Mitochondrial Dysfunction
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- Опубликовано: 21 июл 2024
- In this video, I explain what the mitochondria are, how they play a role in insulin resistance and what you can do to improve your mitochondrial function.
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This is an educational channel for people wanting to learn more about diabetes and how to overcome it with Lifestyle Medicine and mindset. Juliet Richards is the founder of The Diabetes and Health Clinic and she is passionate about helping people to live happy, healthy and disease-free lives. She believes education is power and education plus action is a superpower. She shares her knowledge and expertise to empower people to make educated decisions that are in their best interest.
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Disclaimer: Juliet Richards does not diagnose, treat or prevent any medical conditions, but simply provides health information. All of the videos and comments are for educational purposes only. The information provided is not intended to provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. The information is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or another healthcare provider. Juliet Richards and The Diabetes and Health Clinic are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site. Disclaimer: This video and description may contain affiliate links, which means that if you click on one of the product links we receive a small commission at no cost to you.
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Great on most everything. Very clear and concise.
I did not see the case against saturated fat--which do not oxidize like polyunsaturated oils do. You simply say that clog up the system. Where is the science on that?
Excellent. Also sunlight/infra red light has been found to stimulate the mitochondria to produce melatonin which is a powerful antioxidant that tackles ROS directly. So exercising outdoors is good advice.
Aha yes, I suppose you might be aware of some paper - off the top of my head - that addresses the bound water of cytochrome c oxidase and its being the ultimate target for the infrared radiation leading to improved efficiency? I'll try to find it ...
But that point that you raise is not emphasised enough, that melatonin is produced (I think it might be valid to frame it as recycling perhaps?) for use inside the mitochondria, with other familiar antioxidants not being inferior to melatonin, so much as never making it into the mitochondria - glutathione does go inside the cell, but no further, and vitamin C if I'm not mistaken doesn't go into the cell, let alone mitochondria. Melatonin is not merely a powerful, but the crucial intra-mitochondrial antioxidant.
@@vitrifiedvolcanicvent1500 thanks for the info, it's a fascinating area of study that may be an important correlation or cause to the population scale decline in multiple health conditions.
What is the research data saying that saturated fat is bad? I've heard again and again that it's not bad at all. The Masai have a diet of primarily animal meat, with 50% of their calories coming from saturated fat, and they're just fine. Would welcome any technical explanation, including exact metabolic processes, to explain why saturated fat is bad.
Keep eating it until it clogs you get CAD. Go ahead.
@@Breezeyogi Statin shill detected.
And Massai life expectancy is 55 - 60 years...
@@veganandlovingit Yeah because there are zero other differences between their lifestyle and the American lifestyle besides saturated fat intake. Your comment is irrelevant. The relevant fact is the Masai have no heart disease. Oh also, they live in a part of the world infested with malaria. That may have something to do with it.
Beautifully explained. Even a layman can understand. I am already working on reversing my prediabetic condition and this knowledge shall definitely help a lot. Thank you Juliet Richards.
00:15:41 your problem
00:20:08 the solution
00:27:26 food to avoid at all cost
Thanks❤️
Thanks
EXCELLENT......Best explanation I've run across yet....I FINALLY understood it. Thank you!!!!
Finally, someone shared enough detail for me to know how to explore further and understand why certain processes occur within my body. Most videos on it are so vague... Thank you!
This lecture is the first to educate me on what is happening to my body and elevated blood sugar, and tremendous loss of energy. I am excited to learn from you how to build and restore my mitochondria. I am researching everything I can get my hands on and your wisdom is absolutely brilliant. Thank you, thank you, thank you for your time.
Great, keep up the great teaching. I spent 45 years as s MD and wish they taught this in med school. Of course ,much of this is new knowledge. Even if I am now 80 , I wish to spread the information and live a healthier life.
Did you manage to find a solution for energy levels? I have mitochondrial disease. Exhaustion is unbelievable. No energy to exercise. Medication no help. Hope you improved greatly.
@@jani7166 If you have a genetic MD disorder that this may not work. My solution is a stack of supplements to support the krebs cycle: Niacine-500mg first thing in morning, after late lunch CoQ10-200mg, PQQ-100mg, Vit-B2-100mg, Vit-B6-12mg, GTF Chromium-200mcg, Benfotiamine-300mg, B-12-1mg, and a prescription medication called low dose Naltrexone-6mg. This combination has restored me to the point where I can get out of bed and work again. Miracle to me. Best of everything to you.
Excellent video and clear explanation about mitochondrial function. I studied exercise physiology with a focus on metabolic flexibility and I wish this video had been around when I was in school!
Thank You so much, it's really helped me understand mitochondria health at the core level. Gonna avoid eating so much and processed carbs, didn't know they cause this much damage, and explains my tiredness.
Thanks Doctor. This is the most comprehensive lecture I hear on insulin resistance, cause and effect.
Doctor? What sort of doctor? She does not introduce herself as a doctor in this video, nor list any sort of training and education in her bio as far as I can see. Please clarify.
i came across your channel very late, now I'm watching all your videos.. thanks for the detailed explanation without just wandering around the topic
First half is a good explanation, complies with what I have read in many books on mitochondrial health. But I am sceptic to the part in which you say that saturated fats comming from animals are bad for mitochondria. In ALL good books on this topic (including books written by doctors practitcing the mitochondrial medicine) they say that animal fats are the best fats for mitochondria as they are the best genetical fit for homo sapiens. On the contrary all the seed oils are said o contribute to inflamation, insulin resistance etc. So the question is what is the evidence for what you say about saturated fats? Maybe it is a research showing that fats combined with carbs are bad for mitochondria (that makes a huge difference and should not be used as evidence against animal fats.) Also if we talk about a build up of triglicerides or exidized LDL it also means they come from mainly from carbs and carbbs with trans fats and not from saturated animal fats.
Oh, well, you will inherently get some saturated fats from your diet. Your egg will contain some, your meat does most of the time, some nuts like cashews do, coconuts do. The question really is how much of it we need. We can’t go without fats and some fats like the omega 3s are very important for us to take in. I eat a great variety of food sources and therefore I get all sorts of fats into my body.
One of the best explanations on this topic I have hesrd and I have heard a lot. The illustrations was a great touch.😀
Thanks for all the work you put into this. It's very helpful.
This is the best overall explanation I've been able to find so far - and I've seen quire a few!!
Thank you so much for this. The explanation was very clear, and the diagrams and writing were tidy. Thank you.
Excellent presentation!! The mitochondria functioning is key!!
Best explanation I have seen. I feel empowered and motivated
Thank you so much
Keep up the great work
Thank you for an amazing most detailed scientific explanation to what a very abused subject
I would be interested in what research actually implicates animal fats vs all of the industrial seed oils that are ubiquitous in processed foods and most kitchens, because when people committ to a carnivore diet thecreverse inflammatory diseases, type 2 diabetes, and many common chronic and autoimmune conditions.
Seed oils are toxic 🤢
@@ponzo1967Yes
Forget seed oils. Extra virgin olive oil is the way to go.
Awesome presentation...very helpful
Best video on this topic EVERRRR!!!! Thanks Juliet.
This is a great summary.
Great lecture. Beneficial information. Thank you.
Thank you so much, I was really struggling to understand how they all interlink
One of the best video on this topic in laid man term. Thanks!
Love the way you explained it, thank you.
Thank you for your clear presentation.
Thank you very much Julliet. God bless you.
Though I know everything about mitochrodia dysfunction I still find your video very interesting. Thanks.
I absolutely loved this video. You explained everything so well leaving me with a clearer understanding of mitochondrial dysfunction. I love this so much in fact that I’m going to study it as if I’m going to be tested on it. Why? Because I’d like to be able to explain to others the beneficial knowledge I learnt from you. Thank you so much!
Very well explained, Excercise and eat sensibly....thank you!
Simple but very informative. I subscribed. thanks.
Hi, Juliet. Nice work! You've got a mexican fan. I'm an applied nutritional sciences student trying to do exactly that: educate the population on the latest advances in chronic diseases reversal with lifestyle interventions.
This is my RUclips channel:
ruclips.net/user/Cu%C3%ADdateHoy
Someone should educated doctors, and more importantly incentivised them appropriately to deal with this earlier
EXCELLENT EXCELLENT EXCELLENT..... the most simple and accurate description.... Subscribing your channel. You are sharing true knowledge ma'am in this maze of information bytes overload... God bless!
Thank U for this Video
I have type 1 DM and have noticed tow groups fighting about the cause and pathogenesis of IR
One group is the KETO ( high fat ) and the the other is VEGAN ( low fat )
Believe me the answer is in the middle and with Fasting and exercise.
BUT thanks again for showing the wholemark of the problem
Very informative. Thank you so much 👍
Wonderful explanation 👏 thank you so much
Fantastic and clear explanation easy to understand thanks so ..much and congratulation
That was good work.
Fantastic...Your sweet ...direct analysis on Nutritional intake; garden vegetables ...what we should eat in place processed foods, so interesting, and basic knowledge I had all this time. The Mitochondria cell was what I searched for initially, the power house cell. The delivery system of energy, I think I got that right. Can be over loaded with junk food. Exercise in moderation, you don't need to be an athlete, pressing too break world records. Just workout, walk to your destination. Promote fresh air into your lungs. Again, Brilliant, simplistic for a complicated system we are rapped in..
Great video, thanks!
Thank you so much making this video ...🙏🙏🙏🙏🙏
Thanks Juliet... I could easily understand your lecture. You are genius teacher. Pls make lecture on protein needs
superb explanation. thank you.
Thanks so much for the very clear explanation. Really appeciate your work.
Glad it was helpful!
So helpful, thanks so much!
Thank you for this information
So very helpful.. thank you, thank you, thank you!
Excellent
A key to reversing American Type 2 diabetes in many is to stop overloading the mitochondria with fructose. Right up front, she is clear that what the mitochondria convert to energy are glucose and fat. Fructose is not in that list. So, fructose should be consumed only moderately.
Thanks, very helpful..
Thanks Dr Richards!
What kind of doctor? She calls herself "Diabetes Educator." No info in bio. Physician? Nurse? Dietician? Self taught?
Very nice video!
Good job!
good work
I’m watching all your videos. I hope you’ll make more. I wish I had this in school. Knowing how our body works makes it easier to understand how our health is the result of our choices.
Good podcast. Thanks. Can’t get that info from my doctor.
Thanks, that was very easy to understand and I'm very much a layperson! I just wish I didn't have ME/CFS and the inability to exercise, but at least I can do these other things.
Excellent explanation! - Supplementation for mitochondria would be interesting.
It's the lack of supplementation that's needed here 😁
Methylene Blue might be of interest to you.
Thank you so much!
Great video ❤️❤️❤️
Thanks for watching
Thank you Juliet! This was for me so far, the best explanation of this topic, around mitochondria and the metabolic conditions... Excellent!
Omega 6 LA of process oil does most damage rather than saturated fat
Good challenge
Can you do a video on what vitamins, minerals, molecules or polyphenols can inhibit reactive oxygen and nitrogen species? Good talk!
I hope you have updated your understanding of the value of saturated fat.
I over trained myself doing too much zone 5 work in the pool. This happened about a year ago. I still train, but less, and take longer to recover between workouts, and have generally a much lower amount of energy per day. I'm wondering if somehow I damaged my mitochondria through over use. My muscle tone and other health aspects all measure fine in annual checkup at the doctor. But something permanently changed from just a few months of over training.
Great video! I just don’t know what inshulin is
This was wonderful. I learned so much. Thank you.
Do you think this could cause the on set of chronic fatigue syndrome? Thank you for the video, very helpful.
I agree. That a person suffering with mitochondria disease can not tolerate exercise. If your mito are not supplying the energy to my muscle the only thing that will happen to my muscles is pain. For days if I continue with the exercise. I'd really not want to do something that cause extra pain. Believe me I know first hand. Exercise is needed to keep your body moving. But when you have a disorder that pain affects your muscles. Do what you can. But all means do not go and sign up to an exercise program.
Ben Bikman says the sat. fat you mention around 17:19 is not from exogenous sat. fat - not from consumed fat. It's made - and comes from carbs. It makes no sense to say that saturated fat consumption "causes insulin resistance" - if that's what you're saying - because thousands and thousands of people on keto diets and carnivore diets, eating LOTS of sat. fats, are going into diabetes remission, not getting diabetes - they're essentially curing their diabetes eating fat - including lots of saturated fats.
Helpful overview mam..
For starting my PhD in Diabetic neuropathy..
Thanks
Bhi plz send your number
I have daibates nuropathy
You guys forget that lactate activates the glut-4 transporter thus helping glucose absorption into the cell (without the need of insulin!!) making exercise a key factor in glucose management.
Can You make another video about Mitocondrhia dysfunction in long Covid Syndrome
Perfect thank you. I am interested in it all , and particularly the bit at the end, as I understand it, that says the stressed and struggling mitochondria can damage the DNA which can initiate cancer. So how does this relate to increase in child cancers. So does the fasting kill off the malfunctioning cells to prevent cell messaging and inflammation signalling in metastasis throughout the body.
Thanks a lot....
Most welcome!
amazing
Thank you! Cheers!
So this vid is three years old , so young lady i hope you have learned about fatty acids and ROS in the three years since
Great video. Does Oxygen also help ease disfunction?
Interesting. I have a different interpretation of mitochondrial dysfunction. I see it as a gradual and increasing inability to oxidize fats for energy. The mitochondria become lazy and rely entirely on aerobic glycolysis (which takes less oxygen). Aerobic lipolysis takes more oxygen but ultimately provides more ATP with less CO2 as a byproduct. Yep, gotta keep those mitochondria happy, healthy and preferentially fat-burning.
Agreed.
I believe lectures from Chris Knobbe
ruclips.net/video/pHnPinYI2Yc/видео.html
and Thomas Seyfried explain it well.
ruclips.net/video/06e-PwhmSq8/видео.html
Basically the only problem from fats, on mitochondrial dysfunction are the PUFA, which in excess lead to lipid peroxidation, causing structural problems in the mitochondria.
@@Unsensitive,
Yeah, I gather there's more nuance to it than that. I was listening to Peter Attia's podcast with guest Inigo San Millan (or something). Ha, I have a new computer with Bing (used to have Firefox) and I don't know how to copy and paste a link with it. I'm just hopeless at computers.
Anyway in untrained, overfed people, there is some factor whereby fat can build up inside the cell basically blocking fat metabolism and causing the mitochondria to rely on glucose burning. Highly-trained elite endurance athletes develop the same buildup (known as "athletes paradox") but with no dysfunction.
I've always been skeptical of using elite athletes as a model for what regular people should do.
Clearly the problem with the general low-trained population is overfeeding and being overfat. The solution is just to eat less frequently (with your preferred fasting protocol) and let the system clear itself out. Refined carbohydrates and industrial seed oils, PUFAs, further complicate the situation and should be minimized (ideally eliminated).
@@martinirving3824
I respect much of Peter's approach, using research & data, and have learned quite a lot from his discussions.
My only qualm is he seems a bit biased and anchored to the status quo in a few areas.
He a smarter guy, or maybe just better informed and researched, than myself, so I wouldn't say I'm sure he is incorrect.. but I disagree with his conclusions in a few areas.
Time to go study more, till I can show myself, or him, incorrect.
@@Unsensitive ,
Agreed that Attia is a bit anchored in the status quo in a few areas but it's hardly surprising. He is a product of the medical establishment. For this reason, he carries some baggage with him and tends to be open to pharmaceutical interventions for biohacking and optimizing health. I'm a biohacking "purist" and not open to such things for healthy people. It seems to me, interventions are only helpful to people who are sick or metabolically compromised. It really does boil down to mitochondrial health. If they are healthy any pharmaceutical intervention tends to damage their performance.
Attia is an incredibly smart and accomplished guy (very humbling) but arguably a little "elitist" for the general population. I'm interested in finding things that help regular people. I think the science clearly shows what those things are.. mitochondrial health through...
1. non-industrial food intake
2. preferred fasting option: 16:8 to omad, alternate day, 5:2 Mosely protocol. (and a host of others)
3. exercise: weights and/or HIIT
4. proper sleep in accordance with circadian rhythm
5. (consistent practice of the above)
...but it's very hard to get a clear and consistent message across through all the noise and competing interests (and the distractions of self-promotion and commercialism). It's very frustrating.
@@martinirving3824
I think there may be a place for pharmaceuticals, even in the healthy. We need to know more than we do in most areas, or have very good data, to ensure we're not mucking up the complex machinery of the human body, so I'd say we're clearly not there in moat respects, particularly on aging.
Pretty much on the same page with everything else.
I'm a big fan of daily 20/4, or 23/1(OMAD), but never did longer than 30hr fasting.
Long work day today, so looks like I'll be doing a 24hr fast today 🤣.
Interesting, high concentrations of mitochondria in the eyes, what do you know about ipRGCs and ultraviolet light's role in shaping the eyeballs? I notice lecturer is wearing glasses, interesting.
Do dental implants affect oxidation in cells as well given the rise of titanium in blood?
Mitochondria the key to everything. Symbiosis at its best
What about eliminating trans-fat which was shown to cause liver inflammation as well as vegetable oils (not more olive oil or other MUFAs) which is often loaded with aldehydes and free radicals, also damaging the liver?
I have severe mitochondrial dysfunction what should I do?
Exercise outside and eat healthy clean keto etc intermittent Fasting. Got it
What is the most ancient human diet?
U say stay away from saturated fats but most people say MCT and coconut oil (saturated fat) is good fuel????
Sow me one study that says saturated fats need to be minimized.
A good explanation. However, she made one common mistake in stating saturated fats come from animal products only. We are also animals. ALL the fats which are made from excess glucose is saturated. After that, 60-70% are desaturated, leaving 30-40% saturated. Therefore, saturated fats can come from excess carbs as well.
Also, not all saturated fats are the same. Stearate is known to increase the number of mitochondria. Butyrate is known to increase fatty acid oxidation in the liver. So, she was being a bit dogmatic in that respect.
If fatty acids are so bad, why does a high protein, high fat, low carb diet (keto) work so well to regulate blood sugar in diabetics? I found papers and evidence on FAO disease, but not references to FAO problems in healthy individuals.
When does it clogg up the kidneys?
Vit d. Calorie restriction. Insulin redistence. Resistence exercises nera infra red. Sleep suppimenrs co enzyme 10
Lady, people, protein and saturated fats in the diet are quite literally the solution to diabetes t2. High processed food, carb, and industrial PUFA in the diet cause diabetes.
You're clumping healthy fat together with seed oils which hinder the mitochondria
This is 3 years old time to start over from scatch as this is an important topic
What kind if fats ..l am insulin resistance some are saying blk beans ... how much fat??
What to do?? Healthy far and olive oil ok??
@@joanneclark8256you never fail with olive oil. But also fish and seafood = omega 3. I wouldn’t actually have too much fear of saturated animal fat as well. The reason for T2D is sugar, carbs and processed food. But if you are not convinced: everyone agrees on olive oil.
So ditald .. thank you very mach , and sory abut my inglish (:
excellent presentation
No references 😭 useful info
There's some good info but also some nonsense. Saturated fats go into the fat cells more easily but that is the correct path, otherwise it is likely doing something bad like becoming oxidized and going into the liver. Cows don't live in waste dumps and are not predators so biological accumulation is not an issue. The big pesticide and herbicide threats like roundup are also water soluble not fat soluble. The biggest problem with t2 diabetes is liver fat and the quickest way to get it is overeating carbs.