Это видео недоступно.
Сожалеем об этом.
Transamination : Mechanism and examples of transamination
HTML-код
- Опубликовано: 18 авг 2024
- TRANSAMINATION
DEFINITION: The transfer of amino group from an amino acid to a keto acid is known as transamination.
The name itself indicates that amino group is transferred.
Enzymes catalyzing transmination are called as or aminotransferases.
Coenzyme required is PLP.
Examples of enzymes are: ALT (alanine transminase) and AST (aspartate transaminase)
Exceptions: the amino group from aminoacids i.e lysine,thronine,proline and hydroxy proline can not be removed by transamination.
Significance:
*it is required for the synthesis of non-essential aminoacids.
*for interconvertion of aminoacids
*it is first step in the catabolism of aminoacids
*not only Alpha amino groups but delta amino groups are also transfered by this mechanism.
transamination in biochemistry
process of transamination in biochemistry
enzyme required for transamination
examples of transamination in biochemistry
Transamination is a biochemical process that involves the transfer of an amino group (NH2) from an amino acid to a keto acid, resulting in the formation of a new amino acid and a new keto acid. This reaction is catalyzed by enzymes called transaminases or aminotransferases.
The general reaction can be represented as follows:
Amino Acid 1 + Keto Acid 2 ⇌ Keto Acid 1 + Amino Acid 2
The transfer of the amino group is facilitated by the coenzyme pyridoxal phosphate (PLP), which is derived from vitamin B6. PLP serves as a coenzyme for the transaminase enzymes, allowing the transfer of the amino group between the amino acid and keto acid.
The process of transamination plays a crucial role in amino acid metabolism. It allows for the synthesis of nonessential amino acids, which are amino acids that can be produced by the body and are not required to be obtained through the diet. Transamination reactions also contribute to the interconversion of different amino acids, which is important for maintaining amino acid balance and meeting the body's specific needs.
Transamination reactions occur primarily in the liver, although they can also take place in other tissues. The liver plays a central role in amino acid metabolism, regulating the synthesis and breakdown of amino acids to maintain homeostasis.
It's important to note that transamination is just one step in the broader process of amino acid metabolism. Following transamination, the resulting amino acids can undergo further transformations, such as oxidative deamination or decarboxylation, to be utilized in various metabolic pathways or excreted as waste products.
Overall, transamination is a fundamental process in amino acid metabolism that enables the interconversion and synthesis of amino acids, contributing to the maintenance of amino acid balance and the overall functioning of cellular metabolism.
Amino acid metabolism
Enzyme reaction
Alanine transaminase (ALT)
Aspartate transaminase (AST)
Nitrogen transfer
Alanine-glutamate cycle
Glutamate dehydrogenase (GDH)
Pyruvate dehydrogenase complex (PDC)
Branched-chain amino acids (BCAAs)
Ammonia detoxification
#biology
#biochemistry
#neet
#transamination
#transaminases
#usmle
#liver enzymes
#liverfunctiontest
#liverenzymes
#aminoacid
#aminoacietabolism
#physiotherapy
#bds
#mbbs
#nursing
Join through this link @ / @biochemistryconcepts
To the point, simple and quick to grasp
Thank you very much for your valuable time and feedback 😊
Thank you sir! All my doubts got cleared in 5 min
Very happy to know that it was helpful 😊👍
Thank you very much for watching liking and sharing your feedback 😊👍
Do subscribe 👍
Good luck
Yaa,same🙂
Easily understood. Much appreciated.Thank you!
You are welcome 💐😊👍
Thank you so much for your feedback 😊👍❤️
Thank you sir
Welcome 👍😊
Thank you so much 👍😊
1st time I am understanding this concept ❤
Thank you so much for your feedback 😊 👍 🎉
Thank you very much sir🙂
Welcome 😊👍
Thank you very much for your feedback 😊
Very simple thank you si
You're welcome 🎉😊👍
Thank you so much for your feedback 😊👍🎉
This was helpful, thank you.
Thank you very much for your feedback 👍🙂
Happy to hear..it helped
Neat and clear sir
Thank you very much for your feedback 😊👍
Very helpful..... Thank you so much sir
Most welcome
thank you so much for your feed back
3rd Semester Exam Preperation Nice!
Very nice
Thank you so much for your feedback 😊🤠🎉
@@biochemistryconcepts sir, plz cover entire zoology and biochemistry NEP syllabus of B.Sc .
Definitely will try 👍
@@biochemistryconcepts thankyou so much
Thank you sir 🚩
You are welcome 😊🎉
Thank you so much for your feedback 👍😊
Thankyou sir❤
Welcome 😊🎉
Thank you so much for your feedback 👍😊
Thanks sir ❤️
You are welcome 💐
Thank you so much for your feedback 👍 😊
3:54 you said “ for removal of amino group transamination and deamination is required”
In 1:05 you said “simply transfer of amino group occurs and not removal”
Is this wrong. I’m sorry if I spotted out a correct thing as wrong. 🤝
During metabolism of amino acids,amino group is removed.This removal requires a process called as, transdeamination (transamination +deamination).after transamination,amino groups are transported to liver where deamination takes place.Although transamination and deamination are separately discussed, they occur simultaneously.
Thank you
@@biochemistryconcepts ohh thanks sir😻
🔥
Thank you very much for liking 👍 and giving your feedback 😊
Thank you sir
You are welcome 😊👍💐
Thank you so much for your feedback 👍😊
Thank you sir
You're welcome 🎉😊👍
Thank you so much for your feedback 👍😊