Genomic Sequencing 101: Pros, Cons, and Implications for You and Your Family
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- Опубликовано: 1 июн 2024
- For more information on specific tests and treatments please visit genomicsadviser.com/
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Dr. Mike Evans is a staff physician at St. Michael's Hospital and an Associate Professor of Family Medicine. He is a Scientist at the Li Ka Shing Knowledge Institute and has an endowed Chair in Patient Engagement in Child Nutrition at the University of Toronto.
Produced by Reframe Health Films
Developed by Tim Thomson, Animation Answers
©2016 Michael Evans and Reframe Health Films Inc.
My daughter has two extremely rare genetic deletions. So rare that each have only been documented in less than 15 people. One, only in adults while she’s only three years old. This along with another micro deletion in 16.p11Xxx nearly killed her. In ICU for a week; and we’ve only been home from February 6th-March 15th (with appointments and procedures while we were ‘home’).
We’re currently in the hospital again with a feeding intolerance, which has plagued us since January 1st.
My daughter was a healthy child up until New Years Eve 2020.
Our genetics team has prescribed her a ‘cocktail’ of B-vitamins, and supplements which aid the function of her Mitochondria. They are confident that these supplements can prevent her from regressing back to her state on New Years Eve, and the subsequent stay in ICU.
All this to say that my wife has two of the same deletions as my daughter. She’s currently healthy. But who know what could happen if her immune system takes a hit, and these latent gene deletions reveal themselves.
If you’re on the fence about getting your DNA sequenced... please get off the fence. It might save you or your children’s life.
If you still don’t want to.. at least take your vitamins every day. B-vitamins, C0Q10, Nicotinamide Ribosode Chloride, vitamins C, vitamin D, vitamin D3. Anything that aids the mitochondria aids you.
I just wanna thank you so much for helping me with reflecting
Great timing as my local hospital is advertising this type of testing. Thank you, Doc!
Amazing demonstration video
Yes ,I agree ! Very professional,very clear explainations. Nice job ! From me too !
As with many things related to science, I feel a lot of the public's concern would be aided by better understanding of probability and statistics. I personally wouldn't have a problem learning every detail of my genome. But I know I handle health concern well, find comfort in doing what I can to improve my health, can let go of what I can't control, and also typically understand the role of our genes and the maths of risk. This video is a great intro to those considerations; thank you for making it.
I Just got my results of whole genome sequencing and I have a rare disorder that only 50 people have.Thank you OHIP
iraqidolphin1 what u have ?I get my results next week .
How did it go Kimberly?
Hi, what video editing/ graphics do you use? How do you make your videos?
My advice. Don't get it if bad news will panic you. Never take action in fear only love.
How does changing human dna affect the environment around us and vice versa? Is there a possibility of a negative disruption in humans natural development?
Is this the amazing technology being used to create the Pfizer and Moderna covid-19 vaccines? Who wouldve thought we would come this far! Awesome channel!
Incidental findings are the reason we should not practice genomic sequencing. It’s understanding to want to know what diseases you may be at risk for, but it will cause too much stress and anxiety, which we, as humans, have plenty of on a daily basis. Opening up the door of knowing your genomic sequencing causes too many ripple effects. You should always live a healthy lifestyle by eating right, exercising, and reducing bad habits whether or not you have a high risk of getting diabetes. Your genomic sequencing should not limit you from having kids, or be the deciding factor to possible abort a conceived child. There are so many aspects to genomic sequencing, it just does not make sense to make it a common practice. The human race has done just fine without knowing their genomic sequence and everything it could entail.
Hi Lindsey, while I do agree with many of the points that you have brought up about the dangers of genomic sequencing they can also be looked at as positives. Having an idea of things that could potentially happen to a person in their life time will allow them to become better prepared and potentially be more inclined to see their physician in a timely manner. One example that comes to mind right away is in relation to the benefits of genomic sequencing is BRCA 1 and BRCA 2 genes, which are two genes highly related to breast cancer. If found to have one or both of these genes a persons risk of developing breast cancer increases by 72%-69% according to beBRCAaware.com. By being able to determine if a person is at an increased risk for breast cancer before it develops allows them to be more conscious about their lifestyle along with taking many different preventative measures such as a prophylactic mastectomy. By removing their breast tissue they are reducing their chances of getting breast cancer by 90%, according to the Center For Restorative Breast Surgery. Although, I do agree that this will cause the person to experience an increased sense of anxiety and worry that would only be temporary, because they would be able to take those precautionary measures early and that anxiety will dissipate. As the daughter of a Breast Cancer survivor I find genomic sequencing beneficial to maintaining a healthy life for myself, and as a future physician I believe this goes along with the ethical principle of Beneficence. If I believe that a patient has a predisposition for a particular disease it is my duty to them to suggest they undergo genomic sequencing to promote their good health. I do agree that there are many aspects of genomic sequencing that are not talked about as commonly, but what has been able to be done because of it is just amazing. According to the article “The Benefits of Whole-Genome Sequencing Now and in the Future” published in 2015 within 2 years genomic sequencing has been able to identify 12 new Mendelian genes every month. This has helped to increase the knowledge of physicians and scientists when it comes to understanding the human genome and how it can play a role in a person’s long-term health. There are many people that live everyday not knowing that they have a genetic condition because many are not recognized at birth and develop later on in life, and could be deadly like Huntington’s Disease. So isn’t it better to be able to prepare a person for what is to potentially come in their life rather than to spring it on them when the symptoms begin?
It is always an individuals choice. I'm happy that I had it done. Now I've met other people with the same disorder. Also, now I can take treatment because of the diagnosis. I can do family planning knowing that every child I have has a 50% chance of having it too.
"or what my kids call: T.M.I." what a boomer thing to say!