I love this presentation. I plan to go back and read those studies myself. I have been thinking for a while on the same approach. We leave the job only to those looking for a patentable molecule to get their profit back. This professor is making history!
Wow, just incredible. This confirms my hunch about the pharma industry that the trials are biased and do not include people like me. In particular why is there no research on hormonal effects on women. What about the effects of exercise? What about inflammation often more present in women? I am early on in my journey and using exercise to help. For now it is helping. I am concerned about taking more drugs as the side effects cause Parkinson’s like symptoms.
Multi-factorial causation is not easily studied within the necessity by scientific methodology currently needing to oversimplify by studying each toxicant or inducing factor separately. Additive and synergistic effects are much harder to design adequate research for while maintaining quality assessment and control. Pre-existing exposures accumulated in the individual are often not controlled for adequately, and this greatly complicates clarification of how individual outcomes can differ so commonly. Take just the known toxicology of the variable body burden of the toxic metal lead accumulated over time and stored in the bone after circulating in the blood for only a relatively short time. The assumption is often that once blood lead falls, then the danger from the lead exposures has passed, however... when the body later becomes stressed by pregnancy, old age, or illness and requires the body to seek increased calcium circulating again, lead sneaks out of the bone stores along with the calcium to once again expose the soft tissues to the toxic effects (at precisely the most vulnerable times of life). The levels of assumption by medical practitioners cannot typically take into account such pre-existing conditions, yet a huge number of patients with poor outcomes during hospitalization are adversely affected by the complication. There are many 'pre-existing' deficiencies and accumulations known to be scientifically important to immunologic system preparedness for effective responses, zinc, vitamin D3, B1, etc. and lead, cadmium, arsenic, as well, that are commonly NOT assessed for during medical assessment and treatment. IMHO Better monitoring of such factors in the future will bring much better assessment of pre-existing specificity to computer diagnostic and treatment Individuals that have one of these deficiencies, very often have more of them. Inner city minorities commonly are exposed to, and have medical conditions complicated by, many of these immunologic disadvantaging statuses. None of any of us, are free of all of them (e.g. we all have hundreds of times the accumulated bone lead than prehistoric bone contains). Reading the scientific literature on lead toxicology quickly points out the huge medical outcome implications, such as reduced glutathione, and per-oxidation of lipids variably damaging protective membranes, etc. Variable outcomes are to be expected, given the ubiquity of co-morbidities brought on by nutritional deficiencies. But, the more science that gets done well, the more we know and can take into account for prophylaxis and treatment of medical conditions in timely fashion with better outcomes. IMHO (just some guy on the internet).
In mis-folded proteins found, do any have any lead (Pb) or glyphosate in them? If Pb can replace Zn in zinc fingers, and glyphosate might possibly replace glycine in amino acid chains resulting in mis-folding, is there a quantitative difference in these mis-folded/correctly folded if large amounts can be analyzed and compared?
If Cu is found in correctly folded a-synuclein readily, does mis-folded have less CU present? Can Pb substitute for some of the copper, resulting in mis-folding?
@@raykinney9907Your question is above my level of understanding but the concept I meant to present is that once proteins no longer are in their normal, soluble configuration, they cannot function. The narrative in our field has overlooked the ceasing of function when proteins aggregate, instead attributing toxicity (by a variety of different mechanisms) to what is in effect an amyloid state of proteins: too stable to actually be toxic or "replicate".
@@aespay Yes, good point to get across. My sense of general concern, after reading significant amounts of the research by specialists, is that it is extremely important for generalists to review a broad swath of the research to inform a generalist viewpoint. The generalists need to be free to speak up, indeed have a responsibility to speak up, to guide the path forward with science more than politic. Your presentation encouraged me, in that I felt you were accomplishing this significantly. IMHO, all research needs careful attention to be aware of the funding biases as much as possible. Science needs public funding, taxation for this, and is essential for our future.
@@teacherslearn Hi Melanie. This is beyond my limited expertise but I think this refers to mitochondrial and lysosomal biogenesis being activated following PINK1/parkin-mediated mitophagy. See: pubmed.ncbi.nlm.nih.gov/26509433/
SYMBYX a Photobiomodulation device claims this laser devise can do wonders for PD patients. Your comment/ advice will be greatly appreciated It is a very expansive device $ 1770.
As of 2024, the sun is (still) free of charge - depending on where you are ... I hope this doesn't come across as a facile response, it was my earnest intention to note this with gravity. Roger Seheult provides good starting points, there are many researchers that acknowledge that sunlight can provide the frequencies / wavelengths they are studying, with the ability to hold its own versus products of technological sophistication.
april 2023: your hypothesis got confirmeds old mouse studdy : not all genetic variants of PD come with missfolded alpha sync. BUT, there is still this mouse studdy where they put missfolded alpha sync in the intestin, and mices got PD.
If, it becomes further clarified that people taking sildenafil, or taldalafil, can have greatly reduced later occurrence of AD? Can the insurance data that suggested this for AD, possibly show similar effect? Does more nitric oxide relax small diameter blood vessels in the brain, to allow better RBC flow through to deliver better O2 supplies to mitochondria in neurons?
Apparently, 40 hz light and sound stimulation of gamma wave sleep can result in microglial inducement of blood vessel diameter, increasing flow. This increases blood O2 supply to mitochondria to increase efficiency for ATP production and ROS cleanup?
I love this presentation. I plan to go back and read those studies myself. I have been thinking for a while on the same approach. We leave the job only to those looking for a patentable molecule to get their profit back. This professor is making history!
Wow, just incredible. This confirms my hunch about the pharma industry that the trials are biased and do not include people like me. In particular why is there no research on hormonal effects on women. What about the effects of exercise? What about inflammation often more present in women?
I am early on in my journey and using exercise to help. For now it is helping.
I am concerned about taking more drugs as the side effects cause Parkinson’s like symptoms.
Amazing 👏 love from Bangladesh 🇧🇩
Multi-factorial causation is not easily studied within the necessity by scientific methodology currently needing to oversimplify by studying each toxicant or inducing factor separately. Additive and synergistic effects are much harder to design adequate research for while maintaining quality assessment and control. Pre-existing exposures accumulated in the individual are often not controlled for adequately, and this greatly complicates clarification of how individual outcomes can differ so commonly. Take just the known toxicology of the variable body burden of the toxic metal lead accumulated over time and stored in the bone after circulating in the blood for only a relatively short time. The assumption is often that once blood lead falls, then the danger from the lead exposures has passed, however... when the body later becomes stressed by pregnancy, old age, or illness and requires the body to seek increased calcium circulating again, lead sneaks out of the bone stores along with the calcium to once again expose the soft tissues to the toxic effects (at precisely the most vulnerable times of life). The levels of assumption by medical practitioners cannot typically take into account such pre-existing conditions, yet a huge number of patients with poor outcomes during hospitalization are adversely affected by the complication. There are many 'pre-existing' deficiencies and accumulations known to be scientifically important to immunologic system preparedness for effective responses, zinc, vitamin D3, B1, etc. and lead, cadmium, arsenic, as well, that are commonly NOT assessed for during medical assessment and treatment. IMHO Better monitoring of such factors in the future will bring much better assessment of pre-existing specificity to computer diagnostic and treatment
Individuals that have one of these deficiencies, very often have more of them. Inner city minorities commonly are exposed to, and have medical conditions complicated by, many of these immunologic disadvantaging statuses. None of any of us, are free of all of them (e.g. we all have hundreds of times the accumulated bone lead than prehistoric bone contains). Reading the scientific literature on lead toxicology quickly points out the huge medical outcome implications, such as reduced glutathione, and per-oxidation of lipids variably damaging protective membranes, etc. Variable outcomes are to be expected, given the ubiquity of co-morbidities brought on by nutritional deficiencies.
But, the more science that gets done well, the more we know and can take into account for prophylaxis and treatment of medical conditions in timely fashion with better outcomes.
IMHO (just some guy on the internet).
Very interesting!
In mis-folded proteins found, do any have any lead (Pb) or glyphosate in them? If Pb can replace Zn in zinc fingers, and glyphosate might possibly replace glycine in amino acid chains resulting in mis-folding, is there a quantitative difference in these mis-folded/correctly folded if large amounts can be analyzed and compared?
If Cu is found in correctly folded a-synuclein readily, does mis-folded have less CU present? Can Pb substitute for some of the copper, resulting in mis-folding?
@@raykinney9907Your question is above my level of understanding but the concept I meant to present is that once proteins no longer are in their normal, soluble configuration, they cannot function. The narrative in our field has overlooked the ceasing of function when proteins aggregate, instead attributing toxicity (by a variety of different mechanisms) to what is in effect an amyloid state of proteins: too stable to actually be toxic or "replicate".
@@aespay Yes, good point to get across. My sense of general concern, after reading significant amounts of the research by specialists, is that it is extremely important for generalists to review a broad swath of the research to inform a generalist viewpoint. The generalists need to be free to speak up, indeed have a responsibility to speak up, to guide the path forward with science more than politic. Your presentation encouraged me, in that I felt you were accomplishing this significantly. IMHO, all research needs careful attention to be aware of the funding biases as much as possible. Science needs public funding, taxation for this, and is essential for our future.
Thankyou very interesting
How can I sign up for this study he is talking about?
not 100% sure to be honest- perhaps if you are on twitter then you could message him directly
@@nosilverbullet4pd998 what is this "parking" and "pink" you speak of?
@@teacherslearn Hi Melanie. This is beyond my limited expertise but I think this refers to mitochondrial and lysosomal biogenesis being activated following PINK1/parkin-mediated mitophagy. See: pubmed.ncbi.nlm.nih.gov/26509433/
Please see cureparkinsons.org.uk/research/amtakepart/
SYMBYX a Photobiomodulation device claims this laser devise can do wonders for PD patients.
Your comment/ advice will be greatly appreciated
It is a very expansive device $ 1770.
Thanks. Where to find it?
As of 2024, the sun is (still) free of charge - depending on where you are ... I hope this doesn't come across as a facile response, it was my earnest intention to note this with gravity. Roger Seheult provides good starting points, there are many researchers that acknowledge that sunlight can provide the frequencies / wavelengths they are studying, with the ability to hold its own versus products of technological sophistication.
april 2023: your hypothesis got confirmeds old mouse studdy : not all genetic variants of PD come with missfolded alpha sync. BUT, there is still this mouse studdy where they put missfolded alpha sync in the intestin, and mices got PD.
11 minutes - maybe if the neurons die, they are gone and the Lewy bodies that were in them are gone too?
If, it becomes further clarified that people taking sildenafil, or taldalafil, can have greatly reduced later occurrence of AD? Can the insurance data that suggested this for AD, possibly show similar effect? Does more nitric oxide relax small diameter blood vessels in the brain, to allow better RBC flow through to deliver better O2 supplies to mitochondria in neurons?
The same effects for some PD?
Apparently, 40 hz light and sound stimulation of gamma wave sleep can result in microglial inducement of blood vessel diameter, increasing flow. This increases blood O2 supply to mitochondria to increase efficiency for ATP production and ROS cleanup?
O
What about quantum mechanics? Didn’t they change the laws of physics?