I have a genetic mutation on gene ADPRHL2 . Please specify the complementary DNA of mutation : ADPRHL2 gene : (NM_017825.2) c.[14C>T];[14C>T] (p.[Ala5Val];[Ala5Val]) Many thanks. It helps for CRISPR .
I have a doubt mam... In 4.15 u have said that the lymphocytes are taken out from the patients... But they are immunodeficient(SCID) ... Then how come they have LYMPHOCYTES
@@ribinkilambu8845 u r missing the point here.. in order to extract lymphocytes.. one must contain na! Ab ADA hai hi nai so lymphocytes kaha se aayenge?
I think an improper gene would still produce marginal amounts of lymphocytes and they could be harvested. Because no individual can survive till 4 years of age without cell meditated immunity.
Mam my question is after the birth of child if we supply the lymphocytes with ADA Will it be a permanent cure to the problem.. or it is only possible in the fetal stage??
Arkaprava Bhattacharya look if we supply lymphocytes with zygote stage and it will go out next mitosis forms 2 cell which will contain lymphocytes then 4 which also will have lymphocytes then 8,16, 32,64.................... That is a complete foetus having lymphocytes will form so we don't have to give it to each and every cell it will automatically go in all cell by normal mitosis But If u do it in grown up stage then u have to give it to all cells of body ( which should have lymphocytes as major function) that is million cells so it is very difficult and it(lymphocytes) will finish very soon after doing their work but see in zygotic stage it will go to other cell by division it will also go in second case but the ratio is 100: 5(aur less) so it is easy and comfortable to apply it to zygotic stage
Arkaprava Bhattacharya this question is not for lymphocytes bcoz u can give it from. Outside but for other difficient substances which are needed in each and every cell are used for this
Visit www.neelabakoretutorials.in for a well planned road map to help students score 360 marks in NEET (Biology). Please let others know about it too !!
Hi Doc, My name is Jugal Kishore. I am 44 years old. I am suffering from muscular distrophy. I am on bed and can't walk at all. Is there any treatment possible with the help of Gene therapy. If yes, then how much are chances that i will be able to walk again on my own. Awaiting for your reply. Regards Jugal Kishore
thanq mam so much.. your video really helped in understanding many biological topics... mam i also want to understand fat metabolism.. so mam plz as soon as possible plz upload that video...
hello mam i have a question main home science (pg ) in arts students hun kya app energy content in food and its assimilation in the human body vdo karng
U have explained in v confined and simple way. Absolutely admirable.
We need teachers like you mam.
mam..we need ecology too...plz take it as a request..
Right
S exactly
aab kya karega leke 2 saal bad tk n aayi ecology too bta yrr teri bat kisine n suni
@@hannahanujakshi7397 saach bat h n
I have a genetic mutation on gene ADPRHL2 . Please specify the complementary DNA of mutation :
ADPRHL2 gene : (NM_017825.2) c.[14C>T];[14C>T] (p.[Ala5Val];[Ala5Val])
Many thanks. It helps for CRISPR .
Really admire your explanation, I have gone through your videos. TQ very much.
Hearty thanks mam for clearing my concept on gene therapy....😊
your explanation has helped me a lott..thank you ma'am
From where do we get the correct gene to replace the faulty one???
thankuuu mam.....it is very helpfull😊😊
too good lecture helped me a lot thank you!!!!
Mam what process was used to infuse the transformed lymphocytes to the patient
kindly add mechanism of gene therapy to it . how a gene is inserted into the cell how it becomes functional etc
It was nice clases mam.. Try to do more classes.. And thank you.. For a giving such a nice class..
ma'am ur lctures r relly very helpful. Thanks a lot....
very thankful
I have a doubt mam... In 4.15 u have said that the lymphocytes are taken out from the patients... But they are immunodeficient(SCID) ... Then how come they have LYMPHOCYTES
@meko thanks a lot
Thank you so much ma'am
Hats off to you mam 😀😀
Thanks alot mam....ur video is awesome and easily understood by me
Meet_ social_Motivater okj
U told that Without ADA B and T lymphocytes are not produced. How come ADA was induced in her lymphocytes??
Promud Das exactly ! I was wondering too
Lymphocyes was taken from.the patients and genetically engeneered with synthesized ADA Then again infused to the body.
@@ribinkilambu8845 u r missing the point here.. in order to extract lymphocytes.. one must contain na! Ab ADA hai hi nai so lymphocytes kaha se aayenge?
How🤔🤔
I think an improper gene would still produce marginal amounts of lymphocytes and they could be harvested. Because no individual can survive till 4 years of age without cell meditated immunity.
Excellent explanation madam plz make more videos.
Thanks mam for better explaining gene therapy
thanku so much mam.......for explaning all the topics in such a good way
thank you mam for the video you help me alot
Explaination is very brief didnt discuss gene replacement targeting and other topics
Thank you so much !!
Mam u r teaching is best ever
Queen of biology 🙏🙏
Mam my question is after the birth of child if we supply the lymphocytes with ADA Will it be a permanent cure to the problem.. or it is only possible in the fetal stage??
Arkaprava Bhattacharya .. according to ncert it can be permanently cured...at early embryonic stage....
Arkaprava Bhattacharya look if we supply lymphocytes with zygote stage and it will go out next mitosis forms 2 cell which will contain lymphocytes then 4 which also will have lymphocytes then 8,16, 32,64.................... That is a complete foetus having lymphocytes will form so we don't have to give it to each and every cell it will automatically go in all cell by normal mitosis
But
If u do it in grown up stage then u have to give it to all cells of body ( which should have lymphocytes as major function) that is million cells so it is very difficult and it(lymphocytes) will finish very soon after doing their work but see in zygotic stage it will go to other cell by division it will also go in second case but the ratio is 100: 5(aur less) so it is easy and comfortable to apply it to zygotic stage
Arkaprava Bhattacharya this question is not for lymphocytes bcoz u can give it from. Outside but for other difficient substances which are needed in each and every cell are used for this
NYC explanation mam thanks 4making us understand such topics.
Thank you so much mam😊😊😊
Thanks ma'am!! For this video
Thank you maam
Assalamualaikum mam
Mam plzz I will be very glad if u give us a lecture on recombinant DNA vaccine
Thnks alot Mam
Love u Mam 😇😇😇😇
thank u so much... madam ji
By which method we can recognize that the child is suffering from ADA deficiency
Flow cytometry....i think,, they do in niih kem hospital mumbai
Contact them, they can tell
Thanku so much ma'am
Thank you soo much
Visit www.neelabakoretutorials.in
for a well planned road map to help students score 360 marks in NEET (Biology). Please let others know about it too !!
Superb mam .. thnku so much
Hi Doc,
My name is Jugal Kishore. I am 44 years old. I am suffering from muscular distrophy. I am on bed and can't walk at all. Is there any treatment possible with the help of Gene therapy.
If yes, then how much are chances that i will be able to walk again on my own.
Awaiting for your reply.
Regards
Jugal Kishore
Jugalkishore Goyal you should better go to a real doctor
Nice way explanation
mam plz make video about dna vaccine
mam please explain RNA interference in detail
Exactly I also need this...
Vikram veer Verma 👍👍👍👍
Thanku mam. Please make a Vedio on cell signalling
What is the spelling of video dumbfuk
Mam from which city u r
Mam Wat was the source for the isolation of gene for ADA
from a cDNA library made from the lymphoblastoid cell line MOLT-4
You are rocking mam
Ma'am plz make a video on plant breeding steps
please do human health and disease mam
superb
Thanks mam ☺☺☺☺☺
Nice mam
Ecology please..
thanq mam so much.. your video really helped in understanding many biological topics... mam i also want to understand fat metabolism..
so mam plz as soon as possible plz upload that video...
Very good class maam
Are you teaching in some institution
thanks madam
mam..pllzzzz do a video on crisper cas⁹
i found hard to understand it and i can't understand it yet
hello mam i have a question main home science (pg ) in arts students hun kya app energy content in food and its assimilation in the human body vdo karng
Thank u so much my mentor
Why bone transplant not a permanent cure for this problem (states by Ncert)
Will ur mom give bone marrow??
Mam ecology ka pura topic upload kijiya
Gene therapy ka lecture kuch bhi smaj ni aaya
plz plz plz make all 11 and 12 lesson my all dout are clearing
mam the video and audio time dont match
you are great thank you from Azerbaijan )
Hi mam 😍
ecology
Now is that girl is alive???
Bs
👍👍👍👍👍
Tissue culture nots send me mam
For upsc👍🙏
😍😍😍😍
♥♥♥♥♥♥♥♥♥
mam please explain in hindi
Keep trying to play God and watch what happens.
Thank you so much ma'am
Thank you mam
Thank you mam