Vitamin D, now conclusive
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- Опубликовано: 31 янв 2023
- Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
www.ncbi.nlm.nih.gov/pmc/arti...
(Italy)
Various studies, a association between severe vitamin D deficiency and bad COVID-19 outcomes.
Vitamin D plays a crucial role in immune function and inflammation.
Recent data suggest a protective role of vitamin D against bad outcomes
Nutraceutical approach
Promote the immune response and reduce the inflammatory response
Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D
Immune optimisation and immune boosting
Vitamin D maintains pulmonary barrier function
Determines the production of antimicrobial peptides
Enhances neutrophil activity
Shifts the adaptive immune response to a more T helper cell-2 type
Anti-inflammatory effects of vitamin D
Reduces the production of pro-inflammatory cytokines,
such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma
Increases production of anti-inflammatory cytokines,
such as IL-4, IL-5, IL-10
Patients with a low baseline vitamin D, more benefit
Reduce risk of asthma exacerbations
Prevents acute respiratory infections,
and reducing their complications
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials
www.ncbi.nlm.nih.gov/pmc/arti...
The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups
(RR = 0.46)
Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity.
Meta-analysis and trial sequential analysis (TSA)
Better explain the strength of association
Protective role of vitamin D supplementation,
and risk of mortality / admission to intensive care units
We searched four databases on 20 September 2022.
Screened the randomized clinical trials (RCTs)
Assessed the risk of bias
(how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached)
The pre-specified outcomes of interest
Mortality and ICU admission
78 bibliographic citations
Five RCTs were suitable for our analysis
Results
Vitamin D administration results in a decreased risk of death, 0.49
Vitamin D administration results in a decreased risk of ICU admission, 0.28
Protective role of vitamin D and ICU admission
The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive.
The studies
Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
www.mdpi.com/2072-6643/13/7/2170
(Saudi)
Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study
www.ncbi.nlm.nih.gov/pmc/arti...
(Spain)
Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
www.ncbi.nlm.nih.gov/pmc/arti...
(Spain)
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19
www.ncbi.nlm.nih.gov/pmc/arti...
(Brazil)
Calcifediol treatment and COVID-19-related outcomes
www.ncbi.nlm.nih.gov/pmc/arti...
(Spain)
Medicines & Healthcare products
Regulatory Agency
www.bmj.com/content/377/bmj.o...
86% industry funded
On your advice I started taking 5,000 units in mid 2020 and am glad that I did. Came down with COVID two weeks ago and got through it within 7 days like a champ with just a couple of bad days at the beginning. I'm 76 years old and appreciate all the good advice that you have given us over the last three years.
"I now believe it's unethical .. not to advise vitamin D supplementation" - you heard it hear AGAIN. Well done Dr JC.
In 2021 I contracted COVID and was in the ICU for 3 days. The 1st 2 doctors pushed Remdesivir on me. I refused and had to sign a waiver. I was made to assign a proxy. Then in comes another Dr. And she started me on aggressive D3, Zync, Vitamin C, and saline. She told me that I did right by refusing the Remdesivir, especially since my kidneys were already hurting badly. Anyway...I continue to take D3 and need to add K. I am sharing this video with everyone. Thank you so much!
I am 71, retired Chiropractor and former nurse…my husband is 66. We take 10,000 units vitamin D3, along with zinc and now, K2 +multi. My husband managed 22,000 Union carpenters here in the US , so he was exposed….neither one of us have had covid. We’ve followed you and watched you struggle to get information out to the public. A bell rings in heaven for you Dr. Campbell for probably saving thousands of lives. Thank you and God Bless you.
This man deserves a knighthood for all the lives he has indirectly saved.
When you literally jump up and give the good doctor a standing ovation. And a virtual hug. Thank you, Sir, you are a precious hero to me and my 98-yr old father.
Excellent information Dr John. Not only vitamin D wasn't recommended, they told us to stay indoors, out of the sun.
As a nurse in the US, I wanted to let you know that you’re information has been the only source of medical opinion that I followed since 2020. I told anyone who would listen to also check your posts as I was always asked where get reliable information or advice. I can’t imagine not having you here for guidance and help with understanding the entire medical situation that we have endured. I have not been sick and I have worked continuously at a major hospital in the TriState area of NY/NJ/CT. I do not have any comorbities and only take vitamins (multi, calcium, fish oil, vitamin D3, zinc, B-12 and Co Q-10 ) and use eye drops. Thank you for all that you have done for everyone that listened to you. Appreciation seems so insignificant and slight, you are deserving of so much more. Please know we hear you and are benefiting because of all that you have shared. Exponentially through us you are getting the information out there. I am eternally grateful for you.
It’s okay to be emotional. This IS emotional. It’s devastating for medical professionals who never forgot to First Do No Harm! You are a hero Dr. Campbell. Keep going!!! ❤
we all know the truth now
Dr Campbell should be minister of health!!
I started vitamin D a few years ago and stopped getting respiratory infections and bad coughs that I was getting before. I had covid twice with no respiratory symptoms. I keep sharing your videos with people and trying to get them to listen. I am an example of proof that it works. Thank you so much for all that you do! You are brilliant and your videos are helping many people!
We love you, Dr. Campbell. You actually CARE about us and it shows.
The new vitamin D “extra strength 2,500 IU” tablet format I see in Canada 🇨🇦 is one I tell patients to take when they resist taken 3-4 tabs of 1,000 IU to get their blood levels into the normal range. After highly recommending vitamin D for nearly 20 years, I have about 20% success uptake rate with them. Thanks!! Lotsa love from Toronto ❤❤❤
I was diagnosed with extremely low levels of vitamin D back in 2017. My doctor put me on a huge booster course and then the recommended daily dose. Apart from the odd head cold I’ve not been ill since. I am 76. I have had no covid or covid jabs and I intend to keep it that way.
I'm taking 8000 IU a day to reduce ribcage pains to zero along with vit K2. My doctor wanted to check it wasn't too much and after having a bloodtest he texted me saying I'm fine with a level of 87 and I should continue. So there you go.
I've been taking 5,000 IU daily for 20 years or longer.
My name is Mike Van de Sande from Canada. Not as proud to be a Canadian citizen as I once was.
Stay strong Dr Campbell..as a nurse myself, it's been a tough few years in a profession we once loved. Witnessing the madness and speaking out against hasn't been easy.
Vitamin D supplementation by Canadians is quite common, since our weather is almost as bad as yours. Its value in acute respiratory illness is well-known, but it is nice to see this meta-analysis, and interesting to see the dosing schedule for ICU patients. It appears both protective and therapeutic. If Vit D is not routinely taken by UK residents, it may reflect the reality that deaths per capita were much higher from Covid in the UK than in Canada.