I had a seminar competition to present on this topic @ AIIMS MANGALAGIRI and I stood first just because of your amazing explanation... Thank You Ma'am!
ma'am the question that's confusing me since soo long is that on the one hand we say , the condition for Donnan eqlbm is electroneutrality on both sides and on other hand we are talking abt development of potential across membrane in the state of Donnan eqlbm ... how's this Even possible?
Also within one compartment there is electroneutrality : the sum of positive and negative charges in each compartment has to be the same. In between compartments there is very very little potential difference, with the opposite charges accumulating near the membrane
Ma’am in this case how is it that the sodium and chloride ion flow is stopped at the same potential, given that both of these ions have different nearnst potentials (i.e. the point at which elelctrical and concentration gradients are in equilibrium and ion flow is stopped)? Not just for these too ions but for any set of ions with different nearnst potentials
Very true...if only single ion is involved then Nernst equation gives the potential at which flow stops...if many ions are involved , we use Goldman Hodgkin Katz equation for calculation of the potential...this equation also takes into account the permeability if the membrane to the ions...
You are very perfect but I get confuse on how you made the calculation. How do protein electric back to 6 meanwhile it reduce to5 as a result of patssium move in to cell
Thank you very much 😍 A question please : in case of capillaries , the difference of ions distribution will generate an osmotic pressure , is that what we call oncotic pressure ??
No oncotic pressure is due to difference in protein concentration...interstitial space..almost no proteins since capillaries are not permeable to them. Iconic concentration almost equal on either side of capillaries except minor difference due to Gibbs Donnan effect
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❤❤❤🎉🎉🎉 One of best explanation ever
Thank you so much 😀
I had a seminar competition to present on this topic @ AIIMS MANGALAGIRI and I stood first just because of your amazing explanation... Thank You Ma'am!
Wow...really happy. I never imagined many ways in which the content may help students. Thankful to almighty and to all my students
Being a medical student I can say it was so clear and found really helpful
Glad you liked it and understood 😊😊
Thank you so much mam🙏
One of the best video for donnan effect👌🏻
Really glad. Thanks
Thanks for making us understand this topic in a short time frame.
My pleasure
When saw equation term in equilibrium, I shocked
But u explain it in v simple and in magnified way
Thank you mam 🙏☺️
So glad. Thanks and welcome...keep learning
Well explained, love and support from algeria 🇩🇿 🇮🇳 ❤️
Thank you. Thanks from India
Very well explained and crisp to the point
Thanks😊
The best explanation mam . Crystal clear ❤❤
Thank you 😊
Excellent explanation
Thanks 😊
Mam how is the electroneutalitiy is maitained after equilibrium in each compartments?
sum total of positive and negative ions (both diffusible and non-diffusible) is equal on each side
Thank you so much ma'am for crystal clear explanation 🙏
My pleasure as always
Why addition of protein do not contribute to concentration gradient change?
It doesn't contribute to concentration gradient change for ions..earn we talk about concentration we look at that particular substance only
Thankyou so much ma’am!❤
Most welcome
this is what I was looking for thanks mam !!! ❤
Always😊
excellent explaination, thank you so much
Thankyou...glad you found it good
ma'am the question that's confusing me since soo long is that on the one hand we say , the condition for Donnan eqlbm is electroneutrality on both sides and on other hand we are talking abt development of potential across membrane in the state of Donnan eqlbm ... how's this Even possible?
The difference in ions is very very minute and just besides the cell wall (membrane acts as a capacitor).
@@PhysiologyOpen sorry ma'am but can you please give me an intuition ...like a bit elaborative . I didn't get what you mean by capacitor thing
Also within one compartment there is electroneutrality : the sum of positive and negative charges in each compartment has to be the same.
In between compartments there is very very little potential difference, with the opposite charges accumulating near the membrane
@@PhysiologyOpen ohh now it's clear . Thankyou so much ma'am
It was great, thank you 🙏
😊❤️
Nice explanation
Glad it helped
Understood well❤️
Glad 😊
Ma’am in this case how is it that the sodium and chloride ion flow is stopped at the same potential, given that both of these ions have different nearnst potentials (i.e. the point at which elelctrical and concentration gradients are in equilibrium and ion flow is stopped)?
Not just for these too ions but for any set of ions with different nearnst potentials
Very true...if only single ion is involved then Nernst equation gives the potential at which flow stops...if many ions are involved , we use Goldman Hodgkin Katz equation for calculation of the potential...this equation also takes into account the permeability if the membrane to the ions...
@@PhysiologyOpen thank you ma’am
Can you pl. make video on propogation of action potential in nerve ?
Will do that...currently started work on vision physiology...
You are very perfect but I get confuse on how you made the calculation. How do protein electric back to 6 meanwhile it reduce to5 as a result of patssium move in to cell
Positive ion will reduce negativity
Thank you very much 😍
A question please : in case of capillaries , the difference of ions distribution will generate an osmotic pressure , is that what we call oncotic pressure ??
No oncotic pressure is due to difference in protein concentration...interstitial space..almost no proteins since capillaries are not permeable to them. Iconic concentration almost equal on either side of capillaries except minor difference due to Gibbs Donnan effect
Nice explanation madam
Thank you so much 🙂
thanks mam 😊
😊
can you explain change in electrical gradient for potassium ? how it becomes 4, so many times i have seen video still not understand.
See the change in net charge on both sides...substract the new net charge on each side...to get net charge responsible for electrical gradient
Great explanation🫡🫡😃👍
Thank you 😊❤️
Best
Thank youuuuuu
hello madam, I am desperately waiting form video on propogation of action potential in nerve
Next week release
On your demand. Hope you like this one: ruclips.net/video/--U1mJIMUCI/видео.html
@@PhysiologyOpen I liked and I fully understand the concept, thank you so much..🙏🙏
@@PhysiologyOpen can you please explain physiology of immunisation
Have other videos pending...will do but in some time
are Hindi mein bhi lecture diya karo yaar samajh nahin aata ham desi hai na
Will try
First viewer
Thank you !