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Pharmacokinetics In first-order kinetics More drug ingested than more drug eliminated Clearance is constant i.e. from same volume of plasma the drug is eliminated In zero-order kinetics Amount of drug eliminated is constant Clearance is not constant Aspirin, Ethanol & Phenytoin follows zero-order kinetics
I really cant thank you enough.. there was one question in uworld that I missed and still didn't understand cuz I cant conceptualize the elimination vs clearance thing .. now everything is making sense in perfect way. thank you again
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Pharmacokinetics
In first-order kinetics
More drug ingested than more drug eliminated
Clearance is constant i.e. from same volume of plasma the drug is eliminated
In zero-order kinetics
Amount of drug eliminated is constant
Clearance is not constant
Aspirin, Ethanol & Phenytoin follows zero-order kinetics
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Which drugs follow zero and first order clearance
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