The Fountain of Youth by Targeting Senescent Cells?
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- Опубликовано: 14 май 2024
- Professor Keizer talks about how importance to remove senescent cells during aging and novel anti-senescence compounds were newly developed targeted to extend healthspan and lifespan.
pubmed.ncbi.nlm.nih.gov/28041...
pubmed.ncbi.nlm.nih.gov/28340...
pubmed.ncbi.nlm.nih.gov/20657...
pubmed.ncbi.nlm.nih.gov/36384...
pubmed.ncbi.nlm.nih.gov/35048...
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DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements.
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Content starts at 14:30
thank you
Thankyou kind Sir
Thanks!
Thanks 👌🏾
🙏
Outstanding insights on aging and cellular senescence! Grasping the role of senescent cells and their effects on aging and diseases is essential. The potential for groundbreaking treatments is vast, and the advancements in this field are truly inspiring. The possibilities for extending healthspan and even reversing aspects of aging are promising. Keep up the exceptional work!
It’s amazing what folks are willing to do in order NOT to do what we know works best: fasting. It’s cheap, effective and has no side effects if you do it properly.
I love fasting and OMAD22:2 (One Meal A Day; over 2 hrs).
Yip, and fasting saves money, bonus 😉
@@stevemarshall_uk how much protein do you consume in 2 hours only ?
Facts. However combining fasting with berberine, fisetin, and quercetin makes fasting more effective.
Also, OMAD is fine if your goal is weight loss, but if your goal is anabolism, the best approach is a weekly 1 or 2 day fast, and a high-protein healthy diet 5-6 days per week.
By this logic muslim countries would have the longest lifespans but they don’t.
Fasting is useless
You're wrong, man. Fasting is absolutely horrible for your health.
Oof! You'll need deep pockets for this supplement (FOX04-DRI where 'D' means the dextro instead of laevo form) at $270 per bottle from biotechpeptides. And I think that's just for 10mg of the stuff. In any case, it's stated _"Human or animal use and/or consumption is strictly prohibited by law."_ I'd wait for the properly human form to arrive.
you will be waiting a long time (forever)
pharmas and the WHO arent going to allow scientists to stop aging, its bad for business
If it's prohibited by law, wtf is it even available? That's ridiculous.
That was F0X0 4 p53 inhibitor wasn't it??
@@Mystic_Light You can buy all sorts of things as lab quality compounds for "scientific purposes only." No one will actually stop you from ingesting them, but just the companies cannot be legally be selling them for human use.
Injectable or gel form?
excellent explanation !
Timeline for practical application?
Take your research to China. You'll get the funding and support you need.
It makes sense, removing senescent cells seems reverse aging in mice, as they grow back their hair and look young again.
Double edged sword. Senescent cells aid wound healing but also drive aging.
Wounds wouldn't heal as well or have a higher chance of infections without senescence.
Thoughts on fisetin?
This is info to know for now...but not something usable yet
Any human studies with the FOX04 peptide in the works? Used clinically anywhere?
doxorubicin natural/herbal alternative?
Interesting.
Good and clear explanation!! But you don't say how intervene on these!! Example I heard that quercetin could be a good thing for this!! Right?!!
Which other example supplements we can get ?!! Can you give us some suggestion?!!
What was the peptide being used? You sort of just glanced over that but no details provided.
Absolutely sad we can't find ways of testing these compounds in people. As I always suspected it will be a long time before anything that could affect humans ever hits the market. Most likely there will need to be long term testing on tissues.
Why did the mice die after you killed the senescent cells? You said old age but can you specifically say why they died? Like is it heart failure? Cancer?
Aristotle would laugh hysterically at modern humans stating that his “university” was the first of anything. He himself was taught by far more ancient civilizations who the Greeks themselves pay homage to in teaching them what they learned.
4:05 I know it’s totally outside the purview of this talk as well as this channel, but we never asked the question if our economic model which were all essentially enslaved to across the planet earth is the cause that limit are ability to fix any of these issues
I cringe when the pragmatist who otherwise try to innovate on healthcare does so within our capitalist resource/profit driven model. We even distorted history to make it like there’s no other choice in figuring this out other than looking at things through a cost lens.
This prevents us from looking at the various industrial practices that contribute to the declining health that is literally wasting all of the efforts of medical increases in lifespan. We don’t consider in the slightest curtailing, the various destructive agents that companies and industry create throughout the environment, as well as the artificial food industry that is at the epicenter of Destruction of our health and the cause of our deaths.
Those of us who have jobs or any relationships with industry have strangely rationalize away this straight in our face reason for our health issues.
Such blindness is painfully obvious for those of us who are not impressed by status, academic achievements, presentations or articulate speakers. What we see often shown on the channel as well as shown mostly everywhere is efforts trying to combat a tsunami by gluing back together, a leaf blowing off a branch. we celebrate learnings and association made during that gluing process all the while the tsunami rages on
What cultures? The Minoans? The Cycladic cultures? I’m genuinely curious
you talk you met aristotle. cringe
6:45
So bad cells or senescent cells are doing negative output to the body and if remove the better, instead of fixing them, destroy them and the body work better because dont have cells that work bad and only good cells, sound like fasting but jajaja more steps, do a intense fasting and all those bad senescent cells will not survive or they will die first because they are weak cells, and only the strong cells will survive... you can intensify fasting by oxigen or deep breeding, your metabolism spend way more energy wen breading is deep and in relaxation to the point that all bad cells will die... there you'd be electricity certain frequency that normal cells can whidstand but bad cells die of or light frequency.
Summary pls
No concrete info in this vid, pre-sale pitch. No compounds mentioned. Waste of time.
Eat strawberries.
I thought you could use apoptosis and autophagy from fasting and intermittent fasting to get these results. HMM interesting.
Take 400mg Fisetin and 360,000 spu Serrapeptase once each month.
Slow stimulation of senescent cells by eating more veggies and less processed meat …! Remove the cause of build up of senescence cells instead of treating them.
Remove processed sugars and carbs too. Eat natural sugars sparingly. Oats are ok in moderation if they are eaten raw.
Senescent cells are formed as a result of the aging process, for example, due to telomere shortening, DNA Damage, or viral infections. We cannot prevent the Formation of these cells with nutrition.
@@mikrosurgeonlol you can. Google fisetin from strawberries and quercetin from onions and apples.
No....Cancer and senescence is NOT do to irreparable cells....that's completely not right. Cancer and senescence cells are both repairable.
It isn’t desirable at least in the majority of cancer patients to repair a cell that shouldn’t be there in the first place. You wouldn’t want a tumor to all of the sudden become a normal part of the body especially if it’s in an undesirable location where surgery isn’t able to remove it.
@tsmith3286 Nope...That's not true!!
90% of all cancer cells are reversable !! Because it's a metabolic disease. If you changevyourvdiet. You can reverse your cancer. Both of my parents and I all had different cancers within months of each other. Both of my parents died.
Then when I'm listening to my medical Doctors. And I've been to Harvard...Duke...John Hopkins...Mayo/University of Iowa...Univ. of NC...Univ. of Miami...Will Eye...Wake Forest.
My doctirs were the Head of the Cancer Department. Because my cancer was extremely large...and very rare. So rare...that the Dept. Heads were my Doctors.
And they said we can take your eye out and it will be gone. Yes...but it's melanoma. And what makes it so deadly...is that it metastasis easily and always comes back.
So my question was...what do I eat and do. To make my body not conducive for cancer to even exist....and they had no idea.
So...because as I have a huge medical background...triple major in chemistry, mathematics, Biophysiology and Genetics. I vecspentbthe last 12years pouring thru medical research documents from around the world. And while cancer can be thought of as complex. But...its really not!!
I must have been thru 6,000 studies by now...with about 3,000 documents I have in my inventory. And have been mapping out all the biochemical reactions out!! And one of those misnomer is....
That you shouldn't try to reverse cancer or senescence cell...as it will spark more cancers. NOT TRUE!!
I mean how cancer cell switch to uncontrolled growth...metastisis..cancervatem cells...etc...etc!! I've got it all. And will be drafting this all up....and publishing it.
90% of CANCERS ARE ALL REVERSIBLE!!
Even the misnomer of Telomeres. As well as...diabetes...Alzheimers...heart disesse...etc..etc!! Once you understand one disease....reversing others are a from the same basic science.
I mean...when the Tobacco companies all got sued and lost because of their health damage....I did the medical research at the FDA and others.
I mean even now...they can't even find any scar tissue left from my tumor.
Anyway....
Jeffery....⚘️
"how to age well" ? go back and start over