It's fantastic that the "scientist" in these medical professionals prevails and they take the time to share their findings. And thankyou to this channel for posting. It's gold👌❤
There are so many brilliant minds in this space but not everyone can explain the science so a dumbass like myself can follow along, thanks for taking the time to explain to a general audience and not just your colleagues. I know this works because it has worked for me now I have a better understanding why.
How does the drug Metformin (introduced initially as appetite suppressant/weight loss medicine before it became a standard diabetes Medicine) intervene with Ketone production in the liver?
So basically what he is saying is that ketone production can't happen without gluconeogenesis. Deprive the body of carbs then it has to get glucose from the oxidization of oxyloacetate and because of that we get an increase in Acetyl CoA and the increase in Acetyl CoA results in the production of ketone bodies. Hmm very interesting.
shows how ignorant you are. Chiropractors know more about nutrition and holistic medicine than any MD out there moron. Do your research before bashing these highly trained professionals dipstick.
19:05 - According to one of the other talks on YT (on one of the keto, low carb, Acestral Healt or Paleo channels) protein DOES NOT spike insulin levels IF eaten without carboydrates, or in a fasted state. Sorry I don't recall which speaker reported this, but it is worth checking out. Especially since many people don't get enough protein, especially those over +/- 65 yrs, and the very young. (No wonder, with sugary, starchy foods and drinks being pushed for children. And now we know those grain-based cereals, snack bars, etc are contaminated with significant levels of glyphosate.)
Try breaking your 24 hour fast with a protein only shake, you'd be hypoglycemic for sure. That's your insulin spike from protein shoving already lower amount of glucose(due to fasting) from blood to cells and gluconeogenesis is unable to keep up. Also, because of insulin, ketones are lowered(which were higher before that protein shake due to fasting) and you'd feel like shit. This doesn't mean one should not consume protein, it's essential for growth and recovery. Eat your protein in whole food form during your eating window.
@@abhi0live thank you for this, very interesting. I'm always in a quandary as to what to break my fast with. Read loads of differing info on the internet (hey, welcome to the web ;) ) What is your advice since you've obviously had experience. Thanks very much
Indeed Dr Sher - Food is a general term, in reality it is Chemical Information for the body and each molecule of food has the potential to be a building block, an antagonist, and directly interact with DNA, mitochondrial RNA, and all metabolic pathways."
I still don't get how much insulin is vital to the functioning of the body during nutr. ketosis. As a type 1 diabetic should one reduce their slower acting insulin dose to facilitate and not inhibit ketosis, and if so, by how much depending on the length of the fast?
Slower acting insulin is not what you should reduce on keto, you should reduce fast acting insulin (causes large dips out of ketone production). You don't need fast acting insulin when not eating carbs. You should probably be keeping blood glucose at around 80-90, imo, if you are not exercising frequently. Exercising frequently tends to result in lower blood glucose during exercise (duh) and higher resting blood glucose. Work champion athletes tend to be "diabetic" by blood glucose tests but not so on insulin tests (where they tend to be 3.0 or lower).
That was a great presentation. The quick setup was brilliant and the subject was covered comprehensively at a very useful level. I have been using and studying this system since the early 90's and this has encapsulated almost everything. Just wondering - why is Glucogon not mentioned?
I agree! This, for me, confirms that those extra few strawberries really DID cancel our weight loss, a few days back, as did the cooked tomatoes in our Gumbo, at lunch (along with the Stevia in our Lemon Water, which we've been warned can trigger an insulin response).
IMO, our big brain is the main reason we make so many ketones. Other mammals dont make a lot of ketones. To be healthy you have to be a fat burner and produce ketones. Dont block ketone production with a high carb diet.
You don't have to eat more fat to get into ketosis, fasting will achieve the same thing. Just do an 18:6 diet or 24 hours fast. I stop eating at 8:00 PM and skip breakfast the next day and eat at 12:00pm I have a small number of carbs and medium protein and fat. For dinner a medium amount of carbs, some protein and fat. My weight is low and my numbers are good, and I have no concerns about the long-term effects of eating too much fat .
What I got from this lecture (aside from "cough" "cough" "COUGH" "cough" "cough" "COUGH", followed by stupid creature coughing three feet away from the microphone, which, I assume was the lecture's extra-loud Climax), is that "EVEN A SMALL AMOUNT OF INSULIN AFFECTS OUR ABILITY TO BURN FAT", along with the diary entries showing the dramatic effect of just a "bit of sponge (cake?)" or some toast. That was important enough, to make it worthwhile, to sit through 22 minutes of the Coughing Competition.
What happens if you get stomach pain from too much fat? If I eat chicken skin two days in a row, it feels like someone punched my gut. I have leaky gut and had pancreatitis years ago after giving birth to twins. I was only 100 pounds (it was normal for me, I'm very small) and went up to 147 pounds (the boys were 6 and 7 pounds when they were born). I'm trying to get rid of gut pain and eat low carb. I can't digest fat very well. I'm already using digestive enzymes. With my supper, I'm taking a supplement that has (along with other enzymes) 80 mg of lipase (I take 2). I also have reactive hypoglycemia and adrenal fatigue.
Thanks Dr. Sher, a fan. Good outline and food for thought ... we look at Food as a “General Term”, in reality it is chemical information for the body and our microbiome and each molecule of food has the potential to be a building block, an antagonist, and directly interact with DNA, and mitochondrial RNA. Humans are 1 Million Genes, 4.5 Trillion base pairs, and only 23,000 genes, 2% are human, or 3 Billion base pairs. www.70GoingOn100.com the Centenarian Diet, or maybe 128, the Hayflick limit, … or if a Ray Kurzweil fan then this is a Moot Point …
one big question about ketoacidosis，without insulin, the brain tells the body to burn fat ,product lots of ketones, but why produce a lot , not just the right amount? once the cell get enough ketone(energy), cant the brain get the signal, no need for engergy(ketone),it not logical, or not that simple, forgive my humble thought and pls tell me if im wrong thanks.
What do you think of the Ketostix for monitoring ketones? I believe there's a little bit more of a delay (i.e. you may be in ketosis before the strip says you are) but other than that are they accurate enough?
blowera1 i don’t know the answer but I use keytones blood test strips. I would think that would tell you sooner than keytones in the urine. If I go on a long run (I am in nutritional keytones ) and test 2 hours later my keytones have risen. (Not eating much in carbs like under 30 grams a day)
I'm far from an expert, but it is my understanding that after a while the ketone levels in the urine drops, so it stops being an accurate indicator of ketones in the blood.
It's fantastic that the "scientist" in these medical professionals prevails and they take the time to share their findings. And thankyou to this channel for posting. It's gold👌❤
Carl Senden I totally agree!
thank you Dr. this was superbe information :)
There are so many brilliant minds in this space but not everyone can explain the science so a dumbass like myself can follow along, thanks for taking the time to explain to a general audience and not just your colleagues. I know this works because it has worked for me now I have a better understanding why.
How does the drug Metformin (introduced initially as appetite suppressant/weight loss medicine before it became a standard diabetes
Medicine) intervene with Ketone production in the liver?
Pleeeez stop saying ' the brain needs glucose' without qualifying the statement 😣
So basically what he is saying is that ketone production can't happen without gluconeogenesis. Deprive the body of carbs then it has to get glucose from the oxidization of oxyloacetate and because of that we get an increase in Acetyl CoA and the increase in Acetyl CoA results in the production of ketone bodies. Hmm very interesting.
I was going to say that!
Clearest explanation of the mechanism of ketosis I’ve heard yet. Thank you!
A real doctor vs a chiropractor or someone trying to sell me supplements or bone broth educating me on ketones.
So refreshing!!
shows how ignorant you are. Chiropractors know more about nutrition and holistic medicine than any MD out there moron. Do your research before bashing these highly trained professionals dipstick.
mark sapier I remember using a dipstick when mixing paint at home depot
Snorted so hard the person-next-to-me's coffee sprayed out of my nose!
@@marksapier2603 ah, Descending to ad hominem epithets ("moron") clearly signals the quality of your argument.
His two lectures are the best presentations of the basics of metabolism I've heard.
19:05 - According to one of the other talks on YT (on one of the keto, low carb, Acestral Healt or Paleo channels) protein DOES NOT spike insulin levels IF eaten without carboydrates, or in a fasted state. Sorry I don't recall which speaker reported this, but it is worth checking out. Especially since many people don't get enough protein, especially those over +/- 65 yrs, and the very young. (No wonder, with sugary, starchy foods and drinks being pushed for children. And now we know those grain-based cereals, snack bars, etc are contaminated with significant levels of glyphosate.)
Try breaking your 24 hour fast with a protein only shake, you'd be hypoglycemic for sure. That's your insulin spike from protein shoving already lower amount of glucose(due to fasting) from blood to cells and gluconeogenesis is unable to keep up. Also, because of insulin, ketones are lowered(which were higher before that protein shake due to fasting) and you'd feel like shit. This doesn't mean one should not consume protein, it's essential for growth and recovery. Eat your protein in whole food form during your eating window.
@@abhi0live thank you for this, very interesting. I'm always in a quandary as to what to break my fast with. Read loads of differing info on the internet (hey, welcome to the web ;) ) What is your advice since you've obviously had experience. Thanks very much
Dr. Bikman discusses it. He's amazing!
Indeed Dr Sher - Food is a general term, in reality it is Chemical Information for the body and each molecule of food has the potential to be a building block, an antagonist, and directly interact with DNA, mitochondrial RNA, and all metabolic pathways."
Lol. Someone in audience claimed they had a ketone level of 15. I managed to get to a 4 level on a 4 day fast.
Very informational, thank you.
I still don't get how much insulin is vital to the functioning of the body during nutr. ketosis. As a type 1 diabetic should one reduce their slower acting insulin dose to facilitate and not inhibit ketosis, and if so, by how much depending on the length of the fast?
That's totally my thgouths! I am also T1D for 2 years now and I am trying to find best solution...
No! Type 1 is a very different situation than type 2.
ruclips.net/video/E16hfXmPGcA/видео.html
Slower acting insulin is not what you should reduce on keto, you should reduce fast acting insulin (causes large dips out of ketone production).
You don't need fast acting insulin when not eating carbs. You should probably be keeping blood glucose at around 80-90, imo, if you are not exercising frequently. Exercising frequently tends to result in lower blood glucose during exercise (duh) and higher resting blood glucose.
Work champion athletes tend to be "diabetic" by blood glucose tests but not so on insulin tests (where they tend to be 3.0 or lower).
That was a great presentation. The quick setup was brilliant and the subject was covered comprehensively at a very useful level. I have been using and studying this system since the early 90's and this has encapsulated almost everything. Just wondering - why is Glucogon not mentioned?
Oh my god! That is great explaination ! Thank you Doctor!
I agree! This, for me, confirms that those extra few strawberries really DID cancel our weight loss, a few days back, as did the cooked tomatoes in our Gumbo, at lunch (along with the Stevia in our Lemon Water, which we've been warned can trigger an insulin response).
IMO, our big brain is the main reason we make so many ketones. Other mammals dont make a lot of ketones. To be healthy you have to be a fat burner and produce ketones. Dont block ketone production with a high carb diet.
Thank you for posting very informative
Weird, Doron Sher wasn't that funny in his other presentation. In this one, he's hilarious. What happened? Does it have to do with ketones?
Excellent presentation. Thank you!
Re 5 min statement: Volek showed fat adapted athletes can make glycogen without eating CHO.
I really enjoy the simplicity and clarity of these presentations, very easy to understand for people with no scientific background.
Keep up the good work!
I'm dependent of this channel. Thanks! :D
GREAT VIDEO!
You don't have to eat more fat to get into ketosis, fasting will achieve the same thing. Just do an 18:6 diet or 24 hours fast.
I stop eating at 8:00 PM and skip breakfast the next day and eat at 12:00pm I have a small number of carbs and medium protein and fat. For dinner a medium amount of carbs, some protein and fat.
My weight is low and my numbers are good, and I have no concerns about the long-term effects of eating too much fat .
The only long term affect of eating lots of fat is more fat soluble vitamins!
What I got from this lecture (aside from "cough" "cough" "COUGH" "cough" "cough" "COUGH", followed by stupid creature coughing three feet away from the microphone, which, I assume was the lecture's extra-loud Climax), is that "EVEN A SMALL AMOUNT OF INSULIN AFFECTS OUR ABILITY TO BURN FAT", along with the diary entries showing the dramatic effect of just a "bit of sponge (cake?)" or some toast. That was important enough, to make it worthwhile, to sit through 22 minutes of the Coughing Competition.
What happens if you get stomach pain from too much fat? If I eat chicken skin two days in a row, it feels like someone punched my gut. I have leaky gut and had pancreatitis years ago after giving birth to twins. I was only 100 pounds (it was normal for me, I'm very small) and went up to 147 pounds (the boys were 6 and 7 pounds when they were born). I'm trying to get rid of gut pain and eat low carb. I can't digest fat very well. I'm already using digestive enzymes. With my supper, I'm taking a supplement that has (along with other enzymes) 80 mg of lipase (I take 2). I also have reactive hypoglycemia and adrenal fatigue.
Ketone are the same
thank you! :)
Thank you
Thanks Dr. Sher, a fan. Good outline and food for thought ... we look at Food as a “General Term”, in reality it is chemical information for the body and our microbiome and each molecule of food has the potential to be a building block, an antagonist, and directly interact with DNA, and mitochondrial RNA. Humans are 1 Million Genes, 4.5 Trillion base pairs, and only 23,000 genes, 2% are human, or 3 Billion base pairs.
www.70GoingOn100.com the Centenarian Diet, or maybe 128, the Hayflick limit, … or if a Ray Kurzweil fan then this is a Moot Point …
Great description. Thankyou.
This is very interesting about this I would love to tried some of these ketones
Where can I get one of these blood testers?
Explained well and easy to understand, thank you
one big question about ketoacidosis，without insulin, the brain tells the body to burn fat ,product lots of ketones, but why produce a lot , not just the right amount?
once the cell get enough ketone(energy), cant the brain get the signal, no need for engergy(ketone),it not logical, or not that simple, forgive my humble thought and pls tell me if im wrong thanks.
Because the off signal is insulin and insulin is unavailable.
What do you think of the Ketostix for monitoring ketones? I believe there's a little bit more of a delay (i.e. you may be in ketosis before the strip says you are) but other than that are they accurate enough?
blowera1 i don’t know the answer but I use keytones blood test strips. I would think that would tell you sooner than keytones in the urine.
If I go on a long run (I am in nutritional keytones ) and test 2 hours later my keytones have risen. (Not eating much in carbs like under 30 grams a day)
The experts say testing blood far more accurate than testing urine.
I'm far from an expert, but it is my understanding that after a while the ketone levels in the urine drops, so it stops being an accurate indicator of ketones in the blood.
Sorry Doron, but you really need to brush up on your biochemistry. Dig up even your old biochemistry textbook and study the chapter on lipids.
Why do you think he needs to do that?
@Nasr Anaizi Yes where is Dr Sher not right? Please elaborate. After all, this talk is for lay folk. Not slanted towards biochemists.
You said it yourself. You are no biochemist. Stick to what you know or capable of understanding.