Have you considered that the acid sensitivity is as simple as the basicity of hydroxide vs the basicity of fluoride? going from pH 6 to pH 5, you'd see a 10x drop in hydroxide concentration, thus reducing the amount available to remineralize into hydroxapatite. fluoride, however, is a weak base and won't start to protonate until the pH drops below 4ish (given that the pKa of HF is around 3).
Yea, what I learned from the feedback to this video is that I don't remember my pchem fundamentals NEARLY as well as I remember my biochem fundamentals. I bit off more than I could chew--completely forgot to mention pKa in this ENTIRE video, and instead of a real paper, my primary source was an article funded by a toothpaste company. Complete scripting disaster from back to front. This video is _close_ to accurate--but not close enough. However, I really like your comment because it summarizes the problems with my script really well. So, if you're cool with it--I'm pinning this comment. After this video I got a lot more fact checking support from my network, specifically my community over a the Biocord discord server. Maybe after I crack open my pchem textbook a few more times I'll dip back into videos like this--but definitely not for a while. There are enough proteins for me to write about without reaching too far into the fields I don't remember enough.
Definitely the most detailed video on chemistry behind it on RUclips. Does anyone have suggestions as to where one should look to read on scientific papers on this topic. I'm doing a research project on Le Chatelier, equilibrium, pH...I need chemical equations regarding products and reactants, acids and bases, conjugate acids and conjugate bases...does anyone have a link with detailed info on this?
The 'glorious clockwork' eh'? I can even see how one eyed ,color blind, and dead the lens you look at this living universe is from the PowerPoint thing. I kant even rn, Humen. ✌
I am a retired dental hygiene educator. I am working on a presentation for nutrition students on oral health as it relates to cariology, dietary counseling and saliva testing. In preparation I've been viewing a lot of videos lately and THIS is short, to the point, simplified science and awesome for visual learners. Thank you so much!
I am a dentist and stumbled upon this post. Let me say that you did a wonderful job. Like one of the other correspondence, I too grabbed a toothbrush and brushed my teeth after viewing this post. You did ask for corrections and clarifications which is most commendable and thus I assume you follow scientific principles of getting things right. I ran this by a dental materials PhD. Here is his assessment of your explanation: "Apart from it being somewhat inaccurate, the topic is well presented. Fluoride has an anti-cavity effect, and the epidemiological evidence is good. However nobody knows precisely how or why it works. The solubility differences mentioned in the post is minute (x0.6). Fluoroapatite is not formed - CaF2 is. The solubility ratio is constant over a large pH range, and there is NO switch point: it is an artifact of bad data plotting and analysis. Do it right and the illusion vanishes. Tooth mineral is not Hydroxyapatite, but a biological apatite with many important differences. Remineralization is not actually true. The fact is, it is an embarrassment to the folks that work on fluoride that they cannot explain the exact mechanism. However we do know with great certainty that fluoride does reduce tooth decay and is safe in therapeutic doses." Please note that I offer this as a constructive critique. I highly regard the manner with which you attempt to explain difficult and complex biological concepts in an understandable fashion for the lay public. Keep up the good work.
How one answers your question, is dependent on your knowledge-base. If you are a scientist, you would know that I would need pages of evidence to give an honest and accurate answer. This format is not conducive to such an effort. If you are not a scientist, or a health-care provider, then the most honest answer I might offer is that proper oral hygiene with fluoride containing toothpaste, in conjunction with community water fluoridation and a well-balance diet to avoid excess sugary snacks is the best way to avoid tooth decay and gum disease. If you do the above conscientiously then, you need not worry about remineralization. The topic is complex and fraught with misconceptions that might possibly deceive the buying public. If you need a short answer, once enamel is sufficiently demineralized , it cannot be reconstituted to what it was. Some form of mineral uptake may take place if concentration gradients allow, but this should not be equated with enamel repairing itself. Sorry, but Biology is complex.
so the exact mechanism of fluoride in tooth Health has been kind of an imponderable for me. this morning I finally decided to look on some RUclips videos for answers. I was very impressed with the angle you take and describing the processes and understanding that the limits of your personal knowledge are not bounded and open to review as well as editing from your peers. good job!
This was a great video! I just got my first huge cavity a week ago--dentist appointment is next week--and so I've been on an education binge on what to do to help treat it. You are exactly right that most coverage of the effects of fluoride end at just saying "do it, it makes your teeth stronger". That infuriates me to no end! I wanted to know WHY it works, and your video did an excellent job of clearing it up. I truly appreciate the work you put in, I'll be subscribing for sure!
PhDs who study fluoride and teeth don't even know exactly how it helps. I imagine it is much more frustrating to them, but it explains why the explanation we get is simply, "it just works". -source: a dentist in the comments who was quoting a PhD expert in this field
I’m glad you mention that over-fluoridated water can be toxic; while we know it to strengthen teeth, I‘d like to know more about what happens when it’s ingested.
3years on… Taking the “drug” prescribed by municipal water districts (do they have a license to practice medicine…!) systemically (internally) affects only your teeth and has no impact whatsoever on your soft tissues organs or any other part of your body… Trust me, I am a scientist. Butcher…
Briefly about fluorine: the fluorine atom is small enough and has the highest electronegativity. As a result of the formation of bonds, the electron that took the fluorine is very close to the nucleus, and the screening effect is minimal. Therefore, it is much more difficult to expel fluorine from apatite than the hydroxyl group.
Kurzgesagt, or less commonly known but technically still valid, “in a nutshell,” does not deal with biochemistry. So they could coexist. Also he may have ran out of topics, at which point he would need suggestions
First of all thank you for this useful presentation I really enjoyed the chemistry part but around fluoride may cause damage or discolored your teeth it may cause that if someones receive excessive fluoride systematically during tooth development stages so excessive fluoride in your mouth do not cause discoloration unless you swallow it at time where tooth are in develop stage before they erupt
Could you cite any research that indicates or proves that ingesting the specific type of fluoride that we drink in our tap water? Also why did you seem to imply that it's the same kind that's in our toothpaste?
Ive always used sodium flouride toothpaste twice a day, still have teeth problems. Im switching to stannous flouride toothpaste and cutting back on sugar to see if it helps strengthen my teeth
Could other ions (strontium, chloride, heck- uranium theoretically) be used to replace the OH in apatite for an even more acid-resistant matrix than fluoride? Why don’t we use other ions besides fluoride?
Because fluoride is the best. You can use chloride to make clorapatite but that is weaker than hydroxyapatite. Hypothetically you could use bromine or any other halogen too but that would be even worse. Fluorine is the most electronegative element in the periodic, it pulls together those ions because it really wants their electrons. That’s just it.
Thanks for this video. I haven't looked this up, but I do have a PhD in Inorganic Chem. F forms really strong bonds. So, I doubt that F- (ionic) is the correct way to picture the compound. F is ionic in some salts but my guess is that P-F (covalent) is a better representation. These days PFAS (also known as forever chemicals) are big in the news. C-F bonds just don't break; hence, the "forever" nature of these compounds - produced only industrially but now found everywhere from penguins to polar bears and everyone in-between. P-F bonds are more stable than P=O or P-O bonds under mildly acidic conditions. Incidentally, HF was featured in the show Breaking Bad as a way to dissolve human bones although I doubt aqueous HF would dissolve a whole human quickly if at all. Gaseous HF is highly toxic and should be handled with great care.
It's definitely that fluorine is super electronegative. That what makes Teflon never bond to anything, fluorine bonds more strongly than any other atom to the structure
thank you i learned alot from ur video .. would like to ask if u have topic related to fluorosis .. could u talk about it why we get the white yellow spot related to fluoride consumtion. thank u
Btw, if you ever wondered what video would be able to make your type of content blow up. In my experience, it would be something connected with reproducing. It's just a kind of trend I noticed in the most popular RUclips channels of this thematic. Just an observation.
Only Calcium Fluoride strengthens and protects teeth not the industrial version Sodium Fluoride! There is no safe minimum dose of elemental Fluoride! I suggest redoing the video after more research.
from what little I know of chemistry, the positive ion needs to be shed for the negative to re-bind with other positive ions. so maybe the positive ion doesn't matter so much!?
6:21 for someone who supposedly loves learning, please learn how to use “begs the question” correctly. It’s a huge red flag when people who are trying to convey information use this phrase in a completely inapplicable way.
It has more than one definition. It's not just the rhetorical fallacy. From the OED: 1. (of a fact or action) raise a question or point that has not been dealt with; invite an obvious question.
The fluoride will make the dentin in the tooth become brittle and will make it easier to snap the tooth. If you stop consuming sugar and high levels of carbs you won't have to worry about the acid from bacteria decaying the teeth. A good alternative for tooth paste is pure olive oil soap, flossing, hydrogen peroxide, mouthwash, and 40-75% ethanol right after consuming food.
my real question is not why fluorine is better but more why didnt our body already got fluorine there. Well I guess it doesnt like dealing with fluorine because fluorine is... a bit mean.
Have you considered that the acid sensitivity is as simple as the basicity of hydroxide vs the basicity of fluoride? going from pH 6 to pH 5, you'd see a 10x drop in hydroxide concentration, thus reducing the amount available to remineralize into hydroxapatite. fluoride, however, is a weak base and won't start to protonate until the pH drops below 4ish (given that the pKa of HF is around 3).
Yea, what I learned from the feedback to this video is that I don't remember my pchem fundamentals NEARLY as well as I remember my biochem fundamentals. I bit off more than I could chew--completely forgot to mention pKa in this ENTIRE video, and instead of a real paper, my primary source was an article funded by a toothpaste company. Complete scripting disaster from back to front. This video is _close_ to accurate--but not close enough. However, I really like your comment because it summarizes the problems with my script really well. So, if you're cool with it--I'm pinning this comment.
After this video I got a lot more fact checking support from my network, specifically my community over a the Biocord discord server. Maybe after I crack open my pchem textbook a few more times I'll dip back into videos like this--but definitely not for a while. There are enough proteins for me to write about without reaching too far into the fields I don't remember enough.
Chemistry of aqueous solutions! :DDDDD
Definitely the most detailed video on chemistry behind it on RUclips. Does anyone have suggestions as to where one should look to read on scientific papers on this topic. I'm doing a research project on Le Chatelier, equilibrium, pH...I need chemical equations regarding products and reactants, acids and bases, conjugate acids and conjugate bases...does anyone have a link with detailed info on this?
Could you elaborate Morgan......
The 'glorious clockwork' eh'? I can even see how one eyed ,color blind, and dead the lens you look at this living universe is from the PowerPoint thing. I kant even rn, Humen. ✌
I am a retired dental hygiene educator. I am working on a presentation for nutrition students on oral health as it relates to cariology, dietary counseling and saliva testing. In preparation I've been viewing a lot of videos lately and THIS is short, to the point, simplified science and awesome for visual learners. Thank you so much!
Indeed. I loved the way this video conveyed the importance of balance
♎
I am a dentist and stumbled upon this post. Let me say that you did a wonderful job. Like one of the other correspondence, I too grabbed a toothbrush and brushed my teeth after viewing this post. You did ask for corrections and clarifications which is most commendable and thus I assume you follow scientific principles of getting things right. I ran this by a dental materials PhD. Here is his assessment of your explanation: "Apart from it being somewhat inaccurate, the topic is well presented. Fluoride has an anti-cavity effect, and the epidemiological evidence is good. However nobody knows precisely how or why it works. The solubility differences mentioned in the post is minute (x0.6). Fluoroapatite is not formed - CaF2 is. The solubility ratio is constant over a large pH range, and there is NO switch point: it is an artifact of bad data plotting and analysis. Do it right and the illusion vanishes. Tooth mineral is not Hydroxyapatite, but a biological apatite with many important differences. Remineralization is not actually true.
The fact is, it is an embarrassment to the folks that work on fluoride that they cannot explain the exact mechanism.
However we do know with great certainty that fluoride does reduce tooth decay and is safe in therapeutic doses."
Please note that I offer this as a constructive critique. I highly regard the manner with which you attempt to explain difficult and complex biological concepts in an understandable fashion for the lay public. Keep up the good work.
'Remineralization is not actually true.' ??????
How one answers your question, is dependent on your knowledge-base. If you are a scientist, you would know that I would need pages of evidence to give an honest and accurate answer. This format is not conducive to such an effort. If you are not a scientist, or a health-care provider, then the most honest answer I might offer is that proper oral hygiene with fluoride containing toothpaste, in conjunction with community water fluoridation and a well-balance diet to avoid excess sugary snacks is the best way to avoid tooth decay and gum disease. If you do the above conscientiously then, you need not worry about remineralization. The topic is complex and fraught with misconceptions that might possibly deceive the buying public. If you need a short answer, once enamel is sufficiently demineralized , it cannot be reconstituted to what it was. Some form of mineral uptake may take place if concentration gradients allow, but this should not be equated with enamel repairing itself. Sorry, but Biology is complex.
As a fellow biochemist, I love how you explain this stuff great job cant wait to see you make more!
Your modesty and sense of humor make this already fascinating video even more lovable.
This was so fascinating and the animation is really beautiful. Amazing video - can't wait to see your next one!
so the exact mechanism of fluoride in tooth Health has been kind of an imponderable for me. this morning I finally decided to look on some RUclips videos for answers. I was very impressed with the angle you take and describing the processes and understanding that the limits of your personal knowledge are not bounded and open to review as well as editing from your peers. good job!
This was a great video! I just got my first huge cavity a week ago--dentist appointment is next week--and so I've been on an education binge on what to do to help treat it. You are exactly right that most coverage of the effects of fluoride end at just saying "do it, it makes your teeth stronger". That infuriates me to no end! I wanted to know WHY it works, and your video did an excellent job of clearing it up. I truly appreciate the work you put in, I'll be subscribing for sure!
I recently learned about xylitol ,after every meal or drink ,use a xylitol gum ,balls or pearls
PhDs who study fluoride and teeth don't even know exactly how it helps. I imagine it is much more frustrating to them, but it explains why the explanation we get is simply, "it just works".
-source: a dentist in the comments who was quoting a PhD expert in this field
Coming from a biochem grad student, this channel is awesome!! Keep up the great work!
Amazing video, this explanation makes a lot of sense and I like the message in the end. Looking forward to your next video!
I’m glad you mention that over-fluoridated water can be toxic; while we know it to strengthen teeth, I‘d like to know more about what happens when it’s ingested.
3years on…
Taking the “drug” prescribed by municipal water districts (do they have a license to practice medicine…!) systemically (internally) affects only your teeth and has no impact whatsoever on your soft tissues organs or any other part of your body…
Trust me, I am a scientist.
Butcher…
It's a neurotoxin and an adjuvant for other heavy metals. Half the fluoride ingested stays in your body building up.
@@DASLAKILL lol. Tea and grapes have 10 times more fluorine you ever may consume from tap water, unless you in China as the exclusion
Why does it need to be ingested ?
Briefly about fluorine: the fluorine atom is small enough and has the highest electronegativity. As a result of the formation of bonds, the electron that took the fluorine is very close to the nucleus, and the screening effect is minimal. Therefore, it is much more difficult to expel fluorine from apatite than the hydroxyl group.
Gorgeous video, loved the final message
here before this channel becomes the next kurzgesagt ;)
It didn't
He stop making video 2 year ago so sadly it will never be the next kurzgesagt
Edit: He is making a season 2 it might aswell be the next kurzgesagt
Kurzgesagt, or less commonly known but technically still valid, “in a nutshell,” does not deal with biochemistry. So they could coexist. Also he may have ran out of topics, at which point he would need suggestions
@@bmw_m4255it will
@@bintanglintangerlangga1983he’s making a season 2 as views have increased 🎉🎉🎉🎉
Banging video. Made me brush teeth instantly. Subbed
Great explanation thanks
Loved the visuals too
That was fun to listen to. Thank you for compounding knowledge.
Excellent content! Well done!
Earned a sub, great video.
Amazing! Thanks for this video. It’s so easy to understand and learn about the different parts of the body. Can’t wait for your next video!! xx
as a dentist, this is amazing. well done
Amazing. Subscribing a minute in, because this is just so good.
You can also get hydroxyapatite toothpaste which will do this better
Are you ever going to continue to make videos? Your content is wonderful!
So good quality!
A huge thanks to the person who shared this video on reddit
Привет из Беларуси спасибо за это видео!
First of all thank you for this useful presentation I really enjoyed the chemistry part but around fluoride may cause damage or discolored your teeth it may cause that if someones receive excessive fluoride systematically during tooth development stages so excessive fluoride in your mouth do not cause discoloration unless you swallow it at time where tooth are in develop stage before they erupt
This is gold
Love this. Thank you!
No--thank YOU for taking the time to reach out!
very good just what I was looking for thankyou
Could you cite any research that indicates or proves that ingesting the specific type of fluoride that we drink in our tap water? Also why did you seem to imply that it's the same kind that's in our toothpaste?
A customer cured is a customer lost, just remember that.
I'm not American, so this doesn't apply
Dental health is power💪
6:20 me too I cant find a definitive answer
Such an amazing show
Great Channel!
Can see why John Green gave this a recommendation
Subscribed for more Awesome Learning 😁
👏🏼✌🏽❤🙏🏽
Has this channel finally been blessed by the almighty algorithm? I hope he starts uploading again!
Ive always used sodium flouride toothpaste twice a day, still have teeth problems. Im switching to stannous flouride toothpaste and cutting back on sugar to see if it helps strengthen my teeth
Could other ions (strontium, chloride, heck- uranium theoretically) be used to replace the OH in apatite for an even more acid-resistant matrix than fluoride? Why don’t we use other ions besides fluoride?
Because we now know nano-mhap is much more safe and fast and nice than F.
Because fluoride is the best.
You can use chloride to make clorapatite but that is weaker than hydroxyapatite. Hypothetically you could use bromine or any other halogen too but that would be even worse.
Fluorine is the most electronegative element in the periodic, it pulls together those ions because it really wants their electrons. That’s just it.
Thanks for this video. I haven't looked this up, but I do have a PhD in Inorganic Chem. F forms really strong bonds. So, I doubt that F- (ionic) is the correct way to picture the compound. F is ionic in some salts but my guess is that P-F (covalent) is a better representation. These days PFAS (also known as forever chemicals) are big in the news. C-F bonds just don't break; hence, the "forever" nature of these compounds - produced only industrially but now found everywhere from penguins to polar bears and everyone in-between. P-F bonds are more stable than P=O or P-O bonds under mildly acidic conditions. Incidentally, HF was featured in the show Breaking Bad as a way to dissolve human bones although I doubt aqueous HF would dissolve a whole human quickly if at all. Gaseous HF is highly toxic and should be handled with great care.
Is there a way to reverse tooth wear then? Mild mini cracks?
Wow awesome guy awesome script... Great
great video!
It bothers me how the woman is brushing her teeth incorrectly with that electric toothbrush!!
03:35 is posible to make this font smaller?
:)
Hi from Vert Dider!
It's definitely that fluorine is super electronegative. That what makes Teflon never bond to anything, fluorine bonds more strongly than any other atom to the structure
Does fluoridated water turn your teeth yellow over time?
no the quantity of fluoride in both tape water and toothpaste have no harm on your teeth and your health
U could have explained why stannous fluoride works so much better than sodium fluoride.
I love this video 🥰🦷
this video was fucking great! solid information and well spoken!
thank you i learned alot from ur video .. would like to ask if u have topic related to fluorosis .. could u talk about it why we get the white yellow spot related to fluoride consumtion. thank u
No more videos :( ?
So why not use Hydroxyapatite toothpaste instead of Fluoride?
Hydroxyapatite is a crystal, how are they going to put that in a tube?
@@Nxck2440grind it up into a fine powder and add it to the liquid mix
naaaaaooo so tem 12 videos nesse canal 😭😭😭😭😭😭
I use miswak never had toothpain since.
Why do we even need to injest flouride? Why not jist rinse with it.
u don't and shouldn't
What if you don't eat carbs and eat lets say, meat instead?
Your website links say Website Expired
Best biochem channel right now. Perfect animation, informative and just, so sexy. This will blow up soon.
I never brushed with toothpaste before, lol i guess i should start doing that
I wonder about fluoride in toothpaste, I feel just not eating sugary foods would be better.
What about streptococcus salivarius m18?
Are u a researcher?
Thanks for the info ! 👍 your very humble dude it's refreshing ✌
many yt vdo about whitening teeth using vinegar, baking soda, etc....
wonder what damage they would cause to teeth?
Так поддержал канал, осталось выучить английский. Спасибо vert dider за перевод
thnks from Kiev
Got here from a Corporis video : )
hell yea friend--thanks for letting me know! Hope this channel someday catches up to him in quality!
_interlinked_
*within cells interlinked within cells interlinked within cells interlinked*
Healthy enamel is actually stronger than steel. :)
I brush my teeth with garlic. It strengthens enamel.
From Vert Dider.
I don’t know nothin bout teeth, but lemme tell you about frogs…
Iiiiiirons iiiiiirons iiiiiirons ⚒️⚒️⚒️
Btw, if you ever wondered what video would be able to make your type of content blow up. In my experience, it would be something connected with reproducing. It's just a kind of trend I noticed in the most popular RUclips channels of this thematic. Just an observation.
skip to 0:45 to get to the actual topic.
Only Calcium Fluoride strengthens and protects teeth not the industrial version Sodium Fluoride!
There is no safe minimum dose of elemental Fluoride!
I suggest redoing the video after more research.
from what little I know of chemistry, the positive ion needs to be shed for the negative to re-bind with other positive ions. so maybe the positive ion doesn't matter so much!?
2024 comeback???
6:21 for someone who supposedly loves learning, please learn how to use “begs the question” correctly. It’s a huge red flag when people who are trying to convey information use this phrase in a completely inapplicable way.
It has more than one definition. It's not just the rhetorical fallacy. From the OED: 1. (of a fact or action) raise a question or point that has not been dealt with; invite an obvious question.
@@makego Cite your reference.
❤
Is flouride good for my teeth or not please just someone answer and help me
Yeah it’s good for you’re teeth 🙃 Like everything it’s good in moderation, most places in the world don’t have too much fluoride
Fluoride is a neurotoxin, and a waste product of heavy industry. None of it in any quantity is good for you.
fluorapatite causes differential erosion of teeth which then further quickly erodes the hydroxyapatite sections of your mouth
Flourise is toxic!
Hello from Kazakhstan. Good lack to your channel
The fluoride will make the dentin in the tooth become brittle and will make it easier to snap the tooth. If you stop consuming sugar and high levels of carbs you won't have to worry about the acid from bacteria decaying the teeth. A good alternative for tooth paste is pure olive oil soap, flossing, hydrogen peroxide, mouthwash, and 40-75% ethanol right after consuming food.
I use a homemade toothpaste of coconut oil, hydrogen peroxide, baking soda, and clove oil. Stuff makes my teeth feel pristine.
спасибо за полезную информацию. подача отличная! привет из России))
my real question is not why fluorine is better but more why didnt our body already got fluorine there. Well I guess it doesnt like dealing with fluorine because fluorine is... a bit mean.
Drink carbonated things, even water through a straw & chew gum often.