S1 Episode 3: Treating Rectal Cancer: PROSPECT, PRODIGE, or OPRA?

Join Drs Benjamin Schlechter and Harvey Mamon as they discuss treatment options for patients with stage II and III rectal cancer based on new data from the most recent clinical trial results.
Relevant disclosures can be found with the episode show notes on Medscape (www.medscape.c.... The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Colon Cancer emedicine.meds...
Colon Cancer Staging emedicine.meds...
Signal Transduction www.cancer.gov...
Preoperative Treatment of Locally Advanced Rectal Cancer pubmed.ncbi.nl...
Neoadjuvant Chemotherapy Without Routine Use of Radiation Therapy for Patients With Locally Advanced Rectal Cancer: A Pilot Trial pubmed.ncbi.nl...
FOLFOX Regimen www.cancer.gov...
Cancer Therapy Evaluation Program ctep.cancer.gov/
Common Terminology Criteria for Adverse Events (CTCAE) v5.0 ctep.cancer.go...
Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048) pubmed.ncbi.nl...
Abdominoperineal Resection www.ncbi.nlm.n...
The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer pubmed.ncbi.nl...
Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy pubmed.ncbi.nl...
Total Neoadjuvant Therapy (TNT) Versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis pubmed.ncbi.nl...
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation (JANUS) classic.clinic...
Factors Influencing Downstaging After Neoadjuvant Long-Course Chemoradiotherapy in Rectal Carcinoma pubmed.ncbi.nl...
Carcinoembryonic Antigen www.ncbi.nlm.n...
Short-Course Radiotherapy Followed by Chemotherapy Before Total Mesorectal Excision (TME) Versus Preoperative Chemoradiotherapy, TME, and Optional Adjuvant Chemotherapy in Locally Advanced Rectal Cancer (RAPIDO): A Randomised, Open-Label, Phase 3 Trial pubmed.ncbi.nl...
Neoadjuvant Chemotherapy With FOLFIRINOX and Preoperative Chemoradiotherapy for Patients With Locally Advanced Rectal Cancer (UNICANCER-PRODIGE 23): A Multicentre, Randomised, Open-Label, Phase 3 Trial pubmed.ncbi.nl...
FOLFIRINOX Regimen www.cancer.gov...
Locoregional Failure During and After Short-Course Radiotherapy Followed by Chemotherapy and Surgery Compared to Long-Course Chemoradiotherapy and Surgery - A Five-Year Follow-Up of the RAPIDO Trial pubmed.ncbi.nl...