The consequences of angering God.

Supernatural. Season 15, Episode 10.
Dean and Sam are two brothers. Born into the Winchester family, they have an inherent responsibility in their blood - to become "hunters" who specialize in dealing with demons and supernatural forces that harm mankind. 22 years ago, their mother was poisoned by a demon, so their father John spent many years trying to hunt down the demon while training the two brothers to become excellent hunters.