A Bodybuilder Mistook An Aphrodisiac for Pre-Workout Supplement. This Is What Happened To His Brain.
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- Опубликовано: 14 май 2024
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Patient JC by Chad Collins, PA Tristyn Smith, Special Thanks to Jena Marx
Music by @Lifeformed ► lifeformed.bandcamp.com
More music by T4N3 ► / t4n3
Good Playlist ► • Medicine
Timestamps:
0:00 A Bodybuilder 💪 Mistook An Aphrodisiac 😳 for Pre-Workout Supplement
0:22 JC was getting ready 🏋️ for a show
0:55 A wild 😲 supplement appears
1:35 Hey IRS 💵 we doing research 👨🔬 and development
1:50 Good ☁️ powder
2:16 haha preworkout 💪 go glug 😳 glug
3:13 The emergency 🚑 room where we are now
4:07 How does 🌳 do all of these??
4:50 Rumors of this toxicity... are not exaggerated at all. It's not good.
5:50 Neuro 🧠 transmitters gotta 😳 go 😲 fast
6:48 Inside you(r autonomic nervous system) are 2 wolves (just kidding, they're more nervous systems)
7:27 What happens 😳 here?
8:16 Alpha vs beta (not alpha male vs beta male)
9:11 In the central nervous system
9:47 Feedback 🛑 mechanism (in normal function)
10:51 The CEO of systemic... response to adrenergic agents
11:35 Multiple reports in existence
12:02 "Just pull it out of his body bro"
12:23 An Antidote 🐴 But How 🤔 Did We Find It?
14:45 Yea lets not use that here, but we could use something else
15:15 It takes 5 half lives to reach steady state, but Half Life 3 still isn't 😞 here
I don't think anyone reads anything that's written here. But here's for the metadata: this video is explicitly about adrenergic receptors. More specifically, the Alpha subtype, and even more specifically, Alpha 2 Adrenergic Receptors. This thing throws a massive curveball to learners in all medical disciplines because Alpha 2 agonism / antagonism are opposite of Alpha 1. The topic of these receptors can be a few weeks long in a Pharm course in Medical and Pharmacy schools, and that course would be dedicated specifically to cardiac pharmacology, so this is as much I can cover in an 18 minute video. There might be people who will go "nooooo u cant just say that about my tree bark supplement" but the point is and has always been to teach about the pharmacology, its mechanism and how the setting of excess changes the pharmacokinetics-- the agent serves as a means for me to teach that because it has that activity. If it didn't have that activity, I'd talk about something else that does in this setting. It's a fascinating molecule, like all natural products. If you don't need to ingest it, don't ingest it, but I trust you are well in your best capacity to make decisions for yourself.
These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
References:
Acute neurotoxicity after yohimbine ingestion by a bodybuilder. pubmed.ncbi.nlm.nih.gov/19640...
Yohimbine: a clinical review. pubmed.ncbi.nlm.nih.gov/11744...
Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear. academic.oup.com/ijnp/article...
Adrenergic receptors: structure and function. pubmed.ncbi.nlm.nih.gov/2164898
Biopharmaceutics and metabolism of yohimbine in humans. pubmed.ncbi.nlm.nih.gov/10494...
Yohimbe bark extract. ntp.niehs.nih.gov/sites/defau...
Yohimbine or NO-himbine? A Potentially Fatal Over-the-Counter Supplement. www.vumc.org/poison-control/t...
[PREPRINT] Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to naloxone administration. www.biorxiv.org/content/10.11...
Xylazine, an Emerging Adulterant. www.acep.org/talem/newsroom/o...
Yohimbine. pubmed.ncbi.nlm.nih.gov/4037464/ 
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tree 🌳 bark good
PS thanks to all who picked up a slipper in the cool kids' club test, you helped make my mom's lifelong dream a reality, and we got to donate to charity! ShipStation who we used to help ship for the test (we paid as regular customers and love it!) is offering 60-day free trials at www.shipstation.com/chubbyemu/ !
tree bark not good
b
I like tree bark too
i hate trees!!!
i love tree bark
Bro was training his 3rd leg 🗿
💀💀💀
😂🤣 just got dumbbell on it doing curls
Vascularity on point
I didn’t know 3rd Leg day was a thing
Should have skipped Third Leg Day...😂
Shoutout to one of the most useful talents of the animal kingdom: barfing. It sounds like he vomited profusely very shortly after ingesting the compound, so it's very possible that he managed to prevent way more than half of it from getting into his bloodstream. And he probably needed to be conscious for that to happen, so he did a good job by not passing out immediately. Some toxins can directly cause someone to vomit. But very often, the reason we vomit is because when we are conscious, we sometimes assess an altered state. Dizziness, headache, numbness, hallucinations, a sense of dread. The body's instincts say, "Maybe we ate something that is poisonous and it's affecting our brain. Let's throw up!" But the brain doesn't know it's in an altered state if it's in standby mode at the time. If you're not conscious, you won't know if you're dizzy, hallucinating, etc.
The massive release of norepinephrine definitely makes one nauseous, I’ve been there. Never had any issues like this though!
Vomiting is a big win LOL. But yeah I've felt this, and I'm sure most people have also felt this. I ate some pizza one night and a combination of anxiety and a migraine caused me to go into a panic attack as I felt that sense of doom lurking over me. And, because of that doom, my body definitely felt like that pizza I ate had to come back up, even if it wasn't actually bad.
@@SneakingMOUSE It's even been suggested that the reason seeing someone else vomit or smelling someone else's vomit can cause us to throw up is because we have evolved as social eaters who share food. So if my cousin over there is throwing up, maybe we've both eaten something toxic, and it just hasn't kicked in yet for me.
@@tom_something Yeah, that's interesting. I enjoy learning more about the brain. I never put much thought into why we vomit, it's always been a simple answer to me. But, there's much more to it of course! Evolution has taken its course, but we still show an incredible amount of traits from our long distant ancestors.
Fact: some animals, like horses, cannot vomit. We’re lucky I guess
"Full recovery" Every time I hear those words my heart is glad. The nervous system is an amazing thing.
The body is an absolute unit 💪
Stop spoiling 😂😂
Tbh. I doubt it is ever a full recovery after such a hit to your body.
@@josephdahdouh2725you would be suprised how good the body is a healing and how resilient it is
My system is always nervous
this literally saved my life, im taking this to my neurologist this wednesday, i took an excess amount of yohimbine and i’ve been suffering the same effects not to the degree as j.c. though. i’ve been to so many doctors and they’ve all just waved me off or found some way to pine the issue off on some other doctor. this is the video i needed exactly, i honestly can’t thank you enough for making this
Holy shit that’s unbelievable I’m glad you finally have an answer! It’s so frustrating when the medical system waves you off and you KNOW there’s something wrong
The stuff does have some rather harsh side effects even at a normal dose. For weight loss, I would've done better to cut out the cheeseburgers! Anyway, I'm glad you figured out what the problem was.
You should do your homework better
Yeah, a lot of Yohimbine products (yohim*be* is the tree whose bark contains many alkaloids, yohim*bine* is a single alkaloid that was isolated from the bark-) fall into this legal grey area. If they’re not claiming to treat anything the FDA really can’t do much.
So you never know 100% what you’re getting and how much.
I think humans rarely ever get it in drug form…we give it to animals to reverse xylazine (Anased/Rompun) anesthesia but all of those are pretty much animal only.
What were ya talking yohimbe for??
Now he can warn others to be extra careful when handling workout powders that happen to look identical to each other.
Ilegal drugs are not your typical "workout powders"...
@@cdjxwubcyex what does that have to do with Yohimbine
spoiler allert!
A man mistook Miralax for his body-building powder, this is what happened to his bathroom...
only "workout powder" you will ever need is creatine monohydrate. and perhaps some form of protein supplement if you're not getting enough from your diet. everything else (BCAA, EAA, Glutamine, etc) is a scam.
I had food poisoning a few days ago, and kept imagining Chubbyemu narrating my situation... Fortunately, my body did its job getting rid of the bug without needing to resort to a hospital visit. It wasn't fun, though.
"So he thought... "
I also thought that when I had food poisoning a week prior to Halloween... hooooowever, mine DID result in a very expensive ride with a bed and a hospital stay. I was 109lbs going in and was 115 after 9hrs. 3+ liters of fluid IVs and some meds.
*edit* "Presenting to the ER..."
Had I not watch that video about him and the gummy vitamins I very well could have been in that situation too
Same bro
"or so he thought"
The more videos of your's that I watch, the more I realise why it takes over 7 years of medical school before one is even able to consult a patient here in the UK. The shear amount of chemistry and biology going on in just one seamingly boring human cell is unfothamble! I thought I'd learned the basics of biology at college, before settling on phisics and ultimately engineering.... here I am 25 years later, still completly befuddled by the complexity of biology! Thank you for the professional insights, truely a great channel, and a testoment to this platform👍
Your body is a temple to another world we can only dream of comprehending
Glad to hear he made a *full* recovery. Resilient creatures, aren't we? Natural response mechanisms like throwing up, add to that advanced healthcare, science. When I hear about such cases, I really am in awe of our bodies and our entire species.
Fuckin same it’s crazy
Seriously. We're pretty impressive when you think about it
yes, the medicine was very Resilient.
@@eli-hk8tp the medicine was impressive
I love evolution
I was actually researching yohimbine a while ago as an addon to my pre-workout for the same reason the patient in the video took it, but after reading the mechanism of action, I saw that it's contraindicated with clonidine and decided it wasn't worth it. I take clonidine for stimulant induced motor tics, and I can say, without a doubt, I'd rather have stubborn fat without tics than to have tics without stubborn fat. Also, this video is amazing, even for those who can hardly understand how the body works, and helped me understand what's happening when two opposing pharmacological substances are combined (in this case, clonidine administered as an antidote[?] for yohimbine overdose.)
DMAA IS GODLY AS A PRE WORKOUT, LASER EYES AND SUPER ADRENALINE AND DOPAMINE FOR INSANE WORKOUTS, U SHOULD TRY IT
It is like psychedelic speed, but not In a good way like mdma. In a bad, wired, paranoid kinda high.
Yeah it's rather potent. I actually have some here but have only used it a couple times. Don't really feel like touching it, well I might do a tiny dose if I was going to have intercourse but I'm a loser loner so that isn't very often. Definitely works well for sex though. Stuff is very strong and the dosage is just a tiny tiny little scoop.
I've used preworkout with yohimbine and had to give it up immediately because it gave me the shakes (like the low overdose symptoms at 11:31 now that I see it) and even worse the shits,then switched like ADHD meds and made me tired. So I'd take the preworkout and even down at the caffeine level of a cup of coffee instead of going hard for a workout I'd be on the toilet shaking and dropping outright sludge until I went back to bed. Whole day ruined.
@@ffwast Stimulants effect the stomach. Some people get the runs when they do a big amount of coke or amphetamines. And yeah the shakes weren't good and it reminded me of an uncomfortable level of caffeine. Caffeine overdose is still the most uncomfortable I have been from a drug (I didn't mean to do a bunch of caffeine but my barista friend kind of screwed me over unknowingly).
Also funny how ADHD meds make people with actual ADHD tired and make everyone else wired.
Very glad to hear JC recovered. I suppose it's lucky he was in the gym when he passed out, I don't imagine he would have gotten the assistance he needed quick enough to survive had he passed out at home.
definitely. he was very fortunate to A) have vomited to get some of the stimulant out and B) having someone around to quickly call EMS c:
I'm a veterinarian and I've been using Xylazine for a good decade now. Yohimbine is a very good antidote to Xylazine so immediately I thought "What if we give some Xy..." This is a very interesting video to watch. Thanks for making them!
Thanks for that Almighty Gabe jumpscare at 15:17, it's 2am and I needed something to give me a jolt.
Funny. It’s 2 am as I watch it now.
Whos that guy ??
I loved the half life reference lol
@@SeVeCiKGabe Newell funded half-life and Steam
Half 👹 Life
Confusing aphrodisiac for preworkout 🤝 confusing caffeine for amino acids
Confusing Gatorade for pesticides to complete the trio.
Imagine the overstimulation if both had happened to the same person...
I've learned so much about medicine, illness and the body thanks to your videos. They're even better than watching an episode of House or Forensic Files.
Except they make you super paranoid 😂
@@NboOfficialAuscame here to say the same thing - love House, but it’s not good for me mentally lol
House is great
This is edutainment 1st those are entertainmemt 1st. I want him to have a soap opera plot side sometimes tho as i zone out despite having been in biotech 😊 who will be marry will he recover from the coma etc etc
this is an educational channel. that tv bs is just entertainment.
Just wanted to say thanks for all the great videos you're doing.
Thank you!!
@@chubbyemu You're most welcome. Just keep your great videos coming.
@@chubbyemudo I subscribe?
This channel is a real treasure. The logical progression is very well done and the amount of detail you are able to get across without diving too deep into something while also explaining enough to help the viewer get to the conclusion step by step. It's all so well done, thank you for all the hard work you put into your videos.
Wow, a lot going on in this episode. As Chubby says ," if you don't have to put it in your body, don't do it ". And how sweet to see Mom. Cheers.
Bruh it's the age of yolo, crack, and prostitutes.
@@twilightexposure8431 To be fair, most people don't put prostitutes in their body, so unless you pay for the deluxe package you're Emu Approved
@@twilightexposure8431 That age has been going on for decades...
@@twilightexposure8431amen
Alcohol go brrrrrr
I took some of this once, about 5mg for pre-workout. It felt like dying: I started sweating, breathing rapidly, everything got really bright, and my heart was racing. It was all in a few minutes of taking it, lasted about 15 minutes at the highest intensity, then tapered off in about an hour. Never took it again.
Sheesh usually 2-3 mg max 3 is even too much that must have been rough
I take 15mg(three 5mg nutricost pills) what are you guys talking about? You base dose off of bodyweight. It does kinda give a cracked out jittery high but it's great for cardio. Be careful combining with caffeine though, it can get too intense so just take one or the other. Also what's cool about yohimbine is the "high" goes away once you introduce carbs. You have to be fasted for it to work.
@@jam9297 my mistake I was thinking of the extract I was taking, not the plant matter itself.
@@jam9297 Your stuff is underdosed. I take 1.5mg with a few other things from gorillamind and my heart is racing. 220 lbs, 6 foot
don't inject unapproved things into your body. Even approved things can be later found to have harmful side effects!
A.B. a 46 yo Truck Driver drove for 11 hours taking only 30 minutes break time allowed by DOT.
AB notices a new episode uploaded recently and pulled over. That’s where are now.
After watching the recently episode of @Chubbyemu, AB felt rested and was able to finish his load. 😂😂😂
even after all this, JC didn't forget his sponsorship deal.
mad props
as an epileptic when you said "sense of doom" I knew exactly what you meant man its what my aura is many times, for those who don't know an aura is a feeling one gets before a seizure like a warning from the body some epileptics get these and some don't
This is the first time I find the "aura" with this meaning.
@@eeaotly auras can feel like a lot of different things and can be quite hard to describe mine can also feel a lot like nostalgia or a feeling Ive been here before. An aura being a prewarning to a seizure is the only one ive ever heard other than maybe an aura being like "the aura one gives off"
@@torin8871 A lot of people with alternative believes like psychics use aura as a meaning of someones "energy" or "soul". Hense why they "feel" someones aura.
As a person who used to suffer panic attacks (and therefore, an excess of fight-or-flight chemicals), I also really felt that. I hope you're doing well, @torin8871.
Some step into haunted houses and feel an ominous aura
Uh, I read your notes everytime. I have a grandson who is a bodybuilder. I will forward this episode to him. Thank you.
Be careful when making your own supplements or buying them from untrustworthy sources! That's the greatest takeaway
I'm always so happy when the patients make a full recovery! It's my little dopamine boost of the evening.
It’s nice to see your Mother included on this one. No doubt she is super proud to have a son like you. Hope i can make my Mum proud like that someday soon!
This was significantly more detailed than usual. As someone who's taken SSRIs and is currently on medicine for ADHD and generalized anxiety, including beta blockers, the details on signal transmitters were particularly interesting.
Beta blockers are used for anti-anxiolytics?
@@ferretyluv Hey, I just learned a new word 😂 And it appears it's just anxiolytics, as those are anti-anxiety medications 😊
Yes, my regular doctor prescribed those early on. Not sure if that's normal... 🤔 But they do calm people down, myself included. I understand many people use them before high-stress situations in order to keep calmer, for instance orchestral musicians are known to use them before tests. I gave some to my niece who had failed her driving exam thrice, and they helped her pass the fourth time.
In my case, they only helped a little. I can only eat two a day, or I start to get really dizzy. And my anxiety is pretty hefty, so they really didn't help much on their own. This was before I started with my psychiatrist (there's at least a waiting time of half a year for psychiatrists here in Denmark, as there aren't enough around to keep up with demand). Eventually, we discovered Pregabalin, which is very effective, but I've kept taking the beta blockers, as they help a little, and my blood pressure has also gotten high as a result of my weight increasing a lot over the past couple of years.
Edit: I should note that my ADHD was also undiagnosed at this point, so I was completely unmedicated then.
Yes, they can work to inhibit the physical symptoms of anxiety such as clammy hands.
@@brittaschwab8513 I was on beta blockers for years to treat my chronic tachycardia, and people didn't seem to believe me when I said it wasn't helping my anxiety disorders. I would still have just as much anxiety, but I wouldn't have any physical reaction to it.
@@ferretyluv yeah propranolol is commonly used by performers to help with stage fright. It only helps with the physical effects of anxiety like sweating, shaking, and feeling restless but that actually goes a long way to reduce anxiety in many people.
Thanks for putting the sponsor at the end. That really helps not to interrupt the story. As always, your narration is great.
All the cases you present are so interesting! I wish you were my A&P instructor 31 years ago when I was in Paramedic school! I wouldn’t have been such a wreck! Also, I am so glad your mom was able to fulfill her dream and at the same time, help others!
I think there was a similar video on this channel where someone mislabeled their supplements and accidentally dry scooped some crazy amount of caffeine. I guess the real lesson is always know what you're putting into your body.
Yeah he scooped caffeine instead of creatine or sth
yup, the caffeine video
Also, labeling things properly is so important. He did another video where a guy put pesticide in a Gatorade bottle and accidentally drank it and it was too much to do anything about unfortunately.
@@internetuser8922 Yeah ive always done it fairly meticulously, but at one point i was sorting my medicine drawer, got tired and decided to finish it later, well in the panic of wakeing up to a pending migrane and being unable to see very well past the hallucinations i ended up mistakeing adderall for advill and takeing twice what i normally would while also takeing the normal sumatriptian and zofran combo,
that was, an experience, never again, always keep everything perfectly sorted
That sponsor transition was downright criminal in its smoothness.
lol i usually fast forward ads but i let that one play out of respect for the hustle
Was a bit dishonest tbh, not that I'm against it, but just the way it was phrased.
I know you said you think nobody reads the captions, but I do😁 They help me understand the video more. I'm a follow-along learner, so this helps me sooo much in my field of study!!❤
Without a doubt, this is absolutely one of the best channels in the vast sea of RUclips in my humble opinion.
I always find it fascinating when "sense of doom" is a symptom.
Ask anyone who has ever suffered a massive panic attack…”a sense of DOOM” sums the whole episode up perfectly lol.
Yep Always the first thing that warns me I am about to have a potential anxiety attack. Luckily I have learned to recognize these warnings and can generally work myself through it before it becomes a shitstorm. That aside I just don't understand why people can't just eat food instead of powdered chemicals, the whole body builder fitness culture eludes me entirely. Enjoy your heart disease. @@adamterry550
It's like your brain knows death is imminent based on the systems that are failing, and "translates" that electrical and chemical information into the concept of the End or "doom" in order to communicate how serious these symptoms are. Cool and kind of creepy lol
@@gordoncamacho8649 Its fascinating to Analize after youve experienced it,
experiencing it on the other hand, well the title says it all,
I've experienced it during more than a week after being unsuspectingly drugged by an unknown substance. Firefighters rescued me with a noose already aroound my neck, i was hallucinating horribly for a long time and thought i've died and went to hell with demons (psychiatrists). The sad thing, that sense is still lingering in background when i fail to reach my goals.
Yay! JC made a full recovery. Also, next time Mom makes slippers, let me know 😊
she saw this comment! she has been making more and we will have another batch soon!
I would love to buy a pair!
@@chubbyemu Is she single?
@@chubbyemuWhat's the mysterious picture inserted in the video at 15:17?
@@alexandredefaveri5984 Gabe Newell
Did anyone else see a Gabe Newell flash @ around 15:00 ? Also that was the smoothest ad integration i ever saw 👌
A long lecture of neurophysiology, very precise and detailed.
Watching the video few times helps the understanding of this complex matter.
Thank you Dr Chubbyemu...
People who put all kinds of complex chemicals in their bodies to "enhance" their appearance or push their bodies to extremes are playing with fire. Not really surprising that they F it up quite often.
Hmm. 😊
17:15 from beginning to end one of the best ad transitions for a sponsor. But also the most sweetest ad from beginning to end. I’m extremely happy you were able to make your mother wish come true! And thank you to ShipStation! The last part of this video is so wholesome n sweet.
Right? That was probably one of the smoothest segues I've seen in a long time.
@@ex-navyspook it low key made me tear up man! I don’t know why it hit me so deep but seeing children make their parents dream wishes come true. It’s just such a beautiful sight to see, and not to mention donating the money from profits. It’s just wholesome overload man. So happy for them. And yes I would agree, by far one of the most seamless transitions to an ad I’ve seen in a long while.
Speaking of the end of the video, personally I liked the Half Life 3 joke.
As a large animal veterinarian my first instinct was to give him xylazine 😅 Always interesting to learn about human physiology
Mixed practice technician here thinking the same, you are not alone!
That there is a connection between opioid effects and Beta-2 is heavily indicated. We use Clonidine sometimes in cases where there is opioid dependancy that renders normal pain management difficult. Clonidin enhances effects of opiods but has side effects that needs to be monitored but can be used in hospital. This case was very enlightening and indicates that there are more connections between the adrenergic and opioid related systems that needs to be understood. Also highlights the danger of people playing with these substances and ordering them on internet!
Funnily enough, it is also used to ease symptoms of restless leg syndrome during opioid withdrawal.
They give clonidine to both opioid addicts and alcoholics in rehab/detox centers to help with withdrawal symptoms. I think they also give it to people in psych wards to help them sleep.
@@dewilew2137 Yep, it's off label use as sleep aid is increasing substantially but I've heard reports that it has abuse/ addiction potential in of itself.
Ive been in recovery a little more than 7 years, and I've been prescribed clonidine, along with a couple other non-narcotic meds to manage withdrawal symtoms.
I can say from experience they just barely take the edge off. Which is a good thing. There are other meds which are significantly more effective but require professional assessment of a specialized doctor.
The clonidine basically allows you to relax *just* enough to be able to fall asleep for a little bit. Ive also been prescribed these meds while in jail, which is an incredible comfort even if the meds aren't very effective and theyll only dose you about half as many times as the script actually instructs
I believe the overdose was an accident vs something he was "playing with." My hospital accidentally tried to give me another patient's medication while I was admitted...they made a mistake, just like J.C. Thankfully, I was alert enough to tell them they made a mistake. They wanted to believe I was just being difficult until they realized I was right. Then they just laughed it off like it was no big deal to mix up meds. I can only hope I never "present to the emergency room unconscious "...no telling what will happen.
Fantastic video! I was not expecting a massive deep dive into the intricacies of stimulants and depressants in the body. Also loved the Gabe Logan Newell subliminal Half life flash at 15:17 :)
I was wondering who the heck that was, spent the last couple minutes trying to pause to see what that flash was!
Reduce the playback speed to 0.25 and you get it easy. Took me a few minutes to do that as well.@@WolfNymph
@@WolfNymphin addition to what’s been said, you can use the dot and comma keys on a computer to go frame-by-frame
Or if you're on mobile you can slow down playback speed to .25 and just pinpoint it. It looks like the pic was flashed on the first frame of the 18 second mark 15 minutes into the video
Thanks I captured the screenshot but had no idea who that was lol
Current watching the video but I want to thank you already for always bringing amazing videos! It's not only entertaining but informative as well, I love all types of science but body-centered the most and english it's not my first language so it helps a ton watching you! It increases both my knowledge in medical science and english language, lots of love and take care! 🖤 From: 🇧🇷!
Muito bom esses vídeos né? Não trabalho com medicina mas acho os videos dele bem interessantes, acabo tomando mais cuidado com o que entra no meu corpo.
Are you a fan of Motörhead? Lots of Brazilians are. Search for Going To Brazil Motörhead. You especially want a live version from 2004. It's a fantastic high-energy song about Brazil.
Those slippers are just the most adorable things ever. Great job Mum!
Fascinating as always! Thank you for these videos.
Glad to see you thriving good work man!
Oh, my my. Two chubbyemu videos within the same month, I am in heaven 😁❤
I love when you upload these videos! I've not practiced in coronary critical care and emergency medicine for over 20 years due to 4 neurological disorders; two of which are progressive. These cases are reminiscent of similar patients I'd seen particularly in the emergency department setting. I have forgotten some of the knowledge that I had once. You help to keep me not just current, but to clean out the cobwebs in my brain!❤
Thank you, Gaben for this informative episode.
i just wanna say thankyou to you you`ve taught me everything I know in medicine and more I still continue to watch your videos daily and you`ve biology way eaiser for me in school
There could probably be a whole series of vids on ways bodybuilders have messed themselves up by ingesting various compounds. In July I committed to competing as a bodybuilder (natural), and I have since immersed myself in the culture. There are a lot of questionable practices, even among the natural competitors. Some of the supplements they take to lean out are extremely dangerous, and they're completely ignorant to the risks. Considering the effects they're going for, it's a dangerous game they're playing. Messing around with stimulants and diuretics can go south very quickly with dire results. I have one friend who suffered a heart attack 22yo from a very popular stimulant/weight loss supplement, he was a dual sport world class athlete. I'm very thankful for my education that allows me identify the potentially harmful substances commonly used in bodybuilding, and avoid them while educating others.
Facts
Using supplements is natural?! Jfc
@@chrism4008 Consuming salt or caffeine to improve performance would be considered a supplement. Anything taken in addition to diet for a specific effect is a supplement. If I meant PEDs I would have said PED.
@@chrism4008 Assume much?
I’m glad that competitions are separated into natural and geared. But I’m sad that it just makes gear more normalized. I’m wondering how many of your natty peers are actually natty and not doping.
You explain science and medicine so well. So logical with the correct emphasis.
Recently discovered this channel and love your format, and how you present facts. I think my favorite part might be you breaking down the etymology of medical terms. I know a lot of of them already, but you are undoubtedly teaching many people.
that ad was adorable. all the best to mum and her business ❤❤
My background is physics and I've always been perplexed by biology and pharmacology - too complex to understand. Really appreciate your videos which help me understand so much more. This is one of your better videos as you go even deeper than usual. Much appreciated.
If you understand physics, you will understand pharmacology. Or, I'm stupid.
As a software engineer, it seems approachable in complexity to me, just a lot of information I haven't taken the time to learn in order to possess that understanding. I'm sure it's attainable to most STEM people if they invested the effort into it
@@margodphdPhysics is more math based and pharmacology is more biology + medical care. Sometimes you don't take medicine for its direct purpose just for the side effects that are useful
You're just missing a step. You see, both biology and pharmacology are technically specific branches of organic chemistry, which is a subset of chemistry in general which is essentially a form of molecular physics.
So, if you were to look into the basics of chemistry, based on your knowledge of physics, it would help you acquire the knowledge needed to understand the basic principles of biology and pharmacology.
@@margodphd Definitely doesn't mean you are stupid but understanding physics is fairly simple - even complex phenomena are generally related to basic principles. Biological systems are much more complex and difficult to understand.
i’m a biochem student, but that entails waaay more chemistry than anything, which I love. your videos always include the chemistry and i love them!
His videos has helped me open my eyes to how much of a chemical machine living organisms are
still loving the formula and entire extistence of this channel. its just so great. can this stuff even ever get boring !?
The production quality on this videos is great, even professional. I love how despite his videos being serious and professional, he still sneaks in some memes and jokes, just look at the chapter names!
That quick flash of Our Lord and Savior Gabe Newell @15:16! Well Played!
"...a FULL recovery" is what I love to hear at the end of all these videos. :)
That level of excitement when I hear, "Full....Recovery." 👌💯
...and the bonus single frame image for this video is Gabe Newell from Valve! These seemingly random single frame pop up images are very strange and very amusing! I'm enjoying these videos, they are consumable even by someone from a very different scientific discipline (of the computer variety). Learning a lot, thanks for the great content!
Obligatory "half life 3 when" comment.
When I make my own gun cotton (nitrocellulose) or even black powder for my old-timer muskets, I am working with powders and acids. All of them look pretty much the same. I am no chemist, failed college chemistry three times before transferring to physics, but even I know that you do NOTHING without checking the label three times over and then give it another look.
Granted, I am not making a drink to ingest, I am making (legal) explosives to use as gunpowder for my cannon and firearms - HEY, ATF, propellant, NOT an explosive charge!
I cannot understand how people inadvertently mix the wrong chemical. You are supposed to have every chemical in a labeled container with each label clearly visible from at least an arm's length away.
I simply do not understand people who mix their own... whatever, and do not pay close attention to what is being scooped, poured or added.
In my case, putting the wrong chemical in the mix in the wrong order equals a blast and fire, so if I screw up, I know it immediately. Because I only make small portions at a time, at worst, I will be missing fingers or have shrapnel from the container pierce my heart and kill me. At best, I will have ruined all my chemicals and workbench.
... but something you consume? I don't care if every chemical is the same color and texture, you put a permanent label on it so you can read it long before you reach for it... and in Sharpie, you write what it is all around the container so it is visible no matter how the container is rotated.
At every angle, "Protein Powder"... "Sugar"... "Caffein" should be legible and then the official label on one side... even on the side of the label (with the fine print on it) use that Sharpie to write what it is.
IT IS COMMON SENSE!
Don't get complacent!
A huge percentage of people these days have turned wilful, gleeful, calculated stupidity into a political position and a sign of moral superiority. Following instructions and taking sensible precautions is a sign of weakness and fear!
heck if i was doing that kind of thing i would throw food coloring in with the powders, when its stuff used in preworkouts that can really screw you up, theres no way im accepting a margin of error
I had a 1963-66 chemistry set and a lot of the little chemical bottles had skulls+crossbones on them!!! It’s amazing how we managed to survive our childhood with the amount of unsupervised materials we had surrounding us?
@@MrReymoclif714 makes you wonder how many dident that you just dont hear about
Exactly this! And if you get interrupted, better to start over. Don't take risks with your health and life!
Hey Emu, quick question: how old are the reports of Xylazine abuse first recorded? I may not be from the US, but a pharmaceutical company sure does export Xylazine to the US, so that really peaked my interest. I personally worked with Xylazine for over 2 years, assuring quality of product every step of the production. It's a helluva drug, I mean, when I worked with it, even with a respirator, gloves and standard PPE, I still would be feeling off at the end of the workday. I have read that there were reported cases of Xylazine use in the Carribean, but man, that really breaks my heart.
Hello! great question. the Reagan-Udall Foundation / FDA hosted an event in DC in October 2023 talking about Xylazine. I attended virtually. From what I remember, Xylazine misuse was known in the Carribean and Puerto Rico from at least the mid-2000s, if not earlier. Geographically, that proximity to the East Coast makes sense as to why it got prominence there first (Philly especially) versus West Coast relative to Continental USA
@@chubbyemuyou literally must be an encyclopedia of medical and substance knowledge
@@tokkirothe posted an hour long video reciting a medical dictionary
@@tokkirot With meme spices.
@@chubbyemu This is really interesting to know. I don’t use illegal drugs anymore, but some of my friends still do + I’m involved in harm reduction circles, and there are confirmations in my area (Pittsburgh) that Xylazine is in the local supply. It’s especially scary because there aren’t accessible ways to test for it like there are with fentanyl.
I stopped using four years ago when I found out my dealer was faking negative fent test strips for her “Xanax” and “ketamine.” I almost died from my usual “Xanax” dose; tested it myself with some free test strips from a local clinic and found out it was fent.
But we don’t have Xylazine test strips here yet and it’s terrifying. Your pill might be fent negative but be tainted with Xylazine and kill you before you have a chance to notice something’s wrong. It’s scary, and we in the harm reduction crowd feel helpless.
how does a veteran bodybuilder, with his own supplement company, not know that you can’t spot-reduce fat?
love the "inside u are two wolves" bit in the timestamps description haha. Fantastic vid 💕
I have been studying alpha-2 adrenergic receptors and how to modulate sympathetic nervous activity.
Hearing you talk about yohimbine and clonidine, feedback control and crosstalk was a delight
But do you study the alpha-male? Nerd
@@bobjoe3492fellas is it gay for a man to study another man
Really interesting stuff and well-explained. Wish books were written like this so that the whole ordeal would be like reading a story and things would stick in the brain better lol
Very good point. Think about the education we are getting in the form of entertainment.
I had a microbiology lecturer in the mid 80s who managed to put us off just about every food imaginable with her stories of food poisoning she used to illustrate her lectures. In the end, you came to realise that so long as you treated the food appropriately, cooked, and stored it correctly, you had no issues.
However, if you cooked some lobster and shrimp in your hotel room in Florida, wrapped it in a plastic bag, then took 3 days, driving back to Michigan then made a seafood dish for your family and wondered how you gave them all Cholera....well.... Her stories stuck in our minds, and we still talk about them today. She was one of the leading microbiology investigators for the Health Department back then and specialised in Salmonella.
Yet another beautifully composed video. I feel like you release videos that directly parallel my class curriculum. Eerie, but appreciated. Today alone I pulled out 3 random facts from your videos at clinicals- so thank you for making me look good! This coming week we are looking at opioid mechanisms and side effects. $50 says I can work some aspect of this video into our discussion! ❤️ (ps if you can magic one up on pregnancy/complications next month it would be astonishing but appreciated!)
That has got to be the best transition from video to advert I've ever seen.
As an individual who has ADHD and depression. I can say that too much dosage of an ADHD medication can be a problem because then you will have trouble falling asleep. I currently take Vyvanse and clonidine to actually get me to sleep. Otherwise I would not be able to get to sleep. ( before the clonidine I was an insomniac maybe getting 3-4 hours sleep and always being cranky) This is a problem in and of itself because I know that taking a stimulant and depressant everyday is probably not good on my body. So I ended up reducing my Vyvanse dosage from 40 mg to 20 mg. It's easier to fall asleep now. But for about 10 years at 40 mg. I was dealing with the heart rate side effect. (Imagine running and exercising but that was my heart rate 24/7 with this medication and I thought that side effect was normal. )But yeah. Don't go as long as I did before I came to my realization that my dosage was a bit too high. I'm just hoping I have no heart problems as I reach 60 or something.
i dont think you will need to worry, the range of elevation is still within what a healthy body can normally handle, if you where experiencing severe tachycardia that would be one thing, but think about it this way, tweakers who run around for sometimes 20 or more years before quitting often dont show heart damage, and those are people ingesting sometimes GRAMS of methamphetamine which is a bit over twice as potent as the dextroamphetamine Vyvanse breaks down into.
i wouldent worry about it too much as long as your keeping you dont have preexisting conditions and keep up on checkups and monitoring
I get 130mg ritalin a day + some antidepressants for 7 years now and still all my organs look healthy somehow
@@user-mj8bg3fw8w stimulants have a very wide therapeutic range, one person might need 80MG adderall to notice an effect, another might be kept up at night by 5MG in the morning, and everything inbetween,
whats right for your body is right for your body
I was taking high doses of Adderall for ADHD and found my ADHD symptoms are much less severe when i take high doses of injected methylcobalamin (B12.) Sharing incase it is helpful for anyone else. ..
@@therideneverends1697 not that I'm a defender of methamphetamine but it's nowhere near twice as potent as dextroamphetamine
This is by far the most digestable form of educational content ever. There's so much amazing information in these videos and they have so much replay value. My life got better when i started watching these, ir changed the way i learn
Great video, as always, and seamless segue way to ShipStation lol
Emu, I think you're my favorite person on the planet. Please make an episode about kratom addiction or obsessive chasing of mental regulation in general. I hope you will always continue to share your knowledge with others. Your kindness towards your fellow man and stewardship of us all is a gift we barely deserve. Thank you for all that you do.
I second this. Kratom is pretty interesting in how it behaves like a stimulant in low doses or opiate type analgesic and sedative in higher doses
I used kratom in place of an opioid Rx for extreme bone pain caused by gadolinium retention after an MRI. It worked much better than opioids (which hardly touched the pain and made me horribly nauseous) but I found only certain varieties did the trick. I tried many varieties and recall a red powder and a green powder working the best. That stuff was a lifesaver. I didn't have any addiction issues...haven't had pain like that again and am quite happy to not need any more kratom. If I had that pain again, I wouldn't hesitate to go back to it. That pain was 10/10. Pure torture.
@@KMx108 Very glad to hear you did not become addicted to it. People in my life have not had as positive of an experience overall. The amount of times I had to help this person suffer through detox because he refused to go to rehab... it was hell.
@@nostalgafriends5465 I think it would definitely be interesting to understand the chemistry underlying it. I'm also curious about how some find it addictive and apparently others (like myself) do not. I've also taken high doses of Adderall for ADHD and didn't have issues with that being addictive, either. I had so many doctors warn me about it, so it seemed like a common problem. I don't take it anymore - turned out I had a functional B12 deficiency and methylcobalamin (B12) injections were what I really needed. My sympathies to anyone dealing with addiction. 🙏
what do you mean "obsessive chasing of mental regulation"? and screw kratom, he should do an episode on 25I-NBOMe
I came for the informative videos but fell in love with Doc's humor that goes brrrr 😂❤
I appreciate the research with all of these cases I have learned so much throughout your videos. This is my medicine. I understand it takes a while to get the facts but I wish we could get more. I'm addicted to these videos!
it makes me happy when patient makes full recovery at the end 😄
I always enjoy your videos, i also love your heme review podcast, i enjoy learning about what you talk about.
New setup and soft lighting look great Dr. Bernard - great work as always!
Great video with excellent breakdown of the biochemistry in easily understandable parlance. I'm sure your mom is really proud of you! It really is awesome that your mom was finally able to share her talent on a larger scale, and it must have been rewarding to work with her and share her dream with your many followers!
Now that was a smooth as silk sponsor tradition. Very nicely done!
Last year I went back to school to study podiatry. I had no medical background, just started from the bottom. Because I have been watching your videos for a couple of years now and have been doing your quizes I’m in the top 3 of my physiology and pathology classes. And I do read the extra info in your description bar. Thanks for all your hard work 😊
I bet you're going to be a great podiatrist :D
Your way of explaining the different chemicals and their reactions in the brain and body are awesome. This was extremely entertaining and full of excellent information. Nice segue into the sponsor for the video too. Very clever
I appreciate the work you put in, Ive learned so much medical terminology and a better idea of how the body works. You are Awesome---- Thank You
I love the timestamps of every video chubbyemu uploads, lol 😂
this is the video that i become a doctor... ive learned so much, gobless
I freaking love this channel, the explanations, the cases, and the research included are all amazing
This is one of the channels that I watch and rewatch all the time! I've never caught a new video.
It's so cool that your mom finally got to make and sell her crafts with your help.
i just learned about antagonist and agonist in my psychology class, so it's a nice feeling to understand everything being explained.
I actually learned a lot here. You explained things really well. Thank you!
You always make your content easy to understand and enjoyable.
i'm still really happy that you include metadata and references in your video descriptions. it's nice to research these things out of sheer curiosity while also learning and finding resources for further research and prevention/treatment
Boy this is an indepth video i think i have to watch it couple of more times
Chubbyemu Video = Day Better
I remember another story similar to this that he covered. A guy was ordering supplements on line in bulk and mixed them up. Ended up taking 3000 mgs of caffeine or something.
And your mom doesnt look 80, she must be taking care of herself and being well
I wish you had taught my biochem classes. You’re the best, Doc
That ad segue was so smooth 😎
SIck GABEN ! nice one @chubbyemu. Absolutely love the psychopharmacology deep dive. I did guess clonidine Ill finish the rest .
Always high quality, love your videos
I agree
Bro dropped the most wholesome advert in the middle of this, awesome
I'm always relieved when they make a full recovery