteine into Methionine, and with the variants will result in excess Methionine will the B12 even the Hydroxocabalamin make things worse? I understand as well that reducing Methionine foods is the first step.
I took methylcobalamin but itnwas always high so I stopped taking it on my ND's advice. I now take my complex every other day too since it has 1000 methylcobalamin.
Awesome information! Can hydroxycobalamin be given if methylcobalamin doesn't do well with a patient, or should it only be given when nitric oxide is high?
I recently had a VERY bad reaction to Hydroxocobalamin, just one 1000mcg sublingual dose... bad anxiety, almost to the point of panic attack... stomach pain, nausea... nasty!! The next couple of days, with very little eating, I noticed some significant abdominal bloating/distension and still have it several weeks later... my Docs did many tests, liver and kidney function, abdominal ultrasound, etc... so far all normal... saw a gastro Doc, but he was a total quack. No supplements seem to help. I also have pretty bad BPH, so maybe that is contributing... but have had this for a long time, with no abdominal distension... losing weight fast, hopefully due only to my lack of appetite... next up is a pancreas MRI... jeeze... any suggestions would be very welcome.
Start with a much, much smaller dose and SLOWLY work up. One of the key symptoms of B12 deficiency is lack of appetite, and muscle wasting as a result.
What would cause a woman with Hashimoto, not to be able to take vitamin A of any kind ( not even a multi vitamin just once a month, if it has any kind of vitamin A in it ) ? Right away after just 1 vitamin A vitamin it starts doing something really bad to my bones.... they become brittle & all joints start popping & making an awful cracking sounds :'( Even with beta carotene.
Brittle bones and joint problems bring to mind fluoride. Fluoride causes calcification of tendons, ligament and arteries. It also makes teeth and bones brittle and more likely to break. So I actually have no idea about the vitamin A problem. But it seems like A is an important vitamin. I think you can get it in organ meat, like liver. I definitely stay away from beta carotene though.
hello! Would cyanocobalamin still work? Its all i can get at the moment. And i cant get anything else in a healthcare setting i know there's the risk of an allergy and shock so what can i do ?
Sandi tollette, autoimmune disorders are highly related to vitamin a deficiency, however taking vitamin a has been shown to cause toxicity because it is not the same as the vitamin a in natural products. When you are deficient in vitamin a to begin with, you notice a lot quicker the adverse effects of taking vitamin a to begin with. How well do you tolerate carrots?
Autoimmune disorders are more than likely due to Gut issues, not a vitamin, though some may make the problem seem or even be worse. You should only take vitamins to target a issue or cofactor, not just to take it. Example: Hashimoto patients have low T4. T4 is needed to assist in the FAD cycle with riboflavin, so taking B2 might be good for a Hashi patient. I would ask why take the Vitamin A, that is the one vitamin that is usually very abundant in a healthy diet (assuming healthy?). Good luck.
I just under i am taking Methylcobalamin B12 5000 mcg and notice i bend haven acidic reflexes can you please let me know if I'm using the wrong vitamin b12? Thank you
The methyl B12 caused severe bloating, abdominal pain, and diarrhea for me. I have IBS and histamine intolerance issues. Does anyone know which form would be more gentle for my situation - Hydroxy B12 or Adeno B12?
Adeno. I'm trying it out next week when it comes in. My mcv and mch were elevated. Also, try liposomal glutathione and also the other one he said. Just get them and try them and see how you feel. Methyl can lead to those issues if you have the MTHFR gene. You probably need to take adeno. I heard somewhere as well (not sure here) that methyl binds to B12 receptors blocking adeno and that it's BS. Adeno is what is needed. Not sure on hydroxy.
Paul Johnson I was clarifying what Dr. Lynch said regarding methylcobalamin and diet. The OP thought he said you need to eat red meat in order to take meb12.
Vegans can take methylcobalamin yes. What I meant was if you don't eat meat, then you need to supplement with B12 and methylcobalamin can be a game changer.
Carnivore is best for autoimmune. Vegan diet causes autoimmune. This is the truth. I deteriorated quick going vegan and eating balanced and enough calories. On carnivore, most problems went away. I slipped up recently and screwed myself over big time eating loads of processed junk without watching my B12. I'm deficient again. I have a mutation where I don't store B12.
Sorry late reply, but sounds like she used hydroxycobalamin because the COMT SNP will cause dopamine and other catecholamines to build up as COMT cannot clear them out, and hence often you end up with a over-methylated state. Since MethylB12 does not require a CH3 donor, it can make a COMT patient worse, but Hydroxyl still needs the methyl donor, and will serve to not only lower NO (assuming she needed that too) but will address the COMT issue by stablizing her methylation. Hope this makes sense. I have these two mutations +/+ so I know, cannot shut off brain or sleep well, and on top of that I have +/+ for CBS!
@@paulharris9868 Dude, thanks so much for this information, it is invaluable! I've been researching methylation for a long time and this is the first time I've read what you are saying. Thanks again
@@paulharris9868 Can you clarify a bit please? Do you mean to say you cannot shut off your brain or sleep well if you take methylcobalamin? Also, doesn't hydroxocobalamin convert to methyl and/or adeno as needed? Lastly, I'm assuming you're not taking any methylfolate, but are you taking folinic?
The reaction you’re experiencing has puzzled doctors for quite some time. Paradoxically, you may be undermethylated if you have adverse psychological reactions to B vitamins. Many of them reduce your sensitivity to neurotransmitters. Fantastic for overmethylated phenotypes that are overly sensitive, but a negative for undermethylated people that need to become more sensitive. You may want to stick to your grass fed beef or liver for b12, and try slowly adding betaine and enzymes at meal time to better digest your food (and thus increase methylation). You can also try SAM-e or methionine on an empty stomach daily to gradually increase methylation. Be aware that it takes quite awhile to correct. Up to 9 months under heavy supplementation. See a doctor trained in functional medicine, and preferably the Walsh method, for more help with this.
cyano is fine dude, all 4 types are useful and we probably want to feed our body with all of them as they are reported to help the body in different ways. I can't really stand these self proclaimed experts who make money off people giving them their own opinions as 'facts' without fully understanding the topics to begin with.
No. Cyanocobalamin isn’t present at all in nature. Microorganisms produce only three - methylcobalamin, hydroxocobalmin, and adenosylcobalamin. And those are what your body needs. Cyanocobalamin was once thought to be naturally occurring too but later discovery revealed it was activated charcoal purification process that converted some B12 into cyano version thanks to cyanide in charcoal. Industry prefers cyano because of only one reason: extended shelf life. And that’s all. Your body doesn’t need cyano form. Actually once you ingest it your body will swap the cyanide CN out. And then presumably ‘detox’ the CN. Well I’m gonna just take shorter shelf life B12.
Umm 🤔 So which one do I take if I’m compound heterozygous MTHFR? I’m still confused.
With b12, most of the time the worse you feel after taking it, the more extreme the repairs taking place
how long to improve after starting treatment?
Hello Dr. Ben Lynch, in what cases do you recommend Hydroxy Cobalamin Injections and what to do if B12 serum gets above 2000 pg/mL after only two Hydroxy Cobalamin injections? The dose was 1 mg per injection and spaced 1 week apart. The blood 🩸 test was done ✅ 2 months and 11 days after the first Hydroxy Cobalamin shot and I suspect it is possibly one of several reasons for daily Headaches and feeling of pressure inside of the skull 💀 What do I need to do to lower that level? Is this considered to be toxic? My PCP is just going to make me wait till my next appointment on June 30th. and I am still getting Headaches and weird feelings inside of my head... I hope Excedrin Tension Headache 🤕 would alleviate the pain! Than You!
I knew it my doctor gave me trash ,she gave me cyanocobalamin, and I was felling the same way , tired ,pain, memory loss ,and i decided to do a research about B12 and I decided do try Metylcobalamin sublingual 5000mcg ,and I feel great and alive again it was unbelievable!my levels on B12 right now is 180 of/mL and my vitamin D is 10 ng/mL she prescribed me the right amount I think 50000IU but I think 🤔 I may. Need the vitamin K2 to give a little help too! Great video doctor , I wish you could help me with the vitamin D 50000 how to take it , because I think taking the vitamin D this high alone don’t make sense for me! Thank you!
From where did you order sublingual? What name?
@@explore_with_sagan9596 Methylcobalamin sublingual ! Yu can find at iHerb and Amazon
Nah b12 repairs hurt. They hurt worse that the pains from deficiency.
If you have expression of comt and MTHFR, which vitamin b supplement is best and which should you stay away from?
Great video! Looks like I will be getting the one that starts with an A because I have high MMA which means my mitochondria needs a little help. Thank you. very much!!!
Thank you very much for this video, one of the useful on the internet. Could you please tell me if and how the hydroxocobalamin could help improve Methylation?
Hi Dr. LYNCH……… I’m Allergic to Nitrous OXIDE with Samters Triad..
Should I take Hydrox cobalamin?
Tnx kindly 🎉🎉🎉🎉
If methycobalamin needs stomach acid to absorb, than why sublingual tablets and injection methycobalamin is sold? As it does not pass through stomach.😶
Harilal Patel I take vitamin B12 Kirkland brand they are dissolvable vitamins 5000mcg mythycobalamin and it works. It did for me my lab results show that when I went to my doctors they said my B 12 levels were too high. So yeah but don't know if it's a good thing or not that's why I'm searching here. K bye.
@@hiraymondduarte9176
Please don't believe those blood tests
They will always show high while you're using vitamins you have to not take them for at least three weeks to a month before you get somewhat accurate Test please do more research don't let that stop you if you have symptoms keep using them I'm doing injectables and mine always show super high but as long as you have symptoms do not back off
@@hiraymondduarte9176 what about adenosylcobalamin?
@@sergeygayvoronskiy4753 absolutely right, it's a wastage of money to test again and again when we know improvement in symptoms are the real indicators of recovery.
Needs to work on his communication skills for those that are laymen. He rifled off 20 letter words like four letter words. Maybe show a visual.
4:26 I have no idea what you are talking about. I’d like to see this explained in layman’s term.
Cyanocobalamin supports garbage can... :D
Thanks to you I got rid of my OCD :) you are the best
Dr Greger recommends Cyanocobalamin? I'm confused!!
josie parkin so many Drs says dont take cyanocobalamin just because its a synthetic form，they didnt consider if its effective or not
He recommends vegan diet so go figure
@@toja466 Veganism is morally right and can be great for your health.
I''m confused too. different doctors say different things. CVS carries mostly Cyanocobalamin. I had hard time finding methylcobalamin. I recently turned vegan and took cynaocobalamin but it kept giving me acne and I am afraid to try methylcobalamin because it can be more absorbant causing more acne? It's real confusing with different information on internet.....
@@adiohead Stop spreading misinformation and the global elites depopulation diet.
What about methyl B12 and folate methylating metallic mercury and turning it into the much more toxic methyl mercury ?
Nitric Oxide is high in Multiple Chemical Sensitivity too,right? How accurate are the saliva nitric oxide test strips to determine if someones NO levels are too high ?
On my 23andme Report regarding All b12 factors I had homozygous variants on the MTRR A66G, GIF, TNC1 and a single on the TNC2. Thankfully nothing on the FUT & MTR. Also many variants on the NOS2 & NOS3 genes for converting L-Arginine into Nitric Oxide. Hydroxocabalamin B12 has recommended, BUT I have many variants on the MAT gene, resulting in excess Methionine and B12 will convert homocysteine into Methionine, and with the variants will result in excess Methionine will the B12 even the Hydroxocabalamin make things worse? I understand as well that reducing Methionine foods is the first step.
I took methylcobalamin but itnwas always high so I stopped taking it on my ND's advice. I now take my complex every other day too since it has 1000 methylcobalamin.
Try adeno.
Awesome information! Can hydroxycobalamin be given if methylcobalamin doesn't do well with a patient, or should it only be given when nitric oxide is high?
+JeremyKirstin Herbert You're hotcobalamin
+JeremyKirstin Herbert Yes, but you should also supplement adenosylcobalamin with hydroxy-b12.
I recently had a VERY bad reaction to Hydroxocobalamin, just one 1000mcg sublingual dose... bad anxiety, almost to the point of panic attack... stomach pain, nausea... nasty!! The next couple of days, with very little eating, I noticed some significant abdominal bloating/distension and still have it several weeks later... my Docs did many tests, liver and kidney function, abdominal ultrasound, etc... so far all normal... saw a gastro Doc, but he was a total quack. No supplements seem to help. I also have pretty bad BPH, so maybe that is contributing... but have had this for a long time, with no abdominal distension... losing weight fast, hopefully due only to my lack of appetite... next up is a pancreas MRI... jeeze... any suggestions would be very welcome.
Start with a much, much smaller dose and SLOWLY work up. One of the key symptoms of B12 deficiency is lack of appetite, and muscle wasting as a result.
@@DDumbrille Interesting i have had lack of appetite as a symptom!
@@DDumbrille hmm i just started taking b12 and I eat a lot more
What would cause a woman with Hashimoto, not to be able to take vitamin A of any kind ( not even a multi vitamin just once a month, if it has any kind of vitamin A in it ) ? Right away after just 1 vitamin A vitamin it starts doing something really bad to my bones.... they become brittle & all joints start popping & making an awful cracking sounds :'( Even with beta carotene.
Hypersensitivity reaction? Try N.A.E.T. then learn about and apply detoxiification of the body in depth.
Brittle bones and joint problems bring to mind fluoride. Fluoride causes calcification of tendons, ligament and arteries. It also makes teeth and bones brittle and more likely to break. So I actually have no idea about the vitamin A problem. But it seems like A is an important vitamin. I think you can get it in organ meat, like liver. I definitely stay away from beta carotene though.
hello! Would cyanocobalamin still work? Its all i can get at the moment. And i cant get anything else in a healthcare setting i know there's
the risk of an allergy and shock so what can i do ?
From my understanding Hydro b12 is the only kind to help detox metals
Sandi tollette, autoimmune disorders are highly related to vitamin a deficiency, however taking vitamin a has been shown to cause toxicity because it is not the same as the vitamin a in natural products. When you are deficient in vitamin a to begin with, you notice a lot quicker the adverse effects of taking vitamin a to begin with. How well do you tolerate carrots?
Autoimmune disorders are more than likely due to Gut issues, not a vitamin, though some may make the problem seem or even be worse. You should only take vitamins to target a issue or cofactor, not just to take it. Example: Hashimoto patients have low T4. T4 is needed to assist in the FAD cycle with riboflavin, so taking B2 might be good for a Hashi patient. I would ask why take the Vitamin A, that is the one vitamin that is usually very abundant in a healthy diet (assuming healthy?). Good luck.
I just under i am taking Methylcobalamin B12 5000 mcg and notice i bend haven acidic reflexes can you please let me know if I'm using the wrong vitamin b12? Thank you
So I was gonna ask a question but he ain’t answer not one question on here😕
Is mecobalamin and methycobalamin the same?
The methyl B12 caused severe bloating, abdominal pain, and diarrhea for me. I have IBS and histamine intolerance issues. Does anyone know which form would be more gentle for my situation - Hydroxy B12 or Adeno B12?
Adeno. I'm trying it out next week when it comes in. My mcv and mch were elevated. Also, try liposomal glutathione and also the other one he said. Just get them and try them and see how you feel. Methyl can lead to those issues if you have the MTHFR gene. You probably need to take adeno. I heard somewhere as well (not sure here) that methyl binds to B12 receptors blocking adeno and that it's BS. Adeno is what is needed. Not sure on hydroxy.
I think you need to try them to see what works for you. Adeno caused an immediate histamine response in me.
Hey Doc! I was just diagnosed with pernicious anemia. Hydroxo?
I don’t find pills work well for that. You should eat some liver every day.
What's the best way to support glutithione levels?
Coffee, folate, meat based diet
N-Acetyl-Cysteine
Very interesting and informative. Thank you.
Does hydroxycobalmin need glutathione also?? For support
I ate a pound of beef and my heart palpitations were gone for days!
what about taking citrulline if it elevates NO? i have chronic low back pain...
So Vegans should not take the good methy-lcobalamine (because for this you need to eat red meat?), we should take cyno-cobalamine???
No garbage the cyan-cobalamine :)
Vegan's should take methylcobalamin, because they don't eat many natural sources of B12. (Meats, eggs, dairy, etc...)
Careful with blanket statements, they might benefit from hydroxyl B12 more depending on their current methylation state and genome.
Paul Johnson I was clarifying what Dr. Lynch said regarding methylcobalamin and diet. The OP thought he said you need to eat red meat in order to take meb12.
Vegans can take methylcobalamin yes. What I meant was if you don't eat meat, then you need to supplement with B12 and methylcobalamin can be a game changer.
Has anyone cured themselves from any autoimmune disease through vegan or other type of diet?
Horacio Renderos not sure you can ‘cure’ autoimmune diseases, but I take Restore4Life for my coeliac
Gabriel Arruda did, he's on youtube.
Carnivore is best for autoimmune. Vegan diet causes autoimmune. This is the truth. I deteriorated quick going vegan and eating balanced and enough calories. On carnivore, most problems went away. I slipped up recently and screwed myself over big time eating loads of processed junk without watching my B12. I'm deficient again. I have a mutation where I don't store B12.
Is it possible to get adenosylcobalamin injections anywhere?
Arnika-Apo
But just for shits and giggles.. which one is good for high cholesterol.. I didn’t understand nothing you said up there fam
thank you v
for this video it helps me to u understand better had i bought hydroxycobalamin for my COMT val158met mutation
+Stephanie Wilkerson how you treat it?
Sorry late reply, but sounds like she used hydroxycobalamin because the COMT SNP will cause dopamine and other catecholamines to build up as COMT cannot clear them out, and hence often you end up with a over-methylated state. Since MethylB12 does not require a CH3 donor, it can make a COMT patient worse, but Hydroxyl still needs the methyl donor, and will serve to not only lower NO (assuming she needed that too) but will address the COMT issue by stablizing her methylation. Hope this makes sense. I have these two mutations +/+ so I know, cannot shut off brain or sleep well, and on top of that I have +/+ for CBS!
thank you i did order hydroxycobalamin hard to find i do shots weekly
@@paulharris9868 Dude, thanks so much for this information, it is invaluable! I've been researching methylation for a long time and this is the first time I've read what you are saying. Thanks again
@@paulharris9868 Can you clarify a bit please? Do you mean to say you cannot shut off your brain or sleep well if you take methylcobalamin? Also, doesn't hydroxocobalamin convert to methyl and/or adeno as needed? Lastly, I'm assuming you're not taking any methylfolate, but are you taking folinic?
Wow!
Can I take Grass Fed Beef Liver for my vitamin B12 deficiency?? I don't do well on B vitamins, my symptoms become worse
The reaction you’re experiencing has puzzled doctors for quite some time. Paradoxically, you may be undermethylated if you have adverse psychological reactions to B vitamins. Many of them reduce your sensitivity to neurotransmitters. Fantastic for overmethylated phenotypes that are overly sensitive, but a negative for undermethylated people that need to become more sensitive.
You may want to stick to your grass fed beef or liver for b12, and try slowly adding betaine and enzymes at meal time to better digest your food (and thus increase methylation). You can also try SAM-e or methionine on an empty stomach daily to gradually increase methylation. Be aware that it takes quite awhile to correct. Up to 9 months under heavy supplementation. See a doctor trained in functional medicine, and preferably the Walsh method, for more help with this.
cyano is fine dude, all 4 types are useful and we probably want to feed our body with all of them as they are reported to help the body in different ways. I can't really stand these self proclaimed experts who make money off people giving them their own opinions as 'facts' without fully understanding the topics to begin with.
Yes cyano is fine. Cyano is superior in shelf life and stability because it is so stable.
better research on cyano, too -- thanks so much for saying this.
No. Cyanocobalamin isn’t present at all in nature. Microorganisms produce only three - methylcobalamin, hydroxocobalmin, and adenosylcobalamin. And those are what your body needs. Cyanocobalamin was once thought to be naturally occurring too but later discovery revealed it was activated charcoal purification process that converted some B12 into cyano version thanks to cyanide in charcoal.
Industry prefers cyano because of only one reason: extended shelf life. And that’s all. Your body doesn’t need cyano form. Actually once you ingest it your body will swap the cyanide CN out. And then presumably ‘detox’ the CN.
Well I’m gonna just take shorter shelf life B12.
Biased review by the MTHFR-obsessed Dr. Lynch
Mhmm. MTHFR is real and more research is coming out every day.