How to get tested for Vitamin K2 and the dosage is dependent on the APOE Genotype which we carry?
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- Опубликовано: 7 окт 2024
- The Vitamin K2 is very important and crucial for our long-term health and mitigating numerous non communicable diseases. There are two K dependent proteins that can only be activated in the presence of adequate vitamin K2 in the body at the serum and cellular level.
These k dependent proteins are Matrix Gla Protein and Osteocalcin. The Matrix Gla Protein, when activated by vitamin K2, protects the calcium from binding to the arteries and Osteocalcin Protin when actvated helps in transportation of Calcium to the bones. These activations of Matrix Gla Protein and Osteocalcin Protein prevent atherosclerosis and osteopenia/osteoporosis.
The clearance rate of Vitamin K2 depends on the APOE Genotype that an individual cariies which is inherited from our parents. It's a once in lifetime test to know what one's APOE Genotype is. There are basic three alleles of genotype e2, e3 and e4 and the totsl combination of six as e2/e2, e3/e3, e2/e3, e2/e4, e3/e4 and e3/e4.
The Vitamin K2 rate of clearance is e4 greater than e3 greater than e2. It means that folks who carry allele e4 clear k2 very fast (It means they would need more), allele e3 is typical clearance (neither fast nor slow), and allele e2 is slow clearance. Therefore, allele e2 would fare better with vitamin k2 mk4 than mk7 since the half life of mk4 is much shorter than mk7. The alleles e3 and e4 would be fare better with mk7 form.
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Excellent video. Great you found this. I spent years sleepless nights searching on internet
Thanks! There is a lot to learn how the human body works and functions.
Very interesting. Thank you for your work and sharing it with us.
Thanks, and you're welcome! Through this channel, you will always get validated knowledge, which I have used to improve the quality of life. Please take time to watch other vlogs as they are based on years of research, learning, and experience. I am certain you will gain a lot.
Excellent video. I know a bit about K2 and I take it myself. I was doing fine with 45 mcg. When I took 100 mcg, I experienced really bad insomnia.
Based on my reading, people who don't clear k2 fast and store it for longer, they are better of with mk4 form since the half life of mk4 is shorter than mk7.
APOE 3/4 people get lumped in with the majority 3/3. My doc will say “you’re normal” and I say I have to be better than normal. Sorry to say, I’m so glad your wife’s a 3/4 because I get to benefit from your research and knowledge❤ BTW, I have osteoporosis and was taking K2 every other day bc I heard “we” store it. Now it’ll be every day. Thank you!
That was my thinking in 2021 as well. But the scientific literature taught me something different. If someone is with one copy of allele 2, then mk7 will be enough with two days gap or mk4 daily is preferred. Since these folks clear very slowly. Remember, half life of mk4 is about 4 hours, and mk7 is 72 hours. It means mk7 remains in the system longer than mk4. For allele 3 and 4 folks, mk7 is not an issue, but I would be careful with allele 2 folks. That's why may be in Japan, they prescribe 45mg of k2-mk4 as a standard dose for osteoporosis treatment. This dose is spread in 15mg three times a day.
Thankyou for this,I am apoe4 and 2. I have anaemia which I've been taking k2 and D a few days a week as co factors to my iron. Should I be taking alot more than I am taking? Do I need less d? I'm feeling confused and you seem knowledgeable
Apoe 4 needs more and Apoe2 needs less. So, in 4/2 case it will be mixed demand as per the literature. There is no established dosage yet for k2. You may need to consult with your doctor for your case. Preferably a functional medicine doctor or naturopath doctor.
Could you make a video on your wife's osteoporosis protocol
I will do it when I discuss the tests for osteoporosis and why I don't like dexa scan test.
Mk7 gives heart paltipatons for me. I think it caused me resorption instead of making bones
Yes, some folks can get these symptoms, particularly those whose clearance is slow. They do better with mk4. Do you know your ApoE genotype?
I would like to read the paper you talk about but cannot find the reference in your description. Could you please post the reference?
The paper link (its second link) is provided in the description. It's a long paper, but look at the para under the title, importance of Vitamin k for Alzheimer's disease. It reads as
....This inverse relationship results from the fact that vitamin K in plasma is bound to chylomicrons and chylomicron remnants, which carry apolipoprotein E. Clearance of chylomicrons and their remnants from the circulation depends on ApoE’s binding to a hepatic receptor, and the rate at which this binding takes place is greatly influenced by ApoE genotype, occurring rapidly in people carrying one or two alleles for E4 and slowly in those whose genes encode E2. Thus, ApoE genotype significantly impacts blood levels of vitamin K, which are highest in E2, intermediate in E3 and lowest in E4.....
I hope it is clear to you now. Let me know.
@@KnowledgeforQOL Thank You, you are providing very useful information. That is important. There can be theory and hypothesis but what interests me is practical application and demonstrated results. Thank you again.
I just subscribed to your channel.
You're welcome! Please see the other vlogs also. Each and every vlog is very important and based on literature and application evidence. This is about my journey in improving the quality of life for me and my family. Now, I am sharing this knowledge to the wider community after validating it through application. Share and spread the knowledge with others for their better understanding and quality of lives.
What dose and type would you recommend for a 4/2?
I am sorry, I can't recommend anything to anyone. Please work with your doctor, particularly if you can find a functional doctor who would know about k2. There is no such thing as an established dose for vitamin k2 yet. Based on the literature, one would need more for allele 4 and less for allele 2, leading to mixed effects on vitamin k2 clearance.
Thank you for the important information. However, I don’t understand why you decided to take more Vitamin K2 MK7 daily if you have a normal range of it in your blood. My understanding was that your wife should take more of it as her APOE is different than yours and taking only 100mg doesn’t help her to get that vitamin in a normal and needed range in her blood. I am confused
Very valid question. I think you haven't seen my other video where I discussed my calcium score, which is atherosclerosis. I have been monitoring this since 2018, and it was 98, then it increased to 169 in 2021. This year, I stopped it completely by increasing the k2 and doing few other interventions which I discussed in other video. In essence people generally try to fix things by addressing only one thing as a silver bullet. But when it comes to heathcare it is a very complex matrix and depends on numerous variables. I take only 500 mcg k2-mk7 and eat natto 2 tbsp, which gives me another 300 mcg of k2-mk7 with enzyme Nattokianase. It helped me very well.
@@KnowledgeforQOL I doubt the so-called optimum range is even known for K2, and I don't believe the testing differentiates between the different mk forms.
Yes, I agree there is no normal or optimal range established yet. We are still learning more and more about this vitamin k2. Yes, you are correct. The test doesn't differentiate the form.
@@KnowledgeforQOLThank you for the answer. Glad to hear you are able to get better results by taking more Vitamin K2-MK7
I'm E2/3
Slow clearance for Apoe2 and typical clearance for Apoe3, resulting in mixed clearance as per the literature.
How much mk4 do you think is needed ? I get low calcium symptoms even with 100mcg where clinical doses are ,45 mg for osteoporosis
Consult with Endocrinologist to see what could be the underlying cause of lower serum calcium? It's not always k2. Just curious, what is your vitamin D level?
@@KnowledgeforQOL my vitamin D is 38, where normal range 30-100. I never had low calcium in my blood. The symptoms like heart paltipatons and insomnia only get better of i supplement calcium and magnesium and potassium and especially calcium supplements only help. May be i need really low k2 mk4
See my other research based vlogs on vitamin D. The optimum is around 60 ng/ml. We keep ours around 80 to 85 ng/ml. D is very crucial in calcium absorption, and it increases the calcium absorption by 20 folds. Besides that, we try to be in normal range for all the other nutrients and verify via tests. Remember, the human body is very complex, and it thrives on each and every vitamin, nutrient, and mineral. I try to cover some key concepts in each and every vlog. My approach to health is very holistic.
You need to know your geno/ metabolictype 😊
Yes, geno metabolictype would help in deciding the type of diet for metabolic health. Also, remember that APOE Genotype is also a carrier of cholesterol. So, the carrier of allele 4 may metabolize dietary cholesterol more than allele 2 folks.
@18:24
Can you please be specific about your comment? Thx
@@KnowledgeforQOL perhaps just a marker, so as to find a way back to a moment of interest in the video at a later point in time.
Thx.
@@y00t00b3r You are correct.