Cortisol and TRT: Can TRT Reset Your Body's Stress Response?
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- Опубликовано: 4 июл 2024
- Testosterone Replacement Therapy and its Impact on Cortisol Levels: A Detailed Review
In this informative video,. We dive deep into the relationship between cortisol and testosterone replacement therapy. Drawing from clinical experience and scientific studies, the video elucidates the stimulating and calming effects of testosterone. It also explores how different doses of testosterone affect cortisol levels, potentially influencing sleep quality and stress levels. Dr. Terranella discusses the results of studies conducted on healthy males and examines the conditions under which testosterone replacement therapy may blunt or enhance cortisol response. The video presents a nuanced perspective on testosterone's impact on cortisol and how an optimal balance is required for a healthy stress response.
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
00:00 Introduction to Cortisol and Testosterone Replacement Therapy
00:47 Effects of Testosterone on Mood and Cortisol Levels
01:47 Clinical Observations and Dose-Dependent Phenomenon
02:07 Scientific Studies on Testosterone and Cortisol Interactions
03:49 Understanding the Mechanism of Testosterone and Cortisol Interactions
05:31 Personal Clinical Experience and Estrogen's Role
06:20 The Bell Curve of Testosterone Replacement Therapy
07:03 Monitoring Cortisol Levels and Final Thoughts
Are you wondering about the connection between cortisol and testosterone replacement therapy? In this video, we're going to look at this specific question. We're going to look at my clinical experience, cortisol and testosterone replacement therapy. I'll also give you some tips and clues on what you can do if you think you might have a problem with cortisol from your testosterone replacement therapy.
Testosterone can work like a mood stabilizer and can also be a bit stimulating to the neurons in the central nervous system. So, in this way, testosterone can both have a calming effect and also a stimulating effect. Strictly speaking to what I see in my practice, this is more or less what I observe in some people, and at certain doses, testosterone will raise cortisol. With this raise in cortisol, there can be impairments in sleep quality. On the other hand, in other people, there can be improvements in stress levels and stress tolerance. Sleep function and actual cortisol levels can improve as well. This improvement in the stress response can happen at doses that are higher than what's seen in people who are having the opposite kind of response. So, it can be difficult to predict what kind of response you're going to have, but that increased stress response, increased cortisol response is not that common, even in people who tend to have more anxiety or higher stress. However, these are the people that generally you want to be more cautious with in terms of the dose that you're going to give because it does seem to be a dose-dependent phenomenon. But what's actually occurring here to create such divergent effects in different people? Let's see what kind of evidence we can find for either of these situations. In one study, it suggests that testosterone replacement therapy has a suppressive or blunting effect on the cortisol response at the adrenal glands. Still, we want to interpret this study with caution because it was a smaller study. Let's look at it in a little more detail. The study involved healthy male volunteers age 18-45, and they didn't have any medical or psychiatric problems.
There were 11 male participants who had undergone suppression of the hypothalamic-pituitary-gonadal axis. Some were given testosterone replacement therapy and some were not. In addition, the corticotropin-releasing hormone, which is what comes from the brain and stimulates the pituitary, which then stimulates the adrenals to make cortisol, was given as a stimulation test to assess the type of response under high or low testosterone conditions, or just normal testosterone conditions. What they found was that those receiving testosterone replacement therapy resulted in a blunted cortisol response to the corticotropin-releasing hormone stimulation. They found an overall decrease in total cortisol and a decrease in peak cortisol production. This actually occurred even though the testosterone replacement therapy led to an increase in the ACTH response compared to placebo. So, the ACTH, which comes from the pituitary, was stimulated by the corticotropin-releasing hormone to be produced. But then that ACTH is what stimulates the adrenal glands to make cortisol. What this study seems to suggest is that there may be a reduced cortisol response during testosterone administration in terms of the sensitivity to the ACTH at the adrenal gland, so there's not as much output of cortisol being produced. 
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Hello Dr, thanks for uploading this info.
So, in short, what is making cortisol go down is a high E2?
Am i right?
I had horrible flares of Arthritis Rheumatoid, so i was suspecting of low cortisol.
My blood test showed T. Free 91,5 pg/ml and E2 90pg/ml when the normal values are 6,1pg-26,5pg for T, and up to 56pg for E2.
I am getting better as i lower the dose to half, that is 0,3ml of Cipionate monday and 0,3ml Thrursday. Thats about 100mg of testosterone a week without the ester.
So higher Estradiol = Lower Cortisol?
What this research suggests is the “right amount” of testosterone can lower cortisol. not everyone is the same that way though as was suggested in the video. Cortisol naturally lowers inflammation but in chronically inflamed people it can raise inflammation. Our bodies are super intricate and there is a lot we don’t know or can’t measure.hope that helps
Months ago my level crashed after missing my script due to miss communication.Just tested my cortisol levels and was in normal range.but during that time i felt terrible after few weeks and going nack to my .5cyp felt better however still feeling like something is off..hate this feeling almost regretting trt.
Might need to recheck now that you are back on it.
@@swintegrative just got my bloodwork back my numbers was 714 over all 240H estrogen was also high 55 out of range my Rdw was 17.4H and rbc 5.93h everything else was normal range..everything was fine until i crashed i got some extra body fat to lose but damn. Planning to give blood on my next day off to drop rbc down.
Hello. A had to stop a 3 month TRT because in moderate stressful situations I have some kind of anxiety attacks with tachycardia, weakness and sometimes chills. Its been a month since I have stopped but my stress response is still bad. Will it go away by itself? I was taking 250mg testosterone enanthate a week. In how much time will the body adjust estrogen or cortisol in order to heal this problem with stress response?
Difficult for o know for sure it may be best to see a doctor that can help you sort it out. Functional medicine naturopathic doctor.