Boron is noted for lowering SHBG. Also Proviron ( mesterolone ) is effective for lowering SHBG and restoring Testosterone levels in men with symptoms of low testosterone. Proviron is legal and available here in UK to buy for personal use and in most countries but not in USA at the moment...
Boron will increase it for 1-2 weeks, later it will have the opposite effect and increase it alongside estrogen... This is well-known and supported in scientific literature.
@@jordixboy it depends on the dose..various studies using various doses makes a difference...high doses of 10 mg works less effectively at some stage, however a lower off and on dose of 3 mg had a much long term effect...individuals differ.. Best is to see how each person responds .... higher dose usually backfires.. most studies used 10 mg Boron which ultimately has less effect....
shbg - 120 nmol/l --- abnormally high free T - 80.9 pg/ml --- normal range 3 total T results (all within 6 weeks - natural) - 1492, 1500 and 1165 ng/dl - abnormally high My blood panel showed all my other hormone results to be within normal range or just slightly on the high end, but nothing abnormal. Anyone ever experience these similar levels and if so what did you do to get everything back in normal range?
estradiol is likely high d/t high testosterone levels. This will then driving up shbg. If u are not taking something to raise your testosterone you should have an evaluation with a doctor.
@@swintegrative Thanks for the response! Estradiol was at 43 pg/ml which i believe is a bit on the high end, but nothing abnormal. The endocrinologist suggested there was nothing i could do about it and that i would be fine. I respectfully disagree with his diagnosis so i am going to get a second opinion.
@@rob2878 not a bad idea but I would not be too concerned either. The only concern with high testosterone is that it is coming from testicular cancer .once you rule this out, it seems fine. good luck
I have high levels of this, calcium, and cholesterol. Would these 3 things be connected as why they are all 3 high? And what could be the causes of this?
i went on to TRT due to low T symptoms. and, to hopefully lower my SHBG. after 7 weeks of 100mg/week of cypionate my total T has gone up significantly, but my free T is so low that it is not testable at all on a blood draw (result is NC). my SHBG is well over 200. my estradoil is not high, but i have gyno.. i'm frustrated and a little worried. i'm fit, healthy, gym training.. and have been all my life. would appreciate some advice..
I'm not a doctor but a small dose of proviron or masteron enanthate would be a great addition to your TRT. Good luck getting a doctor to prescribe you any.
Super active 40 year old male. Healthy diet. Lean body mass: SHBG- 117nmolL Total testosterone- 151.4ng/dl Free testosterone 2.2 pg/dl Dihydrotestosterine 4 ng/dl LH 2.9 Estrodiol
What about iron overload ? I was wondering whether very high SHBG might be a safety mechanism when the red blood count is already too high and the body decides to shut down free T because testosterone increases haemoglobin on its own account. Hemachromatosis is a silent killer after all.
Not that I know of and I don’t think SHBG binds iron. It binds testosterone but the increase in RBC from testosterone is not the same problem of high iron in hemochromatosis. They are different problems and mechanisms.
@@swintegrative I meant: when there is chronic iron overload and there is a risk of RBC getting dangerously high, the body might increases SHBG production (by some currently unknown mechanism) in order to get low FT so that there is no further stimulation of RBC production from that source. I say this because as an otherwise fit and healthy 63, I have extremely high TT (32 nmol) and SHBG (120 nmol), high ferritin saturation and very low (symptomatic) FT.
It all depends what you are optimizing for SHBG in and of itself it not something to be worried about it is in the context of your health symptoms and problems that it is relevant.
Job well done. Question --- since it is produced in the liver. Would focusing on clearing out the liver/liver detox; glutathione and/or NAC be a good place to begin as well? Yes, cleaning up the diet: Gluten/Wheat/Dairy/Soy/Sugar --- of course. My wife has a SHBG of 169.0 and testosterone, serum at 15, Free Testosterone (direct) at 1.4. Her Doctor says the Test values are below normal range and clearing up the liver/diet is a good place to begin. Thank you for your help.
Great Video! 68years old T.729 But B.Globulin 80 nmol/l and Bioavailable 87.6 ng/dl. I think I was on the second day of a 5 day fast when taking. Any thoughts?
Hey there, I’ve got a bit of a weird one personally. 24M, my SHBG is 10, my thyroid, liver, kidney, lipid are perfect. I am lean enough for ab visibility. Muscle mass high, never take anything exogenous. test is in the low range of normal 12nmol/L. oestradiol is above average 132 pmol/L. my endo is saying my shbg is genetic. is this true or do I have something to be worried about?
@@swintegrative okay fair enough. unsure if you’d find this interesting but I got a bit fed up of my hormonal inbalance and started taking an aromatase inhibitor two weeks ago. received my results today and my testosterone has near tripled, oestradiol halved, prolactin halved, LDL decreased and triglycerides also decreased. I call that a successful self diagnoses (albeit a very very meticulously researched one)
Hello doc, I've watched numerous videos regarding SHBG, and I cannot understand couple fundamental things: is the purpose of it to help transfer hormones throughout the body, or to remove excess hormones by binding? Because two functions are contradicting. Some people say that low T increases shbg so there's more chance it grabs and transports T to tissues, some people say low T drops shbg so it doesn't bind and lessens availability of remaining T. so I guess the main question is - how does shbg help transport T to the tissues, if it strongly binds to it and doesn't let go? and if it does let go of T, then why having low free T is a problem? is it and indicator of shbg not letting go T well enough? Much thanks for clarifications on these mechanisms.
not sure i can answer these question simply... when androgens bind to receptors that is when the androgen has its effect. SHBG prevents this binding. It is there so the hormone can get distributed through the body and not bind to every receptor close to where it is secreted. hope that helps.
@@swintegrative thanks for reply. but the mere fact shbg is there to "distribute" means that unbinding is happening at the local site later... otherwise it would not distribute, the free T would still bind all at one concentrated place, and SHBG-T would circulate forever until excreted.... no?
47yo, SHBG is 75, total test is 798, NO free t, no insulin resistance, low estrogen, normal estradial, can't lose weight but don't have much, not diabetic, mild ed, runner and active, no one knows what's going on!
I cannot find any information on men with: low-normal SHGB/low-normal total testosterone/elevated (just over the lab range) of free testosterone. What does this mean? My A1C was high-normal (just before “pre-diabetic”. I have read insulin resistance can lower SHBG, but I’m not even pre-diabetic, yet.
Total Testosterone - 1139.0 Free Testosterone- 15.68 SHBG- 70.3 (High) I’ve been vegan for 8 years, I’ve done intermittent fasting now for 2 years now. I’m 6’5” about 240lb. I workout regularly. Is there anyway to low my SHBH?
Hi, after 5 months of using birth control, my SHBG levels are very high (260 ish). How long does it take to get back to normal limits after quitting the bc pills?
age 23 SHBG:77.9 nmol/l Albumin 5.1 g/dl TT:580 ng/dl Estradiol: 23 pg/ml LH 5.8 miu/ml prolactin 11.4 ng/ml i believe i have this since puberty what are my options i live healthy life style
Hello thank you for the video. My labs recently were Male 30y/o weight 165lbs. Height 5’7”. Body fat 10 percent lifting 4 days per week compound cardio 2 times caloric surplus by 100 a day Total t 704 Free T direct 7.7 low E2 29.1
@@swintegrative Sucks for this to be the only answer. Why is it th guys who take of themselves and family are targeted with something outside of their control. Naturally high shbg plus extremely low free t with normal total t, at age 22, I lift 6 days a week. Feels like I've been cursed. One thing I have noticed that is recurring is that 95 percent of guys with these symptoms are physical active.
@@swintegrative looking forward to it. Everytime I ask a traditional primary care Dr. How to eliminated accumulated fat on the liver as indicated by ultrasound, I get a blank stare. Well, among a lot of things.
Hello Doctor I am from India. My name is Nikunj and I am 14 year old boy. I am suffering, (*sorry) having T1D (Type 1 Diabeties) but actually having a good control on sugar levels as I am taking Insulin and monitering blood sugar levels. But I have other problem in my body, I am growing hair all over my body, like arm hair, chest hair, hairy legs, and unwanted hair growth of forehead and surface of nose. None of my friends have this issue and I think I am having high testesterone. I went to dermatologist and she prescribed me two tests. One is testesterone serum and other one is the thing you are talking (SBHG). The only doubt now I have is, Is it anything connected to T1D? If I take medications for controlling Sbhg or testesterone levels, will it affect my diabeties? Or even any other hormones in my body? If yes, please inform doctor 😊 Subscribed your channel
I found one RUclips video of a fellow saying he lowered his iron saturation and his SHBG decreased. I’m in same boat with high iron sat and high SHBG. Could high iron saturation raise SHBG?
Hi. I have very high SHBG and very low progesterone. Does it mean I can have PCOS? Also suffer from hairloss. Might caused by this hormonal imbalance? Thank you
@@swintegrative Wow! How did you know and high andogrens and DHEA-S according to the DUTCH Test. My serum blood for estrogen and progrsterone is normal.
I saw two endocrinologist. Im a male, My Estrogen is above 250 with two test. Both Endos say this is nothing to worry about. I do not do any HRT. I don't believe them and I'm worried. Any advise?
Estradiol is what is important and you want to check the Ultra sensitive estradiol too. There r genetic alterations in aromatase enzyme but idk without knowing your whole picture…
dd a blood test at 9:00 am . Im 28 y old . Total testosterone higher than norms : 29,5 nmol/L ( normal range 8.64-29) . SHBG extremly high : 84,5 nmol/L (normal range:18,3-54,1) Free testosterone "in the frontiers of low" : 34,9 (normal range: 35-93). Why SHBG are so high ? i mean difference of more than 30 nmol/L makes me concerned ...I measure around 176 cm , 68 kg , muscular wide but with no fat ,and i look way masculine ( i do not have a full beard by the way , but my body shape , face are way masculine) .. And also in the blood test icteria was positive (theres like levels of icteria like +or ++ or +++ i believe by writing " positive" means + Noticed that at 28 years old my larynx "developped and become prominent" , while the length of my neck increased 1 or 2 cm ( before 27 i was more in the 174 cm with a very short neck ) With the neck thing and the larynx who became prominent i mean can be related to thyroid?
Thanks for the video! I just got an at home Testosterone test done and my test levels where normal, but my SHBG was a bit high. I've been in a modest caloric deficit for roughly 14 months losing about 1.5 lbs per month and I've done so via intermittent fasting and tracking my calories. Sounds like there's a decent chance this is the reason for my slightly higher SHBG. Going to go off intermittent fasting and see how I feel and go get retested.
Watched a lot of these videos and no one as of yet tells you the range. I got three blood test, dates 4/6/23 SHBG 68.9 - Range 19.3-76.4 One lab. Second lab: 4/20/23 SHBG 57.2- *Range 22-77; Third lab: 5/15/23 69.5- *Range 21.4-67.8. So the third lab shows out of range according to the range all three were out of range if I used the thrird lab range. Anyone know what the true range is?
Reference ranges are based on the sample population averages so they will vary with said sample size. That’s why when you reach the high end or low end of a reference range, even if within the range, it’s good to look at it more carefully.
Hi, Would you be able to help me. I am 26’year old female. All my blood work came back as normal apart from SHBG. What could this mean? I’m not on any medication or have any health issues. I was also told this is the reason as to why I have irregular period too
Hi Amina, it is hard to know what you mean by "all my blood work" different doctors test for different things. Insulin resistance and high insulin is a very common cause for high SHBG. You need to find a doctor that can look a little deeper than the surface level, like a functional medicine doctor.
I found out I have very high SHBG I also have PMDD so I think that maybe why. I also have low progesterone and estrogen. What do u suggest would be a good way to fix this?
My shbg runs high, free testosterone was low. I recently switched from testosterone cream to injections, due to fear of the cream getting on my children. My estradiol runs on the low side, since I am 45 and perimenopausal. I am on a low dose estradiol patch and 50 mg compounded estrogen, due to very low estradiol levels ( night sweats, fatigue, achy legs, etc). Testing still indicates lower in the range, but within the range estradiol. I am also on a combination of levothyroxine and sublingual Np thyroid. Two questions. 1- could the thyroid medication or transdermal estrogen be driving shbg up, despite my levels being in normal ranges? ( I don’t have a thyroid). 2- it could be a coincidence, but I am noticing that the two days after I inject 15 mg of testosterone cyprionate, I’m irritable and a little sad. Could it be the testosterone? Could taking testosterone cause a temporary increase in shbg, causing these moods, or is it just estradiol that does it? I’m perimenopausal, do I get moody, but it is just weird that it’s the couple days after I inject the testosterone.
Hi Katie Bugs Room. Here are a couple things to keep in mind, estradiol is the main estrogen that should be tested. The ranges for this vary widely through your monthly cycle. If you are not checking at the same time of the your cycle each month, the results don't mean much. The issues mostly like is coming from too much estradiol not too little. Estrogen increase SHBG. Testosterone increases estradiol. Typically women in perimenopause have estrogen dominance already. It is possible that you don't but you might be getting too much now. Hope that makes sense.
Great info ......doc my shbg is 64.1 noml/l total test 19.4 noml/l and free test is 0.266 noml/l ....my doc in uk says it’s normal but iv had low t symptoms for years and it’s affecting my quality of life ....in yr expert opinion from my results do u think I need trt or just something to lower my shbg....I’m 40 years old and would really appreciate yr knowledge...thank u
hi! i’m a 20 year old female and just had a fasting blood test done. my shbg was 190.30 nmol/L and my t3 was slightly high at 4.1 pg/mL. i was wondering if these had any correlation? thanks!
Hi. My total test is 854ng/dl. Free T is 16.3pg/ml , SHBG 54.3 Nmol/l and estradiol 43 pg/ml(slightly higher than normal range). I went to the doctor for mild to moderate. ED. He thinks it’s just psychological and gave me a Cialis Rx. Do you think my slightly higher than normal SHBG and estradiol could be causing it? I was thinking of taking a mild aromatase inhibitor to see if it will lower my estradiol and SHBG. He thinks I’m fine because my testosterone is high
Hello Logan! A free T of 16.3 pg/ml is decent. High or high normal estradiol can have a negative effect on erectile function. It won't do this to everyone though. It may be worth while to have a closer look look at the estradiol and check the MS/LC estradiol. This is a more accurate test.
Hi, I'm confused as to why my SHBG is 173, my total testosterone is 53. I'm a 30 year old female. I have read that it usually isnt like this. I've never had birth control. Any insight on what might be going on? My progesterone to estrogen ratio is 45.16.
Hi Samantha, high estrogen is often a cause but bc estrogen is changing all the time (with your cycles), you have to check at different times of the month. Also you have to check when you are non-fasting as the level will be lower.
Hi Tina, It sounds more like your estrogen is high. Androstenedione is converted into either testosterone or estrogen. Since you have high SHBG I would predict higher estrogen levels. As for the question why is harder to answer but the production of androstenedione comes from adrenal glands and the ovarian tissue. Do you have a direct measurement for estradiol or testosterone?
Hi. I'm a 64-year-old male that works out 3-4 times a week. I do HIIT and lift weights. I also do intermittent fasting 16/8. . My total T is 1086 (high). SHBG is 89.00 (high) Free Adrogen is 42 (normal) and Free Testosterone is 12.9 (normal). I was taking a "natural" testosterone booster which I stopped when I get these results. I did have prostate cancer 3 years ago and did 2 rounds of brachytherapy radiation I am cancer free now. It runs on both sides of my family. I knew I was going to get it, just didn't know when. I didn't know if that could have something to do with this?
Hi My testosterone was high at 42nmol/l and SHBG high at 79nmol/l so it worked out my free testosterone was in normal range. Should I worry or is there anything I can do 🤷♂️?
Hi John C, total testosterone of 756 ng/dl seems normal to me. I would not worry but if you have low T symptoms, you might want to look into it more. You do have to check the SHBG in fed and fasting states bc it will change with this.
hey im 34/male, gym 3-4 times a week, higher protein diet, moderate fats and carbs and eat at maintenance calories and im not to sure why my shbg is so high love to hear your thoughts thanks in advance , my blood results are thyroid fuction : TSH - 4.2 miu/l free thyroxine - 18.100 pmol/l testosterone - 27.4 nmol/l free test - 0.308 nmol/l SHBG - 82.8 nmol/l *** oestradiol - 65.9 pmol/l
Yeah that SHBG seems really high but I am use to different units. Have you had an estradiol done with MS/liquid chromatography? This estrogen seems normal but would be curious what the more accurate test shows. Was the test done fasting?
21 y/0 male = no past medical history only surgeries = Tommy John and Labrum slap 3 repair. Results are below. Seeking clarification = has seen 3 endocrinologist and all have different responses Free T = 899 SHGB = 63.4 Albumin = 5.2n T4 = All within normal range BMP = All within normal range No sex drive, losing weight and body mass, no history of diabetes in the family, loss of appetite, depression. All onset of symptoms for the last 3 months and no reason for this complete overall health change. Please help, I don't know where else to ask for assistance
Hi Beatriz, get a comprehensive evaluation of digestive tract (through a naturopathic or functional medicine doctor). You may not have any overt digestive symptoms but it is a common source for chronic health issues of unknown etiology. Also is that total testosterone or free? what are the units?
Yes it can because if something is causing high SHBG there is less bioavailable testosterone (low free T). Low Free T can cause low libido and ED. The part that does not fit is the sperm count. To my knowledge SHBG does not relate to sperm count.
What would it mean if both my shbg and my testosterone is high? I did start birth control for regulation of hormones/period but I always see that the relationship for the two is that one is high and one is low
Hi Yolinna, high estrogen/ estradiol is a common cause of high SHBG in females. I'm not sure how your BCT will affect affect SHBG. It will reduce your bodies estradiol and therefore reduce SHBG. Because some BCT contain estrogen, it will likely increase SHBG more. There are too many variables to know for sure without and in depth evaluation.
Hi!. I'm 27 male without libido problems, with quite good body composition. There are my last lab results with ranges: Albumin 46.1 g/l (35 - 52) FSH 5.06 mlU/ml (1.50 - 12,40) LH 4,64 mlU/ml (1.70 - 8.60) Estradiol 18,10 pg/ml (11.30 - 43.20) Prolactine 11.70 ng/ml (4.04 - 15.20) Total Testosterone 864 ng/dl (249 - 836) SHBG 65.76 nmol/l (18.30 - 54.10) I've calculated free testosterone, it is 12.2 ng/dL. So basically my total testosterone and SHBG are above range, free testosterone is below. What can be the cause of this result?
I’m a 28 year old male. My total T is 741 ng/dl, free T is 18.09 ng/dl, and my SHBG is 54 nmol/L which all seem to be on the higher end of normal. I don’t understand why my SHBG is this high given the amount of free testosterone I have. My estradiol was measured at 34 pg/ml which is also on the high side of normal. Could that be the reason why my SHBG is on the higher end?
You are underestimating this issue for high shbg low free test one and normal test one. Fix all of these and nothing changes it's like a curse. All of ot these guys with the symptos of mentioned in the beginning are aslo physically active. So its not like their a guy that jacks off all day and eat what ever they want.
First half is a useless intro, second half lists a few irrelevant reasons like infections, but not one useful or relevant piece of info. Waste of time.
![Lil Uzi Vert - Chill Bae [Official Music Video]](http://i.ytimg.com/vi/D7F42F_JM3U/mqdefault.jpg)
Boron is noted for lowering SHBG. Also Proviron ( mesterolone ) is effective for lowering SHBG and restoring Testosterone levels in men with symptoms of low testosterone. Proviron is legal and available here in UK to buy for personal use and in most countries but not in USA at the moment...
Boron will increase it for 1-2 weeks, later it will have the opposite effect and increase it alongside estrogen... This is well-known and supported in scientific literature.
@@jordixboy it depends on the dose..various studies using various doses makes a difference...high doses of 10 mg works less effectively at some stage, however a lower off and on dose of 3 mg had a much long term effect...individuals differ.. Best is to see how each person responds .... higher dose usually backfires.. most studies used 10 mg Boron which ultimately has less effect....
Great video. You should buy a microphone, will make them even better!
Thanks I have a much better setup now.
Mt SHGB is 198... I've been plant -based for the past 10 years.
shbg - 120 nmol/l --- abnormally high
free T - 80.9 pg/ml --- normal range
3 total T results (all within 6 weeks - natural) - 1492, 1500 and 1165 ng/dl - abnormally high
My blood panel showed all my other hormone results to be within normal range or just slightly on the high end, but nothing abnormal.
Anyone ever experience these similar levels and if so what did you do to get everything back in normal range?
estradiol is likely high d/t high testosterone levels. This will then driving up shbg. If u are not taking something to raise your testosterone you should have an evaluation with a doctor.
@@swintegrative Thanks for the response! Estradiol was at 43 pg/ml which i believe is a bit on the high end, but nothing abnormal.
The endocrinologist suggested there was nothing i could do about it and that i would be fine. I respectfully disagree with his diagnosis so i am going to get a second opinion.
@@rob2878 not a bad idea but I would not be too concerned either. The only concern with high testosterone is that it is coming from testicular cancer .once you rule this out, it seems fine. good luck
I have high levels of this, calcium, and cholesterol. Would these 3 things be connected as why they are all 3 high? And what could be the causes of this?
Not likely connected
i went on to TRT due to low T symptoms. and, to hopefully lower my SHBG. after 7 weeks of 100mg/week of cypionate my total T has gone up significantly, but my free T is so low that it is not testable at all on a blood draw (result is NC). my SHBG is well over 200. my estradoil is not high, but i have gyno.. i'm frustrated and a little worried. i'm fit, healthy, gym training.. and have been all my life. would appreciate some advice..
I'm not a doctor but a small dose of proviron or masteron enanthate would be a great addition to your TRT. Good luck getting a doctor to prescribe you any.
Check growth hormone?
Super active 40 year old male. Healthy diet. Lean body mass:
SHBG- 117nmolL
Total testosterone- 151.4ng/dl
Free testosterone 2.2 pg/dl
Dihydrotestosterine 4 ng/dl
LH 2.9
Estrodiol
Hi Mike, check other estrogen tests… estradiol LC/MS and total estrogens. Also growth hormone and low carb low calorie diet may contribute.
Keto diet?
What about iron overload ? I was wondering whether very high SHBG might be a safety mechanism when the red blood count is already too high and the body decides to shut down free T because testosterone increases haemoglobin on its own account. Hemachromatosis is a silent killer after all.
Not that I know of and I don’t think SHBG binds iron. It binds testosterone but the increase in RBC from testosterone is not the same problem of high iron in hemochromatosis. They are different problems and mechanisms.
@@swintegrative I meant: when there is chronic iron overload and there is a risk of RBC getting dangerously high, the body might increases SHBG production (by some currently unknown mechanism) in order to get low FT so that there is no further stimulation of RBC production from that source.
I say this because as an otherwise fit and healthy 63, I have extremely high TT (32 nmol) and SHBG (120 nmol), high ferritin saturation and very low (symptomatic) FT.
Good morning Doctor, thank you for the informative video. Beyond what level (nmol/L) would you begin to be concerned about SHBG blood levels please?
It all depends what you are optimizing for SHBG in and of itself it not something to be worried about it is in the context of your health symptoms and problems that it is relevant.
If you do TRT what do you advice for this than?
Btw thyroid meds and hyperthyroidism can increase shbg :).
Your video was very informative
Yes, true and this makes sense as it fits with the metabolic profile of being in a fasted low insulin state. So many things alter SHBG.
Job well done. Question --- since it is produced in the liver. Would focusing on clearing out the liver/liver detox; glutathione and/or NAC be a good place to begin as well? Yes, cleaning up the diet: Gluten/Wheat/Dairy/Soy/Sugar --- of course. My wife has a SHBG of 169.0 and testosterone, serum at 15, Free Testosterone (direct) at 1.4. Her Doctor says the Test values are below normal range and clearing up the liver/diet is a good place to begin. Thank you for your help.
Hi Mr X, yes these things will not hurt and potentially help. You can also recheck in a non-fasting state.
@@swintegrative Thank you for your response.
Great Video! 68years old T.729 But B.Globulin 80 nmol/l and Bioavailable 87.6 ng/dl. I think I was on the second day of a 5 day fast when taking. Any thoughts?
Thanks for sharing! Well the free would be higher if you were not fasting.
Hey there, I’ve got a bit of a weird one personally. 24M, my SHBG is 10, my thyroid, liver, kidney, lipid are perfect. I am lean enough for ab visibility. Muscle mass high, never take anything exogenous. test is in the low range of normal 12nmol/L. oestradiol is above average 132 pmol/L. my endo is saying my shbg is genetic. is this true or do I have something to be worried about?
I know there are SHBG snps but not something I have studied much. So it could be genetic.
@@swintegrative okay fair enough. unsure if you’d find this interesting but I got a bit fed up of my hormonal inbalance and started taking an aromatase inhibitor two weeks ago. received my results today and my testosterone has near tripled, oestradiol halved, prolactin halved, LDL decreased and triglycerides also decreased. I call that a successful self diagnoses (albeit a very very meticulously researched one)
I have had every single symptom for about 2 years now I am wondering why my SHBG is at 120. I’m a 25 year old male.
Mine was just tested at 110. I’m 27. Iv felt like shit for like a year. Not sure what i did.
Hello doc, I've watched numerous videos regarding SHBG, and I cannot understand couple fundamental things:
is the purpose of it to help transfer hormones throughout the body, or to remove excess hormones by binding?
Because two functions are contradicting.
Some people say that low T increases shbg so there's more chance it grabs and transports T to tissues,
some people say low T drops shbg so it doesn't bind and lessens availability of remaining T.
so I guess the main question is - how does shbg help transport T to the tissues, if it strongly binds to it and doesn't let go? and if it does let go of T, then why having low free T is a problem? is it and indicator of shbg not letting go T well enough?
Much thanks for clarifications on these mechanisms.
not sure i can answer these question simply... when androgens bind to receptors that is when the androgen has its effect. SHBG prevents this binding. It is there so the hormone can get distributed through the body and not bind to every receptor close to where it is secreted. hope that helps.
@@swintegrative thanks for reply. but the mere fact shbg is there to "distribute" means that unbinding is happening at the local site later... otherwise it would not distribute, the free T would still bind all at one concentrated place, and SHBG-T would circulate forever until excreted.... no?
@@spx730 yes but the dissociation of hormones from shbg does occur they don't stay bond forever.
@@swintegrative nice, any ways to speed up that process?
47yo, SHBG is 75, total test is 798, NO free t, no insulin resistance, low estrogen, normal estradial, can't lose weight but don't have much, not diabetic, mild ed, runner and active, no one knows what's going on!
Will 1mg testosterone cream counteract my elevated SHBG or will the SHBG stop TRT from working????? I'm female
Probably a little of both. SHBG is naturally higher in females but testosterone can lower it
@@swintegrative Thanks,🙏🙏
I cannot find any information on men with: low-normal SHGB/low-normal total testosterone/elevated (just over the lab range) of free testosterone.
What does this mean?
My A1C was high-normal (just before “pre-diabetic”. I have read insulin resistance can lower SHBG, but I’m not even pre-diabetic, yet.
You can still have high insulin levels and this would be the first place to look as it is the most common.
@@swintegrative the A1C was 5.5 so that’s definitely high while not yet being type 2 diabetic
Total Testosterone - 1139.0
Free Testosterone- 15.68
SHBG- 70.3 (High)
I’ve been vegan for 8 years, I’ve done intermittent fasting now for 2 years now. I’m 6’5” about 240lb. I workout regularly.
Is there anyway to low my SHBH?
Boron.
Hi, after 5 months of using birth control, my SHBG levels are very high (260 ish). How long does it take to get back to normal limits after quitting the bc pills?
about 1 month.. maybe less
age 23
SHBG:77.9 nmol/l
Albumin 5.1 g/dl
TT:580 ng/dl
Estradiol: 23 pg/ml
LH 5.8 miu/ml
prolactin 11.4 ng/ml
i believe i have this since puberty
what are my options i live healthy life style
How do you feel a year later? Are the numbers about the same?
Hello thank you for the video. My labs recently were
Male 30y/o weight 165lbs. Height 5’7”. Body fat 10 percent lifting 4 days per week compound cardio 2 times caloric surplus by 100 a day
Total t 704
Free T direct 7.7 low
E2 29.1
Every lab since I have been in my twenties has got me at low free t and normal high total t
Growth hormone?
@@swintegrative Sucks for this to be the only answer. Why is it th guys who take of themselves and family are targeted with something outside of their control. Naturally high shbg plus extremely low free t with normal total t, at age 22, I lift 6 days a week. Feels like I've been cursed. One thing I have noticed that is recurring is that 95 percent of guys with these symptoms are physical active.
I am 18 year old male total testerone 970 I play basketball what should free T and SHBG be and estradiol?
subscribed from INDIA ❤
Can non alcoholic fatty liver cause high SHBG? If so, how do you effectively reduce fat on the liver?
Yes it can. There is a video on fatty liver and liver enzymes coming up.
@@swintegrative looking forward to it. Everytime I ask a traditional primary care Dr. How to eliminated accumulated fat on the liver as indicated by ultrasound, I get a blank stare. Well, among a lot of things.
What if SHBG is too low? Mine is under 10, and it required me to do ED injections.
My total testosterone is 524ng/dl
Free t is 1.1 ng/dl
Estrogen is normal
I have low t symptoms
Is high shbg the reason?
If so how to bring it normal
Low free T is caused by high SHBG. There is not one thing you have lo look at the things mentioned in the videos
Hello Doctor I am from India.
My name is Nikunj and I am 14 year old boy. I am suffering, (*sorry) having T1D (Type 1 Diabeties) but actually having a good control on sugar levels as I am taking Insulin and monitering blood sugar levels. But I have other problem in my body, I am growing hair all over my body, like arm hair, chest hair, hairy legs, and unwanted hair growth of forehead and surface of nose. None of my friends have this issue and I think I am having high testesterone. I went to dermatologist and she prescribed me two tests. One is testesterone serum and other one is the thing you are talking (SBHG). The only doubt now I have is, Is it anything connected to T1D? If I take medications for controlling Sbhg or testesterone levels, will it affect my diabeties? Or even any other hormones in my body? If yes, please inform doctor 😊
Subscribed your channel
I found one RUclips video of a fellow saying he lowered his iron saturation and his SHBG decreased. I’m in same boat with high iron sat and high SHBG. Could high iron saturation raise SHBG?
Any answers? That’s me. Iron saturation is at 65 percent and shbg is at 97
Hi. I have very high SHBG and very low progesterone. Does it mean I can have PCOS? Also suffer from hairloss. Might caused by this hormonal imbalance? Thank you
Hi Zuzana usually with PCOS there is low SHBG. Hair loss can be from high androgens but not low progesterone or high SHBG.
@@swintegrative thank you
Is it normal to have a high shgb if you have type 1 diabetes?
Not if you are taking insulin. Insulin usually lowers SHBG.
What if you have high SHBG(close to 200) and you're diagnosed insulin resistant?
You must be a female and producing a lot of estrogen?
@@swintegrative Wow! How did you know and high andogrens and DHEA-S according to the DUTCH Test. My serum blood for estrogen and progrsterone is normal.
@@user-vv6cb9vo7d Just bc your shgb is so high.
Hello, I wanted to know if HIGH CORTISOL =
HIGH SHBG, LOW CORTISOL = LOW SHBG?
I saw two endocrinologist. Im a male, My Estrogen is above 250 with two test. Both Endos say this is nothing to worry about. I do not do any HRT. I don't believe them and I'm worried. Any advise?
Estradiol is what is important and you want to check the Ultra sensitive estradiol too. There r genetic alterations in aromatase enzyme but idk without knowing your whole picture…
@@swintegrative will you see me? do you do telehealth?
@@jerrycaddie838 DrT@swintegrativemedicine.com
My SHBG is on borderline according to my test reports it is 47.1nmol/L at age of 20-24 is it normal please reply ? I am female
I’ve heard Matcha/Green Tea drastically raises SHBG. Is this true?
dd a blood test at 9:00 am . Im 28 y old . Total testosterone higher than norms : 29,5 nmol/L ( normal range 8.64-29) . SHBG extremly high : 84,5 nmol/L (normal range:18,3-54,1) Free testosterone "in the frontiers of low" : 34,9 (normal range: 35-93). Why SHBG are so high ? i mean difference of more than 30 nmol/L makes me concerned ...I measure around 176 cm , 68 kg , muscular wide but with no fat ,and i look way masculine ( i do not have a full beard by the way , but my body shape , face are way masculine) ..
And also in the blood test icteria was positive (theres like levels of icteria like +or ++ or +++ i believe by writing " positive" means +
Noticed that at 28 years old my larynx "developped and become prominent" , while the length of my neck increased 1 or 2 cm ( before 27 i was more in the 174 cm with a very short neck ) With the neck thing and the larynx who became prominent i mean can be related to thyroid?
si puede
Thanks for the video! I just got an at home Testosterone test done and my test levels where normal, but my SHBG was a bit high. I've been in a modest caloric deficit for roughly 14 months losing about 1.5 lbs per month and I've done so via intermittent fasting and tracking my calories. Sounds like there's a decent chance this is the reason for my slightly higher SHBG. Going to go off intermittent fasting and see how I feel and go get retested.
Best of luck! Thanks for sharing and I think that sounds correct.
Watched a lot of these videos and no one as of yet tells you the range. I got three blood test, dates 4/6/23 SHBG 68.9 - Range 19.3-76.4 One lab. Second lab: 4/20/23 SHBG 57.2- *Range 22-77; Third lab: 5/15/23 69.5- *Range 21.4-67.8. So the third lab shows out of range according to the range all three were out of range if I used the thrird lab range. Anyone know what the true range is?
Reference ranges are based on the sample population averages so they will vary with said sample size. That’s why when you reach the high end or low end of a reference range, even if within the range, it’s good to look at it more carefully.
More importantly, why would it be LOW? And how does one fix it?
What are the symptoms?
Hi,
Would you be able to help me. I am 26’year old female. All my blood work came back as normal apart from
SHBG. What could this mean? I’m not on any medication or have any health issues. I was also told this is the reason as to why I have irregular period too
Hi Amina, it is hard to know what you mean by "all my blood work" different doctors test for different things. Insulin resistance and high insulin is a very common cause for high SHBG. You need to find a doctor that can look a little deeper than the surface level, like a functional medicine doctor.
I found out I have very high SHBG I also have PMDD so I think that maybe why. I also have low progesterone and estrogen. What do u suggest would be a good way to fix this?
Could be usually estrogen and SHBG run opposite so u might double check that. It’s different at different times of cycle
My shbg runs high, free testosterone was low. I recently switched from testosterone cream to injections, due to fear of the cream getting on my children. My estradiol runs on the low side, since I am 45 and perimenopausal. I am on a low dose estradiol patch and 50 mg compounded estrogen, due to very low estradiol levels ( night sweats, fatigue, achy legs, etc). Testing still indicates lower in the range, but within the range estradiol. I am also on a combination of levothyroxine and sublingual Np thyroid. Two questions. 1- could the thyroid medication or transdermal estrogen be driving shbg up, despite my levels being in normal ranges? ( I don’t have a thyroid). 2- it could be a coincidence, but I am noticing that the two days after I inject 15 mg of testosterone cyprionate, I’m irritable and a little sad. Could it be the testosterone? Could taking testosterone cause a temporary increase in shbg, causing these moods, or is it just estradiol that does it? I’m perimenopausal, do I get moody, but it is just weird that it’s the couple days after I inject the testosterone.
Hi Katie Bugs Room. Here are a couple things to keep in mind, estradiol is the main estrogen that should be tested. The ranges for this vary widely through your monthly cycle. If you are not checking at the same time of the your cycle each month, the results don't mean much. The issues mostly like is coming from too much estradiol not too little. Estrogen increase SHBG. Testosterone increases estradiol. Typically women in perimenopause have estrogen dominance already. It is possible that you don't but you might be getting too much now. Hope that makes sense.
Hard to take anyone serious with a name like that.
Great info ......doc my shbg is 64.1 noml/l total test 19.4 noml/l and free test is 0.266 noml/l ....my doc in uk says it’s normal but iv had low t symptoms for years and it’s affecting my quality of life ....in yr expert opinion from my results do u think I need trt or just something to lower my shbg....I’m 40 years old and would really appreciate yr knowledge...thank u
Hi mac ss, free T seems a bit low (I'm not use to these units) so raising your free testosterone may help.
@@swintegrative
Hi doctor cld you tell us what are the medicaments or trt protocole which rise free testesteron,thnks
Hi Ali, yes I may do a separate video on this topic.
did you end up getting on TRT? I'm 38 and my free and total T is almost half of what yours is.
@@swintegrative never seen yr reply doc thank you 🤙🏻
hi! i’m a 20 year old female and just had a fasting blood test done. my shbg was 190.30 nmol/L and my t3 was slightly high at 4.1 pg/mL. i was wondering if these had any correlation? thanks!
Hi. My total test is 854ng/dl. Free T is 16.3pg/ml , SHBG 54.3 Nmol/l and estradiol 43 pg/ml(slightly higher than normal range). I went to the doctor for mild to moderate. ED. He thinks it’s just psychological and gave me a Cialis Rx. Do you think my slightly higher than normal SHBG and estradiol could be causing it? I was thinking of taking a mild aromatase inhibitor to see if it will lower my estradiol and SHBG. He thinks I’m fine because my testosterone is high
Hello Logan! A free T of 16.3 pg/ml is decent. High or high normal estradiol can have a negative effect on erectile function. It won't do this to everyone though. It may be worth while to have a closer look look at the estradiol and check the MS/LC estradiol. This is a more accurate test.
@@swintegrative is boron the only way to up the free t
Hi,
I'm confused as to why my SHBG is 173, my total testosterone is 53. I'm a 30 year old female. I have read that it usually isnt like this. I've never had birth control.
Any insight on what might be going on? My progesterone to estrogen ratio is 45.16.
Hi Samantha, high estrogen is often a cause but bc estrogen is changing all the time (with your cycles), you have to check at different times of the month. Also you have to check when you are non-fasting as the level will be lower.
Also 53 total testosterone is not that high.
What is normal? What is high?
I am a 42yo female and my SHBG is high. So is androstenedione. Can you help me understand why? Does it mean my testosterone is high or low?
SHBG is 138 and the range is 30-135. Androstenedione is .915 and the range is .19-.82
Hi Tina,
It sounds more like your estrogen is high. Androstenedione is converted into either testosterone or estrogen. Since you have high SHBG I would predict higher estrogen levels. As for the question why is harder to answer but the production of androstenedione comes from adrenal glands and the ovarian tissue. Do you have a direct measurement for estradiol or testosterone?
Hi. I'm a 64-year-old male that works out 3-4 times a week. I do HIIT and lift weights. I also do intermittent fasting 16/8. . My total T is 1086 (high). SHBG is 89.00 (high) Free Adrogen is 42 (normal) and Free Testosterone is 12.9 (normal). I was taking a "natural" testosterone booster which I stopped when I get these results. I did have prostate cancer 3 years ago and did 2 rounds of brachytherapy radiation I am cancer free now. It runs on both sides of my family. I knew I was going to get it, just didn't know when. I didn't know if that could have something to do with this?
Hi
My testosterone was high at 42nmol/l and SHBG high at 79nmol/l so it worked out my free testosterone was in normal range. Should I worry or is there anything I can do 🤷♂️?
Hi John C, total testosterone of 756 ng/dl seems normal to me. I would not worry but if you have low T symptoms, you might want to look into it more. You do have to check the SHBG in fed and fasting states bc it will change with this.
hey im 34/male, gym 3-4 times a week, higher protein diet, moderate fats and carbs and eat at maintenance calories and im not to sure why my shbg is so high love to hear your thoughts thanks in advance , my blood results are
thyroid fuction :
TSH - 4.2 miu/l
free thyroxine - 18.100 pmol/l
testosterone - 27.4 nmol/l
free test - 0.308 nmol/l
SHBG - 82.8 nmol/l ***
oestradiol - 65.9 pmol/l
Yeah that SHBG seems really high but I am use to different units. Have you had an estradiol done with MS/liquid chromatography? This estrogen seems normal but would be curious what the more accurate test shows. Was the test done fasting?
@@swintegrative will fasting cause it to be high? I did my testosterone blood test when i was fasting
@@Memic86 yes that can make SHBG higher than it would be in a fed state
@@swintegrative i appreciate the quick reply. What about estradiol? Both estradiol and shbg was slightly high. Estradiol at 44 Shbg at 56
@@Memic86 estradiol raises SHBG too
21 y/0 male = no past medical history only surgeries = Tommy John and Labrum slap 3 repair. Results are below. Seeking clarification = has seen 3 endocrinologist and all have different responses
Free T = 899
SHGB = 63.4
Albumin = 5.2n
T4 = All within normal range
BMP = All within normal range
No sex drive, losing weight and body mass, no history of diabetes in the family, loss of appetite, depression. All onset of symptoms for the last 3 months and no reason for this complete overall health change.
Please help, I don't know where else to ask for assistance
Hi Beatriz, get a comprehensive evaluation of digestive tract (through a naturopathic or functional medicine doctor). You may not have any overt digestive symptoms but it is a common source for chronic health issues of unknown etiology. Also is that total testosterone or free? what are the units?
@@swintegrative it is actually for my son, not me. I gave both free and shbg above for him
Hi, could the cause of low sedrive, bad erections and low sperm volume be the cause of high shbg? My total t was fine. Shbg not checkdd yet
Yes it can because if something is causing high SHBG there is less bioavailable testosterone (low free T). Low Free T can cause low libido and ED. The part that does not fit is the sperm count. To my knowledge SHBG does not relate to sperm count.
What would it mean if both my shbg and my testosterone is high? I did start birth control for regulation of hormones/period but I always see that the relationship for the two is that one is high and one is low
Hi Yolinna, high estrogen/ estradiol is a common cause of high SHBG in females. I'm not sure how your BCT will affect affect SHBG. It will reduce your bodies estradiol and therefore reduce SHBG. Because some BCT contain estrogen, it will likely increase SHBG more. There are too many variables to know for sure without and in depth evaluation.
@@swintegrative thanks it was worth a try lol I know our bodies are complicated
What about finasteride?
I would expect finasteride to raise SHBG
Hi!. I'm 27 male without libido problems, with quite good body composition. There are my last lab results with ranges:
Albumin 46.1 g/l (35 - 52)
FSH 5.06 mlU/ml (1.50 - 12,40)
LH 4,64 mlU/ml (1.70 - 8.60)
Estradiol 18,10 pg/ml (11.30 - 43.20)
Prolactine 11.70 ng/ml (4.04 - 15.20)
Total Testosterone 864 ng/dl (249 - 836)
SHBG 65.76 nmol/l (18.30 - 54.10)
I've calculated free testosterone, it is 12.2 ng/dL. So basically my total testosterone and SHBG are above range, free testosterone is below. What can be the cause of this result?
check SHBG in fed state.
I’m a 28 year old male. My total T is 741 ng/dl, free T is 18.09 ng/dl, and my SHBG is 54 nmol/L which all seem to be on the higher end of normal. I don’t understand why my SHBG is this high given the amount of free testosterone I have. My estradiol was measured at 34 pg/ml which is also on the high side of normal. Could that be the reason why my SHBG is on the higher end?
Yes, I would say so.
Thank you sir.
Your welcome.
Sir help me my shbg 57 please help me i am from india i never take supplements
I can send you my blood report but u r not on Instagram
Where i send you my report
Bro same bro I'm From India
Stress, bad diet, low animal protein, and animal saturated fat consumption, vegan diet....watching porn....etc
Haha
You are underestimating this issue for high shbg low free test one and normal test one. Fix all of these and nothing changes it's like a curse. All of ot these guys with the symptos of mentioned in the beginning are aslo physically active. So its not like their a guy that jacks off all day and eat what ever they want.
Use. The. Board. Behind. You.
Thanks for the suggestion. I am working on some changes.
How do we contact you best directly?
You can email me at DrT@swintegrativemedicine.com
I'm sure your are a good doctor but you talk too fast and you are assume we know what you are talking about. Please speak plain English.
Thanks for the feed back
Too scattered
First half is a useless intro, second half lists a few irrelevant reasons like infections, but not one useful or relevant piece of info. Waste of time.