Nitazenes: Fentanyl But Worse?
HTML-код
- Опубликовано: 31 май 2024
- In this video, we discuss Nitazenes - a class of opioid compounds that pose potential risks due to their potency and ease of synthesis. We go into their discovery, history, and recent re-emergence in the drug market. This video is aimed at spreading awareness and understanding.
ChemDraw Template:
chemistry-capital.ck.page/7a0...
Want to discuss chemistry? Feel free to message me on Twitter/X
/ chem
References:
pubs.acs.org/doi/10.1021/acsc...
pubs.acs.org/doi/10.1021/acsc...
www.frontiersin.org/journals/...
www.cureus.com/articles/14059...
www.tandfonline.com/doi/abs/1...
jamanetwork.com/journals/jama...
www.cell.com/iscience/fulltex...
www.sciencedirect.com/science...
www.sciencedirect.com/science...
pubs.acs.org/doi/10.1021/jm00...
Attributions:
vimeo.com/897961325
commons.wikimedia.org/wiki/Fi...
en.wikibooks.org/wiki/File:Mu...
commons.wikimedia.org/wiki/Fi...
en.m.wikipedia.org/wiki/File:...
commons.wikimedia.org/wiki/Fi...
commons.wikimedia.org/wiki/Fi...
commons.wikimedia.org/wiki/Fi...
flickr.com/photos/peabodyprod... 
Наука
I started doing drugs since my teenage, got addicted to fentanyl. Spent my whole life fighting fentanyl addiction. I suffered severe depression and mental disorder. Fentanyl addiction actually destroyed my life. Not until my wife recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 3 years totally clean. Never thought I would be saying this about mushrooms.
Amen God bless people. Save your health save your mind. Life is better without heroin, fentanyl, alcohol and cigarettes. And you have more money in your pocket. God bless everyone who has rejected the devils intentions to be addicted to alcohol and cigarettes etc which can cause so much damage to health.
Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Belgium. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them
YES very sure of Dr.benfungi. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
Congrats! I'm really happy for you that your wife decided to help you. I always admire those who beat their addiction. Knowing it's possible to fix your life knowing there's people out there that have done what I thought was impossible gives me hope I will make it through as well. Those who share their experiences don't know how much it helps when you're about to give up, it gives you the strength knowing somone who actully know what it's like to go through this tell you it's possible, it's not the same somone telling you you can do it when they have no idea what it's like, but hearing somone who knows what it's like that helps a lot since you understand it firsthand and made it out gives so much hope. so thanks for sharing.
Glad you're clean my friend ❤️ nothing nearly as severe (can't even imagine what that withdrawal was like), I can't even quit kratom haha
Its sad and ironic that heroin actually has a better safety profile than these synthetic opioids, especially for recreational use. Regulations have only accelerated the drug war into the abundance of more dangerous substances. Synthetic opioids are a blessing to medicine and a curse to those on the streets. Nitazenes may play a role and if they get regulated too, there will just be another class to take its place. I'm guessing we'll see polypeptides and their GMO production.
Really well thought out comment. The solution doesn't seem straight forward at all.
I don’t think it’s just the drug war. Heroin is way more expensive and harder to source just as a function of its being a crop. Fentanyl and hyperpotent related compounds have a way cheaper cost of production
@@sirranhaal3099 Something China is eagerly exploiting, if certain sources and some accounting are to be believed.
@@sirranhaal3099 That production cost is more about the volume to hit targets. 10x stronger means the same number of doses in 1/10 the volume. Being able to smuggle a year of product in one backpack is why super potent drugs is the new normal. It's all about the logistics.
@@chemistrycapital It is a challenge to the notion that Science However Applied Is Always Good. Like the skilled man Daedalus of ancient myth who in his enthusiasm flew too close to the sun with his wax wings, we can research and develop ourselves into situations we are not ready for through passions we didn't even know lurked beneath the surface.
Now perhaps there will appear opiate-opioid-nitazene proofing medications, and should ICU-monopolization and plain fatality rates approach that of COVID a COVID-scale research effort may be called for, but one has to be careful that they don't muck up our inner normal biological systems to the point of being counterproductive.
An old word warns us that man doesn't live by bread alone. We're already finding that out literally by getting too fat in large numbers, and I'm no exception. I would warn in retrospect. But that also applies to more devious hacks to our biological system. Give those dying or in severe pain their fill of opiates, opioids, and nitazenes -- yes, yes, a thousand times yes. But why waste the potentials of everyone else on the potions of a chemical Bacchus?
Nitazenes are going to be a HUGE problem. Between their potency, some not being reversed by Narcan, and their availability. Anyone who buys chemicals from overseas (legally or illegally) can tell you where to find them for surprisingly cheap. I don’t necessarily know what the solution is, but we’re losing 100k+ people every year just in the USA. That’s nearly DOUBLE the number of deaths from the entire Vietnam war every year.
Better education and improved access to healthcare would prob be a good start
@@GEEZYEA777 maybe, people who are on the streets using drugs don’t really care about education on them in my experience. Just making morphine OTC would probably help too since they could switch to it and decrease their risks exponentially. Portugal has had some luck with decriminalization, but in the US and Canada the mental health facilities were mostly closed in the 70s and 80s which is when we saw a huge increase in the homeless population and the majority were people who need extensive mental health care. It’s a mess on a bunch of different levels.
@@chemistryofquestionablequa6252Education on drug awareness is incredibly important, and many addicted drug users actually care about that kind of stuff. Even better education on general science and/or social skills can develop our minds to make even better decisions in our day-to-day life. Like i said, looking to improve education is a good start.
@@GEEZYEA777I genuinely believe that legalizing opium in the same manner as cannabis, and opening opium dispensaries wouldn’t be a bad idea, considering that a legal & regulated opioid alternative, (not to mention much less potent,) to fentanyl & nitazenes, would cut down overdose deaths
The Vietnam War had between 1 and 3 million deaths.
Wow a RUclips video that actually has sources. Absolutely based.
Haha, thank you. For the next video I am going to organise them in to sections so it is easier to find the reference you’re a looking for.
Based on what?
@@levansegnaro4637based. Like Based God.
@@levansegnaro4637based on scientific research actually 🤓🤓🤓
@@Jack-zj1ugerm actually its acidified on satan
Opium should be legalised. It's difficult to overdose by smoking it. But it will take away cravings and withdrawal side effects. It might help an addict trade for something much less deadly.
If dried Opium latex is swallowed (instead of smoked) the effects last more than 24 hours and its a much better and safer substitute than Methadone. Since raw Opium just contains the natural alcaloids of the poppy plant. It feels much more natural than Methadone or Suboxone and has greatly reduced side effects. But the satanic system wants addicts to suffer or die.
Wishful thinking
In Canada codeine is OTC. Tylenol 1-4 all available for less than $20 a bottle.
Access to pain medicine isn't what caused this and won't fix this.
This is a parenting problem, we are missing something in our rearing and the results are rampant addiction.
We are all a product of our environment, our parents are responsible
Opium is worse in a lot of cases it has a ton of muscle relaxers in it. I know ppl that use poppy tea that say it's a worse kick than heroin. Remember heroin was created and hailed as a miracle to kick and treat in comparison
@@francislutz8027this is absolutely the truth Americans refuse to accept.
Single mothers are 100% the reason for the drug epidemic.
You could technically grow it at home..
Thank you so much for actually talking about the molecular structure and the synthesis! I wish the news would give this level of scientific info. Information content of the news is at a all time low right now, its always just about feelings. "Lets all just cry together instead of learning and fixing the problem"
Glad it was helpful! I think the world would be a different place if the public had a better understanding of chemistry
The news isn't fucking news! It's brainwashing, PROPAGANDA! Seriously turn your fucking tv OFF! You'll thank yourself, get a hobby, go outside, live fucking life! Life isn't working your 40 hr a week slave job just to come home and watch PROGRAMMING, rinse and repeat till you're dead. It controls you more than you could ever realize! TV isn't entertainment, it's called PROGRAMMING for a reason, your thoughts aren't your own, you don't even know who you're... Sounds crazy, I know. Turn it off for a month, you won't want to watch it anymore...
If I wasn't an Ochem student the explanation would just be gibberish. I've tried to explain synthesis to some of my coworkers and their brains just seeze up. It's like I'm speaking alien.
I completely understand n agree where yall comin from, but at the same time as wild as the world is now, they're prolly afraid/hesitant to put out too much info, as if the public knows about it, alot will "Experiment" with this new info.
They weren't crying during the crack era, they were locking everybody up. Energy should be kept the same or the "crying" is 🤔🥱
There is another opiate compound called bromadol. Very very little is know but there is a trip (if you can call it that) report on RUclips. The man describes taking massive amounts of car fentanyl to the point where even massive doses would not do anything to get him high. The guy was into synthesizing drugs and decided to synthesize bromadol and he described the facts as setting in pretty slowly but once they did set in it was deadly. He said and it can't be verified but that it was 50 times stronger than car fentanyl and lasts 12 hours while also not giving any euphoria. He said in under 30 minutes He reached blackout state but due to some act of a higher being he managed to be able to call an ambulance for himself and they administered narcan but quickly the narcan stopped working and he would fall back into overdose and respiratory depression. The hospital had no clue about the substance So he had to describe it best as possible. The hospital had to end up keeping him on a constant narcan drip for 12 hours and oxygen until he started to stabilize and was able to breathe on his own.
Crazy that this is on RUclips, do you have a link to the video?
@@chemistrycapitalit is inaccurate and half the story. At the moment the compounds more potent than car fentanyl are 4Fluor OHmefentanil (18000x morphine) and lofentanil (14500x morphine) bromadol or bdpc is ~500x morphine in animal studies
@@chemistrycapital yes! It's not actually posted by the guy who wrote it tho it's someone retelling it
@@chemistrycapital ruclips.net/video/bDyXglEUhyA/видео.htmlsi=mGD_MxbETo5egz9I
Ok now that I'm rewatching it a few of the details I gave were not true (just the synthesis part of it and how he took car fentanyl before) I may be mixing it up with another report of the same substance
I am opioid free and have been for almost 8 years, but I have to admit, when I learn of new strong opioids, my inner junkie says "heh, I wanna try that shit".
I know you won't, but it's not even fun it's a gamble every time you do it and the high is not as good as your standard old opiates. Stay clean. Peace
@frankfontaine1559 the first few times your lying its the BEST high ive ever experinced, but then comes the perma tolerance where any other opioids do fuck all
10 years clean myself. Getting help was the best decision I ever made. Stay strong.
RIGHT. I was like huh, wonder if they're any good
I am opioid addict, started my addiction with dihydrocodeine, then switched to morphine, and now I use oxycodone.
I tried fentanyl, and it was absolutely no any pleasure. I tried to taper it to withdraw, and one day I woke in hospital with rhabdomyolysis and horrible pain. NEVER DO it. However I heard people getting very intense euphoria with furanylfentanyl or carfentanyl. Though, horrible horrible horrible horrible withdrawal. Absolutely life threatening and insanely dangerous withdrawal symptoms. They even used pure heroin (diacetylated morphine), which worked as ANTAGONIST with that drug. It is insane. If hell exists, this must be what it looks like. Me, when hospital personnel decided to torture me (I live in Poland so they don’t know procedures with opioids), and not give me any medications resulting in cold turkey withdrawal from fentanyl, with rhabdomyolysis which is absolutely the worst pain I ever felt, broken bones must hurt 10 times less than that. I was begging them to kill me, if they don’t want to give me any drugs, even f-cking ibuprofen. They didn’t, and after a week I left hospital with extremely mentally exhausted, not sleeping 5 days due to the pain.
It’s how it feels. Fentanyl - NEVER do this. Literal hell on earth. People introducing it to the market have no heart
very interesting video. thank you for yet another upload. what are you planning on covering next?
Thank you so much! Planning to talk about cross couplings in medchem/drug discovery and a problem I don't see taught much in university's
Fantastic video! Keep up the good work man
Thank you! Will do 💪
Hey! new subscriber here! I love this sort of thing, and very much enjoyed the level of info you provided. I personally like to research things to similar extent. Excellent work friend! I look forward to seeing more videos!
Thank you so much!
Well that's a truly terrifying group of chemicals I'm glad I'll never be near! Thanks for a very informative and well thought out video! Got my sub for sure!
My uncle nearly died of an overdose because the pain pills he bought contained fent. He was dealing with cancer and found a cheaper (black market) source than his prescription.
It was a dumb thing to do but I don't really blame him given his situation.
He'd never used illegal drugs before apart from weed and shrooms afaik. It's possible to get caught up in this BS without ever intending to.
Nitazenes are known to be dysphoric opioids. Some analogues behave as serotonin reuptake inhibitors (like tramadol) which also limits consumption. Finally, ultra-potent opioids tend to saturate receptors quickly, leading to tolerance in a few days of using.
I don't see these molecules becoming a major health issue like fentanyl is. We will always find more potent and easy to synthethise opioids, the problem with fentanyl started with criminal misinformation regarding oxycodone, and lack of regulation for new opioids.
At some point it's just poison anyways and i doubt illicit medical suppliers will go through the effort.
Dysphoric as in they are unpleasant to take?
@@coleramsey6705 no they dont feel good in the way morphine or heroin does like itll still feel good just not as good
tramadol is not a nitazine analog
No high will ever compare to oxycodone. I knew dozens of ppl that just stopped doing drugs after oc was banned. They were only addicted to it. It's the cleanest high ever, no nods or anything just pure opiate energy.
I think the main problem with fentanyl is that doctors won't help with pain now so people have to go to the street a lot of times for medicine which is usually fentanyl. I broke my hip and had hip replacement surgery and only got like 10 5mg pills or something, I had to buy kratom at the gas station for a while because it hurt too bad for regular OTC stuff like Tylenol. Tired of this crap, let people get help with pain or this problem gets worse and worse.
If you are taking kratom try using Blate Papes. They are oblate squares that you put the powder in then swallow. It eliminates the taste and powder kratom is much much cheaper than capsules. I have taken kratom daily for 5 years and oblate papers have been a game changer. They have videos on how to use them and with practice, it becomes second nature.
same here in germany
@@dirtyhiggins5484 that feel when even fucking Kratom is completely illegal in your country (Ausfailure).
a lot of times the doctors are the ones prescribing the medication illegally like hell
"THEY " know that. It is my whole hearted belief that ALL this "epidemic " is COMPLETELY planned and designed... they pumped strong opiates in EXTREME amounts to any and everyone for everything then... out of nowhere cut it off completely. Then, like on que... appears a life ruining, dirt cheap, extremely strong opiate that is EVERYWHERE and can be bought for near nothing. Except for the loss of life and pain and suffering.... I think MANY of the ppl using fent by now had NO PLAN to EVER use such a bs substance but are FORCED to become junkies to it because there is no other option and the bills keep coming so there is no choice... a man will provide for his family... even if they have to use fentanyl to keep going." They" know what they're doing. This is no "coincidence "
The things one can learn on RUclips continues to amaze, I enjoy learning new things STEM related and is why its especially helpful when you stumble upon a video and its thorough & complete with the whole method incl. conclusion / evaluation, etc and has the background information to the main story. A Very interesting video. I've Sub'ed and hit that notification bell! =)
Thank you very much!
Crazy helpful content man
This channel is so underrated
Thank you so much!
It sucks the only opioid drug people have access to in America is fent or zenes, at least in places with heroin, it’s a higher dose so it’s millions of times safer than fentanyl. A lot of lives would be saved if traditional heroin, or another higher dose opioid was brought into the streets
I was a junkies in the uk, and am now in North America, the amount of people that die is insane I’ve only been here a few months and am already seeing regular deaths just by going to the methadone clinic once a week
Something has gotta be done about this as it’s getting ridiculous
Yeah, they fucked everyone when they cracked down on pain pill prescriptions. I'd never lost anyone to overdose before that happened, and I've lost 62 since.
When we pulled out of Afghanistan (lost access to heroin) the Chinese came in to fill the void with fent
Kratom
This is a coordinated attack from china. They are pumping the precursor chemicals for fentanyl into the US to weaken our next generation. Unfortunately our government wants death and destruction to happen so they can claim we need them to protect us. The whole situation is terrible.
It was all planned. Follow the trajectory from Purdue to Florida clinic mills to cartel pressed M boxes to present. Compare to the Crack epidemic in the 80s/90s and the Iran / Contra deals the
C eye A was behind. It's NEVER an accident.
Great now ill never get my painkillers back. I broke my lumbar at 23 and had a failed lumbar fusion. I was on oxycodone for 4 years and had ZERO problems. Never abused them, passed all of my drug tests and did everything to a T. The gov't is more worried about junkies then us who actually need the meds. Thanks guys.
They made a crisis out of the cure
They made a mess out of it. If people had a 2 day supply not to be sold, with 3 virgin laser inscribed needles, resterilized and recycled to the person, it would be cleaner than the rest of healthcare standards where sterilized instruments are recirculating. The problem is this: they just dunmped fentynal on the streets in needless so you have dirty needles going around and people trying to get wasted teenagers hooked on it at parties because as with coke, if somene can get 12 people to get hooked on it their stuff is free. So there's smash and grabs and home invasions to support their $400/day addiction.
Or, there's prescriptions, no more crack house but a regional business with a license. No one is selling any because they will run out, and others can get a prescription. Heroin addictions will burn out, instead the way they dumped it or in the streets they spread it.
Who wants to start a heroin addiction?
You can go get a prescription if you're addicted and the party pyramid structure stops from spreading. It would cost less and ends the crimes people commit while people would be in business with a license. You can afford that plant. 🌿
Now, WW2 was a multi national depop.ulation war
Check this out
45-65 percent of the world would say thanks for a take home fentynal drink with a micro serial number in it and the world wouldn't have to do WW3, 4, 5, 6.
The world would double its available resources to a world only full of those that want to be here, about half, and the average poor person would have 2 houses, 2 cars, 2 cows, ice cream, cheese and oil and clean water to last the planet.
Take fresh lawnmower clippings to be sprayed with water and put in a flash freezer and you might double your cattle production. All the head every week fresh cut from lawns and fields across America
Save 3200 on your property taxes, how somene to more your lawn on the day before pickup, fresh coupons and you qualify, bad nasty bags of grass go to a divided back part of the truck and you lose a little credit. Save 3200 and buy a t-bone and cheese and ice cream and milk while somene has a job mowing lawns! The grass gets taken and sprayed with water and frozen and sent to cattle ranches. As it thaws it picks up more mistrust and the cattle have food and water. On the ranch there is an indoor feeding area where grass comes out of the cooler on a conveyer, or is fresh and cool and ready to eat, and moist. As it comes out of the cooler on the conveyor so a little cool air and it is cooler where the cows eat with a plastic strip door keeping the cooler air inside. After awhile the concept takes The grass back into the cooler so it won't spoil and fresh grass comes out at the other end of the cooler conveyer
Do this asap
This video made me aware of your channel. Fascinating new drugs with an interesting prep
Good luck with you RUclips career, subscribed
Thank you! More videos coming soon
The video is really well made , the only issue is that you need to get a better mic and use some post processing for audio to make it both smoother and louder . You'll easily become one of the next big documentary channels
Thanks for the feedback! Yeah the mic I use is meant for instruments rather than vocals, definitely looking at investing in a mic better suited for voiceovers.
It absolutely doesn't need to be any louder. 🙄
@@chemistrycapitalyou can get away with a 50-70€ mic and a bit of post processing to remove static/bg noise and a little EQ
@@chemistrycapitalI like SHURE and RODE microphones can't go wrong with either brand
Any recommendations for a mic?
Thank your for this PSA, I've lost too many friends already and this information is something critical to spread.
Thank you so much! I will be making more videos like this in the future
Ohmefentanyl is even more potent than carfentanyl or 3-methyl fentanyl. The core issue is the illegality of diamorphine - which can be manufactured for pennies a dose in factories (it’s used an analgesic in the UK). The profit from illegally importing a kilo of a potent synthetic vs heroin is incomparable.
At this point, I don't think we'd be able to get them back on heroin, they've been on fentanyl (or stronger) for years and years already.
Oh Man, I noticed this risk a couple years ago while researching Synthetic opioids for a college paper. Truth is there are a few other different types of drugs that exist from the past that when rediscovered are going to be problems.
Indeed, this isn’t the first and definitely won’t be the last
Old Drugs and New Challenges: A Narrative Review of Nitazenes
www.ncbi.nlm.nih.gov/pmc/articles/PMC10361140/
I've been curious as to when we'll start seeing more GABAergic analogs. Maybe old school barbiturate's? Though I'm sure there are some other classes that someone will run across
Not sure why people would want anything stronger than fentanyl...
Because fentanyl doesn't touch certain pain at all.
70mph motorcycle collision, car pulled in my lane. I'm on suboxone, the ambulance EMT gave me 2 shots of fentanyl ON THE WAY to the hospital and I was still seizing and unable to speak, lay flat or focus as I was in and out.
The ketamine at the hospital was the only thing that touched my pain for my 5 days in ICU.
There ABSOLUTELY is a need for stronger pain medicine if the strongest on the planet has absolutely no effect intravenously on maintenance therapy patients.
holy shit bud this video is absolutely beautiful, you are extremely talented.
Thank you so much!
@@chemistrycapitalI REALLY APPRECIATE AND RESPECT YOU..I HAVE MULTIPLE FRIENDS IN THE PHARMACY INDUSTRY ..I LIVE HERE IN MYRTLE BEACH WOULD LIKE TO CONTACT YOU POSSIBLY FOR A FEW QUESTIONS IF TIME EVER...TY VERY MUCH...
Wow I feel honored to be subbed this early.
Excellent video!
Thank you!
about time we get something with a bit of kick in it
Famous last words
Well, if we could actually cocktail all those neurochemicals into one street drug, I imagine it would be like a rollercoaster ride through the depths of hell and the pearly gates of heaven at the same time. You'd be so high that you'd think you were a unicorn flying through a rainbow, but then you'd crash so hard that you'd feel like a snail stuck in molasses.
But thank goodness we don't have to resort to that kind of experimentation because our brains are already equipped with the perfect cocktail mixer. It's like having your own personal bartender in your head, constantly serving up delicious shots of dopamine, norepinephrine, anandamide, endorphins, and serotonin.
And when we're in flow, it's like we're at the best bar in town, sipping on the most exquisite blend of pleasure drugs that our brains can produce. It's like winning the jackpot in the neurochemical lottery, and we're all in it to win it.
So, let's raise a glass to flow, the most addictive experience on Earth. And who needs drugs when you've got a brain that can mix 'em better than any street dealer? Cheers!
no becuase combining gabaergic with opiodergic would quickly lead to respiratory depression
Did you use chatgpt to write this? Idk why but I get that vibe lol
@@Synky yes 🤣😂
Bro, drugs literally effect brains serotonin, dopamine etc
@@SashaLumi On a certain level, we have a drug store in our brain, the neurochemicals that show up in flow: so dopamine, norepinephrine, anandamide, endorphins, and serotonin. If you were to try to cocktail the street drug version of that, right, you're trying to blend like heroin and speed and coke and acid and weed- and point is, you can't do it. It turns out the brain can cocktail all of 'em at once, which is why people will prefer flow to almost any experience on Earth. It's our favorite experience. It's the most addictive experience on Earth. Why? 'Cause it cocktails five or six of the largest pleasure drugs the brain can produce. We're all capable of so much more than we know. That is a commonality across the board. And one of the big reasons is we're all hardwired for flow, and flow is a massive amplification of what's possible for ourselves.
Very interesting buddy, thanks very much for creating and uploading to youtube :D
My uncle died from heroin overdose. He was like 85 years old. Every time he got outta San Quentin prison, he go back to heroin
Im so sorry for that. Its incredible, but if one were to use clean heroin, and proper usage, heroin axtually isnt that damagaing to thr body, other then depressing brrathing. I was addicted to opioids for about 8 years. My brother is in the same boat, coming out of jail and going back on fentanyl. I believe, it is unfortunate, that people that are constantly abusing opiates are just trying to numb some sort of emotional or mental thing. It could also be a subconscious drive to black out or what called "a death wish" maybe subcobsciiusly.
85 you say?
He must’ve been a dickhead then.
There’s no older tweakers like that, only opioid heads get that old if they don’t die younger..
Same here bro same prison out in cali and when he’d get out went back to the dope and passed away rip uncle woody
Very informative. Thank you. I was a heroin addict, kicked habit by weaning off 30 mg morphine tablets. One month it took. Never sick a day. That was 2001. Methadone is a government ploy.
Considering heroin withdrawal can kill. You're a pathological liar. No ifs ands or buts. Probably took up a different habit if anything.
Withdrawal from methadone is the worst, once they have you on it they own you
Yeah they try and trap you at those clinics. I told them I wanted to only take it for a small amount of time and they tried to give me bullshit about how I needed to get “stable” on the medication, which basically translates to “get addicted so then you HAVE to pay us
Just dont do it
Great informative video.
Great video! I thought nitazines were the same thing as xylazine, which is also being mixed with fentanyl sold on the street.
Please do a video on xylazine!
seriously people didnt have a copy of phihkal or tihkal by shuglin until the 2020s? i bought that book at 16 and was making things in my moms garage.
Can you do a video on JAK inhibitors??
100% sure this will come up at some point!
What’s going on with them ? I had to look it up. It’s just a dermatology drug
When do you find the time to make these videos? They are really detailed . :)
Alongside my job as a medicinal chemist sometimes it's hard to post consistently, trying my best though :)
Oh great, just what we needed.
It is sad that people are prepared to blow away there brain power and ultimately there life for a bit of gratification.
ISOnitazine has been available in place of fent for years already, ppl just didn’t realize it
Yup, lol
Can't wait to try it
great vid, i have a question. Do chemists hypothesise molecular structures of drugs they think might bind to receptors and then figure the synthesis out after?
Most of the time chemists have a “hit” which already binds and they make changes to this structure to improve binding or other properties. Sometimes these changes can be made via the same route, sometimes not. So it depends on the molecule and the changes made
I tell everyone i was addicted to febt but thats just cuz everyone knows that and not nitazenes. I was ACTUALLY addicted to isotonitazene which is by far the most incredible substance ive ever tried. It lasted for 4-6hr, and i had just 33mg. I used to measure out 10mg and dissolve it in 100mL of filtered water with 1.5mL of 10M HCl added and microwaving. Id take just 2-5mL per night about 2-3x a week and nod off... it was so dangerous and kinda pointless, but its also the essence of euphoria. Ive smoked and injected meth and its nowhere near as enjoyable as these drugs. Id hapily go out on iso right now
Damn that’s dark. A Chen I tried that I liked at the time was u-47700, it’s was caustic as hell and caused nosebleeds but it was more potent than heroin
They are old but they are safer than fentanyl due to better separation between effective and letal dose, SR-16017 gives low addiction and habituation
This is true but there is nuance to this. In theory their therapeutic window is larger, but this still leads to lower lethal doses due to their potency.
@@chemistrycapital But the greatest problem with fentanyl is that LD/ED, is very low, half-life short. The high requirement of beta-arrestin, is often said to be extra high with fentanyl. The studies done with a wide range of mu-opioids, have come to very different conclusions regarding this selectivity regarding tolerance development, so more studies should be done. Oliceridine, is the only of the allegedly more selective compounds that are approved for clinical use (but it's a very different structure). Use of fentanyl as dermal patches is the safest way for pain relief in the home. I don't think benzimidazoles are in use, (except for the RC-market)
But in an unregulated market people have no idea the dose or even what compounds they are taking, which is when the low lethal dose is a problem. In a clinical setting where doses are known it’s a different story.
Sounds like the same stuff Purdue pharma said, on a different day.
I know many people with experience using this class and the tolerance builds insanely quick to these. Quicker than for fentanyl and its derivatives. And to top it all off, the withdrawals are the worst of them all.
I predicted it like 3 years ago when i first heard of them, i remember seeing obscure reddit posts about them in certain communities and when googling about them it was immediately obvious they were next on the list. I specifically remember some people who had used fentanyl a lot saying the -zenes are worse, the addiction they subjectively said was stronger and withdrawals were worse than fentanyl.
Reddit always ahead of the curve 😂
@@chemistrycapital i think it was r/opioid_rcs, the mods were warning fentanyl users about them. Thats how you know its bad.
100%, I remember seeing them being mentioned on an RC form wayyy back before they were even in production, people were finding old patents from pharma companies and speculating what will be produced next and zenes were pretty close to the top of the list. I still remember the days of U-47700 burning holes in peoples arms and legs due to its causticity, apparently its back on the market in some places with a new lab that's alot cleaner and less caustic but I still wouldn't go near the stuff.
how u make olmesertan?? the most important drug in the world??
This molecule will come up in the series on top selling pharmaceuticals. Check out the playlist on the channel if you are interested!
What makes it the most important drug in the world?
ruclips.net/video/X0y0PcVJ5Ss/видео.html@@ramseydoon8277
ruclips.net/user/DrTrevorMarshall
Oh yes population reduction in progress
Good👍🏻
@@jerrodbeck1799😂😂😂
Please make a video so people learn Benzodiazepines are literally like Alcohol in pill form. Could really save some lives and families by bringing awareness.
I am sure I will in the future
I od on etomethazene&methadone but hated how long it lasted, is there a longer lasting zene than that one
Fantastic thank you
Very nice historical infos
Thank you!
dope video man,whats your degree and current work position? I study Biochemistry (currently in masters program) and really want to go more into the direction of medicinal chemistry once i've got my masters
Glad you enjoyed it!
@@chemistrycapital edited this comment a little later, so you might not have seen the edit: whats your degree and current work position? I study Biochemistry (currently in masters program) and really want to go more into the direction of medicinal chemistry once i've got my masters..
My degree is in Chemistry and since graduating I have worked at two small Biotech's as a medicinal chemist. A "traditional" medicinal chemistry job involves a lot of hardcore organic chemistry and synthesis.
I can't see anything that binds to the opiate receptors not being addictive.
Once bound for a prolonged period, the unbinding will still produce the same results as with other more known substances.
I would imagine that it's the loss of that binding that creates the "dope sickness"
Good work very informative, I have no interest in chemistry I am a statistics undergrad, but the video was still interesting, keep up the good work!
Glad these videos are interesting to non chemists as well!
@@chemistrycapital yeah, I hate chemistry, but either way it’s still interesting to hear abt stuff that’s so relevant
Great video
Thank you!
What a curiously specific video…
gd work ...keep it up ....
I’ve seen these turn up in north american drug test data with increasing frequency over the last year or so. This is extremely concerning, though it’s exactly what I predicted would happen.
If we find ways to identify and stop nitazenes from making it into the country, it’s only a matter of time until other potent opioid agonists find their way onto the market, just as what happened with fentanyl and nitazenes. The cycle will continue unless we rethink how we handle narcotics in this country.
I wonder why the nitro group makes it that much more potent? We can see this with Benzodiazepines as well. Amateur here, is it because of the nitro's delocalized electrons?
The nitro group is pretty unique in its electron withdrawing ability which can influence pi-pi stacking interactions, which i believe is why nitro benzodiazepines are more potent. It is generally avoided in drug discovery as it can generate reactive species when metabolised in the body.
These compounds along with fentanyl are so fast acting with very little half life which make them terrible for pain management. We need a long acting compound to truly help people in pain.
But they wont give it to people.
Im 37 and Ive been snrt 13 IV @ 14 and I remember my personal switch from classic itchy to something new what I have been hooked and perfer since Freddy Kruger. I don't know why people keep overdosing when the risk is out there. Don't get me wrong I have and I have also tried to go out intentionally and failed. But I never treat the one bag the same as another. I believe there is a middle ground and with proper education, information and understanding what comes with this long term a full life can be lived while in active use. When I was 13 my 36 y/o g/f told me it was just like smoking 10 blunt$ PERIOD. I didn't know anything about the sickness or anything that would come with it. I most certainly didnt feel comfortable telling anyone that I was using this "oh so evil and bad ugly substance" I noticed 4 big changes in what I got and lately after the fourth biggest change when i get sick it is more intense and it is 3-4 hours instead of 6-8 and muscles jerking almost slapping myself unintentionally and only with actual effort will it stop
36 year old gf??? At age 13?? She sucks for getting a child into heroin. So gross. Sheesh. Gross predator.
Wow scary stuff! 😬 That you for the video!👍😃
Glad you enjoyed it
So where can I buy it? I couldn't find it on Amazon.
This is absolutely terrifying. I'm just happy I'm not using anymore. This one is just downright scary.
Hi, I don't know if you'll ever read this message but I think the UK public should know this. I work in a prison and we found out that 3 people had died in the space of 2 weeks in a different prison. Should also be worth noting, in the event of an overdose of nitazine, the officers wouldn't have a chance of administering naloxone (our primary tool to combat opioid overdoses) before you were past saving. The time this drug takes to kill is scary and there isn't much we can do to combat the substance.
I dont participate in the scene anymore but you could buy etezene analogs by kilo like a year an a half ago.
I think it was isoetazene some guy said it was like a speedball extremely euphoric and non reversible. Yeah sounds fun but hella fools are gone due
this kid i knew a few years back got into fent and just died today. the last time i saw him in 2021 he looked 19, i just saw a picture of him after hearing about his death and youd think he was 60. disgusting, i wonder if this stuff had anything to do with his death
I’ve taken ochem 1 and 2, but you must have gone to grad school or really researched that synthesis because that was some complicated stuff.
What’s the longest lasting nitazene
This is similar to the drug classroom, just more thorough. I subscribed since his channel is mostly dead.
I had a couple batches of M30s that had zenes in it. So strong
Where can I get some? Research purposes.
9 days off fentynl cold turkey cravings, crazy. Prayers! Feel lucky…
That’s some scary stuff. What chance do our kids have with this stuff being pushed?
That shits probably already showing up in Kensington PA!!!
Do you think that we'll just endlessly outlaw more and more potent drugs and eventually end up with a sort of Manhatten project level drug that one person overuses and like a whole neighborhood ODs?
Looking at this and laughing. As a frequent user, this does scare me though
Did you know that pharma companies DID find compounds that have high therapeutic index, low potential for abuse, low potential for withdrawal, and low potential for overdose… opioids that are active at the k-opioid receptors… they chose not to pursue them
Which compounds?
Salvinorin analogues. However, they have different side effects, like dissociation and hallucinations, and affect pain very very differently
Your kind of forgetting the reason they chose not to pursue them,
the horrific side effects
Is mitonitazene known as the best one?
Etomethazene was insane for me, had 98% purity and smoking on foil was like Oxy with lots of energy but only last 2-3hrs so tolerance skyrockets
Wonder about salvia because it is a pure chemical not a chemical compound and it is not an opioid but it binds to one of the opioid receptors or maybe two,mu and kappa i believe, wonder if it could be changed from a hallucinogen to something else that would be good for pain management
People do make pain stuff with the salvia plant but it’s so weak an ibuprofen would beat it in terms of pain management. Also not sure what you mean by “pure chemical” lol chemicals are compounds made of different molecules. Unless you see salvinorum on the periodic table then yes it’s a compound
Nitasene has been an issue in Ireland for a year now !!,
Are you sure it's 2 milligrams as fentanyl is usually administered in micrograms, patches can be up to 1600 micrograms and ampoules for IV are around 50 micrograms.
How Much milligrams do you think 1600 micrograms is?
@@thebomb252 1.6mg, I think the reason I originally commented was because the patches are slow release
The max dose was 320mcg when it was given to me after surgery. I hated it because there was no euphoria and I couldn't p. The dilaudid was pure heaven.
Just when we thought it couldn’t get worse.
The thing is i feel like we should study why people turn to drugs in the first place and tackle that
I got a strike for hate speech saying that was a dumb thing to do. I didn’t know any of that was hate speech!!
I jus wanna see those crazy pills from the 80s i heard so much about. Quelude or something😂idk the old man always talked about it like it was some holy Grail of a pill😊 cheers y'all
Last time I checked they still make methaqualone in south africa
They among many other fringe novel opioid agonists will never gain as wide acceptance as fent, oxy or Diacet Morph for this simple reason- theyre too caustic to be snorted or injected regularly. If youd like some perspective from a reformed felon id be happy to fill you in on some of what i know. Theyre very dangerous, thanks for sounding the alarm.
Which is UK chemical of capital ?
Most people would say the “golden triangle” which refers to the area between London, Oxford and Cambridge. Although that area is mainly for research. Up north there are more companies involved in process chemistry.
Why would they use nitazenes when you can use carfentanyl(100x of fentanyl as compared to 10x of fentanyl from nitazene)?
When a nitazene is easier to get
@@pf100andahalf how come?
So how about the side effects? This is awful, my gods 😭 also good informative video bruh, keep it up!
Its the Iron law of prohibition again, the more regulated you make it, the more illicit sources are going to look for more potent, yet unscheduled or lower scheduled analogs. You would think the US would have learned this in the 70s and 80s when regulations turned almost all illicit amphetamine production into methamphetamine, instead of Europe where most amphetamines are just some derivative of amphetamine sulfate or diverted medical dextroamphetamine.
The fentanyl situation was the most prime example of prime examples, take heroin, something thats highly potent on its own, regulate it to the point not even diverted medical supply exists, which also leads to those dealing in it carrying harsher legal penalty's, then what do you know! they go to a schedule 2 compound thats orders of magnitude stronger. Why smuggle a kilo of something with 10,000 dosages when a kilo of another thing has 500,000 dosages?
If additional penalty's are attributed to fentanyl, or fentanyl and its analogs, for their illicit sale and production than by the very nature of the market a stronger compound will quickly be found and make the existing problem worse. This is what happens when the people in charge of writing the laws are illiterate to the materiel reality of what they are trying to regulate.
Scary stuff.
Hey! How about we stop making super strong opioids 😩😩
I have 5 papers on how to synthesize Etozene
Some nitazenes are relatively safe when used responsibly.
very strong
I'm using Protonitazepyne. It's quite a beautiful one but definitely avoid unless your tolerance absolutely demands it. It's unnecessary if things like H, Dilaudid or Fentanyl still work. For me they just dont. Maybe if they were pure if they did but no pharmaceutical grade that's affordable.
Please be safe. You're loved and important and the world needs you here!
Contorta960 idlike to ask u a few questions about that..hate typing out etc. But any way could contact you for questions & knowledge on it...I do "fetty & iso's myself"...Can email you & or send u # contact...TY much
I'm good person & not a fraud or hre to harm you or anyone. I'm with everyone in the battle out there...jus don't have many ppl who actually have any knowledge seems like urself of what pur in your body..LoL..
I can see youre an intelligent person rofl