The Crushing Cost of Cancer Drugs | A lecture

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  • Опубликовано: 23 янв 2025

Комментарии • 56

  • @mynock250
    @mynock250 Год назад +12

    I had stage 2a colon cancer about 5 years ago, went through surgery and chemo, I had great insurance and drug coverage paid almost nothing out of pocket. However i saw the bills that came in, by my estimate the surgery and 7 cycles of chemo was billed to my insurance approximately 700K dollars. I didn’t separate the surgery, or multiple admissions to the hospitals for secondary infections from the poisonous chemotherapy, C dii. sepsis among them.

    • @ArtU4All
      @ArtU4All Год назад +2

      So some entity enriched itself through your suffering of the treatment….
      All those insurance staffers, the labs, the inventors, the pharma…. Thousands of them….
      But you alone remained the lone soldier battling the war on cancer… no matter how much love or support you received from the people close to you 🌿🙏

  • @LTPottenger
    @LTPottenger Год назад +19

    My mother's chemo was 5k a month. She also had many side effects they did not tell her about and said they would be permanent. Thankfully, I got her to do some fasting before and after the chemo, and the side effects like wrecked tendons and blethoris (horrible eye condition with expensive meds) went away even though they said it would not. Fasting also makes the chemo more tolerable! Some of the many benefits of doing occasional extended fasting: Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. High blood pressure is lowered to normal levels very quickly while fasting. Fribrosis/scarring is reversed over time.
    Fasting increases nitric oxide release.
    Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy.
    Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers, but some patients may need continued acid reducation medication while fasting.
    Telomeres are lengthend and fasting also increases anti-aging Yamanaka factors.
    Fasts from 36-96 h actually INCREASE metabolic rate due to norepinephrine release!
    After 72 hours or more fasted, your body recycles as much as 1/3 of all immune bodies and creates new ones, rejuvenating your entire immune system.
    Fasting can help with MS, Depression, BPD, Autism and seizures.
    Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer.
    Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The hunger hormone ghrelin also lowers with extended fasting and rises from dieting.
    Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.
    When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.
    What breaks a fast? Anything with protein or carbohydrates in it will break a fast, though if the amount is tiny you will go back into ketosis very quickly. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many medications are dangerous to take while fasting so you may have to talk to your dr. about discontinuing them during a fast.
    Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building.
    Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS.
    The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!
    Does the body preferentially prefer glucose as a fuel? No, except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose.
    Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses.
    Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which help your immune system and anti-oxidative system, especially in the brain. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with.
    It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!
    When you fast, this stimulates apoptosis in senescent or genetically damaged cells, which destroys them.
    Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
    In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting.
    Fasting also increases telomere length, negating some of the effects of aging at a cellular level.
    A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs.
    Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.
    Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.
    Resources:
    www.nejm.org/doi/full/10.1056/NEJMoa012908
    pubmed.ncbi.nlm.nih.gov/15522942/
    pubmed.ncbi.nlm.nih.gov/31877297/
    pubmed.ncbi.nlm.nih.gov/23707514/
    clinical.diabetesjournals.org/content/36/3/217
    pubmed.ncbi.nlm.nih.gov/27569118/
    www.sciencedirect.com/science/article/pii/S0005272806000223
    www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
    www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7
    www.ncbi.nlm.nih.gov/gene/25712
    www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/
    n.neurology.org/content/88/16_Supplement/P3.090
    www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits
    medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html
    www.ncbi.nlm.nih.gov/pubmed/23876457
    pubmed.ncbi.nlm.nih.gov/2518860/
    pubmed.ncbi.nlm.nih.gov/29727683/
    www.nejm.org/doi/full/10.1056/NEJMc2001176
    pubmed.ncbi.nlm.nih.gov/23408502/
    www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue
    www.clinicaltrials.gov/ct2/show/NCT04375657
    pubmed.ncbi.nlm.nih.gov/7714088/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
    www.sciencedirect.com/science/article/pii/S1931312809002832
    www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/
    www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
    www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
    pubmed.ncbi.nlm.nih.gov/20102774/
    repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
    www.cell.com/cell/fulltext/S0092-8674(19)30849-9
    www.ncbi.nlm.nih.gov/pubmed/25686106
    pubmed.ncbi.nlm.nih.gov/28235195/
    www.ncbi.nlm.nih.gov/pubmed/24905167
    www.ncbi.nlm.nih.gov/pubmed/10859646
    europepmc.org/article/MED/22402737?javascript_support=no
    onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
    pubmed.ncbi.nlm.nih.gov/31890243/
    www.ncbi.nlm.nih.gov/pubmed/10232622
    academic.oup.com/ajcn/article/81/1/69/4607679
    pubmed.ncbi.nlm.nih.gov/25909219/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
    www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
    www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
    pubmed.ncbi.nlm.nih.gov/20921964/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
    faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10
    www.biorxiv.org/node/93305.full
    pubmed.ncbi.nlm.nih.gov/6859089/
    pubmed.ncbi.nlm.nih.gov/21410865/
    This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!
    My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.

    • @greglarson6293
      @greglarson6293 Год назад +3

      If I ever get diagnosed with cancer, I’m doing a hardcore water fast for as long as I can before accepting any medical intervention.

    • @LTPottenger
      @LTPottenger Год назад +3

      @@greglarson6293 Same plan here, though I hope to avoid it from the fasting I already do.

    • @alan2102X
      @alan2102X Год назад +2

      Great info, but Vinay will tell you don't bother because no RCTs. lol

    • @greglarson6293
      @greglarson6293 Год назад +1

      @@alan2102X Ha! Good point.

    • @dedetudor.
      @dedetudor. Год назад

      It's time for everyone 6p wake up.
      Ocrevus increases risk of breast cancer. Look at the drug commercials that list the contraindications and read PI sheets.
      Many many of the cause myriads of other diseases including cancer and even death. It's right there in the description.
      Then they raise the prices for treatments for the diseases they cause.
      Global pharmacological mafia... On the roll.

  • @t.h.1982
    @t.h.1982 Год назад +1

    You are an angel!! 20 years ago I lived in Canada and there was massive media coverage (in Canada) for the cost of Tamiflu in the Canada vs the US. The research and technology as I remember was based in the US but the cost was exponentially higher in the US vs Canada. I'm a pretty centrist person so this is not a left or right post. The US consumers are getting screwed either out of pocket costs, co-pays or the amount insurance carriers are paying.

  • @icestationzebraassociates2460
    @icestationzebraassociates2460 Год назад +8

    Honestly if I get cancer, I'm just going to die. Live out whatever life I have left and make my arrangements.
    I mean...one of the side effects of chemo is....cancer.

    • @dedetudor.
      @dedetudor. Год назад +1

      My brothers story and what they did to him would make the hardest of hearts break down.
      I could fill a novel of the torcher they put him through.

    • @icestationzebraassociates2460
      @icestationzebraassociates2460 Год назад +1

      @@dedetudor. God bless

    • @dedetudor.
      @dedetudor. Год назад +1

      @@icestationzebraassociates2460 🤗 🙏MARANATHA🙏👍

    • @kjm5593
      @kjm5593 Год назад

      They have cures …most antifungals

  • @MK-ih6wp
    @MK-ih6wp Год назад +5

    Fenbendazole, IVM, Tudca, RSO suppositories, turkey tail mushrooms, black seed oil, tumeric, etc.

    • @alan2102X
      @alan2102X Год назад

      All of the anti-parasitics are looking good, including artimisinin/etc. (wormwood compounds).
      Cost about 0.0000001% of the latest cancer drugs. lol
      What is RSO?

    • @kjm5593
      @kjm5593 Год назад

      Yes Yes Yes

    • @kjm5593
      @kjm5593 Год назад

      @@alan2102Xlet’s see if it lets me put

    • @kjm5593
      @kjm5593 Год назад

      @@alan2102Xivermectin cures cancer

    • @kjm5593
      @kjm5593 Год назад

      New v top to c all replies

  • @flcrafter
    @flcrafter Год назад +1

    Agree with everything you said and appreciate who your audience is. I do hope the med students always remember the patient in this equation. I have metastatic breast cancer and would pay 700,000,if I could, for another year of life. Many of these drugs offer hope and just maybe a few extras months of life. Our medical system is broken, that’s a given. But I would also hate to have cost be the only determining factor if a drug was available. A few months more may not seem like much to a doctor but to a patient those months mean the world.

    • @ArtU4All
      @ArtU4All Год назад +3

      Months of living in a hospital? Did they enhance the quality of your life? Would you pay out of pocket to bankrupt your family? - would you want to continue extending your life while they wee losing the roof over their heads and went starving?

  • @novascheller5957
    @novascheller5957 Год назад

    Powerful analysis /presentation. You are a godsend to all of us who are not in Big Pharma!

  • @olibertosoto5470
    @olibertosoto5470 Год назад +5

    It's a general trend - I've seen an obscene ammount of money paid for a small cheap plastic toy figure representing some obscure character simply because the maker only made a handful.
    Still curious about a specific breakdown of the cost to produce these treatments from conception to on the shelf. How much does a test tube a mouse and a lab tech involved in this type of r&d cost?

    • @LTPottenger
      @LTPottenger Год назад +1

      More than half the budget is advertising. Plus large budget for 'lobbying' ie bribes. Most of the rest is for huge cost of FDA trials. The cost for the FDA trials is mainly so high because the effect sizes being measured are often tiny (they don't do anything) and because they actually want them high to block out small pharma companies from forming. The drug idea itself is usually something that is already known in nature and the 'work' is to alter it slightly in such a way they can patent it.

  • @jeromewelch7409
    @jeromewelch7409 Год назад +1

    Bravo, Brother

  • @drdubious2432
    @drdubious2432 Год назад

    This is an excellent example of free-market capitalism working perfectly. The result is a feature, not a bug. Our economic structure is exquisitely effective at maximizing profit, regardless of social benefit. Medicine, research, government, and media have been captured by corporations and Wall Street to serve the interests of the ownership class. Their desire (and mandate) is to optimize profit and minimize liability. This has been achieved to a level beyond the wildest dreams of oligarchs in the past and healthcare is just one example.

  • @dr.patnesbitt
    @dr.patnesbitt Год назад

    Are there any countries that don't have US type marketing skewing their data?

  • @marycollins8215
    @marycollins8215 Год назад

    Thank you.

  • @ememememememe7598
    @ememememememe7598 Год назад

    Isn’t turmeric a dangerous blood thinner?

  • @deborahcharych4490
    @deborahcharych4490 Год назад

    Dr Prasad have you listened to the Odac yesterday on olaparib + abiraterone in mcrpc? Much of what you discuss in plenary session comes up (crossover, inadequate control arm, OS vs surrogates etc). Could be great opportunity! Thank you so much

  • @lchrzan31
    @lchrzan31 Год назад

    I’d always heard that the setting of drug prices also includes the R&D for the drugs that fail/never make it to market. Can you comment on that logic?

    • @ben.tanner
      @ben.tanner Год назад

      He kind of addressed that ~18min

  • @ArtU4All
    @ArtU4All Год назад

    Well…
    Those whose monetary unit is not one $ but one thousand $ - its just easier for them to count the profits.

  • @nbrown5907
    @nbrown5907 Год назад

    Do you realize that the affordable care act threw millions more into the system without bolstering doctors, nurses and facilities. We all get less health care now, but looking at the last few years maybe that is a good thing.

  • @thegamejunkie1
    @thegamejunkie1 Год назад +2

    👍

  • @trippyhippie8630
    @trippyhippie8630 Год назад

    Ringing....for sure. Ironic indeed

  • @artbell259
    @artbell259 Год назад +3

    Never much of a discussion of diet, to patients. The docs are too pressed for time to even designate to others to do a diet review. Not sure people can leave meat, though doing so has helped many people who do youtube videos stay alive. lionel nation, tech youtuber 'lockergnome' being two. Being a vegan still gets you inflammatory Seed oil exposure. Sugar added to 90%+ of all foods sold. It's grim !

    • @dedetudor.
      @dedetudor. Год назад

      They learn nothing about nutrition in medical school.
      And Coca Cola sponsors Nutritionists conferences.

    • @ArtU4All
      @ArtU4All Год назад +1

      Diet doesn’t pay their bills

  • @NovaDexter
    @NovaDexter Год назад +4

    Your major failure to account for is human evilness.

  • @mballer
    @mballer Год назад +1

    One man's crushing cost is another man's proliferation of profit, why are you being so negative?

  • @RealMonoid
    @RealMonoid Год назад

    Make more videos like this one

  • @ivanandreevich8568
    @ivanandreevich8568 Год назад

    Pembrolizumab saved my life. I'm happy to pay the $200K for that.

    • @robyn3349
      @robyn3349 Год назад

      Did you actually pay that?

  • @sgeorg80
    @sgeorg80 Год назад +1

    👍